Cyclosporine

Product NDC
0480-4076
11-digit product format
004804076
Labeler code
0480
Product ID
0480-4076_0dc3c832-fe01-4913-ba52-47cca4c890b4
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Cyclosporine
Dosage form
EMULSION
Route
OPHTHALMIC
Labeler
Teva Pharmaceuticals, Inc.
Application
ANDA203880
Marketing category
ANDA
Marketing start
2025-10-28
Substance
CYCLOSPORINE
Active strength
.5 mg/mL
Pharmacologic classes
Calcineurin Inhibitor Immunosuppressant [EPC], Calcineurin Inhibitors [MoA], Cytochrome P450 3A4 Inhibitors [MoA], P-Glycoprotein Inhibitors [MoA]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A203880-001CYCLOSPORINECYCLOSPORINE0.05%EMULSION / OPHTHALMICAB2023-12-14

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-productTE code
A203880-001AB

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02A203880-001CYCLOSPORINE0.05%EMULSION / OPHTHALMICAB2023-12-14011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A203880-001CYCLOSPORINE0.05%EMULSION / OPHTHALMICAB2023-12-1431067a03dcf5…
2025-08-23 18:47 UTC2025-08A203880-001CYCLOSPORINE0.05%EMULSION / OPHTHALMICAB2023-12-146a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A203880-001CYCLOSPORINE0.05%EMULSION / OPHTHALMICAB2023-12-14fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A203880-001CYCLOSPORINE0.05%EMULSION / OPHTHALMICAB2023-12-14b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A203880-001CYCLOSPORINE0.05%EMULSION / OPHTHALMICAB2023-12-1403ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A203880-001CYCLOSPORINE0.05%EMULSION / OPHTHALMICAB2023-12-142680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A203880-001CYCLOSPORINE0.05%EMULSION / OPHTHALMIC2023-12-145bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A203880-001CYCLOSPORINE0.05%EMULSION / OPHTHALMICAB2023-12-14d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A203880-001CYCLOSPORINE0.05%EMULSION / OPHTHALMIC2023-12-14d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A203880-001CYCLOSPORINE0.05%EMULSION / OPHTHALMIC2023-12-1479d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A203880-001CYCLOSPORINE0.05%EMULSION / OPHTHALMIC2023-12-14301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A203880-001CYCLOSPORINE0.05%EMULSION / OPHTHALMICAB2023-12-141e350fbaab3a…
2024-05-31 18:47 UTC2024-05A203880-001CYCLOSPORINE0.05%EMULSION / OPHTHALMICAB2023-12-148072bd15b7f6…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A203880-001CYCLOSPORINE0.05%EMULSION / OPHTHALMICAB2023-12-146a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A203880-001CYCLOSPORINE0.05%EMULSION / OPHTHALMICAB2023-12-141c564ffb4f44…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A203880-001CYCLOSPORINE0.05%EMULSION / OPHTHALMICAB2023-12-14a50c72e98297…

Observed Orange Book normalized TE history#

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02A203880-001AB1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A203880-001AB131067a03dcf5…
2025-08-23 18:47 UTC2025-08A203880-001AB16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A203880-001AB1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A203880-001AB1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A203880-001AB103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A203880-001AB12680178bc6a6…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A203880-001AB1d8e5a09893c0…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A203880-001AB11e350fbaab3a…
2024-05-31 18:47 UTC2024-05A203880-001AB18072bd15b7f6…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A203880-001AB16a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A203880-001AB11c564ffb4f44…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A203880-001AB1a50c72e98297…

Additional Listing Data#

Finished product
Yes
Brand name base
Cyclosporine
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
CYCLOSPORINE.5 mg/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
83HN0GTJ6DInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
2572292Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
cc64c1e3-19f5-4bf6-a08d-a9725004c97fAvailable on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
1be408a0-e15a-4092-b35e-4e294e65196fProduct name320240216
b3fdee3e-0c46-442f-aad5-aa71941d5621Product name120231023
78fb0708-fce5-decd-6611-5a9fbe3e3decProduct name320230327
54840517-000d-4fcb-b976-a6ddd102faa0Product name120220120
a5ba3bd0-8411-4005-ac3b-a41d8ee0633aProduct name120181029
b1c0d609-8b97-06ee-2cd0-5652a4b1d019Product name120140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
0480-4076-30Cyclosporine6 in 1 CARTONEMULSION66
0480-4076-30Cyclosporine5 in 1 POUCHEMULSION56
0480-4076-60Cyclosporine5 in 1 POUCHEMULSION56
0480-4076-60Cyclosporine12 in 1 CARTONEMULSION126

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
0480-4076-30EA - Each0480-407630619515-01b0-4323-a532-00448bf76ba712025-11-13
0480-4076-60EA - Each0480-4076c8eaf837-650c-404f-a579-681ab3cedeca12025-11-13

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
CyclosporineCYCLOSPORINETeva Pharmaceuticals, Inc.cc64c1e3-19f5-4bf6-a08d-a9725004c97f2024-03-01Warnings, Adverse reactionsExact identifier
application applno (ANDA): 203880
application number: ANDA203880
ndc (product): 0480-4076

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
2572292cycloSPORINE 0.05 % in 0.4 ML Ophthalmic EmulsionPSNcc64c1e3-19f5-4bf6-a08d-a9725004c97f6
25722920.4 ML cyclosporine 0.5 MG/ML Ophthalmic SuspensionSCDcc64c1e3-19f5-4bf6-a08d-a9725004c97f6
2572292cyclosporine 0.05 % per 0.4 ML Ophthalmic EmulsionSYcc64c1e3-19f5-4bf6-a08d-a9725004c97f6
2572292cyclosporine 0.5 MG/ML per 0.4 ML Ophthalmic EmulsionSYcc64c1e3-19f5-4bf6-a08d-a9725004c97f6

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startSampleExclude flagStatus
0480-4076-30004804076306 POUCH in 1 CARTON (0480-4076-30) / 5 VIAL, SINGLE-DOSE in 1 POUCH / .4 mL in 1 VIAL, SINGLE-DOSE6 pouch2025-10-28NoNoCurrent
0480-4076-600048040766012 POUCH in 1 CARTON (0480-4076-60) / 5 VIAL, SINGLE-DOSE in 1 POUCH / .4 mL in 1 VIAL, SINGLE-DOSE12 pouch2025-10-28NoNoCurrent