Signature Care Pain Relief

Product NDC: 21130-111
11-digit product format: 211300111
Labeler code: 21130
Product ID: 21130-111_c77c6d49-4bd8-4359-872c-4cc13aecb583
Type: HUMAN OTC DRUG
Nonproprietary name: Acetaminophen
Dosage form: TABLET
Route: ORAL
Labeler: Safeway
Application: M013
Marketing category: OTC MONOGRAPH DRUG
Marketing start: 2015-09-01
Substance: ACETAMINOPHEN
Active strength: 500 mg/1
NDC exclude flag: No
Listing certified through: 2026-12-31
Current FDA listing: Yes

NDC auxiliary status#

These records are reproduced from FDA’s unfinished, excluded, and compounder listings. They describe what appeared in the source files; a missing record does not establish a regulatory status. View all current auxiliary records, including entries without an NDC. · View the auxiliary file history.

Current NDC status page 1 of 1 · 2 matching rows.

Dataset, Scope, Product NDC table
Dataset	Scope	Product NDC	Package NDC	Code	Status	Reporting period	Source date
excluded package	package	21130-111	21130-111-62	D	Discontinued by firm		2026-10-20
excluded package	package	21130-111	21130-111-90	D	Discontinued by firm		2026-10-20

Observed NDC auxiliary status history#

This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.

Historic NDC status page 1 of 1 · 8 matching rows.

View current auxiliary records. · View the auxiliary file history.

Captured / source date, Package NDC, Snapshot table
Captured / source date	Package NDC	Snapshot	Source SHA-256
2025-12-14 17:58 UTC · source 2025-12-05	21130-111-90	`d630ba8d3edf…`	`732f749b63fb…`
2025-12-14 17:58 UTC · source 2025-12-05	21130-111-62	`d630ba8d3edf…`	`732f749b63fb…`
2025-08-27 00:01 UTC · source 2025-08-26	21130-111-90	`f5e01cc5f278…`	`a2eaf40c39c3…`
2025-08-27 00:01 UTC · source 2025-08-26	21130-111-62	`f5e01cc5f278…`	`a2eaf40c39c3…`
2025-04-01 02:39 UTC · source 2025-03-31	21130-111-90	`2ef7874e63bc…`	`57b86245f4fa…`
2025-03-28 20:22 UTC · source 2025-03-28	21130-111-90	`a1b67e2a42f9…`	`c4cf2c586c0d…`
2025-03-22 03:12 UTC · source 2025-03-21	21130-111-90	`cfe11265f3b6…`	`090c488252e2…`
2025-03-10 12:48 UTC · source 2025-03-10	21130-111-90	`cdf11ea48f46…`	`ba0047e9e063…`

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

Additional Listing Data#

Finished product: Yes
Brand name base: Signature Care Pain Relief
Listing expiration: 2026-12-31

Active Ingredients#

Ingredient, Strength table
Ingredient	Strength
ACETAMINOPHEN	500 mg/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
362O9ITL9D	Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
198440	Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
917bcd06-6dc6-42b3-80b4-c6746b347261	Available on FDA.report

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	SPL version
21130-111-62	Signature Care Pain Relief	1 in 1 CARTON	TABLET	1	5
21130-111-62	Signature Care Pain Relief	24 in 1 BOTTLE	TABLET	24	5
21130-111-71	Signature Care Pain Relief	50 in 1 BOTTLE	TABLET	50	5
21130-111-71	Signature Care Pain Relief	1 in 1 CARTON	TABLET	1	5
21130-111-78	Signature Care Pain Relief	100 in 1 BOTTLE	TABLET	100	5
21130-111-78	Signature Care Pain Relief	1 in 1 CARTON	TABLET	1	5
21130-111-85	Signature Care Pain Relief	1 in 1 CARTON	TABLET	1	5
21130-111-85	Signature Care Pain Relief	250 in 1 BOTTLE	TABLET	250	5
21130-111-90	Signature Care Pain Relief	500 in 1 BOTTLE	TABLET	500	5

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
Ingredient	Type	UNII	DailyMed label	SPL version
ACETAMINOPHEN	ACTIVE INGREDIENT	362O9ITL9D	SIGNATURE CARE PAIN RELIEF (ACETAMINOPHEN) TABLET [SAFEWAY]	1
ACETAMINOPHEN	ACTIVE MOIETY	362O9ITL9D	SIGNATURE CARE PAIN RELIEF (ACETAMINOPHEN) TABLET [SAFEWAY]	1
CARNAUBA WAX	INACTIVE INGREDIENT	R12CBM0EIZ	SIGNATURE CARE PAIN RELIEF (ACETAMINOPHEN) TABLET [SAFEWAY]	1
CROSCARMELLOSE SODIUM	INACTIVE INGREDIENT	M28OL1HH48	SIGNATURE CARE PAIN RELIEF (ACETAMINOPHEN) TABLET [SAFEWAY]	1
HYPROMELLOSES	INACTIVE INGREDIENT	3NXW29V3WO	SIGNATURE CARE PAIN RELIEF (ACETAMINOPHEN) TABLET [SAFEWAY]	1
POLYETHYLENE GLYCOLS	INACTIVE INGREDIENT	3WJQ0SDW1A	SIGNATURE CARE PAIN RELIEF (ACETAMINOPHEN) TABLET [SAFEWAY]	1
POVIDONES	INACTIVE INGREDIENT	FZ989GH94E	SIGNATURE CARE PAIN RELIEF (ACETAMINOPHEN) TABLET [SAFEWAY]	1
STARCH, CORN	INACTIVE INGREDIENT	O8232NY3SJ	SIGNATURE CARE PAIN RELIEF (ACETAMINOPHEN) TABLET [SAFEWAY]	1
STEARIC ACID	INACTIVE INGREDIENT	4ELV7Z65AP	SIGNATURE CARE PAIN RELIEF (ACETAMINOPHEN) TABLET [SAFEWAY]	1

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
21130-111	SIGNATURE CARE PAIN RELIEF (ACETAMINOPHEN) TABLET [SAFEWAY]	5	Current NDC, Legacy NDC, 9 package rows	20240924_917bcd06-6dc6-42b3-80b4-c6746b347261.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 73 of 79 · 1,579 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
PANADOL Extra	ACETAMINOPHEN AND CAFFEINE	Haleon US Holdings LLC	e5c2d88a-d903-4ca0-b895-f27e791dfc4e	2024-02-06	Warnings	Exact identifier application number: M013
PANADOL Extra Strength	ACETAMINOPHEN	Haleon US Holdings LLC	b2fe7f47-1a2e-40ee-8f8f-38f2028dce1b	2024-02-06	Warnings	Exact identifier application number: M013
PANADOL Extra Strength	ACETAMINOPHEN	Haleon US Holdings LLC	9d384e88-5c11-4600-ac6c-a38371570138	2024-02-06	Warnings	Exact identifier application number: M013
PANADOL	ACETAMINOPHEN	Haleon US Holdings LLC	95801755-db54-4ad7-bec1-52671914f6ca	2024-02-06	Warnings	Exact identifier application number: M013
PANADOL PM	ACETAMINOPHEN AND DIPHENHYDRAMINE HCL	Haleon US Holdings LLC	01e7dddb-755c-4745-b701-edcdb6209064	2024-02-06	Warnings, Adverse reactions	Exact identifier application number: M013
PANADOL PM	ACETAMINOPHEN AND DIPHENHYDRAMINE HCL	Haleon US Holdings LLC	fe7cd1f2-9b00-4ded-99c2-8a152c71093c	2024-02-06	Warnings, Adverse reactions	Exact identifier application number: M013
Childrens Pain and Fever	ACETAMINOPHEN	AptaPharma Inc.	9064943f-836f-4853-b6f2-2c4879941eeb	2024-02-02	Warnings	Exact identifier application number: M013
Quality Choice Effervescent Pain Relief	ASPIRIN	CHAIN DRUG MARKETING ASSOCIATION, INC.	079af5d7-1be8-2a93-e063-6294a90a496d	2024-02-01	Warnings	Exact identifier application number: M013
MEDI-FIRST Non-Aspirin	ACETAMINOPHEN	Proficient Rx LP	4c84948d-3a95-4c53-8529-7e7b9d8bb6df	2024-02-01	Warnings	Exact identifier application number: M013
Pharbetol	ACETAMINOPHEN	Proficient Rx LP	9c7d65e4-df2f-47c1-a185-66aaf19aad2b	2024-02-01	Warnings	Exact identifier application number: M013
Childrens Acetaminophen	ACETAMINOPHEN	Proficient Rx LP	57e4820c-b4eb-442e-9c49-93eedfbc5e5e	2024-02-01	Warnings	Exact identifier application number: M013
good sense aspirin	ASPIRIN	Proficient Rx LP	73013074-9c6e-43c7-acde-4d9d8ed0133d	2024-02-01	Warnings	Exact identifier application number: M013
MEDIQUE APAP Extra Strength	ACETAMINOPHEN	Proficient Rx LP	c466a07f-2339-4cf5-8377-e0f109649c52	2024-02-01	Warnings	Exact identifier application number: M013
Percogesic Extra Strength	ACETAMINOPHEN AND DIPHENHYDRAMINE	Medtech Products Inc.	2c5f1140-fb83-42c9-b0b1-5e2bd69340bb	2024-02-01	Warnings	Exact identifier application number: M013
aspirin	ASPIRIN	Proficient Rx LP	3c7783a7-2b28-4968-b766-0a49dc70ce6d	2024-02-01	Warnings	Exact identifier application number: M013
Regular Strength Pain Relief	ACETAMINOPHEN	NuCare Pharmaceuticals,Inc.	102bdcde-cb90-f248-e063-6394a90aac79	2024-01-30	Warnings	Exact identifier application number: M013
Excedrin Extra Strength Headache	ACETAMINOPHEN, ASPIRIN (NSAID), CAFFEINE	Haleon US Holdings LLC	61802b27-c9ec-4386-9d44-45e8b1e558b7	2024-01-28	Warnings	Exact identifier application number: M013
AGRIFEN	ACETAMINOPHEN, ASPIRIN, CAFFEINE	OPMX LLC	0fde22da-cdfc-36cc-e063-6294a90a3885	2024-01-26	Warnings	Exact identifier application number: M013
DOLODOL	ACETAMINOPHEN, ASPIRIN, CAFFEINE	OPMX LLC	e80536f1-92cc-5bb3-e053-2995a90a9540	2024-01-26	Warnings	Exact identifier application number: M013
LOW DOSE ASPIRIN	ASPIRIN	Bryant Ranch Prepack	d913d11f-c7a1-49d2-a2d3-9a29fc032806	2024-01-18	Warnings	Exact identifier application number: M013

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
362O9ITL9D	ACETAMINOPHEN	103-90-2	ACETAMINOPHEN

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUI	RxNorm string	TTY	DailyMed	SPL version
198440	acetaminophen 500 MG Oral Tablet	PSN	917bcd06-6dc6-42b3-80b4-c6746b347261	5
198440	acetaminophen 500 MG Oral Tablet	SCD	917bcd06-6dc6-42b3-80b4-c6746b347261	5
198440	APAP 500 MG Oral Tablet	SY	917bcd06-6dc6-42b3-80b4-c6746b347261	5

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Units	Marketing start	Marketing end	Sample	Exclude flag	Status
21130-111-62	21130011162	1 BOTTLE in 1 CARTON (21130-111-62) > 24 TABLET in 1 BOTTLE	1 bottle	2015-09-01	0000-00-00	No	No	Current
21130-111-71	21130011171	1 BOTTLE in 1 CARTON (21130-111-71) / 50 TABLET in 1 BOTTLE	1 bottle	2015-09-01	0000-00-00	No	No	Current
21130-111-78	21130011178	1 BOTTLE in 1 CARTON (21130-111-78) / 100 TABLET in 1 BOTTLE	1 bottle	2015-09-01	0000-00-00	No	No	Current
21130-111-85	21130011185	1 BOTTLE in 1 CARTON (21130-111-85) / 250 TABLET in 1 BOTTLE	1 bottle	2015-09-01	0000-00-00	No	No	Current
21130-111-90	21130011190	500 TABLET in 1 BOTTLE (21130-111-90)	500 tablet	2015-09-01	0000-00-00	No	No	Current