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warnings
WARNINGS WARNINGSRespiratory Depression:At high doses or in sensitive patients, hydrocodone may produce dose-related respiratory depression by acting directly on the brainstem respiratory center. Hydrocodone also affects the center that controls respiratory rhythm, and may produce irregular and periodicbreathing.Head Injury and Increased Intracranial Pressure:The respiratory depressant effects of narcotics and their capacity to elevate cerebrospinal fluid pressure may be markedly exaggeratedin the presence of head injury, other intracranial lesions or a pre-existing increase in intracranial pressure. Furthermore, narcoticsproduce
ADVERSE REACTIONS adverse reactions which may obscure the clinical course of patients with head injuries.Acute Abdominal Conditions:The administration of narcotics may obscure the diagnosis or clinical course of patients with acute abdominal conditions.