LIDOCAINE HCl and EPINEPHRINE

Product NDC
0264-9378
11-digit product format
002649378
Labeler code
0264
Product ID
0264-9378_5f189f9b-1978-401e-8e5f-1969fe8c8ad7
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
LIDOCAINE HCl and EPINEPHRINE
Dosage form
INJECTION
Route
EPIDURAL; INFILTRATION; INTRACAUDAL; PERINEURAL
Labeler
B. Braun Medical Inc.
Application
ANDA208475
Marketing category
ANDA
Marketing start
2021-09-08
Substance
EPINEPHRINE BITARTRATE; LIDOCAINE HYDROCHLORIDE ANHYDROUS
Active strength
.005; 15 mg/mL; mg/mL
Pharmacologic classes
Adrenergic alpha-Agonists [MoA], Adrenergic beta-Agonists [MoA], Amide Local Anesthetic [EPC], Amides [CS], Antiarrhythmic [EPC], Catecholamine [EPC], Catecholamines [CS], Local Anesthesia [PE], alpha-Adrenergic Agonist [EPC], beta-Adrenergic Agonist [EPC]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINEEPINEPHRINE; LIDOCAINE HYDROCHLORIDE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-productTE code
A208475-001AP

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-0831067a03dcf5…
2025-08-23 18:47 UTC2025-08A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-086a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-0803ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-082680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-085bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-0879d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-081e350fbaab3a…
2024-05-31 18:47 UTC2024-05A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-088072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-085c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-085d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-084b0b4de00fa7…
2022-03-09 01:35 UTC2022-03A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08782e0a99824c…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-086a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-081c564ffb4f44…
2023-12-20 04:57 UTC2023-12A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-089b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-083f0d92c62455…
2023-05-13 08:27 UTC2023-05A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08053a50430f4f…
2023-01-26 05:58 UTC2023-01A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-083bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-083a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08cb3db0bc1861…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A208475-001LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE0.005MG/ML;1.5%INJECTABLE / INJECTIONAP2021-09-08a50c72e98297…

Observed Orange Book normalized TE history#

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02A208475-001AP1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A208475-001AP131067a03dcf5…
2025-08-23 18:47 UTC2025-08A208475-001AP16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A208475-001AP1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A208475-001AP1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A208475-001AP103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A208475-001AP12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A208475-001AP15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A208475-001AP1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A208475-001AP1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A208475-001AP179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A208475-001AP1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A208475-001AP11e350fbaab3a…
2024-05-31 18:47 UTC2024-05A208475-001AP18072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A208475-001AP15c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A208475-001AP15d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A208475-001AP14b0b4de00fa7…
2022-03-09 01:35 UTC2022-03A208475-001AP1bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A208475-001AP1782e0a99824c…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A208475-001AP16a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A208475-001AP11c564ffb4f44…
2023-12-20 04:57 UTC2023-12A208475-001AP1ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A208475-001AP1a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A208475-001AP19b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A208475-001AP1a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A208475-001AP13f0d92c62455…
2023-05-13 08:27 UTC2023-05A208475-001AP1053a50430f4f…
2023-01-26 05:58 UTC2023-01A208475-001AP13bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A208475-001AP13a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A208475-001AP1f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A208475-001AP1e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07A208475-001AP1cb3db0bc1861…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A208475-001AP1a50c72e98297…

Additional Listing Data#

Finished product
Yes
Brand name base
LIDOCAINE HCl and EPINEPHRINE
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
LIDOCAINE HYDROCHLORIDE ANHYDROUS.005 mg/mL
EPINEPHRINE BITARTRATE15 mg/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
EC2CNF7XFPInternal UNII lookup
30Q7KI53AKInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1867998Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
fc83d701-02b2-4595-8e5b-dbebc5e209d5Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
0b4ec9ca-d305-43fc-88dd-7a510313efe0Product name120260105
bb209f42-a85f-4fee-9d3d-c9dded168625Product name120251208
49628fc7-2031-4c28-bd31-0ef3aa8f44a3Product name320251118
cbf85893-59ef-423f-87d4-a573c000a8b9Product name820250731
b5b1095b-40cd-8a9e-b111-502545045b07Product name420250325
e190029e-423b-473c-8e04-2ada59b5b711Product name120250314
860a93dc-4863-49cc-b284-6bbe8191bc48Product name420250214
eaba870a-6a9d-442e-8643-87b3f558a451Product name120250117
e0031c74-3853-42bc-8e10-86dbbe83992eProduct name220231116
f7046b89-2016-499a-adc6-78479172abc6Product name120230425
9b4cf230-fd05-41d5-98c6-5db9ecb27b86Product name120230117
2686d634-e712-4007-8dbf-3d37c6c4d71fProduct name120181121
fa8b5901-e681-426f-82fe-54f6d81ec698Product name420180619
bd49bb86-2d32-4a7a-a594-eeda2e29af42Product name120180118
332d03e4-aa24-4b11-841a-02bf41081920Product name120171221
c08ab52f-2fc8-4409-9d9f-ed8edc0bd070Product name120171221
3becbe78-12d9-4ad2-9b4c-1e36f8d1303aProduct name120170815
68ed98f8-24c2-44a0-944a-6d36e82ce25aProduct name120141222
1cd42bc2-a430-c72b-636d-991b235fbf80Product name120140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
0264-9378-05LIDOCAINE HCl and EPINEPHRINE5 in 1 CARTONINJECTION57
0264-9378-88LIDOCAINE HCl and EPINEPHRINE5 mL in 1 AMPULEINJECTION57

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
0264-9378LIDOCAINE HCL AND EPINEPHRINE INJECTION [B. BRAUN MEDICAL INC.]7Current NDC, Legacy NDC, 2 package rows20211216_fc83d701-02b2-4595-8e5b-dbebc5e209d5.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
LIDOCAINE HCl and EPINEPHRINELIDOCAINE HCL AND EPINEPHRINEB. Braun Medical Inc.fc83d701-02b2-4595-8e5b-dbebc5e209d52021-09-08Warnings, Adverse reactionsExact identifier
application applno (ANDA): 208475
application number: ANDA208475
ndc (product): 0264-9378

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
1867998lidocaine HCl 1.5 % / EPINEPHrine 1:200,000 in 5 ML InjectionPSNfc83d701-02b2-4595-8e5b-dbebc5e209d57
18679985 ML epinephrine 0.005 MG/ML / lidocaine hydrochloride 15 MG/ML InjectionSCDfc83d701-02b2-4595-8e5b-dbebc5e209d57
1867998lidocaine HCl 1.5 % / EPINEPHrine 1:200,000 per 5 ML InjectionSYfc83d701-02b2-4595-8e5b-dbebc5e209d57

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
0264-9378-05002649378055 AMPULE in 1 CARTON (0264-9378-05) / 5 mL in 1 AMPULE (0264-9378-88) 5 ampule2021-09-080000-00-00NoNoCurrent
0264-9378-88002649378885 mL in 1 AMPULE5 mlHistorical