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warnings
WARNINGS Neostigmine Methylsulfate Injection should be used with caution in patients with epilepsy, bronchial asthma, bradycardia, recent coronary occlusion, vagotonia, hyperthyroidism, cardiac arrhythmias or peptic ulcer. When large doses of Neostigmine Methylsulfate Injection are administered, the prior or simultaneous injection of atropine sulfate may be advisable. Separate syringes should be used for the neostigmine methylsulfate and atropine. Because of the possibility of hypersensitivity in an occasional patient, atropine and antishock medication should always be readily available.
ADVERSE REACTIONS Side effects are generally due to an exaggeration of pharmacological effects of which salivation and fasciculation are the most common. Bowel cramps and diarrhea may also occur. The following additional adverse reactions have been reported following the use of either neostigmine bromide or neostigmine methysulfate. Allergic Allergic reactions and anaphylaxis. Neurologic Dizziness, convulsions, loss of consciousness, drowsiness, headache, dysarthria, miosis and visual changes. Cardiovascular Cardiac arrhythmias (including bradycardia, tachycardia, atrioventricular block and nodal rhythm) and nonspecific electrocardiogram changes have been reported, as well as cardiac arrest, syncope and hypotension. These have been predominantly noted following the use of the injectable form of neostigmine methylsulfate. Respiratory Increased oral, pharyngeal and bronchial secretions, dyspnea, respiratory depression, respiratory arrest and bronchospasm. Dermatologic Rash and urticaria. Gastrointestinal Nausea, emesis, flatulence and increased peristalsis. Genitourinary Urinary frequency. Musculoskeletal Muscle cramps and spasm, arthralgia. Miscellaneous Diaphoresis, flushing and weakness.
adverse reactions
Allergic Allergic reactions and anaphylaxis.
adverse reactions
Neurologic Dizziness, convulsions, loss of consciousness, drowsiness, headache, dysarthria, miosis and visual changes.
adverse reactions
Cardiovascular Cardiac arrhythmias (including bradycardia, tachycardia, atrioventricular block and nodal rhythm) and nonspecific electrocardiogram changes have been reported, as well as cardiac arrest, syncope and hypotension. These have been predominantly noted following the use of the injectable form of neostigmine methylsulfate.