Fluorouracil

Product NDC
16729-542
11-digit product format
167290542
Labeler code
16729
Product ID
16729-542_23a8557b-45e6-e3cf-e063-6394a90a4b0d
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Fluorouracil
Dosage form
CREAM
Route
TOPICAL
Labeler
Accord Healthcare Inc.
Application
ANDA214845
Marketing category
ANDA
Marketing start
2021-11-11
Substance
FLUOROURACIL
Active strength
50 mg/g
Pharmacologic classes
Nucleic Acid Synthesis Inhibitors [MoA], Nucleoside Metabolic Inhibitor [EPC]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 42.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A214845-001FLUOROURACILFLUOROURACIL5%CREAM / TOPICALAB2021-10-07

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-productTE code
A214845-001AB

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-08-18 06:07:402026-07A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-07caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-07011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-0731067a03dcf5…
2025-08-23 18:47 UTC2025-08A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-076a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-07fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-07b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-0703ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-072680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-075bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-07d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-07d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-0779d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-07301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-071e350fbaab3a…
2024-05-31 18:47 UTC2024-05A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-078072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-075c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-075d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-074b0b4de00fa7…
2022-03-09 01:35 UTC2022-03A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-07bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-07782e0a99824c…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-076a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-071c564ffb4f44…
2023-12-20 04:57 UTC2023-12A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-07ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-07a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-079b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-07a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-073f0d92c62455…
2023-05-13 08:27 UTC2023-05A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-07053a50430f4f…
2023-01-26 05:58 UTC2023-01A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-073bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-073a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-07f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-07e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-07cb3db0bc1861…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A214845-001FLUOROURACIL5%CREAM / TOPICALAB2021-10-07a50c72e98297…

Observed Orange Book normalized TE history#

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-08-18 06:07:402026-07A214845-001AB1caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A214845-001AB1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A214845-001AB131067a03dcf5…
2025-08-23 18:47 UTC2025-08A214845-001AB16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A214845-001AB1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A214845-001AB1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A214845-001AB103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A214845-001AB12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A214845-001AB15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A214845-001AB1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A214845-001AB1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A214845-001AB179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A214845-001AB1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A214845-001AB11e350fbaab3a…
2024-05-31 18:47 UTC2024-05A214845-001AB18072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A214845-001AB15c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A214845-001AB15d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A214845-001AB14b0b4de00fa7…
2022-03-09 01:35 UTC2022-03A214845-001AB1bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A214845-001AB1782e0a99824c…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A214845-001AB16a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A214845-001AB11c564ffb4f44…
2023-12-20 04:57 UTC2023-12A214845-001AB1ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A214845-001AB1a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A214845-001AB19b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A214845-001AB1a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A214845-001AB13f0d92c62455…
2023-05-13 08:27 UTC2023-05A214845-001AB1053a50430f4f…
2023-01-26 05:58 UTC2023-01A214845-001AB13bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A214845-001AB13a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A214845-001AB1f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A214845-001AB1e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07A214845-001AB1cb3db0bc1861…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A214845-001AB1a50c72e98297…

Additional Listing Data#

Finished product
Yes
Brand name base
Fluorouracil
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
FLUOROURACIL50 mg/g

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
U3P01618RTInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
105583Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
667d4059-de90-4d3f-86c2-c2573def2ecbAvailable on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
7dc9482d-9b87-4471-9708-4f1b4585846bProduct name220250723
a2ca0bf8-8306-49cc-93a3-3e6e4137c7cbProduct name520250630
dc0d2364-4811-4665-a3ee-7ed8c7301465Product name220171219
62fb8671-1693-49d8-8aab-0c1bfdd6794eProduct name120151005
878ca466-81fd-9d24-1349-31baf36065c6Product name220150506
630d1bc2-ae6b-fd31-1264-c4733e788193Product name120140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
16729-542-35Fluorouracil1 in 1 CARTONCREAM15
16729-542-35Fluorouracil40 g in 1 TUBECREAM405

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
16729-542-35GM - Gram16729-54263cfdbe3-c105-4f15-9d93-c22cd504f5d912021-11-09

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
16729-542FLUOROURACIL CREAM [ACCORD HEALTHCARE INC.]5Current NDC, Legacy NDC, 2 package rows20241006_667d4059-de90-4d3f-86c2-c2573def2ecb.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
FluorouracilFLUOROURACILAccord Healthcare Inc.667d4059-de90-4d3f-86c2-c2573def2ecb2024-10-04Warnings, Adverse reactionsExact identifier
application applno (ANDA): 214845
application number: ANDA214845
ndc (product): 16729-542

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
105583fluorouracil 5 % Topical CreamPSN667d4059-de90-4d3f-86c2-c2573def2ecb5
105583fluorouracil 50 MG/ML Topical CreamSCD667d4059-de90-4d3f-86c2-c2573def2ecb5
1055835-5-fluorouracil 50 MG/ML Topical CreamSY667d4059-de90-4d3f-86c2-c2573def2ecb5
1055835-FU 50 MG/ML Topical CreamSY667d4059-de90-4d3f-86c2-c2573def2ecb5
105583fluorouracil 5 % Topical CreamSY667d4059-de90-4d3f-86c2-c2573def2ecb5
105583fluorouracil 5 % Topical CreamPSNf75c4b87-3015-a938-e053-6394a90ac4cb1
105583fluorouracil 50 MG/ML Topical CreamSCDf75c4b87-3015-a938-e053-6394a90ac4cb1
1055835-5-fluorouracil 50 MG/ML Topical CreamSYf75c4b87-3015-a938-e053-6394a90ac4cb1
1055835-FU 50 MG/ML Topical CreamSYf75c4b87-3015-a938-e053-6394a90ac4cb1
105583fluorouracil 5 % Topical CreamSYf75c4b87-3015-a938-e053-6394a90ac4cb1

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
16729-542-35167290542351 TUBE in 1 CARTON (16729-542-35) / 40 g in 1 TUBE1 tube2021-11-110000-00-00NoNoCurrent