FDA.reportPublic FDA data

Signature Care Hydrocortisone

Product NDC
21130-993
11-digit product format
211300993
Labeler code
21130
Product ID
21130-993_2a93d0c8-b2ff-4a3e-9c2b-dcb675498b92
Type
HUMAN OTC DRUG
Nonproprietary name
hydrocortisone
Dosage form
CREAM
Route
TOPICAL
Labeler
Safeway
Application
M017
Marketing category
OTC MONOGRAPH DRUG
Marketing start
2015-11-10
Substance
HYDROCORTISONE
Active strength
1 g/100g
Pharmacologic classes
Corticosteroid Hormone Receptor Agonists [MoA], Corticosteroid [EPC]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

Additional Listing Data#

Finished product
Yes
Brand name base
Signature Care Hydrocortisone
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
HYDROCORTISONE1 g/100g

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
WI4X0X7BPJInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
106258Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
c6b9c4e1-bab8-490d-8c00-c43377ad0857Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
15bd4439-874a-4934-9954-248e5455d460Product name120260310
9962b773-9f2e-22cc-0032-535e48ac417bProduct name320250724
56bb0587-1bf2-48b2-9d93-fc9f59d1eeb2Product name120250325
334fe8d2-68fb-4331-a576-420e302ec069Product name720240320
4d56e8eb-d741-d4a5-de3f-2bab1af75a60Product name720220608
626d7260-31b5-4412-84fd-579746adb6b3Product name120210513
8a011600-5e61-4c59-ab7b-54ab658a3b71Product name220181127
a919621a-248d-3c7a-1084-9f9ce286fdfdProduct name220181009
e7d5a174-836b-a0af-b014-cb0826c69ddcProduct name220181004
fcce390d-6460-4701-87cf-940d8800a1c3Product name220180212
0441a8f5-3835-497c-aedd-bc78cba56b2aProduct name120150317
bf065fa6-1e3b-e4c3-0bde-2dc842ceeea1Product name220150218
02657a3f-1489-66ea-f740-5ab9524e57d7Product name120140508
26f3d783-2cc1-4327-e77d-71804cf675a2Product name120140508
36fdc54c-bbeb-981e-8a53-4d768e283892Product name120140508
58f3f9b7-3b9b-a9c1-1c9f-18ac777192b8Product name120140508
60c52429-fcef-eb54-2387-43bc9e4f296bProduct name120140508
61e59a42-186b-9f4b-aec3-fb49a6debc31Product name120140508
705740e1-dee5-2610-c5a3-4c59cd9d62afProduct name120140508
7bdc4804-3832-c0df-e519-72b6d47c9792Product name120140508
a7051cba-790b-a699-81f8-dbbbdbd9b5acProduct name120140508
abaf203f-619e-f265-559f-8c81af5cb1c2Product name120140508
acc4d8bb-0e29-e9f8-65f8-31e94184a9c0Product name120140508
b045ad64-0f28-9a02-2f9b-b34d94fb2278Product name120140508
bfd28ffb-d550-3fe9-f65b-10bcb7f971fdProduct name120140508
da108d9e-edc8-17a3-8c28-3251c6a8acccProduct name120140508
fe21f3fd-a378-0654-1972-db3c3b64470eProduct name120140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
21130-993-64Signature Care Hydrocortisone1 in 1 CARTONCREAM14
21130-993-64Signature Care Hydrocortisone28 g in 1 TUBECREAM284

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
IngredientTypeUNIIDailyMed labelSPL versionUploaded
HYDROCORTISONEACTIVE INGREDIENTWI4X0X7BPJSIGNATURE CARE HYDROCORTISONE (HYDROCORTISONE) CREAM [SAFEWAY]1
HYDROCORTISONEACTIVE MOIETYWI4X0X7BPJSIGNATURE CARE HYDROCORTISONE (HYDROCORTISONE) CREAM [SAFEWAY]1
.ALPHA.-TOCOPHEROLINACTIVE INGREDIENTH4N855PNZ1SIGNATURE CARE HYDROCORTISONE (HYDROCORTISONE) CREAM [SAFEWAY]1
ALOE VERA LEAFINACTIVE INGREDIENTZY81Z83H0XSIGNATURE CARE HYDROCORTISONE (HYDROCORTISONE) CREAM [SAFEWAY]1
ALUMINUM SULFATEINACTIVE INGREDIENT34S289N54ESIGNATURE CARE HYDROCORTISONE (HYDROCORTISONE) CREAM [SAFEWAY]1
CALCIUM ACETATEINACTIVE INGREDIENTY882YXF34XSIGNATURE CARE HYDROCORTISONE (HYDROCORTISONE) CREAM [SAFEWAY]1
CETOSTEARYL ALCOHOLINACTIVE INGREDIENT2DMT128M1SSIGNATURE CARE HYDROCORTISONE (HYDROCORTISONE) CREAM [SAFEWAY]1
CETYL ALCOHOLINACTIVE INGREDIENT936JST6JCNSIGNATURE CARE HYDROCORTISONE (HYDROCORTISONE) CREAM [SAFEWAY]1
CHOLECALCIFEROLINACTIVE INGREDIENT1C6V77QF41SIGNATURE CARE HYDROCORTISONE (HYDROCORTISONE) CREAM [SAFEWAY]1
CORN OILINACTIVE INGREDIENT8470G57WFMSIGNATURE CARE HYDROCORTISONE (HYDROCORTISONE) CREAM [SAFEWAY]1
GLYCERININACTIVE INGREDIENTPDC6A3C0OXSIGNATURE CARE HYDROCORTISONE (HYDROCORTISONE) CREAM [SAFEWAY]1
ISOPROPYL PALMITATEINACTIVE INGREDIENT8CRQ2TH63MSIGNATURE CARE HYDROCORTISONE (HYDROCORTISONE) CREAM [SAFEWAY]1
LIGHT MINERAL OILINACTIVE INGREDIENTN6K5787QVPSIGNATURE CARE HYDROCORTISONE (HYDROCORTISONE) CREAM [SAFEWAY]1
MALTODEXTRININACTIVE INGREDIENT7CVR7L4A2DSIGNATURE CARE HYDROCORTISONE (HYDROCORTISONE) CREAM [SAFEWAY]1
METHYLPARABENINACTIVE INGREDIENTA2I8C7HI9TSIGNATURE CARE HYDROCORTISONE (HYDROCORTISONE) CREAM [SAFEWAY]1
PETROLATUMINACTIVE INGREDIENT4T6H12BN9USIGNATURE CARE HYDROCORTISONE (HYDROCORTISONE) CREAM [SAFEWAY]1
PROPYLENE GLYCOLINACTIVE INGREDIENT6DC9Q167V3SIGNATURE CARE HYDROCORTISONE (HYDROCORTISONE) CREAM [SAFEWAY]1
PROPYLPARABENINACTIVE INGREDIENTZ8IX2SC1OHSIGNATURE CARE HYDROCORTISONE (HYDROCORTISONE) CREAM [SAFEWAY]1
SODIUM CETOSTEARYL SULFATEINACTIVE INGREDIENT7ZBS06BH4BSIGNATURE CARE HYDROCORTISONE (HYDROCORTISONE) CREAM [SAFEWAY]1
SODIUM LAURYL SULFATEINACTIVE INGREDIENT368GB5141JSIGNATURE CARE HYDROCORTISONE (HYDROCORTISONE) CREAM [SAFEWAY]1
VITAMIN A PALMITATEINACTIVE INGREDIENT1D1K0N0VVCSIGNATURE CARE HYDROCORTISONE (HYDROCORTISONE) CREAM [SAFEWAY]1
WATERINACTIVE INGREDIENT059QF0KO0RSIGNATURE CARE HYDROCORTISONE (HYDROCORTISONE) CREAM [SAFEWAY]1
WHITE WAXINACTIVE INGREDIENT7G1J5DA97FSIGNATURE CARE HYDROCORTISONE (HYDROCORTISONE) CREAM [SAFEWAY]1

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
21130-993SIGNATURE CARE HYDROCORTISONE (HYDROCORTISONE) CREAM [SAFEWAY]4Current NDC, Legacy NDC, 2 package rows20241116_c6b9c4e1-bab8-490d-8c00-c43377ad0857.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 18 of 153 · 3,057 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Biofreeze Overnight Roll-onMENTHOLReckitt Benckiser LLCf67d7b7a-8922-73f6-e053-2995a90a2e802026-05-15WarningsExact identifier
application number: M017
Biofreeze Overnight ReliefMENTHOL, UNSPECIFIED FORMReckitt Benckiser LLC07be6e88-1850-4d6a-946d-f03830b8c4a22026-05-15WarningsExact identifier
application number: M017
Biofreeze Roll-On and Overnight Roll-OnMENTHOLReckitt Benckiser LLC4d3dcb8f-2075-6bbc-e063-6394a90a49922026-05-15WarningsExact identifier
application number: M017
Biofreeze ProfessionalMENTHOL, UNSPECIFIED FORMReckitt Benckiser LLC6bef9ccb-7a5a-4c67-b1bc-a92b167312da2026-05-15WarningsExact identifier
application number: M017
Biofreeze Roll-OnMENTHOLReckitt Benckiser LLCebbbe9cb-b1ce-4dac-9fca-f54a2470c4fb2026-05-15WarningsExact identifier
application number: M017
Biofreeze Precision Relief PenMENTHOLReckitt Benckiser LLCb4cc1db5-a33f-17bc-e053-2995a90ab7eb2026-05-15WarningsExact identifier
application number: M017
Biofreeze ProfessionalMENTHOL, UNSPECIFIED FORMReckitt Benckiser LLCdb982baf-31ea-4f09-90e3-cd5facb5dfe52026-05-15WarningsExact identifier
application number: M017
Biofreeze Professional Roll-OnMENTHOL, UNSPECIFIED FORMReckitt Benckiser LLCf62f8ec3-593d-480a-85a0-01fcd7f1790c2026-05-15WarningsExact identifier
application number: M017
PERFORM COOL AND SOOTHING PAIN RELIEVING ROLL-ONMENTHOLReckitt Benckiser LLC8af185ad-719e-4684-89c0-9c17c12774992026-05-15WarningsExact identifier
application number: M017
PERFORM COOL and SOOTHING PAIN RELIEVINGMENTHOLReckitt Benckiser LLCef158f63-2d75-47a3-b94a-2d821d5118632026-05-15WarningsExact identifier
application number: M017
KY Duration for HimLIDOCAINEReckitt Benckiser LLC83cc86bd-3303-4956-a198-fae85b6e34e12026-05-15WarningsExact identifier
application number: M017
4% LIDOCAINE PATCHES4% LIDOCAINEShenzhen Huayuan Hengsheng Technology Co., Ltd.4f53cfd3-a7c4-e308-e063-6294a90ad6982026-05-14WarningsExact identifier
application number: M017
Cold and Heat Lidocaine Patch Plus MentholLIDOCAINE, MENTHOLCardinal Health, 110 dba LEADER77066d01-75b0-4a8d-88d3-c639626d33262026-05-14WarningsExact identifier
application number: M017
Pain Relief Gel-Roll OnLIDOCAINETrifecta Pharmaceuticals USA51cb6797-55ec-7a7a-e063-6294a90a90ee2026-05-14WarningsExact identifier
application number: M017
Pain Relief Gel-Roll OnMENTHOLTrifecta Pharmaceuticals USA51b403dc-fc9b-0cad-e063-6394a90af0812026-05-13WarningsExact identifier
application number: M017
BiofreezeMENTHOLReckitt Benckiser LLC5edddb99-6596-4a3b-b361-1cc04d032c312026-05-13WarningsExact identifier
application number: M017
BiofreezeMENTHOLReckitt Benckiser LLC684faf63-5e44-4471-8384-e8fa7c0d842a2026-05-13WarningsExact identifier
application number: M017
BiofreezeMENTHOLReckitt Benckiser LLC4c798b06-6ee5-41d1-8a14-f6889512ade32026-05-13WarningsExact identifier
application number: M017
BIOFREEZEMENTHOLReckitt Benckiser LLC83d5c2f2-2413-4d28-83b2-0808d0917b4d2026-05-13WarningsExact identifier
application number: M017
Scalpicin Anti-Itch Maximum StrengthHYDROCORTISONEReckitt Benckiser LLC7b1a29fa-b266-43e6-a87b-aa3c96ab40412026-05-13WarningsExact identifier
application number: M017

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
106258hydrocortisone 1 % Topical CreamPSNc6b9c4e1-bab8-490d-8c00-c43377ad08574
106258hydrocortisone 10 MG/ML Topical CreamSCDc6b9c4e1-bab8-490d-8c00-c43377ad08574
106258hydrocortisone 1 % (as hydrocortisone acetate 1.2 % ) Topical CreamSYc6b9c4e1-bab8-490d-8c00-c43377ad08574
106258hydrocortisone 1 % Topical CreamSYc6b9c4e1-bab8-490d-8c00-c43377ad08574
106258hydrocortisone 1 GM per 100 GM Topical CreamSYc6b9c4e1-bab8-490d-8c00-c43377ad08574

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
21130-993-64211300993641 TUBE in 1 CARTON (21130-993-64) / 28 g in 1 TUBE1 tube2015-11-100000-00-00NoNoCurrent