signature care itch relief

Product NDC: 21130-154
11-digit product format: 211300154
Labeler code: 21130
Product ID: 21130-154_4e0a1cc6-292f-46d7-a5a1-0b8b642ca8fd
Type: HUMAN OTC DRUG
Nonproprietary name: Diphenhydramine Hydrochloride, Zinc Acetate
Dosage form: CREAM
Route: TOPICAL
Labeler: Safeway
Application: M017
Marketing category: OTC MONOGRAPH DRUG
Marketing start: 2015-09-01
Substance: DIPHENHYDRAMINE HYDROCHLORIDE; ZINC ACETATE
Active strength: 2; .1 g/100g; g/100g
Pharmacologic classes: Copper Absorption Inhibitor [EPC], Decreased Copper Ion Absorption [PE], Histamine H1 Receptor Antagonists [MoA], Histamine-1 Receptor Antagonist [EPC]
NDC exclude flag: No
Listing certified through: 2027-12-31
Current FDA listing: Yes

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

Additional Listing Data#

Finished product: Yes
Brand name base: signature care itch relief
Listing expiration: 2026-12-31

Active Ingredients#

Ingredient, Strength table
Ingredient	Strength
DIPHENHYDRAMINE HYDROCHLORIDE	2 g/100g
ZINC ACETATE	.1 g/100g

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
TC2D6JAD40	Internal UNII lookup
FM5526K07A	Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
1087026	Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
3eedcd9f-8312-4d14-a0fe-6b00a00d3e73	Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product concept	Relation	Version	Effective
f47a510b-6679-4664-b2d6-47b5c4afe7cc	Product name	4	20260217
030ce964-9b2d-45aa-b5d3-f78ce03ef61c	Product name	2	20250515
0e2e0f88-b076-afe1-4bdd-32bca4375bec	Product name	3	20250127
0306390c-dd77-4363-afe0-63c58088b2a1	Product name	1	20220120
503ea967-4b9c-48cf-9e87-c7975295849d	Product name	2	20220120
190f2a5b-bbc8-65c7-fcb0-97891307b917	Product name	1	20140508
3e48c9c4-918d-5d23-2f0b-d2398b06be54	Product name	1	20140508
865c72dd-0d94-daac-f728-ddd4ded2a79e	Product name	1	20140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	Strength	SPL version
21130-154-64	signature care itch relief	1 in 1 CARTON	CREAM	1		3
21130-154-64	signature care itch relief	28 g in 1 TUBE	CREAM	28		3

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
Ingredient	Type	UNII	DailyMed label	SPL version
DIPHENHYDRAMINE HYDROCHLORIDE	ACTIVE INGREDIENT	TC2D6JAD40	SIGNATURE CARE ITCH RELIEF (DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE) CREAM [SAFEWAY]	1
ZINC ACETATE	ACTIVE INGREDIENT	FM5526K07A	SIGNATURE CARE ITCH RELIEF (DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE) CREAM [SAFEWAY]	1
DIPHENHYDRAMINE	ACTIVE MOIETY	8GTS82S83M	SIGNATURE CARE ITCH RELIEF (DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE) CREAM [SAFEWAY]	1
ZINC CATION	ACTIVE MOIETY	13S1S8SF37	SIGNATURE CARE ITCH RELIEF (DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE) CREAM [SAFEWAY]	1
CETYL ALCOHOL	INACTIVE INGREDIENT	936JST6JCN	SIGNATURE CARE ITCH RELIEF (DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE) CREAM [SAFEWAY]	1
DIAZOLIDINYL UREA	INACTIVE INGREDIENT	H5RIZ3MPW4	SIGNATURE CARE ITCH RELIEF (DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE) CREAM [SAFEWAY]	1
METHYLPARABEN	INACTIVE INGREDIENT	A2I8C7HI9T	SIGNATURE CARE ITCH RELIEF (DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE) CREAM [SAFEWAY]	1
PEG-2 STEARATE	INACTIVE INGREDIENT	94YQ11Y95F	SIGNATURE CARE ITCH RELIEF (DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE) CREAM [SAFEWAY]	1
PEG-20 STEARATE	INACTIVE INGREDIENT	NBX892EA57	SIGNATURE CARE ITCH RELIEF (DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE) CREAM [SAFEWAY]	1
PROPYLENE GLYCOL	INACTIVE INGREDIENT	6DC9Q167V3	SIGNATURE CARE ITCH RELIEF (DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE) CREAM [SAFEWAY]	1
PROPYLPARABEN	INACTIVE INGREDIENT	Z8IX2SC1OH	SIGNATURE CARE ITCH RELIEF (DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE) CREAM [SAFEWAY]	1
WATER	INACTIVE INGREDIENT	059QF0KO0R	SIGNATURE CARE ITCH RELIEF (DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE) CREAM [SAFEWAY]	1

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
21130-154	SIGNATURE CARE ITCH RELIEF (DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE) CREAM [SAFEWAY]	3	Current NDC, Legacy NDC, 2 package rows	20241015_3eedcd9f-8312-4d14-a0fe-6b00a00d3e73.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 103 of 152 · 3,029 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
IKONIK TONIK	LIDOCAINE HYDROCHLORIDE	IKONIK CARE, LLC	122fdfe8-b5fa-46d1-9fd9-3df9887ed320	2025-01-14	Warnings	Exact identifier application number: M017
elp essential MANTECA DE UBRE	METHYL SALICYLATE, CAMPHOR	Miramar Cosmetics, Inc DBA Miramar Lab	c3964dfe-17fe-4d89-a4c4-cf500f982259	2025-01-13	Warnings	Exact identifier application number: M017
Methylten	METHYL SALICYLATE 10%	Puretek Corporation	28f4093f-803f-0e70-e063-6294a90a98a4	2025-01-13	Warnings	Exact identifier application number: M017
Refill Bundle 7 Large Office	BENZALKONIUM CHLORIDE	CMC Group, Inc.	6620a8f3-098d-d045-e053-2a91aa0a0d94	2025-01-13	Warnings	Exact identifier application number: M017
Jakwork Numbing Cream	NUMBING CREAM	Guangzhou Zanming Trading Co., Ltd.	2ba1de83-494a-6c54-e063-6294a90a9b2d	2025-01-13	Warnings	Exact identifier application number: M017
Arthritis Hot	MENTHOL AND METHYL SALICYLATE	Chattem, Inc.	cc57b9b6-8ba5-4ff3-a5df-97d8f5b1bebd	2025-01-13	Warnings	Exact identifier application number: M017
Re-Lieved Lidocaine Patch	LIDOCAINE PATCH 4%	Transfer Technology	00b40dda-53ad-0458-e063-6394a90aa835	2025-01-11	Warnings	Exact identifier application number: M017
Re-Lieved Lidocaine Patch	LIDOCAINE PATCH 4%	Transfer Technology	00b47eb7-6b43-d9e2-e063-6294a90a9a38	2025-01-11	Warnings	Exact identifier application number: M017
Re-Lieved 4% Lidocaine Fabric Tape	LIDOCAINE 4% FABRIC TAPE	Transfer Technology	e9a894b0-54f2-707e-e053-2a95a90a0f0d	2025-01-11	Warnings	Exact identifier application number: M017
Re-Lieved 3 in 1 Patch	MENTHOL, CAMPHOR, METHYL SALICYLATE PATCH	Transfer Technology	e9ab9a03-b9e3-7317-e053-2995a90a9950	2025-01-11	Warnings	Exact identifier application number: M017
ASTRAPHARM CHILLI BRAND	CAPSAICIN	Dersan Pharmaceutical Co., Ltd	b4c2d4fd-7d5d-4156-ac27-e72ebc9671ec	2025-01-10	Warnings	Exact identifier application number: M017
LABOFLEX Lidocaine Pain Relieving Patch	LIDOCAINE 4%	Laboflex, Inc.	31995f31-c272-afdb-e063-6294a90af3f9	2025-01-10	Warnings	Exact identifier application number: M017
Anti-Itch Cream	DIPHENHYDRAMINE HYDROCHLORIDE 2%, ZINC ACETATE 0.1%	Chain Drug Marketing Association Inc.	2b48cb2f-e6bf-f9de-e063-6394a90a42d4	2025-01-09	Warnings	Exact identifier application number: M017
PAIN-X	MENTHOL	OL PHARMA TECH,LLC	b22bb19a-14e5-3d32-e053-2a95a90ae520	2025-01-09	Warnings	Exact identifier application number: M017
MUSCLE RUB	MENTHOL	OL PHARMA TECH,LLC	b22c7999-52d5-25c3-e053-2a95a90a01f5	2025-01-09	Warnings	Exact identifier application number: M017
Biofreeze Professional Colorless Roll-On	MENTHOL, UNSPECIFIED FORM	A-S Medication Solutions	ce392c4f-cc43-484d-9c49-18fa25e4e5e9	2025-01-09	Warnings	Exact identifier application number: M017
NEW TEROCIN	METHYL SALICYLATE, CAPSAICIN, AND MENTHOL	A-S Medication Solutions	43e5eb27-5541-4b7b-80de-55a79a4dce55	2025-01-09	Warnings	Exact identifier application number: M017
Biofreeze Professional	MENTHOL, UNSPECIFIED FORM	A-S Medication Solutions	cbeac814-59d8-4c13-8e73-bca66f797f8d	2025-01-09	Warnings	Exact identifier application number: M017
Bactine Max	LIDOCAINE	WellSpring Pharmaceutical Corporation	acd7ae37-7c42-4ec7-a2ef-42e7f628388d	2025-01-08	Warnings	Exact identifier application number: M017
THERABLAST MAXIMUM RELIEF	LIDOCAINE, MENTHOL	Releaf Technologies LLC	09809985-3a88-9bb7-e063-6394a90a2f5f	2025-01-08	Warnings	Exact identifier application number: M017

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
TC2D6JAD40	DIPHENHYDRAMINE HYDROCHLORIDE	147-24-0	DIPHENHYDRAMINE HYDROCHLORIDE
FM5526K07A	ZINC ACETATE	5970-45-6	ZINC ACETATE

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUI	RxNorm string	TTY	DailyMed	SPL version
1087026	diphenhydrAMINE HCl 2 % / zinc acetate 0.1 % Topical Cream	PSN	3eedcd9f-8312-4d14-a0fe-6b00a00d3e73	3
1087026	diphenhydramine hydrochloride 20 MG/ML / zinc acetate 1 MG/ML Topical Cream	SCD	3eedcd9f-8312-4d14-a0fe-6b00a00d3e73	3
1087026	diphenhydramine hydrochloride 2 % / zinc acetate 0.1 % Topical Cream	SY	3eedcd9f-8312-4d14-a0fe-6b00a00d3e73	3

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Units	Marketing start	Marketing end	Sample	Exclude flag	Status
21130-154-64	21130015464	1 TUBE in 1 CARTON (21130-154-64) / 28 g in 1 TUBE	1 tube	2015-09-01	0000-00-00	No	No	Current