ADVERSE REACTIONS The local adverse reactions reported with Augmented Betamethasone Dipropionate Ointment applied either once or twice a day during clinical studies are as follows: erythema, 3 per 767 patients; folliculitis, 2 per 767 patients; pruritus, 2 per 767 patients; vesiculation, 1 per 767 patients. The following local adverse reactions are reported infrequently when topical corticosteroids are used as recommended. These reactions are listed in an approximate decreasing order of occurrence: burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, miliaria. Systemic absorption of topical corticosteroids has produced reversible HPA axis suppression, manifestations of Cushing's syndrome, hyperglycemia, and glucosuria in some patients.