Clindamycin Phosphate and Tretinoin Gel 1.2%/0.025%

Product NDC
21922-050
11-digit product format
219220050
Labeler code
21922
Product ID
21922-050_854a8cf5-cfcf-4189-af34-e111363266a1
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Clindamycin Phosphate and Tretinoin Gel 1.2%/0.025%
Dosage form
GEL
Route
TOPICAL
Labeler
Encube Ethicals, Inc.
Application
ANDA216943
Marketing category
ANDA
Marketing start
2023-09-04
Substance
CLINDAMYCIN PHOSPHATE; TRETINOIN
Active strength
10; .25 mg/g; mg/g
Pharmacologic classes
Decreased Sebaceous Gland Activity [PE], Lincosamide Antibacterial [EPC], Lincosamides [CS], Neuromuscular Blockade [PE], Retinoid [EPC], Retinoids [CS]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A216943-001CLINDAMYCIN PHOSPHATE AND TRETINOINCLINDAMYCIN PHOSPHATE; TRETINOIN1.2%;0.025%GEL / TOPICALAB22023-09-01

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-productTE code
A216943-001AB2

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02A216943-001CLINDAMYCIN PHOSPHATE AND TRETINOIN1.2%;0.025%GEL / TOPICALAB22023-09-01011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A216943-001CLINDAMYCIN PHOSPHATE AND TRETINOIN1.2%;0.025%GEL / TOPICALAB22023-09-0131067a03dcf5…
2025-08-23 18:47 UTC2025-08A216943-001CLINDAMYCIN PHOSPHATE AND TRETINOIN1.2%;0.025%GEL / TOPICALAB22023-09-016a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A216943-001CLINDAMYCIN PHOSPHATE AND TRETINOIN1.2%;0.025%GEL / TOPICALAB22023-09-01fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A216943-001CLINDAMYCIN PHOSPHATE AND TRETINOIN1.2%;0.025%GEL / TOPICALAB22023-09-01b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A216943-001CLINDAMYCIN PHOSPHATE AND TRETINOIN1.2%;0.025%GEL / TOPICALAB22023-09-0103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A216943-001CLINDAMYCIN PHOSPHATE AND TRETINOIN1.2%;0.025%GEL / TOPICALAB22023-09-012680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A216943-001CLINDAMYCIN PHOSPHATE AND TRETINOIN1.2%;0.025%GEL / TOPICALAB22023-09-015bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A216943-001CLINDAMYCIN PHOSPHATE AND TRETINOIN1.2%;0.025%GEL / TOPICALAB22023-09-01d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A216943-001CLINDAMYCIN PHOSPHATE AND TRETINOIN1.2%;0.025%GEL / TOPICALAB22023-09-01d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A216943-001CLINDAMYCIN PHOSPHATE AND TRETINOIN1.2%;0.025%GEL / TOPICALAB22023-09-0179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A216943-001CLINDAMYCIN PHOSPHATE AND TRETINOIN1.2%;0.025%GEL / TOPICALAB22023-09-01301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A216943-001CLINDAMYCIN PHOSPHATE AND TRETINOIN1.2%;0.025%GEL / TOPICALAB22023-09-011e350fbaab3a…
2024-05-31 18:47 UTC2024-05A216943-001CLINDAMYCIN PHOSPHATE AND TRETINOIN1.2%;0.025%GEL / TOPICALAB22023-09-018072bd15b7f6…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A216943-001CLINDAMYCIN PHOSPHATE AND TRETINOIN1.2%;0.025%GEL / TOPICALAB22023-09-016a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A216943-001CLINDAMYCIN PHOSPHATE AND TRETINOIN1.2%;0.025%GEL / TOPICALAB22023-09-011c564ffb4f44…
2023-12-20 04:57 UTC2023-12A216943-001CLINDAMYCIN PHOSPHATE AND TRETINOIN1.2%;0.025%GEL / TOPICALAB22023-09-01ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A216943-001CLINDAMYCIN PHOSPHATE AND TRETINOIN1.2%;0.025%GEL / TOPICALAB22023-09-01a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A216943-001CLINDAMYCIN PHOSPHATE AND TRETINOIN1.2%;0.025%GEL / TOPICALAB22023-09-019b2671bbb829…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A216943-001CLINDAMYCIN PHOSPHATE AND TRETINOIN1.2%;0.025%GEL / TOPICALAB22023-09-01a50c72e98297…

Observed Orange Book normalized TE history#

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02A216943-001AB21011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A216943-001AB2131067a03dcf5…
2025-08-23 18:47 UTC2025-08A216943-001AB216a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A216943-001AB21fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A216943-001AB21b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A216943-001AB2103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A216943-001AB212680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A216943-001AB215bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A216943-001AB21d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A216943-001AB21d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A216943-001AB2179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A216943-001AB21301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A216943-001AB211e350fbaab3a…
2024-05-31 18:47 UTC2024-05A216943-001AB218072bd15b7f6…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A216943-001AB216a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A216943-001AB211c564ffb4f44…
2023-12-20 04:57 UTC2023-12A216943-001AB21ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A216943-001AB21a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A216943-001AB219b2671bbb829…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A216943-001AB21a50c72e98297…

Additional Listing Data#

Finished product
Yes
Brand name base
Clindamycin Phosphate and Tretinoin Gel 1.2%/0.025%
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
CLINDAMYCIN PHOSPHATE10 mg/g
TRETINOIN.25 mg/g

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
EH6D7113I8Internal UNII lookup
5688UTC01RInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
882548Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1f772408-52a3-45b2-b053-8fc78948983cAvailable on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
b80ad7bc-1b6f-7ef4-1ed0-86cd9f459d60Product name620251124
77dc03a4-fbfc-e6a3-fe95-285bbae40d75Product name220250814
a46239a7-5963-4008-8cbb-6b9000f497ebProduct name120250721
1426d8f8-b7d5-4053-8554-613df00c0d86Product name220250616
0e7b8bf1-c46c-4de6-b26a-0c50e34364ecProduct name220250521
b382b4e1-6b48-45f6-bffc-e61b00b0ce19Product name320250317
d8f81258-db12-0761-46cc-8ff6e62e9302Product name420240422
b7b2fa42-1c77-d724-81f0-87da60a77e79Product name320240320
b27c7c65-51f2-a62f-e0e6-a26b3a0f8eb0Product name320230425
e2db08c6-133f-4f4f-afb4-e90a2418d6f6Product name120230320
e3af9708-3004-7392-4046-5311eaa8bab5Product name320221128
ffb4bacf-f636-0f7d-0b0d-7a4b151243e3Product name920220928
b72227d6-0388-43bd-995b-b762d2754cd5Product name120220706
a92d22e0-3af4-f301-bc88-27ff030b0070Product name220220316
13e7e7e3-e885-4c79-af6d-dad1aedbb06eProduct name120220128
4a7d44fe-774d-404b-aad0-8a90fe78375aProduct name420211025
ce6d5c06-3ae0-18a6-d5b3-8cd3cc0f8906Product name720210625
f52be47f-7aa7-46c0-b1fa-50c18dd50206Product name120201029
d12e2d7c-bd6b-45d4-94f9-6df8e1b8b27bProduct name320200203
ee5c6de5-d9cd-454f-b250-7b19e5cf2992Product name420190619
503b047e-e62d-4745-9011-522b13bc701bProduct name120181206
11ed6f83-cdd2-4637-8379-b1a1d3ae3cdeProduct name120181101
5ce6ce33-4f2b-3ce0-757d-e520013280cfProduct name520180719
86c45a79-b9f0-4476-a27c-6e10db098497Product name120180125
b92a26f1-6926-4817-be73-e26ab4c2146fProduct name120170602
7d41caa2-0b5d-9b03-ab8d-84271de26ef4Product name220170314
d5e51f11-ad28-caa4-4b49-4143974782adProduct name120150831
50ca9ff5-82dd-9971-4f2c-5845a76a8572Product name220150818
028d6c95-5012-6976-2075-dee0ae6fefe2Product name120140508
0a8118e4-08c6-b395-9ddc-d3e425e0493aProduct name120140508
233bcb0a-cf40-b0a1-b346-c83ac2f43579Product name120140508
468b2c08-8adb-8d0f-8257-c6515a061424Product name120140508
85490a6b-2306-6bf2-c51b-eb63537dc2daProduct name120140508
8959fb29-d86f-c521-666a-b4cb22233594Product name120140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
21922-050-05Clindamycin Phosphate and Tretinoin Gel 1.2%/0.025%30 g in 1 TUBEGEL303
21922-050-05Clindamycin Phosphate and Tretinoin Gel 1.2%/0.025%1 in 1 CARTONGEL13
21922-050-07Clindamycin Phosphate and Tretinoin Gel 1.2%/0.025%1 in 1 CARTONGEL13
21922-050-07Clindamycin Phosphate and Tretinoin Gel 1.2%/0.025%60 g in 1 TUBEGEL603

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
21922-050-05GM - Gram21922-050cd9be1d0-6265-4e50-a900-436f1118948f12024-02-14
21922-050-07GM - Gram21922-050f0c5507d-ca5b-44a7-93df-8a0411a0fb1912024-02-14

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
21922-050CLINDAMYCIN PHOSPHATE AND TRETINOIN GEL 1.2%/0.025% GEL [ENCUBE ETHICALS PRIVATE LIMITED]2Current NDC, 4 package rows20231229_1f772408-52a3-45b2-b053-8fc78948983c.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Clindamycin Phosphate and Tretinoin Gel 1.2%/0.025%CLINDAMYCIN PHOSPHATE AND TRETINOIN GEL 1.2%/0.025%Encube Ethicals, Inc.1f772408-52a3-45b2-b053-8fc78948983c2025-09-05Warnings, Adverse reactionsExact identifier
application applno (ANDA): 216943
application number: ANDA216943
ndc (product): 21922-050

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
882548clindamycin phosphate 1.2 % / tretinoin 0.025 % Topical GelPSN1f772408-52a3-45b2-b053-8fc78948983c3
882548clindamycin phosphate 0.012 MG/MG / tretinoin 0.00025 MG/MG Topical GelSCD1f772408-52a3-45b2-b053-8fc78948983c3
882548clindamycin phosphate 1.2 % (clindamycin 1 % ) / tretinoin 0.025 % Topical GelSY1f772408-52a3-45b2-b053-8fc78948983c3

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startSampleExclude flagStatus
21922-050-05219220050051 TUBE in 1 CARTON (21922-050-05) / 30 g in 1 TUBE1 tube2023-09-04NoNoCurrent
21922-050-07219220050071 TUBE in 1 CARTON (21922-050-07) / 60 g in 1 TUBE1 tube2023-09-04NoNoCurrent