UNBLEMISH Invisible Matte Defense

Product NDC: 14222-2131
11-digit product format: 142222131
Labeler code: 14222
Product ID: 14222-2131_e6fcc289-8076-4e3b-9eb6-0ec9b1ed4f5c
Type: HUMAN OTC DRUG
Nonproprietary name: HOMOSALATE, OCTOCRYLENE, OCTISALATE, AVOBENZONE
Dosage form: GEL
Route: TOPICAL
Labeler: Rodan & Fields
Application: M020
Marketing category: OTC MONOGRAPH DRUG
Marketing start: 2020-03-10
Substance: HOMOSALATE; OCTOCRYLENE; OCTISALATE; AVOBENZONE
Active strength: .1; .1; .05; .03 g/mL; g/mL; g/mL; g/mL
NDC exclude flag: No
Listing certified through: 2026-12-31
Current FDA listing: Yes

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

Additional Listing Data#

Finished product: Yes
Brand name base: UNBLEMISH Invisible Matte Defense
Listing expiration: 2026-12-31

Active Ingredients#

Ingredient, Strength table
Ingredient	Strength
HOMOSALATE	.1 g/mL
OCTOCRYLENE	.1 g/mL
OCTISALATE	.05 g/mL
AVOBENZONE	.03 g/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 4 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
V06SV4M95S	Internal UNII lookup
5A68WGF6WM	Internal UNII lookup
4X49Y0596W	Internal UNII lookup
G63QQF2NOX	Internal UNII lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
9dfe7d50-f347-4671-9657-5e4fbe42b441	Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product concept	Relation	Version	Effective
a46239a7-5963-4008-8cbb-6b9000f497eb	Product name	1	20250721
b382b4e1-6b48-45f6-bffc-e61b00b0ce19	Product name	3	20250317
d9d61457-6a5a-41fc-b418-e5479a2904b7	Product name	2	20230303
32012d5c-25ac-49c7-9d4c-1313177fff7c	Product name	1	20230112
13e7e7e3-e885-4c79-af6d-dad1aedbb06e	Product name	1	20220128
4a7d44fe-774d-404b-aad0-8a90fe78375a	Product name	4	20211025
3f45980c-c196-47e5-0e5e-48b7c57327c5	Product name	5	20200428
d12e2d7c-bd6b-45d4-94f9-6df8e1b8b27b	Product name	3	20200203
ee5c6de5-d9cd-454f-b250-7b19e5cf2992	Product name	4	20190619
ad75fcfd-a339-42a1-9c60-43ba2c654cfa	Product name	1	20170810

FDA-Initiated Inactive NDC Indexing#

NDC, Effective, Action table
NDC	Effective	Action	Document	Indexing SPL	Related label
14222-2131-1	2023-11-29	C162847	48780-1	0191ceaa-71ac-198a-e063-dbdaa90aec3e	Drug Facts
14222-2131-1	2023-07-28	C162847	48780-1	0191ceaa-71ac-198a-e063-dbdaa90aec3e	Drug Facts

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	Strength	SPL version
14222-2131-1	UNBLEMISH Invisible Matte Defense	1 in 1 CARTON	GEL	1		4
14222-2131-1	UNBLEMISH Invisible Matte Defense	30 mL in 1 TUBE	GEL	30		4
14222-2131-2	UNBLEMISH Invisible Matte Defense	1 in 1 CARTON	GEL	1		4
14222-2131-2	UNBLEMISH Invisible Matte Defense	7 mL in 1 TUBE	GEL	7		4
14222-2131-4	UNBLEMISH 30-Day Regimen	15 mL in 1 TUBE	GEL	15 mL	0.1 g in 1mL	1

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
14222-2131	UNBLEMISH INVISIBLE MATTE DEFENSE (HOMOSALATE, OCTOCRYLENE, OCTISALATE, AVOBENZONE) GEL [RODAN & FIELDS]	4	Current NDC, Legacy NDC, 4 package rows	20231130_9dfe7d50-f347-4671-9657-5e4fbe42b441.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 6 of 357 · 7,139 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
Stay Ageless Tinted Mineral Sunscreen	BROAD SPECTRUM SPF30	CORBY, JR., TERRY L.	594443fd-8e27-4ec6-e063-6294a90a3ff0	2026-08-17	Warnings	Exact identifier application number: M020
Meraki Protective Mist Sunscreen	BROAD SPECTRUM SPF 30	MERAKI MEDICAL SPA LLC	59446224-0e97-ae2c-e063-6394a90a2a65	2026-08-17	Warnings	Exact identifier application number: M020
Sun Zapper - Acne Pure Zinc Sunscreen SPF50	ZINC OXIDE	Veganic SKN Limited	3ee435a5-70fb-0c8a-e063-6394a90a650a	2026-08-16	Warnings	Exact identifier application number: M020
Sun Zapper - Anti-ageing pure zinc sunscreen SPF30	ZINC OXIDE SUNSCREEN	VEGANIC SKN LIMITED	3f1dc3b2-c289-5996-e063-6394a90ac622	2026-08-16	Warnings	Exact identifier application number: M020
ISNTREE HYALURONIC ACID SENSITIVE SUNSCREEN	ZINC OXIDE	ISNTREE Inc.	58e38665-0bca-fb02-e063-6394a90ad62a	2026-08-13	Warnings	Exact identifier application number: M020
Neutrogena Ultra Sheer Daily Face Sunscreen Broad Spectrum SPF 70	AVOBENZONE, BEMOTRIZINOL, HOMOSALATE, OCTISALATE	Kenvue Brands LLC	58d3d390-8b88-a6fe-e063-6394a90a9bf8	2026-08-12	Warnings	Exact identifier application number: M020
Neutrogena Clear Face Sunscreen Acne Prone Skin Broad Spectrum SPF 60	AVOBENZONE, BEMOTRIZINOL, HOMOSALATE, OCTISALATE	Kenvue Brands LLC	58d7a3e3-b7df-43ce-e063-6294a90a729c	2026-08-12	Warnings	Exact identifier application number: M020
HEB 50 Marigold Scent Sunscreen	AVOBENZONE, HOMOSALATE, OCTISALATE, OCTOCRYLENE	H.E.B.	58dafa24-24d5-aeb4-e063-6394a90a3c25	2026-08-12	Warnings	Exact identifier application number: M020
TESALOVA Coconut SPF 30 Lip Balm SPF 30	AVOBENZONE, OCTINOXATE, OCTISALATE, OXYBENZONE	Tesalova Viktoriia PMU LLC	58dbb9f1-cfb3-62ac-e063-6394a90a6106	2026-08-12	Warnings	Exact identifier application number: M020
Elta MD Skincare UV Stick Broad Spectrum SPF50	ZINC OXIDE	CP Skin Health Group, Inc	58dd81db-46d4-d763-e063-6394a90abb0b	2026-08-12	Warnings	Exact identifier application number: M020
Basin Coconut SPF 30 Lip Balm SPF 30	AVOBENZONE, OCTINOXATE, OCTISALATE, OXYBENZONE	Retail Concepts of Minnesota, Inc.	4a8e93a6-dcf9-3687-e063-6394a90a73ac	2026-08-12	Warnings	Exact identifier application number: M020
UV Skin Recovery SPF 50 Red Correcting	ZINC OXIDE	CP Skin Health Group, Inc.	26e63890-d1af-d171-e063-6394a90af828	2026-08-12	Warnings	Exact identifier application number: M020
UV Skin Recovery SPF 50	ZINC OXIDE	CP Skin Health Group, Inc.	26d2683f-cfd5-50fd-e063-6394a90a7576	2026-08-12	Warnings	Exact identifier application number: M020
doTERRA Sun Body	MINERAL SUNSCREEN	doTERRA International, LLC	58dcc56f-f093-469c-e063-6394a90a6088	2026-08-12	Warnings	Exact identifier application number: M020
Sonage Protec Plus SPF 30 Mineral Sunscreen	ZINC OXIDE	ASA Universal Inc. dba: Sonage	d92fc1df-bbeb-592a-e053-2a95a90a6951	2026-08-12	Warnings	Exact identifier application number: M020
Colorescience Total Protection Body Shield Glow	ZINC OXIDE	Colorescience	52e1d987-a4f8-195e-e063-6294a90a5629	2026-08-11	Warnings	Exact identifier application number: M020
Stay Ageless Tinted Mineral Sunscreen	BROAD SPECTRUM SPF30	DR. SAMRAO'S OFFICE	58b2ca35-11ed-d848-e063-6294a90a5b37	2026-08-11	Warnings	Exact identifier application number: M020
Ciele Tint and Protect	ZINC OXIDE	Ciele	0162d9c9-07fa-9210-e063-6294a90aa687	2026-08-11	Warnings	Exact identifier application number: M020
NeoStrata Skin Active Matrix Support SPF 30	AVOBENZONE, OCTINOXATE, AND OCTISALATE	NeoStrata Company Inc.	8e4b9c08-b906-4c5f-a243-55838ae28b90	2026-08-10	Warnings	Exact identifier application number: M020
Sunscreen for Kids SPF 50	AVOBENZONE, HOMOSALATE, OCTISALATE	The Kroger Co.	1c7cd904-ffff-48aa-91bd-cc978946b36a	2026-08-10	Warnings, Adverse reactions	Exact identifier application number: M020

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
V06SV4M95S	HOMOSALATE	118-56-9	HOMOSALATE
5A68WGF6WM	OCTOCRYLENE	6197-30-4	OCTOCRYLENE
4X49Y0596W	OCTISALATE	118-60-5	OCTISALATE
G63QQF2NOX	AVOBENZONE	70356-09-1	AVOBENZONE

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUI	RxNorm string	TTY	DailyMed	SPL version
200009	benzoyl peroxide 2.5 % Topical Lotion	PSN	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
865105	salicylic acid 0.5 % Medicated Liquid Soap	PSN	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
200009	benzoyl peroxide 25 MG/ML Topical Lotion	SCD	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
865105	salicylic acid 5 MG/ML Medicated Liquid Soap	SCD	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
200009	benzoyl peroxide 2.5 % Topical Lotion	SY	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
865105	salicylic acid 0.5 % Foaming Cleanser	SY	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
865105	salicylic acid 0.5 % Mask	SY	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
865105	salicylic acid 0.5 % Medicated Liquid Soap	SY	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
865105	salicylic acid 0.5 % Topical Gel Cleanser	SY	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Units	Marketing start	Marketing end	Sample	Exclude flag	Status
14222-2131-1	14222213101	1 TUBE in 1 CARTON (14222-2131-1) / 30 mL in 1 TUBE	1 tube	2020-03-10	0000-00-00	No	No	Current
14222-2131-2	14222213102	1 TUBE in 1 CARTON (14222-2131-2) / 7 mL in 1 TUBE	1 tube	2020-06-01		No	No	Current
14222-2131-4	14222213104	15 mL in 1 TUBE	15 ml					Historical

Title, Manufacturer, Effective date table
Title	Manufacturer	Effective date	Type	Version
UNBLEMISH 30-Day Regimen - Rodan & Fields	Rodan & Fields	2026-04-01	HUMAN OTC DRUG LABEL	1
Drug Facts	Rodan & Fields	2023-11-27	HUMAN OTC DRUG LABEL	4