Indications and uses
For the temporary relief of burning, irritation, and discomfort due to dryness of the eye or exposure to wind or sun. May be used as a protectant against further irritation.
REFRESH OPTIVE Advanced
- Manufacturer
- Allergan, Inc.
- Effective date
- 2022-09-19
- Label type
- HUMAN OTC DRUG LABEL
- Version
- 12
- Source
- daily-update
- Hydrated at
- 2026-10-30 01:02:35
Label at a glance#
ProductREFRESH OPTIVE Advanced
Active ingredientcarboxymethylcellulose sodium, glycerin, polysorbate 80
Label structure10 sections
Dosage and administration
To open, TWIST AND PULL TAB TO REMOVE. Instill 1 or 2 drops in the affected eye(s) as needed and discard container.
Contacts and useful links#
Label contents#
Full prescribing information#
SPL UNCLASSIFIED SECTION
Refresh OPTIVE®ADVANCED (Preservative-free)
Drug Facts
Active ingredients
Carboxymethylcellulose sodium 0.5%
Glycerin 1%
Polysorbate 80 0.5%
Purpose
Eye lubricant
Eye lubricant
Eye lubricant
Uses
- For the temporary relief of burning, irritation, and discomfort due to dryness of the eye or exposure to wind or sun.
- May be used as a protectant against further irritation.
Warnings
- For external use only.
- To avoid contamination, do not touch tip of container to any surface. Do not reuse. Once opened, discard.
- Do not touch unit-dose tip to eye.
- If solution changes color, do not use.
Stop use and ask a doctor if
you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours.
Keep out of reach of children.
If swallowed, get medical help or contact a Poison Control Center right away.
Directions
To open, TWIST AND PULL TAB TO REMOVE. Instill 1 or 2 drops in the affected eye(s) as needed and discard container.
Other information
- Use only if single-use container is intact.
- Use before expiration date marked on container.
- Store at 59°-77°F (15°-25°C).
- RETAIN THIS CARTON FOR FUTURE REFERENCE.
Inactive ingredients
Boric acid; carbomer copolymer type A; castor oil; erythritol; levocarnitine; purified water; and sodium hydroxide (to adjust pH).
Questions or comments?
1.800.678.1605
refresheyedrops.com
v1.0DFL4491
PRINCIPAL DISPLAY PANEL
NDC 0023-4491-30
PRESERVATIVE-FREE
Refresh
OPTIVE®
ADVANCED
Lubricant Eye Drops
with HydroCell®
Triple-Action Relief
For Dry Eyes
30 Vials
0.01 fl oz (0.4 mL) each Sterile
DailyMed Product Concepts#
| Product concept | Relation | Version | Effective |
|---|---|---|---|
| 08c722ec-780f-bb7b-8f14-3d4f7bf0e098 | Product name | 2 | 20240205 |
| e2f276e5-439f-b432-b5e5-b0cfa993da69 | Product name | 3 | 20220609 |
| 4585a4fb-0028-3d95-020c-9b1c40bf15e0 | Product name | 1 | 20140508 |
DailyMed Billing Units#
| Package NDC | Billing unit | Product NDC | DailyMed indexing SPL | SPL version | Effective |
|---|---|---|---|---|---|
| 0023-4491-30 | EA - Each | 0023-4491 | 95847a4a-09ea-46e7-8122-8f177a6123aa | 1 | 2013-07-02 |
DailyMed Socrata Ingredients#
| Ingredient | Type | UNII | SPL version | Uploaded |
|---|---|---|---|---|
| carboxymethylcellulose sodium | ACTIVE INGREDIENT | K679OBS311 | 2 | |
| glycerin | ACTIVE INGREDIENT | PDC6A3C0OX | 2 | |
| polysorbate 80 | ACTIVE INGREDIENT | 6OZP39ZG8H | 2 | |
| carboxymethylcellulose | ACTIVE MOIETY | 05JZI7B19X | 2 | |
| glycerin | ACTIVE MOIETY | PDC6A3C0OX | 2 | |
| polysorbate 80 | ACTIVE MOIETY | 6OZP39ZG8H | 2 | |
| boric acid | INACTIVE INGREDIENT | R57ZHV85D4 | 2 | |
| carbomer copolymer type A | INACTIVE INGREDIENT | 71DD5V995L | 2 | |
| castor oil | INACTIVE INGREDIENT | D5340Y2I9G | 2 | |
| erythritol | INACTIVE INGREDIENT | RA96B954X6 | 2 | |
| levocarnitine | INACTIVE INGREDIENT | 0G389FZZ9M | 2 | |
| sodium hydroxide | INACTIVE INGREDIENT | 55X04QC32I | 2 | |
| water | INACTIVE INGREDIENT | 059QF0KO0R | 2 |
Products#
Every source-derived product name is available through these pages.
- REFRESH OPTIVE Advanced
- carboxymethylcellulose sodium, glycerin, polysorbate 80
- carboxymethylcellulose sodium
- carboxymethylcellulose
- glycerin
- polysorbate 80
- boric acid
- CARBOMER COPOLYMER TYPE A (ALLYL PENTAERYTHRITOL CROSSLINKED)
- castor oil
- erythritol
- levocarnitine
- water
- sodium hydroxide
NDC Codes#
| Product NDC | Package NDC |
|---|---|
| 0023-4491 | 0023-4491-05, 0023-4491-30 |
Ingredients#
Every source-derived ingredient row is available through these pages.
| Name | UNII | Kind |
|---|---|---|
| carboxymethylcellulose sodium | K679OBS311 | ACTIB |
| glycerin | PDC6A3C0OX | ACTIB |
| polysorbate 80 | 6OZP39ZG8H | ACTIB |
| boric acid | R57ZHV85D4 | IACT |
| CARBOMER COPOLYMER TYPE A (ALLYL PENTAERYTHRITOL CROSSLINKED) | 71DD5V995L | IACT |
| castor oil | D5340Y2I9G | IACT |
| erythritol | RA96B954X6 | IACT |
| levocarnitine | 0G389FZZ9M | IACT |
| water | 059QF0KO0R | IACT |
| sodium hydroxide | 55X04QC32I | IACT |
Source Document#
Older Hydrated Versions#
| Version | Effective date | Source | Hydrated |
|---|---|---|---|
| 11 | 2022-09-15 | full-release | 2026-06-01 01:39:00 |
| 10 | 2022-09-15 | full-release | 2026-06-01 00:40:42 |
Inactive ingredient matches#
Inactive Ingredient Database values describe FDA-listed use contexts. The match method and ambiguity count are shown because ingredient names, routes, and dosage forms are not always unique. Browse recovered IID releases and source provenance.
| DailyMed ingredient | IID ingredient | UNII | Dosage form / route | Potency | Maximum daily exposure | Match |
|---|---|---|---|---|---|---|
| castor oil | CASTOR OIL | D5340Y2I9G | EMULSION / OPHTHALMIC | 32 mg | ||
| carbomer copolymer type A | CARBOMER COPOLYMER TYPE A (ALLYL PENTAERYTHRITOL CROSSLINKED) | 71DD5V995L | EMULSION / OPHTHALMIC | 0.05 %w/v | ||
| sodium hydroxide | SODIUM HYDROXIDE | 55X04QC32I | SOLUTION/ DROPS / OPHTHALMIC | ADJ PH | ||
| boric acid | BORIC ACID | R57ZHV85D4 | SOLUTION/ DROPS / OPHTHALMIC | 48 mg | ||
| sodium hydroxide | SODIUM HYDROXIDE | 55X04QC32I | SOLUTION/ DROPS / OPHTHALMIC | ADJ PH | ||
| carbomer copolymer type A | CARBOMER COPOLYMER TYPE A (ALLYL PENTAERYTHRITOL CROSSLINKED) | 71DD5V995L | EMULSION / OPHTHALMIC | 0.05 %w/v | ||
| boric acid | BORIC ACID | R57ZHV85D4 | SOLUTION/ DROPS / OPHTHALMIC | 48 mg | ||
| boric acid | BORIC ACID | R57ZHV85D4 | SOLUTION/ DROPS / OPHTHALMIC | 48 mg | ||
| carbomer copolymer type A | CARBOMER COPOLYMER TYPE A (ALLYL PENTAERYTHRITOL CROSSLINKED) | 71DD5V995L | EMULSION / OPHTHALMIC | 0.05 %w/v | ||
| sodium hydroxide | SODIUM HYDROXIDE | 55X04QC32I | SOLUTION/ DROPS / OPHTHALMIC | ADJ PH | ||
| castor oil | CASTOR OIL | D5340Y2I9G | EMULSION / OPHTHALMIC | 32 mg | ||
| castor oil | CASTOR OIL | D5340Y2I9G | EMULSION / OPHTHALMIC | 32 mg |
openFDA label cross-check#
OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.
| Brand | Generic | Manufacturer | SPL set ID | Effective date | Available safety fields | Join |
|---|---|---|---|---|---|---|
| 74f3d119-623c-4bd1-a5aa-e92db774f116 | ebd0839e-2e1d-4e0e-986c-19f1f5c76358 | 2022-09-15 | Warnings | ebd0839e-2e1d-4e0e-986c-19f1f5c76358 |
Reported adverse events (FAERS/openFDA)#
Adverse event summaries are temporarily unavailable. Other product information remains available.