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warnings
WARNINGS Extreme caution should be exercised in treating patients with a history of mental depression. Reserpine may cause mental depression. Recognition of depression may be difficult because this condition may often be disguised by somatic complaints (Masked Depression). The drug should be discontinued at first signs of depression such as despondency, early morning insomnia, loss of appetite, impotence, or self-deprecation. Drug-induced depression may persist for several months after drug withdrawal and may be severe enough to result in suicide.
ADVERSE REACTIONS The following adverse reactions have been observed with rauwolfia preparations, but there has not been enough systematic collection of data to support an estimate of their frequency. Consequently the reactions are categorized by organ system and are listed in decreasing order of severity and not frequency. Digestive Vomiting, diarrhea, nausea, anorexia, dryness of mouth, hypersecretion. Cardiovascular Arrhythmias (particularly when used concurrently with digitalis or quinidine), syncope, angina-like symptoms, bradycardia, edema. Respiratory Dyspnea, epistaxis, nasal congestion. Neurologic Rare parkinsonian syndrome and other extrapyramidal tract symptoms; dizziness; headache; paradoxical anxiety; depression; nervousness; nightmares; dull sensorium; drowsiness. Musculoskeletal Muscular aches. Genitourinary Pseudolactation, impotence, dysuria, gynecomastia, decreased libido, breast engorgement. Metabolic Weight gain. Special Senses Deafness, optic atrophy, glaucoma, uveitis, conjunctival injection. Hypersensitive Reactions Purpura, rash, pruritus.