Home NDC 0023-4307 REFRESH OPTIVE Advanced
Product NDC 0023-4307
11-digit product format 000234307
Labeler code 0023
Product ID 0023-4307_82284b10-2578-4490-bb19-e38da030a102
Type HUMAN OTC DRUG
Nonproprietary name carboxymethylcellulose sodium, glycerin, and polysorbate 80
Dosage form SOLUTION/ DROPS
Route OPHTHALMIC
Labeler Allergan, Inc.
Application M018
Marketing category OTC MONOGRAPH DRUG
Marketing start 2011-11-30
Substance CARBOXYMETHYLCELLULOSE SODIUM; GLYCERIN; POLYSORBATE 80
Active strength 5; 10; 5 mg/mL; mg/mL; mg/mL
Pharmacologic classes Allergens [CS], Cell-mediated Immunity [PE], Glycerol [CS], Increased Histamine Release [PE], Increased IgG Production [PE], Non-Standardized Chemical Allergen [EPC]
NDC exclude flag No
Listing certified through 2026-12-31
Current FDA listing Yes Observed NDC auxiliary status history# This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.
Historic NDC status page 1 of 1 · 24 matching rows.
View current auxiliary records. · View the auxiliary file history.
Reported adverse events (FAERS/openFDA)# Adverse event summaries are temporarily unavailable. Other product information remains available.
Additional Listing Data#
Finished product Yes
Brand name base REFRESH OPTIVE Advanced
Listing expiration 2026-12-31 Active Ingredients# Ingredient, Strength table Ingredient Strength CARBOXYMETHYLCELLULOSE SODIUM 5 mg/mL GLYCERIN 10 mg/mL POLYSORBATE 80 5 mg/mL
Harmonized UNII identifiers# UNII identifiers page 1 of 1 · 3 matching rows.
Identifier, FDA.report destination table Identifier FDA.report destination K679OBS311 Internal UNII lookup PDC6A3C0OX Internal UNII lookup 6OZP39ZG8H Internal UNII lookup
Harmonized RxCUI identifiers# RxCUI identifiers page 1 of 1 · 1 matching rows.
Identifier, FDA.report destination table Identifier FDA.report destination 1241471 Internal RxNorm lookup
Harmonized SPL set identifiers# SPL set identifiers page 1 of 1 · 1 matching rows.
DailyMed Product Concepts# DailyMed Package Descriptions# Package NDC, Product, Description table Package NDC Product Description Form Quantity Strength SPL version 0023-4307-02 REFRESH OPTIVE Advanced 2 mL in 1 BOTTLE SOLUTION/ DROPS 2 16 0023-4307-02 REFRESH OPTIVE Advanced 1 in 1 CARTON SOLUTION/ DROPS 1 16 0023-4307-03 REFRESH OPTIVE Advanced 1 in 1 CARTON SOLUTION/ DROPS 1 16 0023-4307-03 REFRESH OPTIVE Advanced 3 mL in 1 BOTTLE, DROPPER SOLUTION/ DROPS 3 16 0023-4307-10 REFRESH OPTIVE Advanced 1 in 1 CARTON SOLUTION/ DROPS 1 16 0023-4307-10 REFRESH OPTIVE Advanced 10 mL in 1 BOTTLE, DROPPER SOLUTION/ DROPS 10 16 0023-4307-15 REFRESH OPTIVE Advanced 15 mL in 1 BOTTLE SOLUTION/ DROPS 15 16 0023-4307-15 REFRESH OPTIVE Advanced 1 in 1 CARTON SOLUTION/ DROPS 1 16 0023-4307-20 REFRESH OPTIVE Advanced 10 mL in 1 BOTTLE, DROPPER SOLUTION/ DROPS 10 16 0023-4307-20 REFRESH OPTIVE Advanced 2 in 1 CARTON SOLUTION/ DROPS 2 16
DailyMed Socrata Ingredients# Ingredient, Type, UNII table Ingredient Type UNII DailyMed label SPL version Uploaded carboxymethylcellulose sodium ACTIVE INGREDIENT K679OBS311 REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.] 6 glycerin ACTIVE INGREDIENT PDC6A3C0OX REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.] 6 polysorbate 80 ACTIVE INGREDIENT 6OZP39ZG8H REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.] 6 carboxymethylcellulose ACTIVE MOIETY 05JZI7B19X REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.] 6 glycerin ACTIVE MOIETY PDC6A3C0OX REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.] 6 polysorbate 80 ACTIVE MOIETY 6OZP39ZG8H REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.] 6 boric acid INACTIVE INGREDIENT R57ZHV85D4 REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.] 6 carbomer copolymer type A INACTIVE INGREDIENT 71DD5V995L REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.] 6 castor oil INACTIVE INGREDIENT D5340Y2I9G REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.] 6 erythritol INACTIVE INGREDIENT RA96B954X6 REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.] 6 levocarnitine INACTIVE INGREDIENT 0G389FZZ9M REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.] 6 sodium chlorite INACTIVE INGREDIENT G538EBV4VF REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.] 6 sodium hydroxide INACTIVE INGREDIENT 55X04QC32I REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.] 6 water INACTIVE INGREDIENT 059QF0KO0R REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.] 6
DailyMed Dashboard NDC Coverage# NDC, Dashboard title, SPL version table NDC Dashboard title SPL version Validation Dashboard ZIP 0023-4307 REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.] 15 Current NDC, Legacy NDC, 10 package rows 20241210_aaa943e4-7c38-4c5a-b7c0-5a656d8cafc0.zip
openFDA label cross-check# OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.
Matched openFDA labels page 6 of 25 · 494 matching rows.
DailyMed RxNorm Mappings# Packages# Package NDC, 11-digit format, Description table Package NDC 11-digit format Description Units Marketing start Marketing end Sample Exclude flag Status 0023-4307-02 00023430702 1 BOTTLE in 1 CARTON (0023-4307-02) / 2 mL in 1 BOTTLE 1 bottle 2011-11-30 0000-00-00 Yes No Current 0023-4307-03 00023430703 1 BOTTLE, DROPPER in 1 CARTON (0023-4307-03) > 3 mL in 1 BOTTLE, DROPPER 2011-11-30 0000-00-00 Yes No Current 0023-4307-10 00023430710 1 BOTTLE, DROPPER in 1 CARTON (0023-4307-10) / 10 mL in 1 BOTTLE, DROPPER 2011-11-30 0000-00-00 No No Current 0023-4307-15 00023430715 1 BOTTLE in 1 CARTON (0023-4307-15) > 15 mL in 1 BOTTLE 1 bottle 2011-11-30 0000-00-00 No No Current 0023-4307-20 00023430720 2 BOTTLE, DROPPER in 1 CARTON (0023-4307-20) / 10 mL in 1 BOTTLE, DROPPER 2011-11-30 0000-00-00 No No Current