PHARBEDRYL

Product NDC: 16103-347
11-digit product format: 161030347
Labeler code: 16103
Product ID: 16103-347_3070b1f8-b3c8-4522-8b0f-06cedafc97ed
Type: HUMAN OTC DRUG
Nonproprietary name: Diphenhydramine HCl
Dosage form: CAPSULE
Route: ORAL
Labeler: Pharbest Pharmaceuticals, Inc.
Application: M010
Marketing category: OTC MONOGRAPH DRUG
Marketing start: 2006-10-11
Substance: DIPHENHYDRAMINE HYDROCHLORIDE
Active strength: 50 mg/1
Pharmacologic classes: Histamine H1 Receptor Antagonists [MoA], Histamine-1 Receptor Antagonist [EPC]
NDC exclude flag: No
Listing certified through: 2026-12-31
Current FDA listing: Yes

Observed NDC auxiliary status history#

This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.

Historic NDC status page 1 of 1 · 24 matching rows.

View current auxiliary records. · View the auxiliary file history.

Captured / source date, Dataset, Scope table
Captured / source date	Dataset	Scope	Package NDC	Code	Status	Snapshot	Source SHA-256
2024-11-09 02:27 UTC · source 2024-11-08	excluded product	product		I	Inactivated by FDA	`ad56d346431e…`	`cc804d4bbf1e…`
2024-11-09 02:27 UTC · source 2024-11-08	excluded package	package	16103-347-11	I	Inactivated by FDA	`ad56d346431e…`	`cc804d4bbf1e…`
2024-11-09 02:27 UTC · source 2024-11-08	excluded package	package	16103-347-08	I	Inactivated by FDA	`ad56d346431e…`	`cc804d4bbf1e…`
2024-10-04 04:10 UTC · source 2024-10-03	excluded product	product		I	Inactivated by FDA	`367a005e9d99…`	`383a685ebd0f…`
2024-10-04 04:10 UTC · source 2024-10-03	excluded package	package	16103-347-11	I	Inactivated by FDA	`367a005e9d99…`	`383a685ebd0f…`
2024-10-04 04:10 UTC · source 2024-10-03	excluded package	package	16103-347-08	I	Inactivated by FDA	`367a005e9d99…`	`383a685ebd0f…`
2024-07-10 04:00 UTC · source 2024-07-09	excluded product	product		I	Inactivated by FDA	`557ba5c1ecfa…`	`9c80585c8c6e…`
2024-07-10 04:00 UTC · source 2024-07-09	excluded package	package	16103-347-11	I	Inactivated by FDA	`557ba5c1ecfa…`	`9c80585c8c6e…`
2024-07-10 04:00 UTC · source 2024-07-09	excluded package	package	16103-347-08	I	Inactivated by FDA	`557ba5c1ecfa…`	`9c80585c8c6e…`
2024-05-28 21:12 UTC · source 2024-05-28	excluded product	product		I	Inactivated by FDA	`8af77b9d5b6f…`	`d9bbb34c5368…`
2024-05-28 21:12 UTC · source 2024-05-28	excluded package	package	16103-347-11	I	Inactivated by FDA	`8af77b9d5b6f…`	`d9bbb34c5368…`
2024-05-28 21:12 UTC · source 2024-05-28	excluded package	package	16103-347-08	I	Inactivated by FDA	`8af77b9d5b6f…`	`d9bbb34c5368…`
2024-05-15 03:39 UTC · source 2024-05-14	excluded product	product		I	Inactivated by FDA	`834df4deac94…`	`adcc014656a3…`
2024-05-15 03:39 UTC · source 2024-05-14	excluded package	package	16103-347-11	I	Inactivated by FDA	`834df4deac94…`	`adcc014656a3…`
2024-05-15 03:39 UTC · source 2024-05-14	excluded package	package	16103-347-08	I	Inactivated by FDA	`834df4deac94…`	`adcc014656a3…`
2024-03-11 06:39 UTC · source 2024-03-08	excluded product	product		I	Inactivated by FDA	`1332a3947898…`	`d4bfe170f9cd…`
2024-03-11 06:39 UTC · source 2024-03-08	excluded package	package	16103-347-11	I	Inactivated by FDA	`1332a3947898…`	`d4bfe170f9cd…`
2024-03-11 06:39 UTC · source 2024-03-08	excluded package	package	16103-347-08	I	Inactivated by FDA	`1332a3947898…`	`d4bfe170f9cd…`
2020-12-18 03:04 UTC · source 2020-12-17	excluded product	product		I	Inactivated by FDA	`e2bbac7714bc…`	`27bdfed8d636…`
2020-12-18 03:04 UTC · source 2020-12-17	excluded package	package	16103-347-11	I	Inactivated by FDA	`e2bbac7714bc…`	`27bdfed8d636…`
2020-06-10 20:45 UTC · source 2020-06-10	excluded product	product		I	Inactivated by FDA	`9bebd1f3094a…`	`5416666fcb17…`
2020-06-10 20:45 UTC · source 2020-06-10	excluded package	package	16103-347-11	I	Inactivated by FDA	`9bebd1f3094a…`	`5416666fcb17…`
2019-12-08 06:16 UTC · source 2019-12-05	excluded product	product		E	Excluded after deficient or non-compliant submission was not corrected	`110d247fa046…`	`a55b01930146…`
2019-12-08 06:16 UTC · source 2019-12-05	excluded package	package	16103-347-11	E	Excluded after deficient or non-compliant submission was not corrected	`110d247fa046…`	`a55b01930146…`

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

Additional Listing Data#

Finished product: Yes
Brand name base: PHARBEDRYL
Listing expiration: 2026-12-31

Active Ingredients#

Ingredient, Strength table
Ingredient	Strength
DIPHENHYDRAMINE HYDROCHLORIDE	50 mg/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
TC2D6JAD40	Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
1020477	Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
a19f1edc-d2cf-45fc-8233-d882441b0247	Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product concept	Relation	Version	Effective
0e2e0f88-b076-afe1-4bdd-32bca4375bec	Product name	3	20250127
3e48c9c4-918d-5d23-2f0b-d2398b06be54	Product name	1	20140508
865c72dd-0d94-daac-f728-ddd4ded2a79e	Product name	1	20140508

FDA-Initiated Inactive NDC Indexing#

NDC, Effective, Related label table
NDC	Effective	Related label
16103-347-08	2024-12-31	Drug Facts
16103-347-11	2024-12-31	Drug Facts
16103-347-08	2023-01-30	Drug Facts
16103-347-11	2023-01-30	Drug Facts
16103-347-11	2021-03-30	Drug Facts
16103-347-11	2020-01-31	Drug Facts

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	Strength	SPL version
16103-347-08	PHARBEDRYL	100 in 1 BOTTLE, PLASTIC	CAPSULE	100		4
16103-347-11	PHARBEDRYL	1000 in 1 BOTTLE, PLASTIC	CAPSULE	1000		4

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDC	Billing unit	Product NDC	DailyMed indexing SPL	SPL version	Effective
16103-347-11	EA - Each	16103-347	1c087d47-7f50-486d-9c6d-fc6ee3317b49	1	2012-07-24

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
Ingredient	Type	UNII	DailyMed label	SPL version
DIPHENHYDRAMINE HYDROCHLORIDE	ACTIVE INGREDIENT	TC2D6JAD40	PHARBEDRYL (DIPHENHYDRAMINE HCL) CAPSULE [PHARBEST PHARMACEUTICALS, INC.]	1
DIPHENHYDRAMINE	ACTIVE MOIETY	8GTS82S83M	PHARBEDRYL (DIPHENHYDRAMINE HCL) CAPSULE [PHARBEST PHARMACEUTICALS, INC.]	1
D&C RED NO. 28	INACTIVE INGREDIENT	767IP0Y5NH	PHARBEDRYL (DIPHENHYDRAMINE HCL) CAPSULE [PHARBEST PHARMACEUTICALS, INC.]	1
FD&C BLUE NO. 1	INACTIVE INGREDIENT	H3R47K3TBD	PHARBEDRYL (DIPHENHYDRAMINE HCL) CAPSULE [PHARBEST PHARMACEUTICALS, INC.]	1
FD&C RED NO. 40	INACTIVE INGREDIENT	WZB9127XOA	PHARBEDRYL (DIPHENHYDRAMINE HCL) CAPSULE [PHARBEST PHARMACEUTICALS, INC.]	1
FERROSOFERRIC OXIDE	INACTIVE INGREDIENT	XM0M87F357	PHARBEDRYL (DIPHENHYDRAMINE HCL) CAPSULE [PHARBEST PHARMACEUTICALS, INC.]	1
GELATIN	INACTIVE INGREDIENT	2G86QN327L	PHARBEDRYL (DIPHENHYDRAMINE HCL) CAPSULE [PHARBEST PHARMACEUTICALS, INC.]	1
LACTOSE MONOHYDRATE	INACTIVE INGREDIENT	EWQ57Q8I5X	PHARBEDRYL (DIPHENHYDRAMINE HCL) CAPSULE [PHARBEST PHARMACEUTICALS, INC.]	1
MAGNESIUM STEARATE	INACTIVE INGREDIENT	70097M6I30	PHARBEDRYL (DIPHENHYDRAMINE HCL) CAPSULE [PHARBEST PHARMACEUTICALS, INC.]	1
SILICON DIOXIDE	INACTIVE INGREDIENT	ETJ7Z6XBU4	PHARBEDRYL (DIPHENHYDRAMINE HCL) CAPSULE [PHARBEST PHARMACEUTICALS, INC.]	1
SODIUM LAURYL SULFATE	INACTIVE INGREDIENT	368GB5141J	PHARBEDRYL (DIPHENHYDRAMINE HCL) CAPSULE [PHARBEST PHARMACEUTICALS, INC.]	1

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
16103-347	PHARBEDRYL (DIPHENHYDRAMINE HCL) CAPSULE [PHARBEST PHARMACEUTICALS, INC.]	3	Current NDC, Legacy NDC, 2 package rows	20250101_a19f1edc-d2cf-45fc-8233-d882441b0247.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 10 of 12 · 236 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
DIPHENHYDRAMINE HYDROCHLORIDE	DIPHENHYDRAMINE HYDROCHLORIDE	CVS Pharmacy, Inc.	6e0f7ab7-eb1e-9a19-e053-2991aa0a6d1f	2024-12-02	Warnings	Exact identifier application number: M010
Diphenhydramine HCl	DIPHENHYDRAMINE HCL	CVS Pharmacy, Inc.	6dd802ec-fc26-3913-e053-2a91aa0ad05d	2024-12-02	Warnings	Exact identifier application number: M010
Nighttime Sleep Aid	DIPHENHYDRAMINE HYDROCHLORIDE	PUBLIX SUPER MARKETS INC	236ff457-0ec1-9c49-e063-6394a90a707a	2024-11-26	Warnings	Exact identifier application number: M010
DIPHENHYDRAMINE HYDROCHLORIDE	DIPHENHYDRAMINE HYDROCHLORIDE	Humanwell PuraCap Pharmaceutical (Wuhan), Ltd.	50d74111-6d1b-4681-a264-f7e550320259	2024-11-25	Warnings	Exact identifier application number: M010
DIPHENHYDRAMINE HYDROCHLORIDE	DIPHENHYDRAMINE HYDROCHLORIDE	Humanwell PuraCap Pharmaceutical (Wuhan), Ltd.	efb05387-72c0-4643-8541-b7990c202ce6	2024-11-25	Warnings	Exact identifier application number: M010
Nighttime Sleep Aid, 24-7 Life BY 7-ELEVEN, 6oz	DIPHENHYDRAMINE HCL SOLUTION	Lil' Drug Store Products, Inc.	2781fc28-8a7d-d0fa-e063-6394a90ac793	2024-11-22	Warnings	Exact identifier application number: M010
DIPHENHYDRAMINE HYDROCHLORIDE	DIPHENHYDRAMINE HYDROCHLORIDE	Humanwell PuraCap Pharmaceutical (Wuhan), Ltd.	7830ce18-908a-4f86-a238-8c31cfe47ce6	2024-11-21	Warnings	Exact identifier application number: M010
DIPHENHYDRAMINE HYDROCHLORIDE	DIPHENHYDRAMINE HYDROCHLORIDE	Humanwell PuraCap Pharmaceutical (Wuhan), Ltd.	f8de6605-4a0a-492d-beb5-f414ce8bfb0e	2024-11-20	Warnings	Exact identifier application number: M010
Nighttime SLEEP AID	DIPHENHYDRAMINE HCL 50MG	PuraCap Pharmaceutical LLC	272a7138-2a97-8e62-e063-6394a90a1af1	2024-11-18	Warnings	Exact identifier application number: M010
ZzzQuil	DIPHENHYDRAMINE HYDROCHLORIDE	Lil' Drug Store Products, Inc.	0b2777be-85d4-443d-b65f-6750e0ba97ba	2024-11-18	Warnings	Exact identifier application number: M010
RiteAid Nighttime Sleep Aid	DIPHENHYDRAMINE HYDROCHLORIDE AND ACETAMINOPHEN	RITE AID CORPORATION	54fc0893-9702-4849-a702-3e84dc9ead03	2024-10-30	Warnings	Exact identifier application number: M010
Rite Aid Nighttime Sleep Aid Non Habit Forming	DIPHENHYDRAMINE HYDROCHLORIDE	RITE AID CORPORATION	59ba6824-fa6c-4b3f-9f1f-ea194766c8a1	2024-10-30	Warnings	Exact identifier application number: M010
GOOD REMEDIES Nighttime Sleep Aid Caplets	DIPHENHYDRAMINE HYDROCHLORIDE	Strive Pharmaceuticals Inc.	24fba735-cedf-9d15-e063-6394a90af873	2024-10-29	Warnings	Exact identifier application number: M010
Premier Value Nighttime Sleep-Aid Liquid Sleep-Aid	DIPHENHYDRAMINE HYDROCHLORIDE	Chain Drug Consortium	6d24b6e1-7959-47c6-a09b-c7e00a437495	2024-10-28	Warnings	Exact identifier application number: M010
Nytol	DIPHENHYDRAMINE HCL	Medtech Products Inc.	c81d018a-0170-4396-81e9-2e13a53f868a	2024-10-25	Warnings	Exact identifier application number: M010
Rest Simply	DIPHENHYDRAMINE HYDROCHLORIDE	Marc Glassman, Inc.	2ab3852d-53a4-411b-a9ad-3ef88ab3ee87	2024-10-23	Warnings	Exact identifier application number: M010
nitetime sleep aid	DIPHENHYDRAMINE HCL	Meijer Distribution Inc	43184abd-2525-402a-a388-85af2e5c13ad	2024-10-17	Warnings	Exact identifier application number: M010
Good Sense Sleep Time	DIPHENHYDRAMINE HCL	L. Perrigo Company	164200a9-b1f8-44c9-8598-a7dff5020e9d	2024-10-16	Warnings	Exact identifier application number: M010
Equaline Night Time Sleep Aid	DIPHENHYDRAMINE HCL	United Natural Foods, Inc. dba UNFI	6d34ee3e-3d61-481e-98d6-acfa066e4247	2024-10-16	Warnings	Exact identifier application number: M010
basic care nighttime sleep aid	DIPHENHYDRAMINE HCL	Amazon.com Services LLC	027de5ea-5c07-4960-8a98-8cf2c0e54a92	2024-10-16	Warnings	Exact identifier application number: M010

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
TC2D6JAD40	DIPHENHYDRAMINE HYDROCHLORIDE	147-24-0	DIPHENHYDRAMINE HYDROCHLORIDE

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUI	RxNorm string	TTY	DailyMed	SPL version
1020477	diphenhydrAMINE HCl 50 MG Oral Capsule	PSN	a19f1edc-d2cf-45fc-8233-d882441b0247	4
1020477	diphenhydramine hydrochloride 50 MG Oral Capsule	SCD	a19f1edc-d2cf-45fc-8233-d882441b0247	4
1020477	diphenhydramine HCl 50 MG Oral Capsule	SY	a19f1edc-d2cf-45fc-8233-d882441b0247	4
1020477	diphenhydrAMINE HCl 50 MG Oral Capsule	PSN	58ec2343-4c3b-26fa-e053-2a91aa0a4916	1
1020477	diphenhydramine hydrochloride 50 MG Oral Capsule	SCD	58ec2343-4c3b-26fa-e053-2a91aa0a4916	1
1020477	diphenhydramine HCl 50 MG Oral Capsule	SY	58ec2343-4c3b-26fa-e053-2a91aa0a4916	1

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Units	Marketing start	Marketing end	Sample	Exclude flag	Status
16103-347-08	16103034708	100 CAPSULE in 1 BOTTLE, PLASTIC (16103-347-08)	100 capsule	2006-10-11	0000-00-00	No	No	Current
16103-347-11	16103034711	1000 CAPSULE in 1 BOTTLE, PLASTIC (16103-347-11)	1000 capsule	2006-10-11	0000-00-00	No	No	Current

Title, Manufacturer, Effective date table
Title	Manufacturer	Effective date	Type	Version
Drug Facts	Pharbest Pharmaceuticals, Inc.	2025-12-24	HUMAN OTC DRUG LABEL	4
Diphenhydramine 50 mg #30 006 Drug Facts	Contract Pharmacy Services-PA \| Coupler Enterprises	2017-09-11	HUMAN OTC DRUG LABEL	1