REFRESH OPTIVE Advanced

Product NDC: 0023-4491
11-digit product format: 000234491
Labeler code: 0023
Product ID: 0023-4491_74f3d119-623c-4bd1-a5aa-e92db774f116
Type: HUMAN OTC DRUG
Nonproprietary name: carboxymethylcellulose sodium, glycerin, polysorbate 80
Dosage form: SOLUTION/ DROPS
Route: OPHTHALMIC
Labeler: Allergan, Inc.
Application: M018
Marketing category: OTC MONOGRAPH DRUG
Marketing start: 2013-01-15
Substance: CARBOXYMETHYLCELLULOSE SODIUM; GLYCERIN; POLYSORBATE 80
Active strength: 5; 10; 5 mg/mL; mg/mL; mg/mL
Pharmacologic classes: Allergens [CS], Cell-mediated Immunity [PE], Glycerol [CS], Increased Histamine Release [PE], Increased IgG Production [PE], Non-Standardized Chemical Allergen [EPC]
NDC exclude flag: No
Listing certified through: 2026-12-31
Current FDA listing: Yes

Observed NDC auxiliary status history#

This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.

Historic NDC status page 1 of 1 · 2 matching rows.

View current auxiliary records. · View the auxiliary file history.

Captured / source date, Dataset, Scope table
Captured / source date	Dataset	Scope	Product NDC	Package NDC	Code	Status	Reporting period	Archive	Snapshot	Source SHA-256
2024-11-09 02:27 UTC · source 2024-11-08	excluded package	package	0023-4491	0023-4491-05	D	Discontinued by firm		excluded / ndc_excluded.zip	`ad56d346431e…`	`cc804d4bbf1e…`
2024-10-04 04:10 UTC · source 2024-10-03	excluded package	package	0023-4491	0023-4491-05	D	Discontinued by firm		excluded / ndc_excluded.zip	`367a005e9d99…`	`383a685ebd0f…`

Additional Listing Data#

Finished product: Yes
Brand name base: REFRESH OPTIVE Advanced
Listing expiration: 2026-12-31

Active Ingredients#

Ingredient, Strength table
Ingredient	Strength
CARBOXYMETHYLCELLULOSE SODIUM	5 mg/mL
GLYCERIN	10 mg/mL
POLYSORBATE 80	5 mg/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 3 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
K679OBS311	Internal UNII lookup
PDC6A3C0OX	Internal UNII lookup
6OZP39ZG8H	Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
1241471	Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
ebd0839e-2e1d-4e0e-986c-19f1f5c76358	Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product concept	Relation	Version	Effective
08c722ec-780f-bb7b-8f14-3d4f7bf0e098	Product name	2	20240205
e2f276e5-439f-b432-b5e5-b0cfa993da69	Product name	3	20220609
4585a4fb-0028-3d95-020c-9b1c40bf15e0	Product name	1	20140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	SPL version
0023-4491-05	REFRESH OPTIVE Advanced	0.4 mL in 1 VIAL, SINGLE-USE	SOLUTION/ DROPS	0.4	11
0023-4491-05	REFRESH OPTIVE Advanced	5 in 1 CARTON	SOLUTION/ DROPS	5	11
0023-4491-30	REFRESH OPTIVE Advanced	30 in 1 CARTON	SOLUTION/ DROPS	30	11
0023-4491-30	REFRESH OPTIVE Advanced	0.4 mL in 1 VIAL, SINGLE-USE	SOLUTION/ DROPS	0.4	11

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDC	Billing unit	Product NDC	DailyMed indexing SPL	SPL version	Effective
0023-4491-30	EA - Each	0023-4491	95847a4a-09ea-46e7-8122-8f177a6123aa	1	2013-07-02

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
Ingredient	Type	UNII	DailyMed label	SPL version
carboxymethylcellulose sodium	ACTIVE INGREDIENT	K679OBS311	REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.]	2
glycerin	ACTIVE INGREDIENT	PDC6A3C0OX	REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.]	2
polysorbate 80	ACTIVE INGREDIENT	6OZP39ZG8H	REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.]	2
carboxymethylcellulose	ACTIVE MOIETY	05JZI7B19X	REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.]	2
glycerin	ACTIVE MOIETY	PDC6A3C0OX	REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.]	2
polysorbate 80	ACTIVE MOIETY	6OZP39ZG8H	REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.]	2
boric acid	INACTIVE INGREDIENT	R57ZHV85D4	REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.]	2
carbomer copolymer type A	INACTIVE INGREDIENT	71DD5V995L	REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.]	2
castor oil	INACTIVE INGREDIENT	D5340Y2I9G	REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.]	2
erythritol	INACTIVE INGREDIENT	RA96B954X6	REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.]	2
levocarnitine	INACTIVE INGREDIENT	0G389FZZ9M	REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.]	2
sodium hydroxide	INACTIVE INGREDIENT	55X04QC32I	REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.]	2
water	INACTIVE INGREDIENT	059QF0KO0R	REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.]	2

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
0023-4491	REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.]	10	Current NDC, Legacy NDC, 4 package rows	20241207_ebd0839e-2e1d-4e0e-986c-19f1f5c76358.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 26 · 512 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
Vedlube	MINERAL OIL AND WHITE PETROLATUM LUBRICANT EYE OINTMENT	VEDCO INC	55d126fa-7489-4307-824e-b6957e57d4e9	2026-07-31	Warnings	Exact identifier application number: M018
Neutraflush	EYEWASH STATION ADDITIVE CONCENTRATE	Aero Healthcare	1d9ff2ef-9c9b-f367-e063-6294a90afa0e	2026-07-24	Warnings	Exact identifier application number: M018
Droptics Dry Eye Relief	CARBOXYMETHYLCELLULOSE SODIUM,GLYCERIN,POLYSORBATE 80	Droptics LLC	29d7614b-f4b7-48e2-97c5-d1bff27731d2	2026-07-22	Warnings	Exact identifier application number: M018
GOOD NEIGHBOR PHARMACY ARTIFICAL TEARS LUBRICANT EYE DROPS	POLYVINYL ALCOHOL, POVIDONE	AmerisourceBergen	ce6852a8-c5e6-403d-a7b4-a2e85d1ebb1f	2026-07-22	Warnings	Exact identifier application number: M018
Eyewash Station Additive Concentrate	CHLORHEXIDINE GLUCONATE AND PROPYLENE GLYCOL	Global Equipment Company	bc93a1e8-aa3c-6735-e053-2995a90ad6e8	2026-07-16	Warnings	Exact identifier application number: M018
Revitalize Energizing Eye Drops	NAPHAZOLINE HYDROCHLORIDE ,PROPYLENE GLYCOL	Revitalize Energy Inc.	518aac87-1642-4b2f-bca1-b74d21261eea	2026-07-16	Warnings	Exact identifier application number: M018
Polyvinyl Alcohol	POLYVINYL ALCOHOL	AvPAK	f18b61da-4033-341a-e053-2a95a90a8ebf	2026-07-07	Warnings	Exact identifier application number: M018
Artificial Tears	ARTIFICIAL TEARS	AvPAK	f18bebf2-1936-658f-e053-2a95a90a5012	2026-07-07	Warnings	Exact identifier application number: M018
Retaine CMC	CARBOXYMETHYLCELLULOSE SODIUM	OCuSOFT LLC	a3698c71-0c80-4246-be52-5e7d96f6c540	2026-07-06	Warnings	Exact identifier application number: M018
Eyesaline Eyewash Concentrate	PURIFIED WATER	Protective Industrial Products, Inc.	558e5926-9027-d3f6-e063-6294a90ab121	2026-07-02	Warnings	Exact identifier application number: M018
Fendall 2000 Pure Flow	PURIFIED WATER	Protective Industrial Products, Inc.	55a1d07e-0006-0c75-e063-6394a90a7acc	2026-07-02	Warnings	Exact identifier application number: M018
Fendall 1000 Pure Flow	PURIFIED WATER	Protective Industrial Products, Inc.	55a2f4da-bb1e-8ead-e063-6394a90af72e	2026-07-02	Warnings	Exact identifier application number: M018
Sterile Eyesaline Eyewash	STERILE EYESALINE EYEWASH	Protective Industrial Products, Inc.	55a290e8-8310-8be4-e063-6394a90abdce	2026-07-02	Warnings	Exact identifier application number: M018
Eyesaline Emergency Eyewash	PURIFIED WATER	Protective Industrial Products, Inc.	55a261c2-725d-6765-e063-6294a90a3260	2026-07-02	Warnings	Exact identifier application number: M018
OHTrust Artifical Eyedrop	SODIUM CHLORIDE	Nanoplus Technology Co., Limited	2ea26d96-704b-17bb-e063-6394a90a7e27	2026-07-01	Warnings	Exact identifier application number: M018
Fendall 2000 Pure Flow	PURIFIED WATER	Honeywell Safety Products USA, Inc.	37dead3e-60cb-88ae-e063-6294a90a8f70	2026-06-24	Warnings	Exact identifier application number: M018
Rohto Cool Relief	NAPHAZOLINE HYDROCHLORIDE, POLYSORBATE 80	The Mentholatum Company	dc8f1ff3-87ae-47ca-815f-5a0e34f8cf30	2026-06-19	Warnings	Exact identifier application number: M018
Rohto Sun and Sport	HYPROMELLOSE, POVIDONE	The Mentholatum Company	8bcc8882-b886-4b55-9bc4-d4b92a41358f	2026-06-19	Warnings	Exact identifier application number: M018
Rohto Dual Light Relief	HYPROMELLOSE, POVIDONE	The Mentholatum Company	1b597f83-d7f1-cf93-e063-6394a90a99f7	2026-06-19	Warnings	Exact identifier application number: M018
Lubricant Eye	CARBOXYMETHYLCELLULOSE SODIUM 0.5%	CARDINAL HEALTH 110, LLC. DBA LEADER	51a2d74f-5ff3-9921-e063-6294a90a345a	2026-06-15	Warnings	Exact identifier application number: M018

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
PDC6A3C0OX	GLYCERIN	56-81-5	GLYCERIN
6OZP39ZG8H	POLYSORBATE 80	9005-65-6	POLYSORBATE 80

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUI	RxNorm string	TTY	DailyMed	SPL version
1241471	carboxymethylcellulose sodium 0.5 % / glycerin 1 % / polysorbate 80 0.5 % Ophthalmic Solution	PSN	ebd0839e-2e1d-4e0e-986c-19f1f5c76358	11
1241471	carboxymethylcellulose sodium 5 MG/ML / glycerin 10 MG/ML / polysorbate 80 5 MG/ML Ophthalmic Solution	SCD	ebd0839e-2e1d-4e0e-986c-19f1f5c76358	11
1241471	carboxymethylcellulose sodium 0.5 % / glycerin 1 % / polysorbate 80 0.5 % Ophthalmic Solution	SY	ebd0839e-2e1d-4e0e-986c-19f1f5c76358	11

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Marketing start	Marketing end	Sample	Exclude flag	Status
0023-4491-05	00023449105	5 VIAL, SINGLE-USE in 1 CARTON (0023-4491-05) / .4 mL in 1 VIAL, SINGLE-USE	2013-01-15	0000-00-00	Yes	No	Current
0023-4491-30	00023449130	30 VIAL, SINGLE-USE in 1 CARTON (0023-4491-30) / .4 mL in 1 VIAL, SINGLE-USE	2013-01-15	0000-00-00	No	No	Current