Promethazine Hydrochloride and Dextromethorphan Hydrobromide

Product NDC
17856-4024
11-digit product format
178564024
Labeler code
17856
Product ID
17856-4024_50223b67-c0bd-f577-e063-6394a90a8d8f
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Promethazine Hydrochloride and Dextromethorphan Hydrobromide
Dosage form
SYRUP
Route
ORAL
Labeler
Atlantic Biologicals Corp.
Application
ANDA088864
Marketing category
ANDA
Marketing start
2025-04-07
Substance
DEXTROMETHORPHAN HYDROBROMIDE; PROMETHAZINE HYDROCHLORIDE
Active strength
15; 6.25 mg/5mL; mg/5mL
Pharmacologic classes
Phenothiazine [EPC], Phenothiazines [CS], Sigma-1 Agonist [EPC], Sigma-1 Receptor Agonists [MoA], Uncompetitive N-methyl-D-aspartate Receptor Antagonist [EPC], Uncompetitive NMDA Receptor Antagonists [MoA]
NDC exclude flag
No
Listing certified through
2027-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 42.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A088864-001PROMETHAZINE W/ DEXTROMETHORPHANDEXTROMETHORPHAN HYDROBROMIDE; PROMETHAZINE HYDROCHLORIDE15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-04

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-productTE code
A088864-001AA

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 42 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-08-18 06:07:402026-07A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-04caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-04011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-0431067a03dcf5…
2025-08-23 18:47 UTC2025-08A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-046a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-04fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-04b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-0403ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-042680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-045bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-04d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-04d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-0479d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-04301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-041e350fbaab3a…
2024-05-31 18:47 UTC2024-05A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-048072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-045c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-045d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-044b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-0474a2ff9319b5…
2022-03-09 01:35 UTC2022-03A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-04bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-04782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-0487673890dc5c…
2021-03-12 10:30 UTC2021-03A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-045aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-048869cabd3fbd…
2020-11-12 02:37 UTC2020-11A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-04c0c555d07b60…
2019-12-14 00:12 UTC2019-12A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-043f01610625f2…
2019-09-15 20:21 UTC2019-09A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-04b00525d2431f…
2019-07-19 19:46 UTC2019-07A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-04ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-046a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-041c564ffb4f44…
2023-12-20 04:57 UTC2023-12A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-04ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-04a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-049b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-04a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-043f0d92c62455…
2023-05-13 08:27 UTC2023-05A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-04053a50430f4f…
2023-01-26 05:58 UTC2023-01A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-043bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-043a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-04f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A088864-001PROMETHAZINE W/ DEXTROMETHORPHAN15MG/5ML;6.25MG/5MLSYRUP / ORALAA1985-01-04e64feba35796…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 2 · 42 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-08-18 06:07:402026-07A088864-001AA1caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A088864-001AA1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A088864-001AA131067a03dcf5…
2025-08-23 18:47 UTC2025-08A088864-001AA16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A088864-001AA1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A088864-001AA1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A088864-001AA103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A088864-001AA12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A088864-001AA15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A088864-001AA1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A088864-001AA1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A088864-001AA179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A088864-001AA1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A088864-001AA11e350fbaab3a…
2024-05-31 18:47 UTC2024-05A088864-001AA18072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A088864-001AA15c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A088864-001AA15d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A088864-001AA14b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A088864-001AA174a2ff9319b5…
2022-03-09 01:35 UTC2022-03A088864-001AA1bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A088864-001AA1782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A088864-001AA187673890dc5c…
2021-03-12 10:30 UTC2021-03A088864-001AA15aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A088864-001AA18869cabd3fbd…
2020-11-12 02:37 UTC2020-11A088864-001AA1c0c555d07b60…
2019-12-14 00:12 UTC2019-12A088864-001AA13f01610625f2…
2019-09-15 20:21 UTC2019-09A088864-001AA1b00525d2431f…
2019-07-19 19:46 UTC2019-07A088864-001AA1ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A088864-001AA16a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A088864-001AA11c564ffb4f44…
2023-12-20 04:57 UTC2023-12A088864-001AA1ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A088864-001AA1a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A088864-001AA19b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A088864-001AA1a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A088864-001AA13f0d92c62455…
2023-05-13 08:27 UTC2023-05A088864-001AA1053a50430f4f…
2023-01-26 05:58 UTC2023-01A088864-001AA13bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A088864-001AA13a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A088864-001AA1f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A088864-001AA1e64feba35796…

Additional Listing Data#

Finished product
Yes
Brand name base
Promethazine Hydrochloride and Dextromethorphan Hydrobromide
Listing expiration
2027-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
PROMETHAZINE HYDROCHLORIDE6.25 mg/5mL
DEXTROMETHORPHAN HYDROBROMIDE15 mg/5mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
R61ZEH7I1IInternal UNII lookup
9D2RTI9KYHInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
991528Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
5022379d-05ef-63f2-e063-6294a90a2189Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
bf324df6-7127-7deb-def5-2681c136cd03Product name320250325
3036445d-7d13-4411-a100-f2ac5ab8a276Product name120240110
43a1ed49-eae2-4840-8075-cb4b33478540Product name120230425
2e7222fb-e3f1-febd-962f-ddbb495d6b5fProduct name220220126
09d8330d-4fec-be98-3a66-f985140646b2Product name220210513
ba088a92-ab5e-b2d4-e908-f5ea691b7587Product name720210201
c5cd4727-ac49-4409-82b1-5bd8006c3ec7Product name120171122
4f881de7-085a-407e-abc2-faa3c0127432Product name120170811
e0b6c8be-f2bd-9f86-a9fc-3ed56ffaa814Product name320150910
76633df9-0d59-4b88-03ed-21dee1b966f8Product name120140508
d51697af-7f97-0559-95d1-fe94f3f031d5Product name120140508
e949165d-714d-e548-2b76-0cb5def16f30Product name120140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
17856-4024-1Promethazine Hydrochloride and Dextromethorphan Hydrobromide5 mL in 1 CUP, UNIT-DOSESYRUP51
17856-4024-1Promethazine Hydrochloride and Dextromethorphan Hydrobromide72 in 1 CASESYRUP721

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 4 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Promethazine Hydrochloride and Dextromethorphan HydrobromidePROMETHAZINE HYDROCHLORIDE AND DEXTROMETHORPHAN HYDROBROMIDEAtlantic Biologicals Corp.5022379d-05ef-63f2-e063-6294a90a21892026-04-23Warnings, Adverse reactionsExact identifier
application applno (ANDA): 088864
application number: ANDA088864
ndc (product): 17856-4024
Promethazine Hydrochloride and Dextromethorphan HydrobromidePROMETHAZINE HYDROCHLORIDE AND DEXTROMETHORPHAN HYDROBROMIDEA-S Medication Solutions87f9e9fb-5433-478b-9f23-e16883a9d2a92025-09-23Warnings, Adverse reactionsExact identifier
application applno (ANDA): 088864
application number: ANDA088864
Promethazine Hydrochloride and Dextromethorphan HydrobromidePROMETHAZINE HYDROCHLORIDE AND DEXTROMETHORPHAN HYDROBROMIDEXttrium Laboratories, Inc30c9d769-bc74-04d2-e063-6294a90a665a2025-04-07Warnings, Adverse reactionsExact identifier
application applno (ANDA): 088864
application number: ANDA088864
Promethazine Hydrochloride and Dextromethorphan HydrobromidePROMETHAZINE HYDROCHLORIDE AND DEXTROMETHORPHAN HYDROBROMIDEA-S Medication Solutionsee227c52-2cd8-4a06-a2de-a257f1f4732a2023-07-11Warnings, Adverse reactionsExact identifier
application applno (ANDA): 088864
application number: ANDA088864

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
991528promethazine HCl 6.25 MG / dextromethorphan HBr 15 MG in 5 mL Oral SolutionPSN5022379d-05ef-63f2-e063-6294a90a21891
991528dextromethorphan hydrobromide 3 MG/ML / promethazine hydrochloride 1.25 MG/ML Oral SolutionSCD5022379d-05ef-63f2-e063-6294a90a21891
991528dextromethorphan HBr 15 MG / promethazine HCl 6.25 MG per 5 ML Oral SolutionSY5022379d-05ef-63f2-e063-6294a90a21891

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionMarketing startSampleExclude flagStatus
17856-4024-11785640240172 CUP, UNIT-DOSE in 1 CASE (17856-4024-1) / 5 mL in 1 CUP, UNIT-DOSE2026-04-24NoNoCurrent