Osmitrol

Product NDC
0338-0353
Requested package NDC
0338-0353-03
11-digit product format
003380353
Labeler code
0338
Product ID
0338-0353_3911fd42-2b73-4509-9c4c-92ceba4e6d34
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Mannitol
Dosage form
INJECTION, SOLUTION
Route
INTRAVENOUS
Labeler
Baxter Healthcare Company
Application
NDA013684
Marketing category
NDA
Marketing start
1964-06-08
Substance
MANNITOL
Active strength
10 g/100mL
Pharmacologic classes
Increased Diuresis [PE], Osmotic Activity [MoA], Osmotic Diuretic [EPC]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 8 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
N013684-001OSMITROL 5% IN WATERMANNITOL5GM/100MLINJECTABLE / INJECTIONAPApproved before 1982
N013684-002OSMITROL 10% IN WATERMANNITOL10GM/100MLINJECTABLE / INJECTIONAPApproved before 1982
N013684-003OSMITROL 20% IN WATERMANNITOL20GM/100MLINJECTABLE / INJECTIONAPApproved before 1982
N013684-004OSMITROL 15% IN WATERMANNITOL15GM/100MLINJECTABLE / INJECTIONAPApproved before 1982
N013684-005OSMITROL 5% IN WATER IN PLASTIC CONTAINERMANNITOL5GM/100MLINJECTABLE / INJECTIONAPApproved before 1982
N013684-006OSMITROL 10% IN WATER IN PLASTIC CONTAINERMANNITOL10GM/100MLINJECTABLE / INJECTIONAPApproved before 1982
N013684-007OSMITROL 20% IN WATER IN PLASTIC CONTAINERMANNITOL20GM/100MLINJECTABLE / INJECTIONAPRLD, RS, Approved before 1982
N013684-008OSMITROL 15% IN WATER IN PLASTIC CONTAINERMANNITOL15GM/100MLINJECTABLE / INJECTIONAPApproved before 1982

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 8 matching rows.

Application-product, TE code table
Application-productTE code
N013684-001AP
N013684-002AP
N013684-003AP
N013684-004AP
N013684-005AP
N013684-006AP
N013684-007AP
N013684-008AP

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 9 · 328 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02N013684-001OSMITROL 5% IN WATER5GM/100MLINJECTABLE / INJECTIONAPApproved before 1982011fe1cb6892…
2026-02-19 14:30 UTC2026-02N013684-002OSMITROL 10% IN WATER10GM/100MLINJECTABLE / INJECTIONAPApproved before 1982011fe1cb6892…
2026-02-19 14:30 UTC2026-02N013684-003OSMITROL 20% IN WATER20GM/100MLINJECTABLE / INJECTIONAPApproved before 1982011fe1cb6892…
2026-02-19 14:30 UTC2026-02N013684-004OSMITROL 15% IN WATER15GM/100MLINJECTABLE / INJECTIONAPApproved before 1982011fe1cb6892…
2026-02-19 14:30 UTC2026-02N013684-005OSMITROL 5% IN WATER IN PLASTIC CONTAINER5GM/100MLINJECTABLE / INJECTIONAPApproved before 1982011fe1cb6892…
2026-02-19 14:30 UTC2026-02N013684-006OSMITROL 10% IN WATER IN PLASTIC CONTAINER10GM/100MLINJECTABLE / INJECTIONAPApproved before 1982011fe1cb6892…
2026-02-19 14:30 UTC2026-02N013684-007OSMITROL 20% IN WATER IN PLASTIC CONTAINER20GM/100MLINJECTABLE / INJECTIONAPRLD, RS, Approved before 1982011fe1cb6892…
2026-02-19 14:30 UTC2026-02N013684-008OSMITROL 15% IN WATER IN PLASTIC CONTAINER15GM/100MLINJECTABLE / INJECTIONAPApproved before 1982011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N013684-001OSMITROL 5% IN WATER5GM/100MLINJECTABLE / INJECTIONAPApproved before 198231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N013684-002OSMITROL 10% IN WATER10GM/100MLINJECTABLE / INJECTIONAPApproved before 198231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N013684-003OSMITROL 20% IN WATER20GM/100MLINJECTABLE / INJECTIONAPApproved before 198231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N013684-004OSMITROL 15% IN WATER15GM/100MLINJECTABLE / INJECTIONAPApproved before 198231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N013684-005OSMITROL 5% IN WATER IN PLASTIC CONTAINER5GM/100MLINJECTABLE / INJECTIONAPApproved before 198231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N013684-006OSMITROL 10% IN WATER IN PLASTIC CONTAINER10GM/100MLINJECTABLE / INJECTIONAPApproved before 198231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N013684-007OSMITROL 20% IN WATER IN PLASTIC CONTAINER20GM/100MLINJECTABLE / INJECTIONAPRLD, RS, Approved before 198231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N013684-008OSMITROL 15% IN WATER IN PLASTIC CONTAINER15GM/100MLINJECTABLE / INJECTIONAPApproved before 198231067a03dcf5…
2025-08-23 18:47 UTC2025-08N013684-001OSMITROL 5% IN WATER5GM/100MLINJECTABLE / INJECTIONAPApproved before 19826a471c1ec25d…
2025-08-23 18:47 UTC2025-08N013684-002OSMITROL 10% IN WATER10GM/100MLINJECTABLE / INJECTIONAPApproved before 19826a471c1ec25d…
2025-08-23 18:47 UTC2025-08N013684-003OSMITROL 20% IN WATER20GM/100MLINJECTABLE / INJECTIONAPApproved before 19826a471c1ec25d…
2025-08-23 18:47 UTC2025-08N013684-004OSMITROL 15% IN WATER15GM/100MLINJECTABLE / INJECTIONAPApproved before 19826a471c1ec25d…
2025-08-23 18:47 UTC2025-08N013684-005OSMITROL 5% IN WATER IN PLASTIC CONTAINER5GM/100MLINJECTABLE / INJECTIONAPApproved before 19826a471c1ec25d…
2025-08-23 18:47 UTC2025-08N013684-006OSMITROL 10% IN WATER IN PLASTIC CONTAINER10GM/100MLINJECTABLE / INJECTIONAPApproved before 19826a471c1ec25d…
2025-08-23 18:47 UTC2025-08N013684-007OSMITROL 20% IN WATER IN PLASTIC CONTAINER20GM/100MLINJECTABLE / INJECTIONAPRLD, RS, Approved before 19826a471c1ec25d…
2025-08-23 18:47 UTC2025-08N013684-008OSMITROL 15% IN WATER IN PLASTIC CONTAINER15GM/100MLINJECTABLE / INJECTIONAPApproved before 19826a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N013684-001OSMITROL 5% IN WATER5GM/100MLINJECTABLE / INJECTIONAPApproved before 1982fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N013684-002OSMITROL 10% IN WATER10GM/100MLINJECTABLE / INJECTIONAPApproved before 1982fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N013684-003OSMITROL 20% IN WATER20GM/100MLINJECTABLE / INJECTIONAPApproved before 1982fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N013684-004OSMITROL 15% IN WATER15GM/100MLINJECTABLE / INJECTIONAPApproved before 1982fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N013684-005OSMITROL 5% IN WATER IN PLASTIC CONTAINER5GM/100MLINJECTABLE / INJECTIONAPApproved before 1982fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N013684-006OSMITROL 10% IN WATER IN PLASTIC CONTAINER10GM/100MLINJECTABLE / INJECTIONAPApproved before 1982fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N013684-007OSMITROL 20% IN WATER IN PLASTIC CONTAINER20GM/100MLINJECTABLE / INJECTIONAPRLD, RS, Approved before 1982fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N013684-008OSMITROL 15% IN WATER IN PLASTIC CONTAINER15GM/100MLINJECTABLE / INJECTIONAPApproved before 1982fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N013684-001OSMITROL 5% IN WATER5GM/100MLINJECTABLE / INJECTIONAPApproved before 1982b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N013684-002OSMITROL 10% IN WATER10GM/100MLINJECTABLE / INJECTIONAPApproved before 1982b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N013684-003OSMITROL 20% IN WATER20GM/100MLINJECTABLE / INJECTIONAPApproved before 1982b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N013684-004OSMITROL 15% IN WATER15GM/100MLINJECTABLE / INJECTIONAPApproved before 1982b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N013684-005OSMITROL 5% IN WATER IN PLASTIC CONTAINER5GM/100MLINJECTABLE / INJECTIONAPApproved before 1982b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N013684-006OSMITROL 10% IN WATER IN PLASTIC CONTAINER10GM/100MLINJECTABLE / INJECTIONAPApproved before 1982b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N013684-007OSMITROL 20% IN WATER IN PLASTIC CONTAINER20GM/100MLINJECTABLE / INJECTIONAPRLD, RS, Approved before 1982b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N013684-008OSMITROL 15% IN WATER IN PLASTIC CONTAINER15GM/100MLINJECTABLE / INJECTIONAPApproved before 1982b8a1b40f171c…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 9 · 328 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02N013684-001AP1011fe1cb6892…
2026-02-19 14:30 UTC2026-02N013684-002AP1011fe1cb6892…
2026-02-19 14:30 UTC2026-02N013684-003AP1011fe1cb6892…
2026-02-19 14:30 UTC2026-02N013684-004AP1011fe1cb6892…
2026-02-19 14:30 UTC2026-02N013684-005AP1011fe1cb6892…
2026-02-19 14:30 UTC2026-02N013684-006AP1011fe1cb6892…
2026-02-19 14:30 UTC2026-02N013684-007AP1011fe1cb6892…
2026-02-19 14:30 UTC2026-02N013684-008AP1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N013684-001AP131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N013684-002AP131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N013684-003AP131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N013684-004AP131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N013684-005AP131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N013684-006AP131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N013684-007AP131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N013684-008AP131067a03dcf5…
2025-08-23 18:47 UTC2025-08N013684-001AP16a471c1ec25d…
2025-08-23 18:47 UTC2025-08N013684-002AP16a471c1ec25d…
2025-08-23 18:47 UTC2025-08N013684-003AP16a471c1ec25d…
2025-08-23 18:47 UTC2025-08N013684-004AP16a471c1ec25d…
2025-08-23 18:47 UTC2025-08N013684-005AP16a471c1ec25d…
2025-08-23 18:47 UTC2025-08N013684-006AP16a471c1ec25d…
2025-08-23 18:47 UTC2025-08N013684-007AP16a471c1ec25d…
2025-08-23 18:47 UTC2025-08N013684-008AP16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N013684-001AP1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N013684-002AP1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N013684-003AP1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N013684-004AP1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N013684-005AP1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N013684-006AP1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N013684-007AP1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N013684-008AP1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N013684-001AP1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N013684-002AP1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N013684-003AP1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N013684-004AP1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N013684-005AP1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N013684-006AP1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N013684-007AP1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N013684-008AP1b8a1b40f171c…

Additional Listing Data#

Finished product
Yes
Brand name base
Osmitrol
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
MANNITOL10 g/100mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
3OWL53L36AInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 6 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
206536Internal RxNorm lookup
1791395Internal RxNorm lookup
1791403Internal RxNorm lookup
1791404Internal RxNorm lookup
1791408Internal RxNorm lookup
1791409Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
0d914965-7001-45cb-ba51-d7c5964b05bcAvailable on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
a62a50ac-1535-4461-9768-8ae703e2e9fbProduct name120210525
9514609b-a2a9-f8ec-6ba6-3f8e5ee89877Product name120140508
bc07ef78-e82d-0c19-31f4-31f263780582Product name120140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
0338-0353-03Osmitrol500 mL in 1 BAGINJECTION, SOLUTION50016

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
0338-0353-03ML - Milliliter0338-03532a2bdc99-cc36-48e6-a813-fceebf32763f12012-07-24
0338-0353-04ML - Milliliter0338-03530d95cd58-3613-4571-9e37-713a20d33be912012-07-24

DailyMed Socrata Ingredients#

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
0338-0353OSMITROL (MANNITOL) INJECTION, SOLUTION [BAXTER HEALTHCARE COMPANY]14Current NDC, Legacy NDC, 1 package rows20250519_0d914965-7001-45cb-ba51-d7c5964b05bc.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
OsmitrolMANNITOLBaxter Healthcare Company0d914965-7001-45cb-ba51-d7c5964b05bc2025-08-26Warnings, Adverse reactionsExact identifier
application applno (NDA): 013684
application number: NDA013684
ndc (package): 0338-0353-03
ndc (product): 0338-0353
ndc11 (package): 00338035303

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
1791395mannitol 10 % in 500 ML InjectionPSN0d914965-7001-45cb-ba51-d7c5964b05bc16
1791403mannitol 20 % in 250 ML InjectionPSN0d914965-7001-45cb-ba51-d7c5964b05bc16
1791408mannitol 20 % in 500 ML InjectionPSN0d914965-7001-45cb-ba51-d7c5964b05bc16
206536OSMITROL 10 % in 500 ML InjectionPSN0d914965-7001-45cb-ba51-d7c5964b05bc16
1791404OSMITROL 20 % in 250 ML InjectionPSN0d914965-7001-45cb-ba51-d7c5964b05bc16
1791409OSMITROL 20 % in 500 ML InjectionPSN0d914965-7001-45cb-ba51-d7c5964b05bc16
1791404250 ML mannitol 200 MG/ML Injection [Osmitrol]SBD0d914965-7001-45cb-ba51-d7c5964b05bc16
206536500 ML mannitol 100 MG/ML Injection [Osmitrol]SBD0d914965-7001-45cb-ba51-d7c5964b05bc16
1791409500 ML mannitol 200 MG/ML Injection [Osmitrol]SBD0d914965-7001-45cb-ba51-d7c5964b05bc16
1791403250 ML mannitol 200 MG/ML InjectionSCD0d914965-7001-45cb-ba51-d7c5964b05bc16
1791395500 ML mannitol 100 MG/ML InjectionSCD0d914965-7001-45cb-ba51-d7c5964b05bc16
1791408500 ML mannitol 200 MG/ML InjectionSCD0d914965-7001-45cb-ba51-d7c5964b05bc16
1791404250 ML Osmitrol 200 MG/ML InjectionSY0d914965-7001-45cb-ba51-d7c5964b05bc16
206536500 ML Osmitrol 100 MG/ML InjectionSY0d914965-7001-45cb-ba51-d7c5964b05bc16
1791409500 ML Osmitrol 200 MG/ML InjectionSY0d914965-7001-45cb-ba51-d7c5964b05bc16
1791395mannitol 10 % per 500 ML InjectionSY0d914965-7001-45cb-ba51-d7c5964b05bc16
1791403mannitol 20 % per 250 ML InjectionSY0d914965-7001-45cb-ba51-d7c5964b05bc16
1791408mannitol 20 % per 500 ML InjectionSY0d914965-7001-45cb-ba51-d7c5964b05bc16
206536Osmitrol 10 % per 500 ML InjectionSY0d914965-7001-45cb-ba51-d7c5964b05bc16
1791404Osmitrol 20 % per 250 ML InjectionSY0d914965-7001-45cb-ba51-d7c5964b05bc16
1791409Osmitrol 20 % per 500 ML InjectionSY0d914965-7001-45cb-ba51-d7c5964b05bc16

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
0338-0353-0300338035303500 mL in 1 BAG (0338-0353-03) 500 ml1964-06-080000-00-00NoNoCurrent