Methadone Hydrochloride

Product NDC
0406-4123
11-digit product format
004064123
Labeler code
0406
Product ID
0406-4123_f3e27571-1978-4639-a625-a7ff53e446d6
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Methadone Hydrochloride
Dosage form
CONCENTRATE
Route
ORAL
Labeler
SpecGx LLC
Application
ANDA207368
Marketing category
ANDA
Marketing start
2021-06-18
Substance
METHADONE HYDROCHLORIDE
Active strength
10 mg/mL
Pharmacologic classes
Full Opioid Agonists [MoA], Opioid Agonist [EPC]
DEA schedule
CII
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 42.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A207368-001METHADONE HYDROCHLORIDEMETHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-22

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-productTE code
A207368-001AA

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 41 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-08-18 06:07:402026-07A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-22caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-22011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-2231067a03dcf5…
2025-08-23 18:47 UTC2025-08A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-226a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-22fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-22b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-2203ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-222680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-225bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-22d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-22d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-2279d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-22301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-221e350fbaab3a…
2024-05-31 18:47 UTC2024-05A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-228072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-225c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-225d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-224b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-2274a2ff9319b5…
2022-03-09 01:35 UTC2022-03A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-22bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-22782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-2287673890dc5c…
2021-03-12 10:30 UTC2021-03A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-225aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-228869cabd3fbd…
2020-11-12 02:37 UTC2020-11A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-22c0c555d07b60…
2019-12-14 00:12 UTC2019-12A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-223f01610625f2…
2019-09-15 20:21 UTC2019-09A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-22b00525d2431f…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-226a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-221c564ffb4f44…
2023-12-20 04:57 UTC2023-12A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-22ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-22a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-229b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-22a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-223f0d92c62455…
2023-05-13 08:27 UTC2023-05A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-22053a50430f4f…
2023-01-26 05:58 UTC2023-01A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-223bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-223a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-22f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-22e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07A207368-001METHADONE HYDROCHLORIDE10MG/MLCONCENTRATE / ORALAA2019-08-22cb3db0bc1861…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 2 · 41 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-08-18 06:07:402026-07A207368-001AA1caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A207368-001AA1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A207368-001AA131067a03dcf5…
2025-08-23 18:47 UTC2025-08A207368-001AA16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A207368-001AA1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A207368-001AA1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A207368-001AA103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A207368-001AA12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A207368-001AA15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A207368-001AA1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A207368-001AA1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A207368-001AA179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A207368-001AA1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A207368-001AA11e350fbaab3a…
2024-05-31 18:47 UTC2024-05A207368-001AA18072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A207368-001AA15c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A207368-001AA15d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A207368-001AA14b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A207368-001AA174a2ff9319b5…
2022-03-09 01:35 UTC2022-03A207368-001AA1bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A207368-001AA1782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A207368-001AA187673890dc5c…
2021-03-12 10:30 UTC2021-03A207368-001AA15aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A207368-001AA18869cabd3fbd…
2020-11-12 02:37 UTC2020-11A207368-001AA1c0c555d07b60…
2019-12-14 00:12 UTC2019-12A207368-001AA13f01610625f2…
2019-09-15 20:21 UTC2019-09A207368-001AA1b00525d2431f…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A207368-001AA16a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A207368-001AA11c564ffb4f44…
2023-12-20 04:57 UTC2023-12A207368-001AA1ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A207368-001AA1a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A207368-001AA19b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A207368-001AA1a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A207368-001AA13f0d92c62455…
2023-05-13 08:27 UTC2023-05A207368-001AA1053a50430f4f…
2023-01-26 05:58 UTC2023-01A207368-001AA13bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A207368-001AA13a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A207368-001AA1f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A207368-001AA1e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07A207368-001AA1cb3db0bc1861…

Additional Listing Data#

Finished product
Yes
Brand name base
Methadone Hydrochloride
Listing expiration
2027-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
METHADONE HYDROCHLORIDE10 mg/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
229809935BInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
991147Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
14f7b1d8-344a-4eaa-a1bf-bc1a00c3ab58Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
bc6c52c8-e3e2-9042-21d0-6770dcf1a49bProduct name320250819
e2db08c6-133f-4f4f-afb4-e90a2418d6f6Product name120230320
c6f86816-7da6-43ea-8c25-ac9758311cc5Product name120220118
a48f0261-b6cc-12b3-49fd-ed131bc5aa96Product name420210902
ce6d5c06-3ae0-18a6-d5b3-8cd3cc0f8906Product name720210625
f52be47f-7aa7-46c0-b1fa-50c18dd50206Product name120201029
00dcb24c-d95e-78f6-6c1b-4d7b709bb2b9Product name620200708
a6a96832-f31d-b458-45cb-abb8bd940b44Product name220200304
11ed6f83-cdd2-4637-8379-b1a1d3ae3cdeProduct name120181101
86c45a79-b9f0-4476-a27c-6e10db098497Product name120180125
252e11b6-1a9a-4283-a242-df2c129c496dProduct name320170717
d5e51f11-ad28-caa4-4b49-4143974782adProduct name120150831

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
0406-4123-03Methadone Hydrochloride30 mL in 1 BOTTLE, DROPPERCONCENTRATE307
0406-4123-03Methadone Hydrochloride1 in 1 CARTONCONCENTRATE17
0406-4123-10Methadone Hydrochloride1000 mL in 1 BOTTLECONCENTRATE10007

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
0406-4123-03ML - Milliliter0406-4123bb861e94-8d97-4ec2-a7e0-b2830efbcbe512021-09-07
0406-4123-10ML - Milliliter0406-41234acffaea-c11f-42fd-8821-9cac1c4fd9a512021-09-07

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
0406-4123METHADONE HYDROCHLORIDE CONCENTRATE [SPECGX LLC]4Current NDC, Legacy NDC, 3 package rows20241116_14f7b1d8-344a-4eaa-a1bf-bc1a00c3ab58.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Methadone HydrochlorideMETHADONE HYDROCHLORIDESpecGx LLC14f7b1d8-344a-4eaa-a1bf-bc1a00c3ab582026-07-29Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 207368
application number: ANDA207368
ndc (product): 0406-4123

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
991147methadone HCl 10 MG in 1 mL Concentrate for Oral SolutionPSN14f7b1d8-344a-4eaa-a1bf-bc1a00c3ab587
991147methadone hydrochloride 10 MG/ML Oral SolutionSCD14f7b1d8-344a-4eaa-a1bf-bc1a00c3ab587
991147methadone hydrochloride 10 MG per 1 ML Oral SolutionSY14f7b1d8-344a-4eaa-a1bf-bc1a00c3ab587
991147methadone hydrochloride 5 MG per 0.5 ML Oral SolutionSY14f7b1d8-344a-4eaa-a1bf-bc1a00c3ab587

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
0406-4123-03004064123031 BOTTLE, DROPPER in 1 CARTON (0406-4123-03) / 30 mL in 1 BOTTLE, DROPPER2021-06-180000-00-00NoNoCurrent
0406-4123-10004064123101000 mL in 1 BOTTLE (0406-4123-10) 1000 ml2021-06-180000-00-00NoNoCurrent