Durvet IVERMECTIN POUR-ON (ivermectin topical solution) for Cattle

Contains 5 mg ivermectin/mL

Parasiticide

Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.

Ivermectin Pour-On (ivermectin topical solution) delivers internal and external parasite control in one convenient low-volume application. Ivermectin Pour-On (ivermectin topical solution) contains ivermectin, a unique chemical entity.

Ivermectin is a member of the macrocylic lactone class of endectocides which have a unique mode of action. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells.

This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligand -gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).

The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels, the macrocylic lactones have a low affinity for other mammalian ligand-gated chloride channels and they do not readily cross the blood-brain barrier.

Ivermectin Pour-On (ivermectin topical solution) applied at the recommended dose level of 500 mcg/kg is indicated for the effective control of these parasites.

Gastrointestinal Roundworms

Mites

Sarcoptes scabiei var. bovis

Lice

Linognathus vituli

Haematopinus eurysternus

Damalinia bovis

Solenopotes capillatus

Horn Flies

Haematobia irritans

Ivermectin Pour-On (ivermectin topical solution) has been proved to effectively control infections and to protect cattle from re-infection with: Oesophagostomum radiatum and Dictyocaulus viviparus for 28 days after treatment; Cooperia punctata and Trichostrongylus axei for 21 days after treatment; Ostertagia ostertagi, Haemonchus placei, Cooperia oncophora and Cooperia surnabada for 14 days after treatment; Damalinia bovis for 56 days after treatment.

Ivermectin Pour-On (ivermectin topical solution) controls horn flies (Haematobia irritans) for up to 28 days after dosing. For best results Ivermectin Pour-On should be part of a parasite control program for both internal and external parasites based on the epidemiology of these parasites. Consult your veterinarian or an entomologist for the most effective timing of applications.

The dose rate is 1 mL for each 22 lb of body weight. The formulation should be applied along the topline in a narrow strip extending from the withers to the tailhead.

Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance.

Studies conducted in the U.S.A. have demonstrated the safety margin for ivermectin. Based on plasma levels, the topically applied formulation is expected to be at least as well tolerated by breeding animals as is the subcutaneous formulation which had no effect on breeding performance.

NOT FOR USE IN HUMANS

Keep this and all drugs out of the reach of children.

The Safety Data Sheet (SDS) contains more detailed occupational safety Information. To report suspected adverse drug events, for technical assistance or to obtain a copy of the SDS, contact Norbrook at 1-866-591-5777. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at www.fda.gov/reportanimalae.

WARNING! FLAMMABLE!

KEEP AWAY FROM HEAT, SPARKS, OPEN FLAME, AND OTHER SOURCES OF IGNITION.

This product should not be applied to self or others because it may be irritating to human skin and eyes and absorbed through the skin. To minimize accidental skin contact, the user should wear a long-sleeved shirt and rubber gloves. If accidental skin contact occurs, wash immediately with soap and water. If accidental eye exposure occurs, flush eyes immediately with water and seek medical attention.

• Store at or below 25°C (77°F), excursions permitted up to 40°C (104°F). Protect from light.
• Use only in well-ventilated areas or outdoors.
• Close container tightly when not in use.
• Cattle should not be treated when hair or hide is wet since reduced efficacy may be experienced.
• Do not use when rain is expected to wet cattle within six hours after treatment.
• This product is for application to skin surface only. Do not give orally or parenterally.
• Cloudiness in the formulation may occur when Ivermectin Pour-On is stored at temperatures below 32° F. Allowing it to warm at room temperature will restore the normal appearance without affecting efficacy.
• Antiparasitic activity of ivermectin will be impaired if the formulation is applied to areas of the skin with mange scabs or lesions, or with dermatoses or adherent materials, e.g. caked mud or manure.
• Ivermectin has been associated with adverse reactions in sensitive dogs; therefore, Ivermectin Pour-On (ivermectin topical solution) is not recommended for use in species other than cattle.

Parasite resistance may develop to any dewormer, and has been reported for most classes of dewormers.

Treatment with a dewormer used in conjunction with parasite management practices appropriate to the geographic area and the animal(s) to be treated may slow the development of parasite resistance.

Fecal examinations or other diagnostic tests and parasite management history should be used to determine if the product is appropriate for the herd/flock, prior to the use of any dewormer. Following the use of any dewormer, effectiveness of treatment should be monitored (for example, with the use of a fecal egg count reduction test or another appropriate method).

A decrease in a drug's effectiveness over time as calculated by fecal egg count reduction tests may indicate the development of resistance to the dewormer administered. Your parasite management plan should be adjusted accordingly based on regular monitoring.

Ivermectin Pour-On (ivermectin topical solution) is available in a 33.8 fl oz/1L bottle with a measure-squeeze-pour-system or in an 84.5 fl oz/2.5 L or 169 oz/5 L collapsible pack, or 676 fl oz/20 L container intended for use with appropriate automatic dosing equipment.

Restricted Drug - California. Use Only as Directed.

Approved by FDA under ANADA # 200-272

Manufactured for:
DURVET, INC.
Blue Springs, Missouri 64014

www.durvet.com

Rev. 03/20 009215I04

durvet

IVERMECTIN POUR-ON

(ivermectin topical solution)
for Cattle

Contains 5 mg ivermectin/mL

Parasiticide

Kills: Roundworms (including Brown Stomach Worm),
Lungworms, Grubs, Sucking Lice, Biting Lice, Mange Mites,
Horn Flies.

Contains 200 - 550 lb doses

Approved by FDA under ANADA # 200-272

169 fl oz (5 L)

durvet

IVERMECTIN POUR-ON

(ivermectin topical solution)
for Cattle

Contains 5 mg ivermectin/mL

Parasiticide

Kills:

Roundworms, (including Brown Stomach Worm), Lungworms, Grubs,
Sucking Lice, Biting Lice, Mange Mites, Horn Flies.

Manufactured for:

DURVET, INC.

Blue Springs, Missouri 64014

www.durvet.com

Approved by FDA under ANADA # 200-272

169 fl oz (5 L)