LIDOCAINE HCl and EPINEPHRINE

Product NDC
0264-9378
11-digit product format
002649378
Labeler code
0264
Product ID
0264-9378_5f189f9b-1978-401e-8e5f-1969fe8c8ad7
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
LIDOCAINE HCl and EPINEPHRINE
Dosage form
INJECTION
Route
EPIDURAL; INFILTRATION; INTRACAUDAL; PERINEURAL
Labeler
B. Braun Medical Inc.
Application
ANDA208475
Marketing category
ANDA
Marketing start
2021-09-08
Substance
EPINEPHRINE BITARTRATE; LIDOCAINE HYDROCHLORIDE ANHYDROUS
Active strength
.005; 15 mg/mL; mg/mL
Pharmacologic classes
Adrenergic alpha-Agonists [MoA], Adrenergic beta-Agonists [MoA], Amide Local Anesthetic [EPC], Amides [CS], Antiarrhythmic [EPC], Catecholamine [EPC], Catecholamines [CS], Local Anesthesia [PE], alpha-Adrenergic Agonist [EPC], beta-Adrenergic Agonist [EPC]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 43.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINEEPINEPHRINE; LIDOCAINE HYDROCHLORIDE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-productTE code
A208475-001AP

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-09-14 22:38:342026-08A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-0884e616aacf4f…
2026-08-18 06:07:402026-07A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-0831067a03dcf5…
2025-08-23 18:47 UTC2025-08A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-086a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-0803ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-082680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-085bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-0879d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-081e350fbaab3a…
2024-05-31 18:47 UTC2024-05A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-088072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-085c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-085d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-084b0b4de00fa7…
2022-03-09 01:35 UTC2022-03A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08782e0a99824c…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-086a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-081c564ffb4f44…
2023-12-20 04:57 UTC2023-12A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-089b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-083f0d92c62455…
2023-05-13 08:27 UTC2023-05A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08053a50430f4f…
2023-01-26 05:58 UTC2023-01A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-083bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-083a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08cb3db0bc1861…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08a50c72e98297…

Observed Orange Book normalized TE history#

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-09-14 22:38:342026-08A208475-001AP184e616aacf4f…
2026-08-18 06:07:402026-07A208475-001AP1caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A208475-001AP1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A208475-001AP131067a03dcf5…
2025-08-23 18:47 UTC2025-08A208475-001AP16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A208475-001AP1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A208475-001AP1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A208475-001AP103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A208475-001AP12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A208475-001AP15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A208475-001AP1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A208475-001AP1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A208475-001AP179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A208475-001AP1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A208475-001AP11e350fbaab3a…
2024-05-31 18:47 UTC2024-05A208475-001AP18072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A208475-001AP15c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A208475-001AP15d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A208475-001AP14b0b4de00fa7…
2022-03-09 01:35 UTC2022-03A208475-001AP1bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A208475-001AP1782e0a99824c…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A208475-001AP16a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A208475-001AP11c564ffb4f44…
2023-12-20 04:57 UTC2023-12A208475-001AP1ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A208475-001AP1a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A208475-001AP19b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A208475-001AP1a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A208475-001AP13f0d92c62455…
2023-05-13 08:27 UTC2023-05A208475-001AP1053a50430f4f…
2023-01-26 05:58 UTC2023-01A208475-001AP13bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A208475-001AP13a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A208475-001AP1f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A208475-001AP1e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07A208475-001AP1cb3db0bc1861…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A208475-001AP1a50c72e98297…

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

Additional Listing Data#

Finished product
Yes
Brand name base
LIDOCAINE HCl and EPINEPHRINE
Listing expiration
2027-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
LIDOCAINE HYDROCHLORIDE ANHYDROUS15 mg/mL
EPINEPHRINE BITARTRATE.005 mg/mL

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
0b4ec9ca-d305-43fc-88dd-7a510313efe0Product name120260105
bb209f42-a85f-4fee-9d3d-c9dded168625Product name120251208
49628fc7-2031-4c28-bd31-0ef3aa8f44a3Product name320251118
cbf85893-59ef-423f-87d4-a573c000a8b9Product name820250731
b5b1095b-40cd-8a9e-b111-502545045b07Product name420250325
e190029e-423b-473c-8e04-2ada59b5b711Product name120250314
860a93dc-4863-49cc-b284-6bbe8191bc48Product name420250214
eaba870a-6a9d-442e-8643-87b3f558a451Product name120250117
e0031c74-3853-42bc-8e10-86dbbe83992eProduct name220231116
f7046b89-2016-499a-adc6-78479172abc6Product name120230425
9b4cf230-fd05-41d5-98c6-5db9ecb27b86Product name120230117
2686d634-e712-4007-8dbf-3d37c6c4d71fProduct name120181121
fa8b5901-e681-426f-82fe-54f6d81ec698Product name420180619
bd49bb86-2d32-4a7a-a594-eeda2e29af42Product name120180118
332d03e4-aa24-4b11-841a-02bf41081920Product name120171221
c08ab52f-2fc8-4409-9d9f-ed8edc0bd070Product name120171221
3becbe78-12d9-4ad2-9b4c-1e36f8d1303aProduct name120170815
68ed98f8-24c2-44a0-944a-6d36e82ce25aProduct name120141222
1cd42bc2-a430-c72b-636d-991b235fbf80Product name120140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
0264-9378-05LIDOCAINE HCl and EPINEPHRINE5 in 1 CARTONINJECTION57
0264-9378-88LIDOCAINE HCl and EPINEPHRINE5 mL in 1 AMPULEINJECTION57

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
0264-9378LIDOCAINE HCL AND EPINEPHRINE INJECTION [B. BRAUN MEDICAL INC.]7Current NDC, Legacy NDC, 2 package rows20211216_fc83d701-02b2-4595-8e5b-dbebc5e209d5.zip

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
1867998lidocaine HCl 1.5 % / EPINEPHrine 1:200,000 in 5 ML InjectionPSNfc83d701-02b2-4595-8e5b-dbebc5e209d57
18679985 ML epinephrine 0.005 MG/ML / lidocaine hydrochloride 15 MG/ML InjectionSCDfc83d701-02b2-4595-8e5b-dbebc5e209d57
1867998lidocaine HCl 1.5 % / EPINEPHrine 1:200,000 per 5 ML InjectionSYfc83d701-02b2-4595-8e5b-dbebc5e209d57

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
0264-9378-05002649378055 AMPULE in 1 CARTON (0264-9378-05) / 5 mL in 1 AMPULE (0264-9378-88) 5 ampule2021-09-080000-00-00NoNoCurrent
0264-9378-88002649378885 mL in 1 AMPULE5 mlHistorical