PHARBEDRYL

Product NDC: 16103-347
11-digit product format: 161030347
Labeler code: 16103
Product ID: 16103-347_3070b1f8-b3c8-4522-8b0f-06cedafc97ed
Type: HUMAN OTC DRUG
Nonproprietary name: Diphenhydramine HCl
Dosage form: CAPSULE
Route: ORAL
Labeler: Pharbest Pharmaceuticals, Inc.
Application: M010
Marketing category: OTC MONOGRAPH DRUG
Marketing start: 2006-10-11
Substance: DIPHENHYDRAMINE HYDROCHLORIDE
Active strength: 50 mg/1
Pharmacologic classes: Histamine H1 Receptor Antagonists [MoA], Histamine-1 Receptor Antagonist [EPC]
NDC exclude flag: No
Listing certified through: 2026-12-31
Current FDA listing: Yes

Observed NDC auxiliary status history#

This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.

Historic NDC status page 1 of 1 · 24 matching rows.

View current auxiliary records. · View the auxiliary file history.

Captured / source date, Dataset, Scope table
Captured / source date	Dataset	Scope	Package NDC	Code	Status	Snapshot	Source SHA-256
2024-11-09 02:27 UTC · source 2024-11-08	excluded product	product		I	Inactivated by FDA	`ad56d346431e…`	`cc804d4bbf1e…`
2024-11-09 02:27 UTC · source 2024-11-08	excluded package	package	16103-347-11	I	Inactivated by FDA	`ad56d346431e…`	`cc804d4bbf1e…`
2024-11-09 02:27 UTC · source 2024-11-08	excluded package	package	16103-347-08	I	Inactivated by FDA	`ad56d346431e…`	`cc804d4bbf1e…`
2024-10-04 04:10 UTC · source 2024-10-03	excluded product	product		I	Inactivated by FDA	`367a005e9d99…`	`383a685ebd0f…`
2024-10-04 04:10 UTC · source 2024-10-03	excluded package	package	16103-347-11	I	Inactivated by FDA	`367a005e9d99…`	`383a685ebd0f…`
2024-10-04 04:10 UTC · source 2024-10-03	excluded package	package	16103-347-08	I	Inactivated by FDA	`367a005e9d99…`	`383a685ebd0f…`
2024-07-10 04:00 UTC · source 2024-07-09	excluded product	product		I	Inactivated by FDA	`557ba5c1ecfa…`	`9c80585c8c6e…`
2024-07-10 04:00 UTC · source 2024-07-09	excluded package	package	16103-347-11	I	Inactivated by FDA	`557ba5c1ecfa…`	`9c80585c8c6e…`
2024-07-10 04:00 UTC · source 2024-07-09	excluded package	package	16103-347-08	I	Inactivated by FDA	`557ba5c1ecfa…`	`9c80585c8c6e…`
2024-05-28 21:12 UTC · source 2024-05-28	excluded product	product		I	Inactivated by FDA	`8af77b9d5b6f…`	`d9bbb34c5368…`
2024-05-28 21:12 UTC · source 2024-05-28	excluded package	package	16103-347-11	I	Inactivated by FDA	`8af77b9d5b6f…`	`d9bbb34c5368…`
2024-05-28 21:12 UTC · source 2024-05-28	excluded package	package	16103-347-08	I	Inactivated by FDA	`8af77b9d5b6f…`	`d9bbb34c5368…`
2024-05-15 03:39 UTC · source 2024-05-14	excluded product	product		I	Inactivated by FDA	`834df4deac94…`	`adcc014656a3…`
2024-05-15 03:39 UTC · source 2024-05-14	excluded package	package	16103-347-11	I	Inactivated by FDA	`834df4deac94…`	`adcc014656a3…`
2024-05-15 03:39 UTC · source 2024-05-14	excluded package	package	16103-347-08	I	Inactivated by FDA	`834df4deac94…`	`adcc014656a3…`
2024-03-11 06:39 UTC · source 2024-03-08	excluded product	product		I	Inactivated by FDA	`1332a3947898…`	`d4bfe170f9cd…`
2024-03-11 06:39 UTC · source 2024-03-08	excluded package	package	16103-347-11	I	Inactivated by FDA	`1332a3947898…`	`d4bfe170f9cd…`
2024-03-11 06:39 UTC · source 2024-03-08	excluded package	package	16103-347-08	I	Inactivated by FDA	`1332a3947898…`	`d4bfe170f9cd…`
2020-12-18 03:04 UTC · source 2020-12-17	excluded product	product		I	Inactivated by FDA	`e2bbac7714bc…`	`27bdfed8d636…`
2020-12-18 03:04 UTC · source 2020-12-17	excluded package	package	16103-347-11	I	Inactivated by FDA	`e2bbac7714bc…`	`27bdfed8d636…`
2020-06-10 20:45 UTC · source 2020-06-10	excluded product	product		I	Inactivated by FDA	`9bebd1f3094a…`	`5416666fcb17…`
2020-06-10 20:45 UTC · source 2020-06-10	excluded package	package	16103-347-11	I	Inactivated by FDA	`9bebd1f3094a…`	`5416666fcb17…`
2019-12-08 06:16 UTC · source 2019-12-05	excluded product	product		E	Excluded after deficient or non-compliant submission was not corrected	`110d247fa046…`	`a55b01930146…`
2019-12-08 06:16 UTC · source 2019-12-05	excluded package	package	16103-347-11	E	Excluded after deficient or non-compliant submission was not corrected	`110d247fa046…`	`a55b01930146…`

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

Additional Listing Data#

Finished product: Yes
Brand name base: PHARBEDRYL
Listing expiration: 2026-12-31

Active Ingredients#

Ingredient, Strength table
Ingredient	Strength
DIPHENHYDRAMINE HYDROCHLORIDE	50 mg/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
TC2D6JAD40	Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
1020477	Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
a19f1edc-d2cf-45fc-8233-d882441b0247	Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product concept	Relation	Version	Effective
0e2e0f88-b076-afe1-4bdd-32bca4375bec	Product name	3	20250127
3e48c9c4-918d-5d23-2f0b-d2398b06be54	Product name	1	20140508
865c72dd-0d94-daac-f728-ddd4ded2a79e	Product name	1	20140508

FDA-Initiated Inactive NDC Indexing#

NDC, Effective, Related label table
NDC	Effective	Related label
16103-347-08	2024-12-31	Drug Facts
16103-347-11	2024-12-31	Drug Facts
16103-347-08	2023-01-30	Drug Facts
16103-347-11	2023-01-30	Drug Facts
16103-347-11	2021-03-30	Drug Facts
16103-347-11	2020-01-31	Drug Facts

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	Strength	SPL version
16103-347-08	PHARBEDRYL	100 in 1 BOTTLE, PLASTIC	CAPSULE	100		4
16103-347-11	PHARBEDRYL	1000 in 1 BOTTLE, PLASTIC	CAPSULE	1000		4

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDC	Billing unit	Product NDC	DailyMed indexing SPL	SPL version	Effective
16103-347-11	EA - Each	16103-347	1c087d47-7f50-486d-9c6d-fc6ee3317b49	1	2012-07-24

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
Ingredient	Type	UNII	DailyMed label	SPL version
DIPHENHYDRAMINE HYDROCHLORIDE	ACTIVE INGREDIENT	TC2D6JAD40	PHARBEDRYL (DIPHENHYDRAMINE HCL) CAPSULE [PHARBEST PHARMACEUTICALS, INC.]	1
DIPHENHYDRAMINE	ACTIVE MOIETY	8GTS82S83M	PHARBEDRYL (DIPHENHYDRAMINE HCL) CAPSULE [PHARBEST PHARMACEUTICALS, INC.]	1
D&C RED NO. 28	INACTIVE INGREDIENT	767IP0Y5NH	PHARBEDRYL (DIPHENHYDRAMINE HCL) CAPSULE [PHARBEST PHARMACEUTICALS, INC.]	1
FD&C BLUE NO. 1	INACTIVE INGREDIENT	H3R47K3TBD	PHARBEDRYL (DIPHENHYDRAMINE HCL) CAPSULE [PHARBEST PHARMACEUTICALS, INC.]	1
FD&C RED NO. 40	INACTIVE INGREDIENT	WZB9127XOA	PHARBEDRYL (DIPHENHYDRAMINE HCL) CAPSULE [PHARBEST PHARMACEUTICALS, INC.]	1
FERROSOFERRIC OXIDE	INACTIVE INGREDIENT	XM0M87F357	PHARBEDRYL (DIPHENHYDRAMINE HCL) CAPSULE [PHARBEST PHARMACEUTICALS, INC.]	1
GELATIN	INACTIVE INGREDIENT	2G86QN327L	PHARBEDRYL (DIPHENHYDRAMINE HCL) CAPSULE [PHARBEST PHARMACEUTICALS, INC.]	1
LACTOSE MONOHYDRATE	INACTIVE INGREDIENT	EWQ57Q8I5X	PHARBEDRYL (DIPHENHYDRAMINE HCL) CAPSULE [PHARBEST PHARMACEUTICALS, INC.]	1
MAGNESIUM STEARATE	INACTIVE INGREDIENT	70097M6I30	PHARBEDRYL (DIPHENHYDRAMINE HCL) CAPSULE [PHARBEST PHARMACEUTICALS, INC.]	1
SILICON DIOXIDE	INACTIVE INGREDIENT	ETJ7Z6XBU4	PHARBEDRYL (DIPHENHYDRAMINE HCL) CAPSULE [PHARBEST PHARMACEUTICALS, INC.]	1
SODIUM LAURYL SULFATE	INACTIVE INGREDIENT	368GB5141J	PHARBEDRYL (DIPHENHYDRAMINE HCL) CAPSULE [PHARBEST PHARMACEUTICALS, INC.]	1

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
16103-347	PHARBEDRYL (DIPHENHYDRAMINE HCL) CAPSULE [PHARBEST PHARMACEUTICALS, INC.]	3	Current NDC, Legacy NDC, 2 package rows	20250101_a19f1edc-d2cf-45fc-8233-d882441b0247.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 5 of 12 · 236 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
DIPHENHYDRAMINE HYDROCHLORIDE	DIPHENHYDRAMINE HYDROCHLORIDE CAPSULE, LIQUID FILLED	AMZ789 LLC	12dd2419-b2e0-5466-e063-6394a90a4221	2026-01-07	Warnings	Exact identifier application number: M010
DIPHENHYDRAMINE HYDROCHLORIDE 50mg	DIPHENHYDRAMINE HYDROCHLORIDE 50MG	AMZ789 LLC	af0b1b08-e269-6399-e053-2a95a90ac12d	2026-01-07	Warnings	Exact identifier application number: M010
DIPHENHYDRAMINE HYDROCHLORIDE	DIPHENHYDRAMINE HYDROCHLORIDE	Prodose, Inc.	3b1ea33b-8460-31cf-e063-6394a90a5534	2025-12-31	Warnings	Exact identifier application number: M010
SleepAid Softgels	DIPHENHYDRAMINE HYDROCHLORIDE	PIONEER LIFE SCIENCES, LLC	c1dab616-c3ff-4d0a-be13-e8dc6b1a26cc	2025-12-29	Warnings	Exact identifier application number: M010
Sleep Aid	DIPHENHYDRAMINE HCL 25 MG	Pioneer Life Sciences, LLC	a9678fed-bda5-9513-e053-2995a90a25a1	2025-12-29	Warnings	Exact identifier application number: M010
sleep patches	SLEEP PATCHES	Changsha Maocheng Trading Co., Ltd	25eddec9-1713-c2c8-e063-6394a90af02c	2025-12-29	Warnings	Exact identifier application number: M010
SleepAid Softgels	DIPHENHYDRAMINE HYDROCHLORIDE	PIONEER LIFE SCIENCES, LLC	9d6b5ec1-3aa4-4a19-936e-c44b04b2f3fa	2025-12-29	Warnings	Exact identifier application number: M010
Sleep Aid	DIPHENHYDRAMINE HCL	Safeway, Inc.	65d1a199-0a8e-41b1-a767-f16e3f91ac94	2025-12-26	Warnings	Exact identifier application number: M010
Sleep Aid	DIPHENHYDRAMINE HCL	Safeway, Inc.	837ddc3a-a8d4-454f-974c-979732cb0a22	2025-12-26	Warnings	Exact identifier application number: M010
Pharbedryl	DIPHENHYDRAMINE HCL	Pharbest Pharmaceuticals, Inc.	070e556b-e083-452f-8a7c-aca92470dd61	2025-12-24	Warnings	Exact identifier application number: M010
PHARBEDRYL	DIPHENHYDRAMINE HCL	Pharbest Pharmaceuticals, Inc.	a19f1edc-d2cf-45fc-8233-d882441b0247	2025-12-24	Warnings	Exact identifier application number: M010 ndc (product): 16103-347
NIGHT TIME SLEEP-AID	DIPHENHYDRAMINE HCL	Discount Drug Mart	ac1860cb-da95-45bf-9261-19f39c56ddfe	2025-12-23	Warnings	Exact identifier application number: M010
SleepAid Softgels	DIPHENHYDRAMINE HYDROCHLORIDE	NUVICARE LLC	963c6925-dfbf-4cdc-8d13-5e10b499c4a9	2025-12-19	Warnings	Exact identifier application number: M010
Sleep Aid	DIPHENHYDRAMINE HCL 25 MG	NUVICARE LLC	85391744-3bf5-428e-a77b-464aa95b3a1a	2025-12-19	Warnings	Exact identifier application number: M010
Nighttime Sleep Aid	DIPHENHYDRAMINE HYDROCHLORIDE	VALU MERCHANDISERS COMPANY	70ec6ac1-2fd8-49dd-9ccb-c16e2f09a2b2	2025-12-11	Warnings	Exact identifier application number: M010
Nighttime Sleep Aid	DIPHENHYDRAMINE HYDROCHLORIDE	VALU MERCHANDISERS COMPANY	d337a0e6-09ed-4db0-8883-ec8a5d56bd35	2025-12-11	Warnings	Exact identifier application number: M010
Topcare ZZZ Sleep	DIPHENHYDRAMINE HCL	Topco Associates LLC	27225d04-6deb-436b-89ea-9842c487292e	2025-12-11	Warnings	Exact identifier application number: M010
Nighttime Sleep Aid	DIPHENHYDRAMINE HYDROCHLORIDE	HEB	91426a5b-dc01-a27b-e053-2a95a90a8ff8	2025-12-09	Warnings	Exact identifier application number: M010
Nighttime Sleep Aid, 24-7 Life by 7-Eleven	DOXYLAMINE SUCCINATE TABLET	Lil' Drug Store Products, Inc.	457814bc-535c-a136-e063-6394a90af9a4	2025-12-08	Warnings	Exact identifier application number: M010
Nighttime Sleep Aid	DIPHENHYDRAMINE HYDROCHLORIDE	Shield Pharmaceuticals Corp	97eb3e4d-06b7-49ed-909b-95b523dcce41	2025-12-05	Warnings	Exact identifier application number: M010

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
TC2D6JAD40	DIPHENHYDRAMINE HYDROCHLORIDE	147-24-0	DIPHENHYDRAMINE HYDROCHLORIDE

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUI	RxNorm string	TTY	DailyMed	SPL version
1020477	diphenhydrAMINE HCl 50 MG Oral Capsule	PSN	a19f1edc-d2cf-45fc-8233-d882441b0247	4
1020477	diphenhydramine hydrochloride 50 MG Oral Capsule	SCD	a19f1edc-d2cf-45fc-8233-d882441b0247	4
1020477	diphenhydramine HCl 50 MG Oral Capsule	SY	a19f1edc-d2cf-45fc-8233-d882441b0247	4
1020477	diphenhydrAMINE HCl 50 MG Oral Capsule	PSN	58ec2343-4c3b-26fa-e053-2a91aa0a4916	1
1020477	diphenhydramine hydrochloride 50 MG Oral Capsule	SCD	58ec2343-4c3b-26fa-e053-2a91aa0a4916	1
1020477	diphenhydramine HCl 50 MG Oral Capsule	SY	58ec2343-4c3b-26fa-e053-2a91aa0a4916	1

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Units	Marketing start	Marketing end	Sample	Exclude flag	Status
16103-347-08	16103034708	100 CAPSULE in 1 BOTTLE, PLASTIC (16103-347-08)	100 capsule	2006-10-11	0000-00-00	No	No	Current
16103-347-11	16103034711	1000 CAPSULE in 1 BOTTLE, PLASTIC (16103-347-11)	1000 capsule	2006-10-11	0000-00-00	No	No	Current

Title, Manufacturer, Effective date table
Title	Manufacturer	Effective date	Type	Version
Drug Facts	Pharbest Pharmaceuticals, Inc.	2025-12-24	HUMAN OTC DRUG LABEL	4
Diphenhydramine 50 mg #30 006 Drug Facts	Contract Pharmacy Services-PA \| Coupler Enterprises	2017-09-11	HUMAN OTC DRUG LABEL	1