Valproic

Product NDC
0591-4012
11-digit product format
005914012
Labeler code
0591
Product ID
0591-4012_a64ec7af-329d-4b8c-ad44-eedb68ec8f40
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Valproic Acid
Dosage form
CAPSULE, LIQUID FILLED
Route
ORAL
Labeler
Actavis Pharma, Inc.
Application
ANDA073229
Marketing category
ANDA
Marketing start
2009-09-08
Substance
VALPROIC ACID
Active strength
250 mg/1
Pharmacologic classes
Anti-epileptic Agent [EPC], Decreased Central Nervous System Disorganized Electrical Activity [PE], Mood Stabilizer [EPC]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 42.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A073229-001VALPROIC ACIDVALPROIC ACID250MGCAPSULE / ORALAB1991-10-29

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-productTE code
A073229-001AB

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 42 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-08-18 06:07:402026-07A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-29caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-29011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-2931067a03dcf5…
2025-08-23 18:47 UTC2025-08A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-296a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-29fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-29b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-2903ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-292680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-295bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-29d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-29d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-2979d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-29301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-291e350fbaab3a…
2024-05-31 18:47 UTC2024-05A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-298072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-295c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-295d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-294b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-2974a2ff9319b5…
2022-03-09 01:35 UTC2022-03A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-29bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-29782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-2987673890dc5c…
2021-03-12 10:30 UTC2021-03A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-295aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-298869cabd3fbd…
2020-11-12 02:37 UTC2020-11A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-29c0c555d07b60…
2019-12-14 00:12 UTC2019-12A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-293f01610625f2…
2019-09-15 20:21 UTC2019-09A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-29b00525d2431f…
2019-07-19 19:46 UTC2019-07A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-29ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-296a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-291c564ffb4f44…
2023-12-20 04:57 UTC2023-12A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-29ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-29a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-299b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-29a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-293f0d92c62455…
2023-05-13 08:27 UTC2023-05A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-29053a50430f4f…
2023-01-26 05:58 UTC2023-01A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-293bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-293a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-29f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A073229-001VALPROIC ACID250MGCAPSULE / ORALAB1991-10-29e64feba35796…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 2 · 42 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-08-18 06:07:402026-07A073229-001AB1caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A073229-001AB1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A073229-001AB131067a03dcf5…
2025-08-23 18:47 UTC2025-08A073229-001AB16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A073229-001AB1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A073229-001AB1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A073229-001AB103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A073229-001AB12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A073229-001AB15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A073229-001AB1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A073229-001AB1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A073229-001AB179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A073229-001AB1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A073229-001AB11e350fbaab3a…
2024-05-31 18:47 UTC2024-05A073229-001AB18072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A073229-001AB15c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A073229-001AB15d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A073229-001AB14b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A073229-001AB174a2ff9319b5…
2022-03-09 01:35 UTC2022-03A073229-001AB1bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A073229-001AB1782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A073229-001AB187673890dc5c…
2021-03-12 10:30 UTC2021-03A073229-001AB15aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A073229-001AB18869cabd3fbd…
2020-11-12 02:37 UTC2020-11A073229-001AB1c0c555d07b60…
2019-12-14 00:12 UTC2019-12A073229-001AB13f01610625f2…
2019-09-15 20:21 UTC2019-09A073229-001AB1b00525d2431f…
2019-07-19 19:46 UTC2019-07A073229-001AB1ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A073229-001AB16a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A073229-001AB11c564ffb4f44…
2023-12-20 04:57 UTC2023-12A073229-001AB1ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A073229-001AB1a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A073229-001AB19b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A073229-001AB1a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A073229-001AB13f0d92c62455…
2023-05-13 08:27 UTC2023-05A073229-001AB1053a50430f4f…
2023-01-26 05:58 UTC2023-01A073229-001AB13bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A073229-001AB13a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A073229-001AB1f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A073229-001AB1e64feba35796…

Additional Listing Data#

Finished product
Yes
Brand name base
Valproic
Listing expiration
2027-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
VALPROIC ACID250 mg/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
614OI1Z5WIInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1099681Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
cef3e335-5891-412f-89c4-79fcd2f145b7Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
b10a892b-b985-4cbc-9547-9ac4b72b784fProduct name220250818
7a3a03f1-382a-f9ec-0741-ff24dcbfed69Product name720250624
57fc3d01-4737-4091-9728-9e8a4c9e708dProduct name120200121
5d67ecc7-47c7-ec5e-e9eb-71bf00250645Product name120140508
97fce1a8-50c4-f088-0e31-64d82b6e9081Product name120140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
0591-4012-01Valproic100 in 1 BOTTLECAPSULE, LIQUID FILLED10019

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
0591-4012-01EA - Each0591-401216d18826-a5bb-409f-93e7-d08cf218559312012-07-24

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
IngredientTypeUNIIDailyMed labelSPL versionUploaded
VALPROIC ACIDACTIVE INGREDIENT614OI1Z5WIVALPROIC (VALPROIC ACID) CAPSULE, LIQUID FILLED [ACTAVIS PHARMA, INC.]7
VALPROIC ACIDACTIVE MOIETY614OI1Z5WIVALPROIC (VALPROIC ACID) CAPSULE, LIQUID FILLED [ACTAVIS PHARMA, INC.]7
GELATININACTIVE INGREDIENT2G86QN327LVALPROIC (VALPROIC ACID) CAPSULE, LIQUID FILLED [ACTAVIS PHARMA, INC.]7
GLYCERININACTIVE INGREDIENTPDC6A3C0OXVALPROIC (VALPROIC ACID) CAPSULE, LIQUID FILLED [ACTAVIS PHARMA, INC.]7
PEANUT OILINACTIVE INGREDIENT5TL50QU0W4VALPROIC (VALPROIC ACID) CAPSULE, LIQUID FILLED [ACTAVIS PHARMA, INC.]7
TITANIUM DIOXIDEINACTIVE INGREDIENT15FIX9V2JPVALPROIC (VALPROIC ACID) CAPSULE, LIQUID FILLED [ACTAVIS PHARMA, INC.]7
VALPROIC ACIDACTIVE INGREDIENT614OI1Z5WIVALPROIC (VALPROIC ACID) CAPSULE, LIQUID FILLED [NCS HEALTHCARE OF KY, INC DBA VANGARD LABS]5
VALPROIC ACIDACTIVE MOIETY614OI1Z5WIVALPROIC (VALPROIC ACID) CAPSULE, LIQUID FILLED [NCS HEALTHCARE OF KY, INC DBA VANGARD LABS]5
GELATININACTIVE INGREDIENT2G86QN327LVALPROIC (VALPROIC ACID) CAPSULE, LIQUID FILLED [NCS HEALTHCARE OF KY, INC DBA VANGARD LABS]5
GLYCERININACTIVE INGREDIENTPDC6A3C0OXVALPROIC (VALPROIC ACID) CAPSULE, LIQUID FILLED [NCS HEALTHCARE OF KY, INC DBA VANGARD LABS]5
PEANUT OILINACTIVE INGREDIENT5TL50QU0W4VALPROIC (VALPROIC ACID) CAPSULE, LIQUID FILLED [NCS HEALTHCARE OF KY, INC DBA VANGARD LABS]5
TITANIUM DIOXIDEINACTIVE INGREDIENT15FIX9V2JPVALPROIC (VALPROIC ACID) CAPSULE, LIQUID FILLED [NCS HEALTHCARE OF KY, INC DBA VANGARD LABS]5
VALPROIC ACIDACTIVE INGREDIENT614OI1Z5WIVALPROIC (VALPROIC ACID) CAPSULE, LIQUID FILLED [CONTRACT PHARMACY SERVICES-PA]1
VALPROIC ACIDACTIVE INGREDIENT614OI1Z5WIVALPROIC (VALPROIC ACID) CAPSULE, LIQUID FILLED [PHYSICIANS TOTAL CARE, INC.]1
VALPROIC ACIDACTIVE MOIETY614OI1Z5WIVALPROIC (VALPROIC ACID) CAPSULE, LIQUID FILLED [CONTRACT PHARMACY SERVICES-PA]1
VALPROIC ACIDACTIVE MOIETY614OI1Z5WIVALPROIC (VALPROIC ACID) CAPSULE, LIQUID FILLED [PHYSICIANS TOTAL CARE, INC.]1
GELATININACTIVE INGREDIENT2G86QN327LVALPROIC (VALPROIC ACID) CAPSULE, LIQUID FILLED [CONTRACT PHARMACY SERVICES-PA]1
GELATININACTIVE INGREDIENT2G86QN327LVALPROIC (VALPROIC ACID) CAPSULE, LIQUID FILLED [PHYSICIANS TOTAL CARE, INC.]1
GLYCERININACTIVE INGREDIENTPDC6A3C0OXVALPROIC (VALPROIC ACID) CAPSULE, LIQUID FILLED [CONTRACT PHARMACY SERVICES-PA]1
GLYCERININACTIVE INGREDIENTPDC6A3C0OXVALPROIC (VALPROIC ACID) CAPSULE, LIQUID FILLED [PHYSICIANS TOTAL CARE, INC.]1
PEANUT OILINACTIVE INGREDIENT5TL50QU0W4VALPROIC (VALPROIC ACID) CAPSULE, LIQUID FILLED [CONTRACT PHARMACY SERVICES-PA]1
PEANUT OILINACTIVE INGREDIENT5TL50QU0W4VALPROIC (VALPROIC ACID) CAPSULE, LIQUID FILLED [PHYSICIANS TOTAL CARE, INC.]1
TITANIUM DIOXIDEINACTIVE INGREDIENT15FIX9V2JPVALPROIC (VALPROIC ACID) CAPSULE, LIQUID FILLED [CONTRACT PHARMACY SERVICES-PA]1
TITANIUM DIOXIDEINACTIVE INGREDIENT15FIX9V2JPVALPROIC (VALPROIC ACID) CAPSULE, LIQUID FILLED [PHYSICIANS TOTAL CARE, INC.]1

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
0591-4012VALPROIC (VALPROIC ACID) CAPSULE, LIQUID FILLED [ACTAVIS PHARMA, INC.]16Current NDC, Legacy NDC, 1 package rows20241030_cef3e335-5891-412f-89c4-79fcd2f145b7.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 5 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
ValproicVALPROIC ACIDActavis Pharma, Inc.cef3e335-5891-412f-89c4-79fcd2f145b72026-06-02Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 073229
application number: ANDA073229
ndc (product): 0591-4012
valproic acidVALPROIC ACIDUpsher-Smith Laboratories, LLC7d4df6ad-3d53-4664-9200-749487bf36892025-07-09Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 073229
application number: ANDA073229
ValproicVALPROIC ACIDAphena Pharma Solutions - Tennessee, LLC34a0d45a-4388-7d8b-e063-6394a90a6c3f2025-05-23Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 073229
application number: ANDA073229
Valproic AcidVALPROIC ACIDDirect_Rx8bdbacb1-b38a-3282-e053-2a95a90af0222025-01-20Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 073229
application number: ANDA073229
valproic acidVALPROIC ACIDAphena Pharma Solutions - Tennessee, LLC3904177b-8a26-4356-9080-d2a2e3f468af2017-10-17Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 073229
application number: ANDA073229

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
1099681valproic acid 250 MG Oral CapsulePSN34a0d45a-4388-7d8b-e063-6394a90a6c3f2
1099681valproic acid 250 MG Oral CapsuleSCD34a0d45a-4388-7d8b-e063-6394a90a6c3f2
1099681VPA 250 MG Oral CapsuleSY34a0d45a-4388-7d8b-e063-6394a90a6c3f2
1099681valproic acid 250 MG Oral CapsulePSN31ae5a24-a6a9-4103-acda-b6113052b3861
1099681valproic acid 250 MG Oral CapsulePSN86dd50d5-4890-4b3c-8681-18796eff97b61
1099681valproic acid 250 MG Oral CapsulePSN9fbfe4dc-c4df-4911-a440-099c860cb9231
1099681valproic acid 250 MG Oral CapsuleSCD31ae5a24-a6a9-4103-acda-b6113052b3861
1099681valproic acid 250 MG Oral CapsuleSCD86dd50d5-4890-4b3c-8681-18796eff97b61
1099681valproic acid 250 MG Oral CapsuleSCD9fbfe4dc-c4df-4911-a440-099c860cb9231
1099681VPA 250 MG Oral CapsuleSY31ae5a24-a6a9-4103-acda-b6113052b3861
1099681VPA 250 MG Oral CapsuleSY86dd50d5-4890-4b3c-8681-18796eff97b61
1099681VPA 250 MG Oral CapsuleSY9fbfe4dc-c4df-4911-a440-099c860cb9231

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionMarketing startMarketing endSampleExclude flagStatus
0591-4012-0100591401201100 CAPSULE, LIQUID FILLED in 1 BOTTLE (0591-4012-01) 2009-09-080000-00-00NoNoCurrent