Signature Care Migraine Relief

Product NDC: 21130-569
11-digit product format: 211300569
Labeler code: 21130
Product ID: 21130-569_1e6e02b1-e02b-470a-ab77-ffac79e5c7f6
Type: HUMAN OTC DRUG
Nonproprietary name: Acetaminophen, Aspirin, Caffeine
Dosage form: TABLET, FILM COATED
Route: ORAL
Labeler: Safeway
Application: ANDA075794
Marketing category: ANDA
Marketing start: 2015-09-01
Substance: ACETAMINOPHEN; ASPIRIN; CAFFEINE
Active strength: 250; 250; 65 mg/1; mg/1; mg/1
Pharmacologic classes: Anti-Inflammatory Agents, Non-Steroidal [CS], Central Nervous System Stimulant [EPC], Central Nervous System Stimulation [PE], Cyclooxygenase Inhibitors [MoA], Decreased Platelet Aggregation [PE], Decreased Prostaglandin Production [PE], Methylxanthine [EPC], Nonsteroidal Anti-inflammatory Drug [EPC], Platelet Aggregation Inhibitor [EPC], Xanthines [CS]
NDC exclude flag: No
Listing certified through: 2026-12-31
Current FDA listing: Yes

NDC auxiliary status#

These records are reproduced from FDA’s unfinished, excluded, and compounder listings. They describe what appeared in the source files; a missing record does not establish a regulatory status. View all current auxiliary records, including entries without an NDC. · View the auxiliary file history.

Current NDC status page 1 of 1 · 1 matching rows.

Dataset, Scope, Product NDC table
Dataset	Scope	Product NDC	Package NDC	Code	Status	Reporting period	Source date
excluded package	package	21130-569	21130-569-85	D	Discontinued by firm		2026-08-10

Observed NDC auxiliary status history#

This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.

Historic NDC status page 1 of 1 · 12 matching rows.

View current auxiliary records. · View the auxiliary file history.

Captured / source date, Snapshot, Source SHA-256 table
Captured / source date	Snapshot	Source SHA-256
2025-12-14 17:58 UTC · source 2025-12-05	`d630ba8d3edf…`	`732f749b63fb…`
2025-08-27 00:01 UTC · source 2025-08-26	`f5e01cc5f278…`	`a2eaf40c39c3…`
2025-04-01 02:39 UTC · source 2025-03-31	`2ef7874e63bc…`	`57b86245f4fa…`
2025-03-28 20:22 UTC · source 2025-03-28	`a1b67e2a42f9…`	`c4cf2c586c0d…`
2025-03-22 03:12 UTC · source 2025-03-21	`cfe11265f3b6…`	`090c488252e2…`
2025-03-10 12:48 UTC · source 2025-03-10	`cdf11ea48f46…`	`ba0047e9e063…`
2025-02-02 03:52 UTC · source 2025-01-31	`302b2466d912…`	`e7b80fea0513…`
2025-01-20 13:05 UTC · source 2025-01-20	`ed331223b511…`	`672a5bd82f5f…`
2025-01-11 03:41 UTC · source 2025-01-10	`0efc9e666f02…`	`f202fb6c5f17…`
2024-11-09 02:27 UTC · source 2024-11-08	`ad56d346431e…`	`cc804d4bbf1e…`
2024-10-04 04:10 UTC · source 2024-10-03	`367a005e9d99…`	`383a685ebd0f…`
2024-07-10 04:00 UTC · source 2024-07-09	`557ba5c1ecfa…`	`9c80585c8c6e…`

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-product	Trade name	Ingredient	Strength	Dosage form / route	TE codes	RLD / RS	Approval date
A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	ACETAMINOPHEN; ASPIRIN; CAFFEINE	250MG;250MG;65MG	TABLET / ORAL			2001-11-26

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 41 observed states.

Captured, Edition, Application-product table
Captured	Edition	Application-product	Trade name	Strength	Dosage form / route	Approval date	Source SHA-256
2026-02-19 14:30 UTC	2026-02	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`011fe1cb6892…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`31067a03dcf5…`
2025-08-23 18:47 UTC	2025-08	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`6a471c1ec25d…`
2025-03-22 03:13 UTC · 3 captures of this ZIP	2025-03	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`fd3edfee7708…`
2025-02-26 10:13 UTC · 3 captures of this ZIP	2025-02	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`b8a1b40f171c…`
2025-01-19 17:59 UTC · 7 captures of this ZIP	2025-01	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`03ed91905a0d…`
2024-12-13 21:23 UTC · 2 captures of this ZIP	2024-12	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`2680178bc6a6…`
2024-09-14 05:58 UTC · 2 captures of this ZIP	2024-09	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`5bbf6a4d5a75…`
2024-11-08 22:44 UTC · 3 captures of this ZIP	2024-11	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`d8e5a09893c0…`
2024-10-29 15:01 UTC	2024-10	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`d06236e962d9…`
2024-08-13 05:28 UTC · 3 captures of this ZIP	2024-08	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`79d66fd596c7…`
2024-07-13 05:37 UTC · 2 captures of this ZIP	2024-07	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`301d65b070ca…`
2024-06-18 03:08 UTC · 5 captures of this ZIP	2024-06	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`1e350fbaab3a…`
2024-05-31 18:47 UTC	2024-05	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`8072bd15b7f6…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`5c6f7cd8ea54…`
2022-04-08 23:34 UTC	2022-04	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`5d02ea3f76ae…`
2022-04-04 05:41 UTC	2022-04	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`4b0b4de00fa7…`
2019-12-13 00:20 UTC	2019-12	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`74a2ff9319b5…`
2022-03-09 01:35 UTC	2022-03	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`bb7c543d1eb4…`
2021-12-28 21:50 UTC	2021-12	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`782e0a99824c…`
2021-05-05 16:15 UTC · 3 captures of this ZIP	2021-05	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`87673890dc5c…`
2021-03-12 10:30 UTC	2021-03	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`5aa47cf7b7d7…`
2020-12-22 03:56 UTC	2020-12	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`8869cabd3fbd…`
2020-11-12 02:37 UTC	2020-11	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`c0c555d07b60…`
2019-12-14 00:12 UTC	2019-12	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`3f01610625f2…`
2019-09-15 20:21 UTC	2019-09	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`b00525d2431f…`
2019-07-19 19:46 UTC	2019-07	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`ea99ee380514…`
2024-03-16 18:09 UTC · 4 captures of this ZIP	2024-03	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`6a51e52b5d6a…`
2024-02-18 07:12 UTC	2024-02	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`1c564ffb4f44…`
2023-12-20 04:57 UTC	2023-12	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`ea1830bbd6c7…`
2023-11-28 05:40 UTC · 2 captures of this ZIP	2023-11	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`a72a2bbeb626…`
2023-10-25 00:34 UTC · 2 captures of this ZIP	2023-10	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`9b2671bbb829…`
2023-07-15 15:27 UTC · 2 captures of this ZIP	2023-07	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`a67488948f0b…`
2023-06-13 01:57 UTC · 3 captures of this ZIP	2023-06	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`3f0d92c62455…`
2023-05-13 08:27 UTC	2023-05	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`053a50430f4f…`
2023-01-26 05:58 UTC	2023-01	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`3bdfa0b2c4d7…`
2022-11-12 20:34 UTC · 5 captures of this ZIP	2022-11	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`3a93d1ddd44b…`
2022-10-28 04:53 UTC	2022-10	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`f41ea6bd6efb…`
2022-09-29 23:25 UTC	2022-09	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`e64feba35796…`
2022-07-09 03:26 UTC · 3 captures of this ZIP	2022-07	A075794-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2001-11-26	`cb3db0bc1861…`

Additional Listing Data#

Finished product: Yes
Brand name base: Signature Care Migraine Relief
Listing expiration: 2026-12-31

Active Ingredients#

Ingredient, Strength table
Ingredient	Strength
ACETAMINOPHEN	250 mg/1
ASPIRIN	250 mg/1
CAFFEINE	65 mg/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 3 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
362O9ITL9D	Internal UNII lookup
R16CO5Y76E	Internal UNII lookup
3G6A5W338E	Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
308297	Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
66695667-97a3-4329-8ce0-0fffa8628951	Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product concept	Relation	Version	Effective
7dea7767-9f52-b60a-5435-33cb9cc28bae	Product name	4	20250124
6338270f-96cb-0ecb-6fbb-0a9bc78001f4	Product name	7	20250116
0ca83774-3f79-b837-5d6f-c210102f3bc8	Product name	6	20250114
41b814f3-0166-1c53-c9ef-a0794c7daf9d	Product name	3	20221110
a590be26-846c-8659-a5a1-fb25907965dc	Product name	2	20221110
d7724692-1155-4cc8-a415-22f5fc4aec35	Product name	6	20220216
bde672ba-4805-28d0-1986-73543d41b412	Product name	2	20210201
2dc76302-91c0-4c35-ad78-99adfb049c4b	Product name	1	20200603
e6065d4b-5ae1-476f-a40e-f2851cbb5d2b	Product name	2	20180221
f212291f-05fe-9603-fc7e-bd73e38ce1e6	Product name	2	20161129
ade821ba-260a-47e2-bd89-743e27ac9906	Product name	1	20161121
182f9ab4-4ab5-c449-200f-87ce2ce8e550	Product name	2	20151105
9425d234-4ae1-4b53-adc6-8cc7af6dd657	Product name	1	20150929
2a21311a-89e2-0e83-2ebd-117f9798b2b2	Product name	1	20140508
332e86c3-7875-ca6e-f934-2206d2b31996	Product name	1	20140508
56625fcc-aa34-9d30-d0e9-1c1beb37ea21	Product name	1	20140508
7dfac40f-a405-cd2e-7c06-3059ec0e1092	Product name	1	20140508
9007e8a7-ff50-f9b9-7945-f2a1deadd94e	Product name	1	20140508
96c2be53-8e44-452d-56a2-d255b2f1af2d	Product name	1	20140508
bf8bd5f7-495f-4022-2780-7ded7ea7ea44	Product name	1	20140508
d223c173-c39b-d764-47d4-d671d3088815	Product name	1	20140508
e01133ad-4dcd-c7f3-454b-2ff569ee160a	Product name	1	20140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	SPL version
21130-569-62	Signature Care Migraine Relief	1 in 1 CARTON	TABLET, FILM COATED	1	6
21130-569-62	Signature Care Migraine Relief	24 in 1 BOTTLE	TABLET, FILM COATED	24	6
21130-569-71	Signature Care Migraine Relief	1 in 1 CARTON	TABLET, FILM COATED	1	6
21130-569-71	Signature Care Migraine Relief	50 in 1 BOTTLE	TABLET, FILM COATED	50	6
21130-569-78	Signature Care Migraine Relief	100 in 1 BOTTLE	TABLET, FILM COATED	100	6
21130-569-78	Signature Care Migraine Relief	1 in 1 CARTON	TABLET, FILM COATED	1	6
21130-569-85	Signature Care Migraine Relief	1 in 1 CARTON	TABLET, FILM COATED	1	6
21130-569-85	Signature Care Migraine Relief	250 in 1 BOTTLE	TABLET, FILM COATED	250	6

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
Ingredient	Type	UNII	DailyMed label	SPL version
ACETAMINOPHEN	ACTIVE INGREDIENT	362O9ITL9D	SIGNATURE CARE MIGRAINE RELIEF (ACETAMINOPHEN, ASPIRIN, CAFFEINE) TABLET, FILM COATED [SAFEWAY]	2
ASPIRIN	ACTIVE INGREDIENT	R16CO5Y76E	SIGNATURE CARE MIGRAINE RELIEF (ACETAMINOPHEN, ASPIRIN, CAFFEINE) TABLET, FILM COATED [SAFEWAY]	2
CAFFEINE	ACTIVE INGREDIENT	3G6A5W338E	SIGNATURE CARE MIGRAINE RELIEF (ACETAMINOPHEN, ASPIRIN, CAFFEINE) TABLET, FILM COATED [SAFEWAY]	2
ACETAMINOPHEN	ACTIVE MOIETY	362O9ITL9D	SIGNATURE CARE MIGRAINE RELIEF (ACETAMINOPHEN, ASPIRIN, CAFFEINE) TABLET, FILM COATED [SAFEWAY]	2
ASPIRIN	ACTIVE MOIETY	R16CO5Y76E	SIGNATURE CARE MIGRAINE RELIEF (ACETAMINOPHEN, ASPIRIN, CAFFEINE) TABLET, FILM COATED [SAFEWAY]	2
CAFFEINE	ACTIVE MOIETY	3G6A5W338E	SIGNATURE CARE MIGRAINE RELIEF (ACETAMINOPHEN, ASPIRIN, CAFFEINE) TABLET, FILM COATED [SAFEWAY]	2
CARNAUBA WAX	INACTIVE INGREDIENT	R12CBM0EIZ	SIGNATURE CARE MIGRAINE RELIEF (ACETAMINOPHEN, ASPIRIN, CAFFEINE) TABLET, FILM COATED [SAFEWAY]	2
CELLULOSE, MICROCRYSTALLINE	INACTIVE INGREDIENT	OP1R32D61U	SIGNATURE CARE MIGRAINE RELIEF (ACETAMINOPHEN, ASPIRIN, CAFFEINE) TABLET, FILM COATED [SAFEWAY]	2
CROSPOVIDONE	INACTIVE INGREDIENT	68401960MK	SIGNATURE CARE MIGRAINE RELIEF (ACETAMINOPHEN, ASPIRIN, CAFFEINE) TABLET, FILM COATED [SAFEWAY]	2
HYPROMELLOSES	INACTIVE INGREDIENT	3NXW29V3WO	SIGNATURE CARE MIGRAINE RELIEF (ACETAMINOPHEN, ASPIRIN, CAFFEINE) TABLET, FILM COATED [SAFEWAY]	2
POVIDONES	INACTIVE INGREDIENT	FZ989GH94E	SIGNATURE CARE MIGRAINE RELIEF (ACETAMINOPHEN, ASPIRIN, CAFFEINE) TABLET, FILM COATED [SAFEWAY]	2
PROPYLENE GLYCOL	INACTIVE INGREDIENT	6DC9Q167V3	SIGNATURE CARE MIGRAINE RELIEF (ACETAMINOPHEN, ASPIRIN, CAFFEINE) TABLET, FILM COATED [SAFEWAY]	2
SACCHARIN SODIUM	INACTIVE INGREDIENT	SB8ZUX40TY	SIGNATURE CARE MIGRAINE RELIEF (ACETAMINOPHEN, ASPIRIN, CAFFEINE) TABLET, FILM COATED [SAFEWAY]	2
STEARIC ACID	INACTIVE INGREDIENT	4ELV7Z65AP	SIGNATURE CARE MIGRAINE RELIEF (ACETAMINOPHEN, ASPIRIN, CAFFEINE) TABLET, FILM COATED [SAFEWAY]	2
TITANIUM DIOXIDE	INACTIVE INGREDIENT	15FIX9V2JP	SIGNATURE CARE MIGRAINE RELIEF (ACETAMINOPHEN, ASPIRIN, CAFFEINE) TABLET, FILM COATED [SAFEWAY]	2

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
21130-569	SIGNATURE CARE MIGRAINE RELIEF (ACETAMINOPHEN, ASPIRIN, CAFFEINE) TABLET, FILM COATED [SAFEWAY]	6	Current NDC, Legacy NDC, 8 package rows	20240328_66695667-97a3-4329-8ce0-0fffa8628951.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 2 · 27 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
migraine relief	ACETAMINOPHEN, ASPIRIN, CAFFEINE	Rite Aid Corporation	80e58390-69fb-48f7-ad3a-a13f125cd921	2026-05-27	Warnings	Exact identifier application applno (ANDA): 075794 application number: ANDA075794
good sense migraine formula	ACETAMINOPHEN, ASPIRIN, CAFFEINE	L. Perrigo Company	f052512b-e55a-4369-8c9c-453c9a5686a3	2026-05-13	Warnings	Exact identifier application applno (ANDA): 075794 application number: ANDA075794
migraine formula	ACETAMINOPHEN, ASPIRIN, CAFFEINE	HyVee Inc	76e21832-5c4c-4c73-9f87-1060abbd3d82	2026-05-08	Warnings	Exact identifier application applno (ANDA): 075794 application number: ANDA075794
Up and Up Migraine Relief	ACETAMINOPHEN, ASPIRIN, CAFFEINE	Target Corporation	acaffae6-2964-4529-b61a-19ddfc5fd669	2026-04-29	Warnings	Exact identifier application applno (ANDA): 075794 application number: ANDA075794
Care One migraine relief	ACETAMINOPHEN, ASPIRIN, CAFFEINE	American Sales Company	be6c9dc5-853e-4342-ba6a-e5b7be5afe72	2026-04-09	Warnings	Exact identifier application applno (ANDA): 075794 application number: ANDA075794
MIGRAINE FORMULA	ACETAMINOPHEN, ASPIRIN, CAFFEINE	Meijer, Inc.	529b6ee6-043c-430a-b2e1-b63c81f10291	2026-04-08	Warnings	Exact identifier application applno (ANDA): 075794 application number: ANDA075794
good sense migraine formula	ACETAMINOPHEN, ASPIRIN, CAFFEINE	Sportpharm LLC	2a27da49-23d6-4035-8088-806ee22b98b0	2026-03-06	Warnings	Exact identifier application applno (ANDA): 075794 application number: ANDA075794
migraine relief	ACETAMINOPHEN, ASPIRIN, CAFFEINE	CVS Pharmacy	e130831a-ec50-467a-9e5c-ba6ebc7bef3c	2026-02-26	Warnings	Exact identifier application applno (ANDA): 075794 application number: ANDA075794
Leader Migraine Relief	ACETAMINOPHEN, ASPIRIN, CAFFEINE	Cardinal Health 110, LLC. dba Leader	b74a8baa-c7a2-4eed-8202-888d8ba829b9	2026-01-20	Warnings	Exact identifier application applno (ANDA): 075794 application number: ANDA075794
good sense migraine formula	ACETAMINOPHEN, ASPIRIN, CAFFEINE	L. Perrigo Company	93e7ba56-5682-4184-9a93-3b4b972b0e72	2025-11-10	Warnings	Exact identifier application applno (ANDA): 075794 application number: ANDA075794
migraine relief	ACETAMINOPHEN, ASPIRIN, CAFFEINE	Walgreen Company	36503181-0fda-4127-b3f0-bdb1b56bb0ed	2025-11-01	Warnings	Exact identifier application applno (ANDA): 075794 application number: ANDA075794
migraine formula	ACETAMINOPHEN, ASPIRIN, CAFFEINE	H E B	f2f9b930-7b54-46c5-8631-d673a52a9eb4	2025-09-19	Warnings	Exact identifier application applno (ANDA): 075794 application number: ANDA075794
migraine relief	ACETAMINOPHEN, ASPIRIN, CAFFEINE	Walgreen Company	5dcc2b01-6556-46bc-a451-f09dd0bd1eed	2025-09-04	Warnings	Exact identifier application applno (ANDA): 075794 application number: ANDA075794
Topcare Migraine Relief	ACETAMINOPHEN, ASPIRIN, CAFFEINE	Topco Associates LLC	a2a9fbec-639f-4002-aa34-51b4563fc38e	2025-09-04	Warnings	Exact identifier application applno (ANDA): 075794 application number: ANDA075794
Equaline migraine formula	ACETAMINOPHEN, ASPIRIN, CAFFEINE	United Natural Foods, Inc. dba UNFI	28ab87e5-6b7d-4737-95e8-4f842ecd9408	2025-08-28	Warnings	Exact identifier application applno (ANDA): 075794 application number: ANDA075794
good neighbor pharmacy migraine relief	ACETAMINOPHEN, ASPIRIN, CAFFEINE	Amerisource Bergen	201f101a-3b53-4349-896c-6b86cdd9b831	2025-08-26	Warnings	Exact identifier application applno (ANDA): 075794 application number: ANDA075794
migraine formula	ACETAMINOPHEN, ASPIRIN, CAFFEINE	Meijer Distribution Inc	8f1ee554-1021-4613-ba0e-aa02f8a751f8	2025-06-16	Warnings	Exact identifier application applno (ANDA): 075794 application number: ANDA075794
migraine relief	ACETAMINOPHEN, ASPIRIN, CAFFEINE	Kroger Company	de57809f-d5f8-41b3-84d4-b2ef54e0f6d7	2025-06-11	Warnings	Exact identifier application applno (ANDA): 075794 application number: ANDA075794
foster and thrive migraine relief	ACETAMINOPHEN, ASPIRIN, CAFFEINE	Strategic Sourcing Services LLC	fe9bf032-fc8b-4b2d-8c6b-acdbe1f320bf	2025-06-11	Warnings	Exact identifier application applno (ANDA): 075794 application number: ANDA075794
Signature Care Migraine Relief	ACETAMINOPHEN, ASPIRIN, CAFFEINE	Safeway	66695667-97a3-4329-8ce0-0fffa8628951	2024-03-27	Warnings	Exact identifier application applno (ANDA): 075794 application number: ANDA075794 ndc (product): 21130-569

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
362O9ITL9D	ACETAMINOPHEN	103-90-2	ACETAMINOPHEN
R16CO5Y76E	ASPIRIN	50-78-2	ASPIRIN
3G6A5W338E	CAFFEINE	58-08-2	CAFFEINE

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUI	RxNorm string	TTY	DailyMed	SPL version
308297	acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG Oral Tablet	PSN	66695667-97a3-4329-8ce0-0fffa8628951	6
308297	acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG Oral Tablet	SCD	66695667-97a3-4329-8ce0-0fffa8628951	6
308297	APAP 250 MG / ASA 250 MG / caffeine 65 MG Oral Tablet	SY	66695667-97a3-4329-8ce0-0fffa8628951	6

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Units	Marketing start	Marketing end	Sample	Exclude flag	Status
21130-569-62	21130056962	1 BOTTLE in 1 CARTON (21130-569-62) / 24 TABLET, FILM COATED in 1 BOTTLE	1 bottle	2015-09-01	0000-00-00	No	No	Current
21130-569-71	21130056971	1 BOTTLE in 1 CARTON (21130-569-71) / 50 TABLET, FILM COATED in 1 BOTTLE	1 bottle	2015-09-01	0000-00-00	No	No	Current
21130-569-78	21130056978	1 BOTTLE in 1 CARTON (21130-569-78) / 100 TABLET, FILM COATED in 1 BOTTLE	1 bottle	2015-09-01	0000-00-00	No	No	Current
21130-569-85	21130056985	1 BOTTLE in 1 CARTON (21130-569-85) > 250 TABLET, FILM COATED in 1 BOTTLE	1 bottle	2015-09-01	0000-00-00	No	No	Current