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warnings
WARNINGS This drug should not be used in patients with vascular disease, especially disease of the coronary arteries, except with extreme caution. In such patients, even small doses may precipitate anginal pain, and with larger doses, the possibility of myocardial infarction should be considered. Vasopressin may produce water intoxication. The early signs of drowsiness, listlessness and headaches should be recognized to prevent terminal coma and convulsions.
ADVERSE REACTIONS Local or systemic allergic reactions may occur in hypersensitive individuals. The following side effects have been reported following the administration of vasopressin: Body as a Whole Anaphylaxis (cardiac arrest and/or shock) has been observed shortly after injection of vasopressin. Cardiovascular Cardiac arrest, circumoral pallor, arrhythmias, decreased cardiac output, angina, myocardial ischemia, peripheral vasoconstriction, and gangrene. Gastrointestinal Abdominal cramps, nausea, vomiting, passage of gas. Nervous System Tremor, vertigo, ‘‘pounding’’ in head. Respiratory Bronchial constriction. Skin and Appendages Sweating, urticaria, cutaneous gangrene. Overdosage Water intoxication may be treated with water restriction and temporary withdrawal of vasopressin until polyuria occurs. Severe water intoxication may require osmotic diuresis with mannitol, hypertonic dextrose, or urea alone or with furosemide.
adverse reactions
Body as a Whole Anaphylaxis (cardiac arrest and/or shock) has been observed shortly after injection of vasopressin.