Methadone Hydrochloride

Product NDC
13107-088
11-digit product format
131070088
Labeler code
13107
Product ID
13107-088_73006026-6ba2-49da-824e-a4d05b99a2e7
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Methadone Hydrochloride
Dosage form
TABLET
Route
ORAL
Labeler
Aurolife Pharma, LLC
Application
ANDA203502
Marketing category
ANDA
Marketing start
2015-09-15
Substance
METHADONE HYDROCHLORIDE
Active strength
5 mg/1
Pharmacologic classes
Full Opioid Agonists [MoA], Opioid Agonist [EPC]
DEA schedule
CII
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 2 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A203502-001METHADONE HYDROCHLORIDEMETHADONE HYDROCHLORIDE5MGTABLET / ORALAA2015-08-31
A203502-002METHADONE HYDROCHLORIDEMETHADONE HYDROCHLORIDE10MGTABLET / ORALAA2015-08-31

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 2 matching rows.

Application-product, TE code table
Application-productTE code
A203502-001AA
A203502-002AA

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 3 · 82 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02A203502-001METHADONE HYDROCHLORIDE5MGTABLET / ORALAA2015-08-31011fe1cb6892…
2026-02-19 14:30 UTC2026-02A203502-002METHADONE HYDROCHLORIDE10MGTABLET / ORALAA2015-08-31011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A203502-001METHADONE HYDROCHLORIDE5MGTABLET / ORALAA2015-08-3131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A203502-002METHADONE HYDROCHLORIDE10MGTABLET / ORALAA2015-08-3131067a03dcf5…
2025-08-23 18:47 UTC2025-08A203502-001METHADONE HYDROCHLORIDE5MGTABLET / ORALAA2015-08-316a471c1ec25d…
2025-08-23 18:47 UTC2025-08A203502-002METHADONE HYDROCHLORIDE10MGTABLET / ORALAA2015-08-316a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A203502-001METHADONE HYDROCHLORIDE5MGTABLET / ORALAA2015-08-31fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A203502-002METHADONE HYDROCHLORIDE10MGTABLET / ORALAA2015-08-31fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A203502-001METHADONE HYDROCHLORIDE5MGTABLET / ORALAA2015-08-31b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A203502-002METHADONE HYDROCHLORIDE10MGTABLET / ORALAA2015-08-31b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A203502-001METHADONE HYDROCHLORIDE5MGTABLET / ORALAA2015-08-3103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A203502-002METHADONE HYDROCHLORIDE10MGTABLET / ORALAA2015-08-3103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A203502-001METHADONE HYDROCHLORIDE5MGTABLET / ORALAA2015-08-312680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A203502-002METHADONE HYDROCHLORIDE10MGTABLET / ORALAA2015-08-312680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A203502-001METHADONE HYDROCHLORIDE5MGTABLET / ORALAA2015-08-315bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A203502-002METHADONE HYDROCHLORIDE10MGTABLET / ORALAA2015-08-315bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A203502-001METHADONE HYDROCHLORIDE5MGTABLET / ORALAA2015-08-31d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A203502-002METHADONE HYDROCHLORIDE10MGTABLET / ORALAA2015-08-31d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A203502-001METHADONE HYDROCHLORIDE5MGTABLET / ORALAA2015-08-31d06236e962d9…
2024-10-29 15:01 UTC2024-10A203502-002METHADONE HYDROCHLORIDE10MGTABLET / ORALAA2015-08-31d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A203502-001METHADONE HYDROCHLORIDE5MGTABLET / ORALAA2015-08-3179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A203502-002METHADONE HYDROCHLORIDE10MGTABLET / ORALAA2015-08-3179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A203502-001METHADONE HYDROCHLORIDE5MGTABLET / ORALAA2015-08-31301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A203502-002METHADONE HYDROCHLORIDE10MGTABLET / ORALAA2015-08-31301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A203502-001METHADONE HYDROCHLORIDE5MGTABLET / ORALAA2015-08-311e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A203502-002METHADONE HYDROCHLORIDE10MGTABLET / ORALAA2015-08-311e350fbaab3a…
2024-05-31 18:47 UTC2024-05A203502-001METHADONE HYDROCHLORIDE5MGTABLET / ORALAA2015-08-318072bd15b7f6…
2024-05-31 18:47 UTC2024-05A203502-002METHADONE HYDROCHLORIDE10MGTABLET / ORALAA2015-08-318072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A203502-001METHADONE HYDROCHLORIDE5MGTABLET / ORALAA2015-08-315c6f7cd8ea54…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A203502-002METHADONE HYDROCHLORIDE10MGTABLET / ORALAA2015-08-315c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A203502-001METHADONE HYDROCHLORIDE5MGTABLET / ORALAA2015-08-315d02ea3f76ae…
2022-04-08 23:34 UTC2022-04A203502-002METHADONE HYDROCHLORIDE10MGTABLET / ORALAA2015-08-315d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A203502-001METHADONE HYDROCHLORIDE5MGTABLET / ORALAA2015-08-314b0b4de00fa7…
2022-04-04 05:41 UTC2022-04A203502-002METHADONE HYDROCHLORIDE10MGTABLET / ORALAA2015-08-314b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A203502-001METHADONE HYDROCHLORIDE5MGTABLET / ORALAA2015-08-3174a2ff9319b5…
2019-12-13 00:20 UTC2019-12A203502-002METHADONE HYDROCHLORIDE10MGTABLET / ORALAA2015-08-3174a2ff9319b5…
2022-03-09 01:35 UTC2022-03A203502-001METHADONE HYDROCHLORIDE5MGTABLET / ORALAA2015-08-31bb7c543d1eb4…
2022-03-09 01:35 UTC2022-03A203502-002METHADONE HYDROCHLORIDE10MGTABLET / ORALAA2015-08-31bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A203502-001METHADONE HYDROCHLORIDE5MGTABLET / ORALAA2015-08-31782e0a99824c…
2021-12-28 21:50 UTC2021-12A203502-002METHADONE HYDROCHLORIDE10MGTABLET / ORALAA2015-08-31782e0a99824c…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 3 · 82 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02A203502-001AA1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A203502-002AA1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A203502-001AA131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A203502-002AA131067a03dcf5…
2025-08-23 18:47 UTC2025-08A203502-001AA16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A203502-002AA16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A203502-001AA1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A203502-002AA1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A203502-001AA1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A203502-002AA1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A203502-001AA103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A203502-002AA103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A203502-001AA12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A203502-002AA12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A203502-001AA15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A203502-002AA15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A203502-001AA1d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A203502-002AA1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A203502-001AA1d06236e962d9…
2024-10-29 15:01 UTC2024-10A203502-002AA1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A203502-001AA179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A203502-002AA179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A203502-001AA1301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A203502-002AA1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A203502-001AA11e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A203502-002AA11e350fbaab3a…
2024-05-31 18:47 UTC2024-05A203502-001AA18072bd15b7f6…
2024-05-31 18:47 UTC2024-05A203502-002AA18072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A203502-001AA15c6f7cd8ea54…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A203502-002AA15c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A203502-001AA15d02ea3f76ae…
2022-04-08 23:34 UTC2022-04A203502-002AA15d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A203502-001AA14b0b4de00fa7…
2022-04-04 05:41 UTC2022-04A203502-002AA14b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A203502-001AA174a2ff9319b5…
2019-12-13 00:20 UTC2019-12A203502-002AA174a2ff9319b5…
2022-03-09 01:35 UTC2022-03A203502-001AA1bb7c543d1eb4…
2022-03-09 01:35 UTC2022-03A203502-002AA1bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A203502-001AA1782e0a99824c…
2021-12-28 21:50 UTC2021-12A203502-002AA1782e0a99824c…

Additional Listing Data#

Finished product
Yes
Brand name base
Methadone Hydrochloride
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
METHADONE HYDROCHLORIDE5 mg/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
229809935BInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
864706Internal RxNorm lookup
864718Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
6984eb5a-57a3-4686-bc67-91bc3e7a531eAvailable on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
bc6c52c8-e3e2-9042-21d0-6770dcf1a49bProduct name320250819
a48f0261-b6cc-12b3-49fd-ed131bc5aa96Product name420210902
00dcb24c-d95e-78f6-6c1b-4d7b709bb2b9Product name620200708
a6a96832-f31d-b458-45cb-abb8bd940b44Product name220200304

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
13107-088-01Methadone Hydrochloride100 in 1 BOTTLETABLET10018
13107-088-30Methadone Hydrochloride30 in 1 BOTTLETABLET3018
13107-088-99Methadone Hydrochloride1000 in 1 BOTTLETABLET100018

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
13107-088-01EA - Each13107-088c4a07e19-5922-4c5c-81d6-abfc95d1010212016-01-13

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
IngredientTypeUNIIDailyMed labelSPL versionUploaded
METHADONE HYDROCHLORIDEACTIVE INGREDIENT229809935BMETHADONE HYDROCHLORIDE TABLET [AUROLIFE PHARMA, LLC]3
METHADONEACTIVE MOIETYUC6VBE7V1ZMETHADONE HYDROCHLORIDE TABLET [AUROLIFE PHARMA, LLC]3
CELLULOSE, MICROCRYSTALLINEINACTIVE INGREDIENTOP1R32D61UMETHADONE HYDROCHLORIDE TABLET [AUROLIFE PHARMA, LLC]3
LACTOSE MONOHYDRATEINACTIVE INGREDIENTEWQ57Q8I5XMETHADONE HYDROCHLORIDE TABLET [AUROLIFE PHARMA, LLC]3
MAGNESIUM STEARATEINACTIVE INGREDIENT70097M6I30METHADONE HYDROCHLORIDE TABLET [AUROLIFE PHARMA, LLC]3
SILICON DIOXIDEINACTIVE INGREDIENTETJ7Z6XBU4METHADONE HYDROCHLORIDE TABLET [AUROLIFE PHARMA, LLC]3
STARCH, CORNINACTIVE INGREDIENTO8232NY3SJMETHADONE HYDROCHLORIDE TABLET [AUROLIFE PHARMA, LLC]3

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
13107-088METHADONE HYDROCHLORIDE TABLET [AUROLIFE PHARMA, LLC]16Current NDC, Legacy NDC, 3 package rows20240704_6984eb5a-57a3-4686-bc67-91bc3e7a531e.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Methadone HydrochlorideMETHADONE HYDROCHLORIDEAurolife Pharma, LLC6984eb5a-57a3-4686-bc67-91bc3e7a531e2025-12-23Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 203502
application number: ANDA203502
ndc (product): 13107-088

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
864706methadone HCl 10 MG Oral TabletPSN6984eb5a-57a3-4686-bc67-91bc3e7a531e18
864718methadone HCl 5 MG Oral TabletPSN6984eb5a-57a3-4686-bc67-91bc3e7a531e18
864706methadone hydrochloride 10 MG Oral TabletSCD6984eb5a-57a3-4686-bc67-91bc3e7a531e18
864718methadone hydrochloride 5 MG Oral TabletSCD6984eb5a-57a3-4686-bc67-91bc3e7a531e18

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
13107-088-0113107008801100 TABLET in 1 BOTTLE (13107-088-01) 100 tablet2015-09-150000-00-00NoNoCurrent
13107-088-301310700883030 TABLET in 1 BOTTLE (13107-088-30) 30 tablet2015-09-150000-00-00NoNoCurrent
13107-088-99131070088991000 TABLET in 1 BOTTLE (13107-088-99) 1000 tablet2015-09-150000-00-00NoNoCurrent