Home NDC 0006-3862 EMEND
Product NDC 0006-3862
11-digit product format 000063862
Labeler code 0006
Product ID 0006-3862_428f7828-6d1c-438b-a17d-b4af0700c740
Type HUMAN PRESCRIPTION DRUG
Nonproprietary name aprepitant
Dosage form KIT
Labeler Merck Sharp & Dohme LLC
Application NDA021549
Marketing category NDA
Marketing start 2003-03-26
NDC exclude flag No
Listing certified through 2026-12-31
Current FDA listing Yes Source provenance: Browse the complete Orange Book source catalog · source snapshot 42 .
Orange Book products# Current product rows page 1 of 1 · 3 matching rows.
Application-product, Trade name, Ingredient table Application-product Trade name Ingredient Strength Dosage form / route TE codes RLD / RS Approval date N021549-001 EMEND APREPITANT 80MG CAPSULE / ORAL AB RLD 2003-03-26 N021549-002 EMEND APREPITANT 125MG CAPSULE / ORAL AB RLD, RS 2003-03-26 N021549-003 EMEND APREPITANT 40MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** CAPSULE / ORAL RLD 2006-06-30
Therapeutic equivalence codes# Current TE-code rows page 1 of 1 · 2 matching rows.
Orange Book patents# Current patent rows page 1 of 1 · 6 matching rows.
Application-product, Patent, Expiration table Application-product Patent Expiration Use code Coverage / status Submission date N021549-001 8258132 2027-09-26 U-1743 Drug product 2012-09-27 N021549-001 8258132 2027-09-26 U-901 Drug product 2012-09-27 N021549-002 8258132 2027-09-26 U-1743 Drug product N021549-002 8258132 2027-09-26 U-901 Drug product N021549-003 8258132 2027-09-26 U-1743 Drug product N021549-003 8258132 2027-09-26 U-901 Drug product
Observed Orange Book product history# Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.
Product history page 1 of 4 · 126 observed states.
Captured, Edition, Application-product table Captured Edition Application-product Trade name Strength Dosage form / route Product TE source text RLD / RS Approval date Source SHA-256 2026-08-18 06:07:40 2026-07 N021549-001 EMEND 80MG CAPSULE / ORAL AB RLD 2003-03-26 caaa826d4ba7…2026-08-18 06:07:40 2026-07 N021549-002 EMEND 125MG CAPSULE / ORAL AB RLD, RS 2003-03-26 caaa826d4ba7…2026-08-18 06:07:40 2026-07 N021549-003 EMEND 40MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** CAPSULE / ORAL RLD 2006-06-30 caaa826d4ba7…2026-02-19 14:30 UTC 2026-02 N021549-001 EMEND 80MG CAPSULE / ORAL AB RLD 2003-03-26 011fe1cb6892…2026-02-19 14:30 UTC 2026-02 N021549-002 EMEND 125MG CAPSULE / ORAL AB RLD, RS 2003-03-26 011fe1cb6892…2026-02-19 14:30 UTC 2026-02 N021549-003 EMEND 40MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** CAPSULE / ORAL RLD 2006-06-30 011fe1cb6892…2025-12-14 10:44 UTC · 2 captures of this ZIP 2025-12 N021549-001 EMEND 80MG CAPSULE / ORAL AB RLD 2003-03-26 31067a03dcf5…2025-12-14 10:44 UTC · 2 captures of this ZIP 2025-12 N021549-002 EMEND 125MG CAPSULE / ORAL AB RLD, RS 2003-03-26 31067a03dcf5…2025-12-14 10:44 UTC · 2 captures of this ZIP 2025-12 N021549-003 EMEND 40MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** CAPSULE / ORAL RLD 2006-06-30 31067a03dcf5…2025-08-23 18:47 UTC 2025-08 N021549-001 EMEND 80MG CAPSULE / ORAL AB RLD 2003-03-26 6a471c1ec25d…2025-08-23 18:47 UTC 2025-08 N021549-002 EMEND 125MG CAPSULE / ORAL AB RLD, RS 2003-03-26 6a471c1ec25d…2025-08-23 18:47 UTC 2025-08 N021549-003 EMEND 40MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** CAPSULE / ORAL RLD 2006-06-30 6a471c1ec25d…2025-03-22 03:13 UTC · 3 captures of this ZIP 2025-03 N021549-001 EMEND 80MG CAPSULE / ORAL AB RLD 2003-03-26 fd3edfee7708…2025-03-22 03:13 UTC · 3 captures of this ZIP 2025-03 N021549-002 EMEND 125MG CAPSULE / ORAL AB RLD, RS 2003-03-26 fd3edfee7708…2025-03-22 03:13 UTC · 3 captures of this ZIP 2025-03 N021549-003 EMEND 40MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** CAPSULE / ORAL RLD 2006-06-30 fd3edfee7708…2025-02-26 10:13 UTC · 3 captures of this ZIP 2025-02 N021549-001 EMEND 80MG CAPSULE / ORAL AB RLD 2003-03-26 b8a1b40f171c…2025-02-26 10:13 UTC · 3 captures of this ZIP 2025-02 N021549-002 EMEND 125MG CAPSULE / ORAL AB RLD, RS 2003-03-26 b8a1b40f171c…2025-02-26 10:13 UTC · 3 captures of this ZIP 2025-02 N021549-003 EMEND 40MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** CAPSULE / ORAL RLD 2006-06-30 b8a1b40f171c…2025-01-19 17:59 UTC · 7 captures of this ZIP 2025-01 N021549-001 EMEND 80MG CAPSULE / ORAL AB RLD 2003-03-26 03ed91905a0d…2025-01-19 17:59 UTC · 7 captures of this ZIP 2025-01 N021549-002 EMEND 125MG CAPSULE / ORAL AB RLD, RS 2003-03-26 03ed91905a0d…2025-01-19 17:59 UTC · 7 captures of this ZIP 2025-01 N021549-003 EMEND 40MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** CAPSULE / ORAL RLD 2006-06-30 03ed91905a0d…2024-12-13 21:23 UTC · 2 captures of this ZIP 2024-12 N021549-001 EMEND 80MG CAPSULE / ORAL AB RLD 2003-03-26 2680178bc6a6…2024-12-13 21:23 UTC · 2 captures of this ZIP 2024-12 N021549-002 EMEND 125MG CAPSULE / ORAL AB RLD, RS 2003-03-26 2680178bc6a6…2024-12-13 21:23 UTC · 2 captures of this ZIP 2024-12 N021549-003 EMEND 40MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** CAPSULE / ORAL RLD 2006-06-30 2680178bc6a6…2024-09-14 05:58 UTC · 2 captures of this ZIP 2024-09 N021549-001 EMEND 80MG CAPSULE / ORAL AB RLD 2003-03-26 5bbf6a4d5a75…2024-09-14 05:58 UTC · 2 captures of this ZIP 2024-09 N021549-002 EMEND 125MG CAPSULE / ORAL AB RLD, RS 2003-03-26 5bbf6a4d5a75…2024-09-14 05:58 UTC · 2 captures of this ZIP 2024-09 N021549-003 EMEND 40MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** CAPSULE / ORAL RLD 2006-06-30 5bbf6a4d5a75…2024-11-08 22:44 UTC · 3 captures of this ZIP 2024-11 N021549-001 EMEND 80MG CAPSULE / ORAL AB RLD 2003-03-26 d8e5a09893c0…2024-11-08 22:44 UTC · 3 captures of this ZIP 2024-11 N021549-002 EMEND 125MG CAPSULE / ORAL AB RLD, RS 2003-03-26 d8e5a09893c0…2024-11-08 22:44 UTC · 3 captures of this ZIP 2024-11 N021549-003 EMEND 40MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** CAPSULE / ORAL RLD 2006-06-30 d8e5a09893c0…2024-10-29 15:01 UTC 2024-10 N021549-001 EMEND 80MG CAPSULE / ORAL AB RLD 2003-03-26 d06236e962d9…2024-10-29 15:01 UTC 2024-10 N021549-002 EMEND 125MG CAPSULE / ORAL AB RLD, RS 2003-03-26 d06236e962d9…2024-10-29 15:01 UTC 2024-10 N021549-003 EMEND 40MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** CAPSULE / ORAL RLD 2006-06-30 d06236e962d9…2024-08-13 05:28 UTC · 3 captures of this ZIP 2024-08 N021549-001 EMEND 80MG CAPSULE / ORAL AB RLD 2003-03-26 79d66fd596c7…2024-08-13 05:28 UTC · 3 captures of this ZIP 2024-08 N021549-002 EMEND 125MG CAPSULE / ORAL AB RLD, RS 2003-03-26 79d66fd596c7…2024-08-13 05:28 UTC · 3 captures of this ZIP 2024-08 N021549-003 EMEND 40MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** CAPSULE / ORAL RLD 2006-06-30 79d66fd596c7…2024-07-13 05:37 UTC · 2 captures of this ZIP 2024-07 N021549-001 EMEND 80MG CAPSULE / ORAL AB RLD 2003-03-26 301d65b070ca…2024-07-13 05:37 UTC · 2 captures of this ZIP 2024-07 N021549-002 EMEND 125MG CAPSULE / ORAL AB RLD, RS 2003-03-26 301d65b070ca…2024-07-13 05:37 UTC · 2 captures of this ZIP 2024-07 N021549-003 EMEND 40MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** CAPSULE / ORAL RLD 2006-06-30 301d65b070ca…2024-06-18 03:08 UTC · 5 captures of this ZIP 2024-06 N021549-001 EMEND 80MG CAPSULE / ORAL AB RLD 2003-03-26 1e350fbaab3a…
Observed Orange Book normalized TE history# Normalized TE history page 1 of 3 · 86 observed states.
Observed Orange Book patent history# Patent history page 1 of 7 · 252 observed states.
Captured, Edition, Application-product table Captured Edition Application-product Patent Expiration Use code Coverage / status Submission date Source SHA-256 2026-08-18 06:07:40 2026-07 N021549-001 8258132 2027-09-26 U-1743 Drug product 2012-09-27 caaa826d4ba7…2026-08-18 06:07:40 2026-07 N021549-001 8258132 2027-09-26 U-901 Drug product 2012-09-27 caaa826d4ba7…2026-08-18 06:07:40 2026-07 N021549-002 8258132 2027-09-26 U-901 Drug product caaa826d4ba7…2026-08-18 06:07:40 2026-07 N021549-002 8258132 2027-09-26 U-1743 Drug product caaa826d4ba7…2026-08-18 06:07:40 2026-07 N021549-003 8258132 2027-09-26 U-901 Drug product caaa826d4ba7…2026-08-18 06:07:40 2026-07 N021549-003 8258132 2027-09-26 U-1743 Drug product caaa826d4ba7…2026-02-19 14:30 UTC 2026-02 N021549-001 8258132 2027-09-26 U-1743 Drug product 2012-09-27 011fe1cb6892…2026-02-19 14:30 UTC 2026-02 N021549-001 8258132 2027-09-26 U-901 Drug product 2012-09-27 011fe1cb6892…2026-02-19 14:30 UTC 2026-02 N021549-002 8258132 2027-09-26 U-901 Drug product 011fe1cb6892…2026-02-19 14:30 UTC 2026-02 N021549-002 8258132 2027-09-26 U-1743 Drug product 011fe1cb6892…2026-02-19 14:30 UTC 2026-02 N021549-003 8258132 2027-09-26 U-901 Drug product 011fe1cb6892…2026-02-19 14:30 UTC 2026-02 N021549-003 8258132 2027-09-26 U-1743 Drug product 011fe1cb6892…2025-12-14 10:44 UTC · 2 captures of this ZIP 2025-12 N021549-001 8258132 2027-09-26 U-1743 Drug product 2012-09-27 31067a03dcf5…2025-12-14 10:44 UTC · 2 captures of this ZIP 2025-12 N021549-001 8258132 2027-09-26 U-901 Drug product 2012-09-27 31067a03dcf5…2025-12-14 10:44 UTC · 2 captures of this ZIP 2025-12 N021549-002 8258132 2027-09-26 U-901 Drug product 31067a03dcf5…2025-12-14 10:44 UTC · 2 captures of this ZIP 2025-12 N021549-002 8258132 2027-09-26 U-1743 Drug product 31067a03dcf5…2025-12-14 10:44 UTC · 2 captures of this ZIP 2025-12 N021549-003 8258132 2027-09-26 U-901 Drug product 31067a03dcf5…2025-12-14 10:44 UTC · 2 captures of this ZIP 2025-12 N021549-003 8258132 2027-09-26 U-1743 Drug product 31067a03dcf5…2025-08-23 18:47 UTC 2025-08 N021549-001 8258132 2027-09-26 U-1743 Drug product 2012-09-27 6a471c1ec25d…2025-08-23 18:47 UTC 2025-08 N021549-001 8258132 2027-09-26 U-901 Drug product 2012-09-27 6a471c1ec25d…2025-08-23 18:47 UTC 2025-08 N021549-002 8258132 2027-09-26 U-901 Drug product 6a471c1ec25d…2025-08-23 18:47 UTC 2025-08 N021549-002 8258132 2027-09-26 U-1743 Drug product 6a471c1ec25d…2025-08-23 18:47 UTC 2025-08 N021549-003 8258132 2027-09-26 U-901 Drug product 6a471c1ec25d…2025-08-23 18:47 UTC 2025-08 N021549-003 8258132 2027-09-26 U-1743 Drug product 6a471c1ec25d…2025-03-22 03:13 UTC · 3 captures of this ZIP 2025-03 N021549-001 8258132 2027-09-26 U-1743 Drug product 2012-09-27 fd3edfee7708…2025-03-22 03:13 UTC · 3 captures of this ZIP 2025-03 N021549-001 8258132 2027-09-26 U-901 Drug product 2012-09-27 fd3edfee7708…2025-03-22 03:13 UTC · 3 captures of this ZIP 2025-03 N021549-002 8258132 2027-09-26 U-901 Drug product fd3edfee7708…2025-03-22 03:13 UTC · 3 captures of this ZIP 2025-03 N021549-002 8258132 2027-09-26 U-1743 Drug product fd3edfee7708…2025-03-22 03:13 UTC · 3 captures of this ZIP 2025-03 N021549-003 8258132 2027-09-26 U-901 Drug product fd3edfee7708…2025-03-22 03:13 UTC · 3 captures of this ZIP 2025-03 N021549-003 8258132 2027-09-26 U-1743 Drug product fd3edfee7708…2025-02-26 10:13 UTC · 3 captures of this ZIP 2025-02 N021549-001 8258132 2027-09-26 U-1743 Drug product 2012-09-27 b8a1b40f171c…2025-02-26 10:13 UTC · 3 captures of this ZIP 2025-02 N021549-001 8258132 2027-09-26 U-901 Drug product 2012-09-27 b8a1b40f171c…2025-02-26 10:13 UTC · 3 captures of this ZIP 2025-02 N021549-002 8258132 2027-09-26 U-901 Drug product b8a1b40f171c…2025-02-26 10:13 UTC · 3 captures of this ZIP 2025-02 N021549-002 8258132 2027-09-26 U-1743 Drug product b8a1b40f171c…2025-02-26 10:13 UTC · 3 captures of this ZIP 2025-02 N021549-003 8258132 2027-09-26 U-901 Drug product b8a1b40f171c…2025-02-26 10:13 UTC · 3 captures of this ZIP 2025-02 N021549-003 8258132 2027-09-26 U-1743 Drug product b8a1b40f171c…2025-01-19 17:59 UTC · 7 captures of this ZIP 2025-01 N021549-001 8258132 2027-09-26 U-1743 Drug product 2012-09-27 03ed91905a0d…2025-01-19 17:59 UTC · 7 captures of this ZIP 2025-01 N021549-001 8258132 2027-09-26 U-901 Drug product 2012-09-27 03ed91905a0d…2025-01-19 17:59 UTC · 7 captures of this ZIP 2025-01 N021549-002 8258132 2027-09-26 U-901 Drug product 03ed91905a0d…2025-01-19 17:59 UTC · 7 captures of this ZIP 2025-01 N021549-002 8258132 2027-09-26 U-1743 Drug product 03ed91905a0d…
Additional Listing Data#
Finished product Yes
Brand name base EMEND
Listing expiration 2026-12-31 Harmonized UNII identifiers# UNII identifiers page 1 of 1 · 1 matching rows.
Identifier, FDA.report destination table Identifier FDA.report destination 1NF15YR6UY Internal UNII lookup
Harmonized RxCUI identifiers# RxCUI identifiers page 1 of 1 · 10 matching rows.
Identifier, FDA.report destination table Identifier FDA.report destination 403810 Internal RxNorm lookup 403811 Internal RxNorm lookup 404465 Internal RxNorm lookup 404466 Internal RxNorm lookup 644088 Internal RxNorm lookup 644278 Internal RxNorm lookup 754508 Internal RxNorm lookup 754509 Internal RxNorm lookup 1729308 Internal RxNorm lookup 1729311 Internal RxNorm lookup
Harmonized SPL set identifiers# SPL set identifiers page 1 of 1 · 1 matching rows.
DailyMed Product Concepts# DailyMed Package Descriptions# Package NDC, Product, Description table Package NDC Product Description Form Quantity Strength SPL version 0006-3862-03 EMEND 1 in 1 DOSE PACK KIT 1 42 0006-3862-13 EMEND 1 in 1 DOSE PACK KIT 1 42
DailyMed Socrata Ingredients# Ingredient, Type, UNII table Ingredient Type UNII DailyMed label SPL version Uploaded aprepitant ACTIVE INGREDIENT 1NF15YR6UY EMEND (APREPITANT) CAPSULE EMEND (APREPITANT) KIT [MERCK SHARP & DOHME CORP.] 24 aprepitant ACTIVE MOIETY 1NF15YR6UY EMEND (APREPITANT) CAPSULE EMEND (APREPITANT) KIT [MERCK SHARP & DOHME CORP.] 24 cellulose, microcrystalline INACTIVE INGREDIENT OP1R32D61U EMEND (APREPITANT) CAPSULE EMEND (APREPITANT) KIT [MERCK SHARP & DOHME CORP.] 24 ferric oxide red INACTIVE INGREDIENT 1K09F3G675 EMEND (APREPITANT) CAPSULE EMEND (APREPITANT) KIT [MERCK SHARP & DOHME CORP.] 24 ferric oxide yellow INACTIVE INGREDIENT EX438O2MRT EMEND (APREPITANT) CAPSULE EMEND (APREPITANT) KIT [MERCK SHARP & DOHME CORP.] 24 gelatin INACTIVE INGREDIENT 2G86QN327L EMEND (APREPITANT) CAPSULE EMEND (APREPITANT) KIT [MERCK SHARP & DOHME CORP.] 24 hydroxypropyl cellulose (type H) INACTIVE INGREDIENT RFW2ET671P EMEND (APREPITANT) CAPSULE EMEND (APREPITANT) KIT [MERCK SHARP & DOHME CORP.] 24 silicon dioxide INACTIVE INGREDIENT ETJ7Z6XBU4 EMEND (APREPITANT) CAPSULE EMEND (APREPITANT) KIT [MERCK SHARP & DOHME CORP.] 24 sodium lauryl sulfate INACTIVE INGREDIENT 368GB5141J EMEND (APREPITANT) CAPSULE EMEND (APREPITANT) KIT [MERCK SHARP & DOHME CORP.] 24 sucrose INACTIVE INGREDIENT C151H8M554 EMEND (APREPITANT) CAPSULE EMEND (APREPITANT) KIT [MERCK SHARP & DOHME CORP.] 24 titanium dioxide INACTIVE INGREDIENT 15FIX9V2JP EMEND (APREPITANT) CAPSULE EMEND (APREPITANT) KIT [MERCK SHARP & DOHME CORP.] 24 APREPITANT ACTIVE INGREDIENT 1NF15YR6UY EMEND (APREPITANT) CAPSULE EMEND (APREPITANT) KIT [PHYSICIANS TOTAL CARE, INC.] 3 APREPITANT ACTIVE MOIETY 1NF15YR6UY EMEND (APREPITANT) CAPSULE EMEND (APREPITANT) KIT [PHYSICIANS TOTAL CARE, INC.] 3 CELLULOSE, MICROCRYSTALLINE INACTIVE INGREDIENT OP1R32D61U EMEND (APREPITANT) CAPSULE EMEND (APREPITANT) KIT [PHYSICIANS TOTAL CARE, INC.] 3 FERRIC OXIDE RED INACTIVE INGREDIENT 1K09F3G675 EMEND (APREPITANT) CAPSULE EMEND (APREPITANT) KIT [PHYSICIANS TOTAL CARE, INC.] 3 FERRIC OXIDE YELLOW INACTIVE INGREDIENT EX438O2MRT EMEND (APREPITANT) CAPSULE EMEND (APREPITANT) KIT [PHYSICIANS TOTAL CARE, INC.] 3 GELATIN INACTIVE INGREDIENT 2G86QN327L EMEND (APREPITANT) CAPSULE EMEND (APREPITANT) KIT [PHYSICIANS TOTAL CARE, INC.] 3 HYDROXYPROPYL CELLULOSE INACTIVE INGREDIENT RFW2ET671P EMEND (APREPITANT) CAPSULE EMEND (APREPITANT) KIT [PHYSICIANS TOTAL CARE, INC.] 3 SILICON DIOXIDE INACTIVE INGREDIENT ETJ7Z6XBU4 EMEND (APREPITANT) CAPSULE EMEND (APREPITANT) KIT [PHYSICIANS TOTAL CARE, INC.] 3 SODIUM LAURYL SULFATE INACTIVE INGREDIENT 368GB5141J EMEND (APREPITANT) CAPSULE EMEND (APREPITANT) KIT [PHYSICIANS TOTAL CARE, INC.] 3 SUCROSE INACTIVE INGREDIENT C151H8M554 EMEND (APREPITANT) CAPSULE EMEND (APREPITANT) KIT [PHYSICIANS TOTAL CARE, INC.] 3 TITANIUM DIOXIDE INACTIVE INGREDIENT 15FIX9V2JP EMEND (APREPITANT) CAPSULE EMEND (APREPITANT) KIT [PHYSICIANS TOTAL CARE, INC.] 3
DailyMed Dashboard NDC Coverage# NDC, Dashboard title, SPL version table NDC Dashboard title SPL version Validation Dashboard ZIP 0006-3862 EMEND (APREPITANT) CAPSULE EMEND (APREPITANT) KIT EMEND (APREPITANT) POWDER, FOR SUSPENSION [MERCK SHARP & DOHME LLC] 41 Current NDC, Legacy NDC, 2 package rows 20240719_696f9e80-9cae-403b-de9e-078343ce4713.zip
openFDA label cross-check# OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.
Matched openFDA labels page 1 of 1 · 1 matching rows.
DailyMed RxNorm Mappings# Packages# Package NDC, 11-digit format, Description table Package NDC 11-digit format Description Units Marketing start Marketing end Sample Exclude flag Status 0006-3862-03 00006386203 1 KIT in 1 DOSE PACK (0006-3862-03) * 1 CAPSULE in 1 CAPSULE * 1 CAPSULE in 1 CAPSULE 1 kit 2003-03-26 0000-00-00 No No Current 0006-3862-13 00006386213 1 KIT in 1 DOSE PACK (0006-3862-13) * 1 CAPSULE in 1 CAPSULE * 1 CAPSULE in 1 CAPSULE 1 kit 2003-03-26 0000-00-00 No No Current