Buprenorphine Hydrochloride

Product NDC
0143-9246
11-digit product format
001439246
Labeler code
0143
Product ID
0143-9246_8ba9787c-d429-4a5d-8424-e13be15cb9f1
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Buprenorphine Hydrochloride
Dosage form
INJECTION
Route
INTRAMUSCULAR; INTRAVENOUS
Labeler
Hikma Pharmaceuticals USA Inc.
Application
ANDA076931
Marketing category
ANDA
Marketing start
2005-05-25
Substance
BUPRENORPHINE HYDROCHLORIDE
Active strength
.324 mg/mL
Pharmacologic classes
Partial Opioid Agonist [EPC], Partial Opioid Agonists [MoA]
DEA schedule
CIII
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 42.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A076931-001BUPRENORPHINE HYDROCHLORIDEBUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-02

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-productTE code
A076931-001AP

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 42 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-08-18 06:07:402026-07A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-02caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-02011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-0231067a03dcf5…
2025-08-23 18:47 UTC2025-08A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-026a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-02fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-02b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-0203ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-022680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-025bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-02d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-02d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-0279d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-02301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-021e350fbaab3a…
2024-05-31 18:47 UTC2024-05A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-028072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-025c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-025d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-024b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-0274a2ff9319b5…
2022-03-09 01:35 UTC2022-03A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-02bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-02782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-0287673890dc5c…
2021-03-12 10:30 UTC2021-03A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-025aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-028869cabd3fbd…
2020-11-12 02:37 UTC2020-11A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-02c0c555d07b60…
2019-12-14 00:12 UTC2019-12A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-023f01610625f2…
2019-09-15 20:21 UTC2019-09A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-02b00525d2431f…
2019-07-19 19:46 UTC2019-07A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-02ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-026a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-021c564ffb4f44…
2023-12-20 04:57 UTC2023-12A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-02ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-02a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-029b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-02a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-023f0d92c62455…
2023-05-13 08:27 UTC2023-05A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-02053a50430f4f…
2023-01-26 05:58 UTC2023-01A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-023bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-023a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-02f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A076931-001BUPRENORPHINE HYDROCHLORIDEEQ 0.3MG BASE/MLINJECTABLE / INJECTIONAP2005-03-02e64feba35796…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 2 · 42 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-08-18 06:07:402026-07A076931-001AP1caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A076931-001AP1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A076931-001AP131067a03dcf5…
2025-08-23 18:47 UTC2025-08A076931-001AP16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A076931-001AP1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A076931-001AP1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A076931-001AP103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A076931-001AP12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A076931-001AP15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A076931-001AP1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A076931-001AP1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A076931-001AP179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A076931-001AP1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A076931-001AP11e350fbaab3a…
2024-05-31 18:47 UTC2024-05A076931-001AP18072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A076931-001AP15c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A076931-001AP15d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A076931-001AP14b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A076931-001AP174a2ff9319b5…
2022-03-09 01:35 UTC2022-03A076931-001AP1bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A076931-001AP1782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A076931-001AP187673890dc5c…
2021-03-12 10:30 UTC2021-03A076931-001AP15aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A076931-001AP18869cabd3fbd…
2020-11-12 02:37 UTC2020-11A076931-001AP1c0c555d07b60…
2019-12-14 00:12 UTC2019-12A076931-001AP13f01610625f2…
2019-09-15 20:21 UTC2019-09A076931-001AP1b00525d2431f…
2019-07-19 19:46 UTC2019-07A076931-001AP1ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A076931-001AP16a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A076931-001AP11c564ffb4f44…
2023-12-20 04:57 UTC2023-12A076931-001AP1ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A076931-001AP1a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A076931-001AP19b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A076931-001AP1a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A076931-001AP13f0d92c62455…
2023-05-13 08:27 UTC2023-05A076931-001AP1053a50430f4f…
2023-01-26 05:58 UTC2023-01A076931-001AP13bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A076931-001AP13a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A076931-001AP1f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A076931-001AP1e64feba35796…

Additional Listing Data#

Finished product
Yes
Brand name base
Buprenorphine Hydrochloride
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
BUPRENORPHINE HYDROCHLORIDE.324 mg/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
56W8MW3EN1Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
238129Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
adc1167e-910e-4d7b-abdc-751d3df0c3dcAvailable on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
68654759-f50b-79ef-24c5-544d94fe7d87Product name320251114
08a295bb-88df-4ab0-a120-a75a789a74f1Product name120231013
cb89b86a-369e-4204-8910-ae797c503af3Product name120230706
ab841ac7-728a-4fc9-be0a-35b96cecbf39Product name420230306
100316cc-94a9-474e-97ad-9b5c6ddec605Product name520230125
539bc5d3-546b-4af6-9c31-058ce6c459d3Product name220220210
b871fccd-1de6-4c7f-b9e5-045304641ee6Product name820220118
d4880ace-a516-8c47-8dfd-73a4ba5887d7Product name220180830
7cda52fc-125f-421c-8fea-bc1974370c49Product name220180703
31e16ab2-c562-4617-a3e8-ed285320e16eProduct name120180201
4c23a34c-e8fc-424c-8fa0-ee064ba6eaefProduct name120170706
a5920611-4285-f024-69b9-39ff338b81eaProduct name520170609
3df867ed-9d48-45cf-bded-1394beaea0b1Product name320161206
973da5bf-b1f9-4de0-81ee-7ca066c98ca4Product name120160712
0ca1d589-929b-4b33-bc5b-1d84abdafa6aProduct name120150324
fc363c46-397b-4476-ac0f-70e43e8e4592Product name120150324

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
0143-9246-01Buprenorphine Hydrochloride1 mL in 1 VIALINJECTION18
0143-9246-05Buprenorphine Hydrochloride5 in 1 CARTONINJECTION58

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
0143-9246-01ML - Milliliter0143-9246613f41eb-c021-4951-b4fe-320d3d1f309b12020-05-08
0143-9246-05ML - Milliliter0143-9246a50f3db0-965d-44ec-b772-cb19503e744612020-05-08

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
0143-9246BUPRENORPHINE HYDROCHLORIDE INJECTION [HIKMA PHARMACEUTICALS USA INC.]8Current NDC, Legacy NDC, 2 package rows20250316_adc1167e-910e-4d7b-abdc-751d3df0c3dc.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Buprenorphine HydrochlorideBUPRENORPHINE HYDROCHLORIDEHikma Pharmaceuticals USA Inc.adc1167e-910e-4d7b-abdc-751d3df0c3dc2025-03-13Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 076931
application number: ANDA076931
ndc (product): 0143-9246

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
238129buprenorphine HCl 0.3 MG in 1 ML InjectionPSNadc1167e-910e-4d7b-abdc-751d3df0c3dc8
2381291 ML buprenorphine 0.3 MG/ML InjectionSCDadc1167e-910e-4d7b-abdc-751d3df0c3dc8
238129buprenorphine 0.3 MG/ML (as buprenorphine HCl 0.324 MG/ML) InjectionSYadc1167e-910e-4d7b-abdc-751d3df0c3dc8
238129buprenorphine HCl 0.3 MG per 1 ML InjectionSYadc1167e-910e-4d7b-abdc-751d3df0c3dc8

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
0143-9246-01001439246011 mL in 1 VIAL1 mlHistorical
0143-9246-05001439246055 VIAL in 1 CARTON (0143-9246-05) / 1 mL in 1 VIAL (0143-9246-01) 5 vial2019-07-120000-00-00NoNoCurrent