Overnight Cold and Flu

Product NDC: 0363-6980
11-digit product format: 003636980
Labeler code: 0363
Product ID: 0363-6980_446afe14-2e44-2cf8-e063-6394a90af70e
Type: HUMAN OTC DRUG
Nonproprietary name: Acetaminophen, Dextromethorphan HBr, Triprolidine HCl
Dosage form: SOLUTION
Route: ORAL
Labeler: WALGREENS CO
Application: M010
Marketing category: OTC MONOGRAPH DRUG
Marketing start: 2020-01-28
Substance: ACETAMINOPHEN; DEXTROMETHORPHAN HYDROBROMIDE; TRIPROLIDINE HYDROCHLORIDE
Active strength: 650; 20; 2.5 mg/20mL; mg/20mL; mg/20mL
Pharmacologic classes: Sigma-1 Agonist [EPC], Sigma-1 Receptor Agonists [MoA], Uncompetitive N-methyl-D-aspartate Receptor Antagonist [EPC], Uncompetitive NMDA Receptor Antagonists [MoA]
NDC exclude flag: No
Listing certified through: 2026-12-31
Current FDA listing: Yes

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

Additional Listing Data#

Finished product: Yes
Brand name base: Overnight Cold and Flu
Listing expiration: 2026-12-31

Active Ingredients#

Ingredient, Strength table
Ingredient	Strength
ACETAMINOPHEN	650 mg/20mL
DEXTROMETHORPHAN HYDROBROMIDE	20 mg/20mL
TRIPROLIDINE HYDROCHLORIDE	2.5 mg/20mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 3 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
362O9ITL9D	Internal UNII lookup
9D2RTI9KYH	Internal UNII lookup
YAN7R5L890	Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
2173667	Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
807e8ace-2901-4c5f-96dc-04c755484b95	Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product concept	Relation	Version	Effective
bf324df6-7127-7deb-def5-2681c136cd03	Product name	3	20250325
43a1ed49-eae2-4840-8075-cb4b33478540	Product name	1	20230425
ba088a92-ab5e-b2d4-e908-f5ea691b7587	Product name	7	20210201
c5cd4727-ac49-4409-82b1-5bd8006c3ec7	Product name	1	20171122
30c51294-7ae9-8007-7de6-58222684a0be	Product name	1	20140508
76633df9-0d59-4b88-03ed-21dee1b966f8	Product name	1	20140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	Strength	SPL version
0363-6980-06	Overnight Cold and Flu	180 mL in 1 BOTTLE	SOLUTION	180		7

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
0363-6980	OVERNIGHT COLD AND FLU (ACETAMINOPHEN, DEXTROMETHORPHAN HBR, TRIPROLIDINE HCL) SOLUTION [WALGREENS CO]	6	Current NDC, Legacy NDC, 1 package rows	20241113_807e8ace-2901-4c5f-96dc-04c755484b95.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 6 of 12 · 236 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
Unisom SleepMelts Nighttime Sleep-Aid	DIPHENHYDRAMINE HYDROCHLORIDE	QUALITY CHOICE (CHAIN DRUG MARKETING ASSOCIATION)	f50cc038-0973-4c4b-84a7-1c68f41c2410	2025-12-04	Warnings	Exact identifier application number: M010
Walgreens Childrens	NIGHTTIME COUGH	WALGREENS CO.	a270cbe3-bf0a-44da-9359-00e218eba239	2025-12-01	Warnings	Exact identifier application number: M010
ZzzQuil ULTRA, Travel BASIX	DOXYLAMINE SUCCINATE	Lil' Drug Store Products, Inc.	0f8c7219-7b40-27c6-e063-6294a90a27d9	2025-12-01	Warnings	Exact identifier application number: M010
Nighttime Sleep-Aid	DIPHENHYDRAMINE HCL	BIONPHARMA INC.	141b00b7-a283-40ab-e063-6294a90aec77	2025-12-01	Warnings	Exact identifier application number: M010
Nighttime Sleep-Aid	DIPHENHYDRAMINE HCL	BIONPHARMA INC.	1f74e760-9ba9-ac47-e063-6394a90acdff	2025-12-01	Warnings	Exact identifier application number: M010
Nighttime Sleep-Aid	DIPHENHYDRAMINE HCL	DISCOUNT DRUG MART, INC.	116e8192-0c2f-39ed-e063-6294a90abaf3	2025-12-01	Warnings	Exact identifier application number: M010
Nighttime Sleep-Aid	DIPHENHYDRAMINE HCL	AMERISOURCE BERGEN	16b2edd2-c16b-5713-e063-6394a90acf46	2025-12-01	Warnings	Exact identifier application number: M010
Nighttime Sleep-Aid	DIPHENHYDRAMINE HCL	VALU MERCHANDISERS COMPANY	08a38cd2-04ae-1ef9-e063-6294a90a8868	2025-12-01	Warnings	Exact identifier application number: M010
Nighttime Sleep-Aid	DIPHENHYDRAMINE HCL	KROGER COMPANY	0f2c1c6a-29bc-e4a8-e063-6394a90a28cb	2025-12-01	Warnings	Exact identifier application number: M010
Nighttime Sleep-Aid	DIPHENHYDRAMINE HCL	Whole Foods Market, INC.	35acf7d9-e567-996d-e063-6394a90a1cf6	2025-12-01	Warnings	Exact identifier application number: M010
Nighttime Sleep Aid	DIPHENHYDRAMINE HYDROCHLORIDE	WALGREEN COMPANY	048cfa3a-4519-400d-a5ab-ce05c9cc4ec8	2025-11-26	Warnings	Exact identifier application number: M010
Sleep Aid Nighttime	DIPHENHYDRAMINE HCL	CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED	fe58ce40-ae88-4dc5-9486-e67041f6d852	2025-11-26	Warnings	Exact identifier application number: M010
nighttime sleep aid	DIPHENHYDRAMINE HYDROCHLORIDE	H E B	b72c47a3-cae3-4b98-ae85-e1313b6fd501	2025-11-25	Warnings	Exact identifier application number: M010
Nighttime Wal Flu Severe Cold and Cough	ACETAMINOPHEN, DIPHENHYDRAMINE, PHENYLEPHRINE	WALGREEN CO.	e88f7777-9987-4e3c-a3d5-3da60f190bfd	2025-11-25	Warnings	Exact identifier application number: M010
Overnight Cold and Flu	ACETAMINOPHEN, DEXTROMETHORPHAN HBR, TRIPROLIDINE HCL	WALGREENS CO	807e8ace-2901-4c5f-96dc-04c755484b95	2025-11-25	Warnings	Exact identifier application number: M010 ndc (product): 0363-6980
Sleep	DIPHENHYDRAMINE HCL	Salado Sales, Inc.	837c02dd-971b-4451-98d8-9c438c9db696	2025-11-24	Warnings	Exact identifier application number: M010
Nighttime SleepAid	DIPHENHYDRAMINE HYDROCHLORIDE	AMERIFOODS TRADING COMPANY	3802d57e-7943-c0c2-e063-6394a90a7580	2025-11-20	Warnings	Exact identifier application number: M010
Sleep-Aid Nighttime	DIPHENHYDRAMINE HCL	CVS PHARMACY	6bd1ad2e-8f47-412d-8620-b149ad90c292	2025-11-17	Warnings	Exact identifier application number: M010
Nighttime Sleep-Aid	DIPHENHYDRAMINE HCL	Rite Aid Corporation	f8d50b4e-735d-4d91-a18d-be3537e46e99	2025-11-15	Warnings	Exact identifier application number: M010
SLEEP AID	DIPHENHYDRAMINE HYDROCHLORIDE	Company name: Topco Associates, LLC	7aec7b1b-39dc-4e99-9f92-d45af0a4a6ec	2025-10-31	Warnings	Exact identifier application number: M010

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
362O9ITL9D	ACETAMINOPHEN	103-90-2	ACETAMINOPHEN
9D2RTI9KYH	DEXTROMETHORPHAN HYDROBROMIDE	6700-34-1	DEXTROMETHORPHAN HYDROBROMIDE
YAN7R5L890	TRIPROLIDINE HYDROCHLORIDE	6138-79-0	TRIPROLIDINE HYDROCHLORIDE

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUI	RxNorm string	TTY	DailyMed	SPL version
2173667	acetaminophen 650 MG / dextromethorphan HBr 20 MG / triprolidine HCl 2.5 MG in 20 mL Oral Solution	PSN	807e8ace-2901-4c5f-96dc-04c755484b95	7
2173667	acetaminophen 32.5 MG/ML / dextromethorphan hydrobromide 1 MG/ML / triprolidine hydrochloride 0.125 MG/ML Oral Solution	SCD	807e8ace-2901-4c5f-96dc-04c755484b95	7
2173667	acetaminophen 650 MG / dextromethorphan hydrobromide 20 MG / triprolidine hydrochloride 2.5 MG per 20 mL Oral Solution	SY	807e8ace-2901-4c5f-96dc-04c755484b95	7
2173667	APAP 32.5 MG/ML / Dextromethorphan Hydrobromide 1 MG/ML / Triprolidine Hydrochloride 0.125 MG/ML Oral Solution	SY	807e8ace-2901-4c5f-96dc-04c755484b95	7

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Units	Marketing start	Marketing end	Sample	Exclude flag	Status
0363-6980-06	00363698006	180 mL in 1 BOTTLE (0363-6980-06)	180 ml	2020-01-28	0000-00-00	No	No	Current