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warnings
WARNINGS Atropine is a highly potent drug and due care is essential to avoid overdosage, especially with intravenous administration. Pediatric populations are more susceptible than adults to the toxic effects of anticholinergic agents. Atropine I.V. decreased the rate of mexiletine absorption without altering the relative oral bioavailability; this delay in mexiletine absorption was reversed by the combination of atropine and intravenous metoclopramide during pretreatment for anesthesia. Atropine is not removed by dialysis. This drug is effective in very low dosage and overdose may cause permanent damage or death, especially in children. This product contains Benzyl Alcohol which has been associated with a fatal gasping syndrome in infants and neonates.
ADVERSE REACTIONS Individual tolerance varies greatly, but these systemic doses are likely to produce the following effects: 0.5 mg - Slight dryness of nose and mouth, bradycardia. 1 mg - Greater dryness of nose and mouth, with thirst; slowing, then acceleration of heart; slight mydriasis. 2 mg - Very dry mouth, tachycardia, with palpitation, mydriasis, slight blurring of near vision. 5 mg - Increase in the above symptoms plus disturbance of speech, difficulty in swallowing, headache, hot, dry skin, restlessness with asthenia. 10 mg and over - Above symptoms to extreme degree, plus ataxia, excitement, disorentation, hallucinations, delirium and coma. 65 mg - May be fatal. A scarlatiniform rash may occur. Atropine may produce fever, particularly in children, through inhibition of heat loss by evaporation. Although large doses of atropine may cause an alarming condition, recovery is usual.
adverse reactions table
<table><colgroup><col/><col/></colgroup><tbody><tr><td> 0.5 mg -</td><td> Slight dryness of nose and mouth, bradycardia.</td></tr><tr><td> 1 mg -</td><td> Greater dryness of nose and mouth, with thirst; slowing, then acceleration of heart; slight mydriasis.</td></tr><tr><td> 2 mg -</td><td> Very dry mouth, tachycardia, with palpitation, mydriasis, slight blurring of near vision.</td></tr><tr><td> 5 mg -</td><td> Increase in the above symptoms plus disturbance of speech, difficulty in swallowing, headache, hot, dry skin, restlessness with asthenia.</td></tr><tr><td> 10 mg and over -</td><td> Above symptoms to extreme degree, plus ataxia, excitement, disorentation, hallucinations, delirium and coma.</td></tr><tr><td> 65 mg -</td><td> May be fatal.</td></tr></tbody></table>