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warnings
WARNINGS Priscoline stimulates gastric secretion and may activate stress ulcers. Through this mechanism, it can produce significant hypochloremic alkalosis. Pretreatment of infants with antacids may prevent gastrointestinal bleeding. Patients should be observed closely for signs of systemic hypotension, and supportive therapy should be instituted if needed. In patients with mitral stenosis, parenterally administered Priscoline may produce a rise or fall in pulmonary artery pressure and total pulmonary resistance; therefore, it must be used with caution in patients with known or suspected mitral stenosis.
ADVERSE REACTIONS The following adverse reactions have been observed, but there are insufficient data to support an estimate of their frequency: Cardiovascular : Hypotension, tachycardia, cardiac arrhythmias, hypertension, pulmonary hemorrhage. Digestive and Hepatic : Gastrointestinal hemorrhage, nausea, vomiting, diarrhea, hepatitis. Skin : Flushing, increased pilomotor activity with tingling or chilliness, rash. Hematologic : Thrombocytopenia, leukopenia. Renal : Edema, oliguria, hematuria.