signature care itch relief

Product NDC: 21130-154
11-digit product format: 211300154
Labeler code: 21130
Product ID: 21130-154_4e0a1cc6-292f-46d7-a5a1-0b8b642ca8fd
Type: HUMAN OTC DRUG
Nonproprietary name: Diphenhydramine Hydrochloride, Zinc Acetate
Dosage form: CREAM
Route: TOPICAL
Labeler: Safeway
Application: M017
Marketing category: OTC MONOGRAPH DRUG
Marketing start: 2015-09-01
Substance: DIPHENHYDRAMINE HYDROCHLORIDE; ZINC ACETATE
Active strength: 2; .1 g/100g; g/100g
Pharmacologic classes: Copper Absorption Inhibitor [EPC], Decreased Copper Ion Absorption [PE], Histamine H1 Receptor Antagonists [MoA], Histamine-1 Receptor Antagonist [EPC]
NDC exclude flag: No
Listing certified through: 2026-12-31
Current FDA listing: Yes

Additional Listing Data#

Finished product: Yes
Brand name base: signature care itch relief
Listing expiration: 2026-12-31

Active Ingredients#

Ingredient, Strength table
Ingredient	Strength
DIPHENHYDRAMINE HYDROCHLORIDE	2 g/100g
ZINC ACETATE	.1 g/100g

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
TC2D6JAD40	Internal UNII lookup
FM5526K07A	Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
1087026	Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
3eedcd9f-8312-4d14-a0fe-6b00a00d3e73	Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product concept	Relation	Version	Effective
f47a510b-6679-4664-b2d6-47b5c4afe7cc	Product name	4	20260217
030ce964-9b2d-45aa-b5d3-f78ce03ef61c	Product name	2	20250515
0e2e0f88-b076-afe1-4bdd-32bca4375bec	Product name	3	20250127
0306390c-dd77-4363-afe0-63c58088b2a1	Product name	1	20220120
503ea967-4b9c-48cf-9e87-c7975295849d	Product name	2	20220120
190f2a5b-bbc8-65c7-fcb0-97891307b917	Product name	1	20140508
3e48c9c4-918d-5d23-2f0b-d2398b06be54	Product name	1	20140508
865c72dd-0d94-daac-f728-ddd4ded2a79e	Product name	1	20140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	Strength	SPL version
21130-154-64	signature care itch relief	1 in 1 CARTON	CREAM	1		3
21130-154-64	signature care itch relief	28 g in 1 TUBE	CREAM	28		3

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
Ingredient	Type	UNII	DailyMed label	SPL version
DIPHENHYDRAMINE HYDROCHLORIDE	ACTIVE INGREDIENT	TC2D6JAD40	SIGNATURE CARE ITCH RELIEF (DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE) CREAM [SAFEWAY]	1
ZINC ACETATE	ACTIVE INGREDIENT	FM5526K07A	SIGNATURE CARE ITCH RELIEF (DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE) CREAM [SAFEWAY]	1
DIPHENHYDRAMINE	ACTIVE MOIETY	8GTS82S83M	SIGNATURE CARE ITCH RELIEF (DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE) CREAM [SAFEWAY]	1
ZINC CATION	ACTIVE MOIETY	13S1S8SF37	SIGNATURE CARE ITCH RELIEF (DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE) CREAM [SAFEWAY]	1
CETYL ALCOHOL	INACTIVE INGREDIENT	936JST6JCN	SIGNATURE CARE ITCH RELIEF (DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE) CREAM [SAFEWAY]	1
DIAZOLIDINYL UREA	INACTIVE INGREDIENT	H5RIZ3MPW4	SIGNATURE CARE ITCH RELIEF (DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE) CREAM [SAFEWAY]	1
METHYLPARABEN	INACTIVE INGREDIENT	A2I8C7HI9T	SIGNATURE CARE ITCH RELIEF (DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE) CREAM [SAFEWAY]	1
PEG-2 STEARATE	INACTIVE INGREDIENT	94YQ11Y95F	SIGNATURE CARE ITCH RELIEF (DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE) CREAM [SAFEWAY]	1
PEG-20 STEARATE	INACTIVE INGREDIENT	NBX892EA57	SIGNATURE CARE ITCH RELIEF (DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE) CREAM [SAFEWAY]	1
PROPYLENE GLYCOL	INACTIVE INGREDIENT	6DC9Q167V3	SIGNATURE CARE ITCH RELIEF (DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE) CREAM [SAFEWAY]	1
PROPYLPARABEN	INACTIVE INGREDIENT	Z8IX2SC1OH	SIGNATURE CARE ITCH RELIEF (DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE) CREAM [SAFEWAY]	1
WATER	INACTIVE INGREDIENT	059QF0KO0R	SIGNATURE CARE ITCH RELIEF (DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE) CREAM [SAFEWAY]	1

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
21130-154	SIGNATURE CARE ITCH RELIEF (DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE) CREAM [SAFEWAY]	3	Current NDC, Legacy NDC, 2 package rows	20241015_3eedcd9f-8312-4d14-a0fe-6b00a00d3e73.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 157 · 3,129 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
JenGufun LIDOCAINE KNEE Patch	LIDOCAINE KNEE PATCH	Henan Kangdi Medical Devices Co., Ltd.	5b1d8508-b993-7a8d-e063-6294a90ae306	2026-09-10	Warnings	Exact identifier application number: M017
Wart Corn Remover	SALICYLIC ACID	HONG KONG FOREVER YOUNG TRADING CO., LIMITED	5b0cd6e0-f220-4ebd-e063-6294a90ade67	2026-09-09	Warnings	Exact identifier application number: M017
Magic Cream	PAIN RELIEVING OINTMENT	Jiangxi Baikang Medical Products Co., Ltd.	5b0f2515-47e9-603f-e063-6294a90af9d4	2026-09-09	Warnings	Exact identifier application number: M017
Burn Gel	LIDOCAINE HCI	Trifecta Pharmaceuticals USA LLC	e9d3e9be-1036-fad0-e053-2a95a90a6efe	2026-09-09	Warnings	Exact identifier application number: M017
4% Lidocaine Pain Relief Patch	LIDOCAINE 4%	Guangxi Keyun E-commerce Co., Ltd.	5b197cd8-542f-38b4-e063-6294a90ad7d3	2026-09-09	Warnings	Exact identifier application number: M017
Pain Relieving Lidocaine Patch	LIDOCAINE	YYBA CORP	af8c84fd-224c-72b3-e053-2a95a90a9568	2026-09-07	Warnings	Exact identifier application number: M017
American Safety First Aid	LIDOCAINE HCL	Orazen Inc	ea2f776b-dfd0-6ce4-e053-2995a90af009	2026-09-07	Warnings	Exact identifier application number: M017
MEDI-FIRST Topical Analgesic	LIDOCAINE HCI	Ultra Distributors Inc	b6f288f7-9ae3-215e-e053-2a95a90aedf6	2026-09-07	Warnings	Exact identifier application number: M017
MEDI-FIRST	BENZALKONIUM CHLORIDE, LIDOCAINE	Orazen Inc	f508434f-5948-7134-e053-2a95a90a03d7	2026-09-05	Warnings	Exact identifier application number: M017
MEDI-FIRST	BENZALKONIUM CHLORIDE, LIDOCAINE	Orazen Inc	f522fb0b-3d86-b228-e053-2a95a90a55e9	2026-09-05	Warnings	Exact identifier application number: M017
SurviveX Anti-itch Cream	SURVIVEX HYDROCORTISONE	Nantong Health & Beyond Hygienic Products Inc.	5a7a1141-d3b1-0ee8-e063-6294a90a16aa	2026-09-04	Warnings	Exact identifier application number: M017
NeuroNesic Pain Relieving Cream	CAPSAICIN	Blaine Labs Inc.	7107c13d-bf59-4c0a-84fe-725a9fca2691	2026-09-04	Warnings	Exact identifier application number: M017
FREEZE EASE	MENTHOL 4%	Global America Group LLC	16553eda-ec34-485a-a11c-f51260efd9fa	2026-09-03	Warnings	Exact identifier application number: M017
Neoteric Diabetic Skin Care 1 oz.	DIMETHICONE	RNA PHARMA LLC	5a944486-9591-f583-e063-6394a90aa04b	2026-09-03	Warnings	Exact identifier application number: M017
Equate Menthol Pain Relieving	MENTHOL	Wal-Mart Stores Inc	d5b0a7f1-4e23-426b-bb7e-aaa251ad4ffc	2026-09-03	Warnings	Exact identifier application number: M017
ZHI Technologies	LIDOCAINE, MENTHOL	ZHI Technologies, Inc.	6717e995-4d2d-49e8-8ecf-7c62557dfdef	2026-09-03	Warnings	Exact identifier application number: M017
Komxsum LIDOCAINE Cream	LIDOCAINE 4% CREAM	Wenzhou Yuyuan Pharmaceutical Co., Ltd.	5a9feae0-9be4-e736-e063-6294a90abe55	2026-09-03	Warnings	Exact identifier application number: M017
FREEZE EASE Roll-On	MENTHOL	Global America Group LLC	1869cc0d-a056-45de-aede-23b09b61ed12	2026-09-02	Warnings	Exact identifier application number: M017
Gaimoa Lidocaine Pain Relief Gel Patches	LIDOCAINE PAIN RELIEF GEL PATCHES	Henan Enokon Medical Instrument Co., Ltd.	5a68fe67-5c15-af9a-e063-6294a90a7ec1	2026-09-01	Warnings	Exact identifier application number: M017
CVS Cortisone Liquid	HYDROCORTISONE	CVS Pharmacy	42df45a9-d449-090a-e063-6394a90a9ee4	2026-09-01	Warnings	Exact identifier application number: M017

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
TC2D6JAD40	DIPHENHYDRAMINE HYDROCHLORIDE	147-24-0	DIPHENHYDRAMINE HYDROCHLORIDE
FM5526K07A	ZINC ACETATE	5970-45-6	ZINC ACETATE

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUI	RxNorm string	TTY	DailyMed	SPL version
1087026	diphenhydrAMINE HCl 2 % / zinc acetate 0.1 % Topical Cream	PSN	3eedcd9f-8312-4d14-a0fe-6b00a00d3e73	3
1087026	diphenhydramine hydrochloride 20 MG/ML / zinc acetate 1 MG/ML Topical Cream	SCD	3eedcd9f-8312-4d14-a0fe-6b00a00d3e73	3
1087026	diphenhydramine hydrochloride 2 % / zinc acetate 0.1 % Topical Cream	SY	3eedcd9f-8312-4d14-a0fe-6b00a00d3e73	3

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Units	Marketing start	Marketing end	Sample	Exclude flag	Status
21130-154-64	21130015464	1 TUBE in 1 CARTON (21130-154-64) / 28 g in 1 TUBE	1 tube	2015-09-01	0000-00-00	No	No	Current