ADVERSE REACTIONS Cardiovascular Effects. Tachycardia, arrhythmias and hypertension have been reported with ocular administration of epinephrine. Local Effects. The most frequent side effects reported with PROPINE ® alone were injection in 6.5% of patients and burning and stinging in 6%. Follicular conjunctivitis, eye pain, mydriasis, blurry vision, eye pruritus, headache and allergic reaction to PROPINE ® ophthalmic solution have been reported. Epinephrine therapy can lead to adrenochrome deposits in the conjunctiva and cornea.