Sirolimus

Product NDC
0904-7248
11-digit product format
009047248
Labeler code
0904
Product ID
0904-7248_6b65f460-e55e-4196-af44-b9dd0e293e76
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Sirolimus
Dosage form
TABLET, FILM COATED
Route
ORAL
Labeler
Major Pharmaceuticals
Application
ANDA214753
Marketing category
ANDA
Marketing start
2021-03-13
Substance
SIROLIMUS
Active strength
1 mg/1
Pharmacologic classes
Decreased Immunologic Activity [PE], Kinase Inhibitor [EPC], Protein Kinase Inhibitors [MoA], mTOR Inhibitor Immunosuppressant [EPC], mTOR Inhibitors [MoA]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 42.

Orange Book products#

Current product rows page 1 of 1 · 3 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A214753-001SIROLIMUSSIROLIMUS0.5MGTABLET / ORALAB2021-03-12
A214753-002SIROLIMUSSIROLIMUS1MGTABLET / ORALAB2021-03-12
A214753-003SIROLIMUSSIROLIMUS2MGTABLET / ORALAB2021-03-12

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 3 matching rows.

Application-product, TE code table
Application-productTE code
A214753-001AB
A214753-002AB
A214753-003AB

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 3 · 105 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-08-18 06:07:402026-07A214753-001SIROLIMUS0.5MGTABLET / ORALAB2021-03-12caaa826d4ba7…
2026-08-18 06:07:402026-07A214753-002SIROLIMUS1MGTABLET / ORALAB2021-03-12caaa826d4ba7…
2026-08-18 06:07:402026-07A214753-003SIROLIMUS2MGTABLET / ORALAB2021-03-12caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A214753-001SIROLIMUS0.5MGTABLET / ORALAB2021-03-12011fe1cb6892…
2026-02-19 14:30 UTC2026-02A214753-002SIROLIMUS1MGTABLET / ORALAB2021-03-12011fe1cb6892…
2026-02-19 14:30 UTC2026-02A214753-003SIROLIMUS2MGTABLET / ORALAB2021-03-12011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A214753-001SIROLIMUS0.5MGTABLET / ORALAB2021-03-1231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A214753-002SIROLIMUS1MGTABLET / ORALAB2021-03-1231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A214753-003SIROLIMUS2MGTABLET / ORALAB2021-03-1231067a03dcf5…
2025-08-23 18:47 UTC2025-08A214753-001SIROLIMUS0.5MGTABLET / ORALAB2021-03-126a471c1ec25d…
2025-08-23 18:47 UTC2025-08A214753-002SIROLIMUS1MGTABLET / ORALAB2021-03-126a471c1ec25d…
2025-08-23 18:47 UTC2025-08A214753-003SIROLIMUS2MGTABLET / ORALAB2021-03-126a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A214753-001SIROLIMUS0.5MGTABLET / ORALAB2021-03-12fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A214753-002SIROLIMUS1MGTABLET / ORALAB2021-03-12fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A214753-003SIROLIMUS2MGTABLET / ORALAB2021-03-12fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A214753-001SIROLIMUS0.5MGTABLET / ORALAB2021-03-12b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A214753-002SIROLIMUS1MGTABLET / ORALAB2021-03-12b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A214753-003SIROLIMUS2MGTABLET / ORALAB2021-03-12b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A214753-001SIROLIMUS0.5MGTABLET / ORALAB2021-03-1203ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A214753-002SIROLIMUS1MGTABLET / ORALAB2021-03-1203ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A214753-003SIROLIMUS2MGTABLET / ORALAB2021-03-1203ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A214753-001SIROLIMUS0.5MGTABLET / ORALAB2021-03-122680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A214753-002SIROLIMUS1MGTABLET / ORALAB2021-03-122680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A214753-003SIROLIMUS2MGTABLET / ORALAB2021-03-122680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A214753-001SIROLIMUS0.5MGTABLET / ORALAB2021-03-125bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A214753-002SIROLIMUS1MGTABLET / ORALAB2021-03-125bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A214753-003SIROLIMUS2MGTABLET / ORALAB2021-03-125bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A214753-001SIROLIMUS0.5MGTABLET / ORALAB2021-03-12d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A214753-002SIROLIMUS1MGTABLET / ORALAB2021-03-12d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A214753-003SIROLIMUS2MGTABLET / ORALAB2021-03-12d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A214753-001SIROLIMUS0.5MGTABLET / ORALAB2021-03-12d06236e962d9…
2024-10-29 15:01 UTC2024-10A214753-002SIROLIMUS1MGTABLET / ORALAB2021-03-12d06236e962d9…
2024-10-29 15:01 UTC2024-10A214753-003SIROLIMUS2MGTABLET / ORALAB2021-03-12d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A214753-001SIROLIMUS0.5MGTABLET / ORALAB2021-03-1279d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A214753-002SIROLIMUS1MGTABLET / ORALAB2021-03-1279d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A214753-003SIROLIMUS2MGTABLET / ORALAB2021-03-1279d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A214753-001SIROLIMUS0.5MGTABLET / ORALAB2021-03-12301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A214753-002SIROLIMUS1MGTABLET / ORALAB2021-03-12301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A214753-003SIROLIMUS2MGTABLET / ORALAB2021-03-12301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A214753-001SIROLIMUS0.5MGTABLET / ORALAB2021-03-121e350fbaab3a…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 3 · 105 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-08-18 06:07:402026-07A214753-001AB1caaa826d4ba7…
2026-08-18 06:07:402026-07A214753-002AB1caaa826d4ba7…
2026-08-18 06:07:402026-07A214753-003AB1caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A214753-001AB1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A214753-002AB1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A214753-003AB1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A214753-001AB131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A214753-002AB131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A214753-003AB131067a03dcf5…
2025-08-23 18:47 UTC2025-08A214753-001AB16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A214753-002AB16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A214753-003AB16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A214753-001AB1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A214753-002AB1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A214753-003AB1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A214753-001AB1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A214753-002AB1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A214753-003AB1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A214753-001AB103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A214753-002AB103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A214753-003AB103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A214753-001AB12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A214753-002AB12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A214753-003AB12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A214753-001AB15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A214753-002AB15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A214753-003AB15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A214753-001AB1d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A214753-002AB1d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A214753-003AB1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A214753-001AB1d06236e962d9…
2024-10-29 15:01 UTC2024-10A214753-002AB1d06236e962d9…
2024-10-29 15:01 UTC2024-10A214753-003AB1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A214753-001AB179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A214753-002AB179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A214753-003AB179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A214753-001AB1301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A214753-002AB1301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A214753-003AB1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A214753-001AB11e350fbaab3a…

Additional Listing Data#

Finished product
Yes
Brand name base
Sirolimus
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
SIROLIMUS1 mg/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
W36ZG6FT64Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
349208Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1bef7d8f-524b-4218-8fef-6c3f3628d33eAvailable on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
e68235d1-1e8b-9d8c-fddb-764b8b692c25Product name720250331
594e2c86-3079-4e6e-96c9-48f7a8afc78dProduct name120230718
9344cc31-0398-4e2f-a65e-a24a0de47fc4Product name120230103
741e13fe-61d8-4a4c-8c27-eb206b28f1bfProduct name120220613

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
0904-7248-04Sirolimus30 in 1 CARTONTABLET, FILM COATED304
0904-7248-04Sirolimus1 in 1 BLISTER PACKTABLET, FILM COATED14

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
0904-7248-04EA - Each0904-7248ceba88d3-6efd-4a1e-b3a1-f378902cc94012022-09-12

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
0904-7248SIROLIMUS TABLET [MAJOR PHARMACEUTICALS]2Current NDC, Legacy NDC, 2 package rows20240828_1bef7d8f-524b-4218-8fef-6c3f3628d33e.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 3 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
SirolimusSIROLIMUSMajor Pharmaceuticals1bef7d8f-524b-4218-8fef-6c3f3628d33e2025-11-10Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 214753
application number: ANDA214753
ndc (product): 0904-7248
SirolimusSIROLIMUSAscend Laboratories, LLCcdc49844-3e77-41d3-8287-b16d0c4742c52025-09-18Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 214753
application number: ANDA214753
SirolimusSIROLIMUSREMEDYREPACK INC.74549ff2-74dc-449d-9a01-087260f9f8be2025-07-24Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 214753
application number: ANDA214753

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
349208sirolimus 1 MG Oral TabletPSN1bef7d8f-524b-4218-8fef-6c3f3628d33e4
349208sirolimus 1 MG Oral TabletSCD1bef7d8f-524b-4218-8fef-6c3f3628d33e4

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
0904-7248-040090472480430 BLISTER PACK in 1 CARTON (0904-7248-04) / 1 TABLET, FILM COATED in 1 BLISTER PACK30 blister pack2022-06-210000-00-00NoNoCurrent