Daptomycin

Product NDC
25021-179
11-digit product format
250210179
Labeler code
25021
Product ID
25021-179_4245fbb1-e161-4c27-93b6-6afb59618099
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Daptomycin
Dosage form
INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
Route
INTRAVENOUS
Labeler
Sagent Pharmaceuticals
Application
NDA208385
Marketing category
NDA
Marketing start
2018-01-15
Substance
DAPTOMYCIN
Active strength
350 mg/7mL
Pharmacologic classes
Lipopeptide Antibacterial [EPC], Lipopeptides [CS]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 42.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
N208385-001DAPTOMYCINDAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-12

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-productTE code
N208385-001AP

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 42 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-08-18 06:07:402026-07N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-12caaa826d4ba7…
2026-02-19 14:30 UTC2026-02N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-12011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-1231067a03dcf5…
2025-08-23 18:47 UTC2025-08N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-126a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-12fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-12b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-1203ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-122680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-125bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-12d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-12d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-1279d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-12301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-121e350fbaab3a…
2024-05-31 18:47 UTC2024-05N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-128072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-125c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-125d02ea3f76ae…
2022-04-04 05:41 UTC2022-04N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-124b0b4de00fa7…
2019-12-13 00:20 UTC2019-12N208385-001DAPTOMYCIN350MG/VIALPOWDER / IV (INFUSION)APRLD, RS2017-09-1274a2ff9319b5…
2022-03-09 01:35 UTC2022-03N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-12bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-12782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N208385-001DAPTOMYCIN350MG/VIALPOWDER / IV (INFUSION)APRLD, RS2017-09-1287673890dc5c…
2021-03-12 10:30 UTC2021-03N208385-001DAPTOMYCIN350MG/VIALPOWDER / IV (INFUSION)APRLD, RS2017-09-125aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12N208385-001DAPTOMYCIN350MG/VIALPOWDER / IV (INFUSION)APRLD, RS2017-09-128869cabd3fbd…
2020-11-12 02:37 UTC2020-11N208385-001DAPTOMYCIN350MG/VIALPOWDER / IV (INFUSION)APRLD, RS2017-09-12c0c555d07b60…
2019-12-14 00:12 UTC2019-12N208385-001DAPTOMYCIN350MG/VIALPOWDER / IV (INFUSION)APRLD, RS2017-09-123f01610625f2…
2019-09-15 20:21 UTC2019-09N208385-001DAPTOMYCIN350MG/VIALPOWDER / IV (INFUSION)APRLD, RS2017-09-12b00525d2431f…
2019-07-19 19:46 UTC2019-07N208385-001DAPTOMYCIN350MG/VIALPOWDER / IV (INFUSION)RLD, RS2017-09-12ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-126a51e52b5d6a…
2024-02-18 07:12 UTC2024-02N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-121c564ffb4f44…
2023-12-20 04:57 UTC2023-12N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-12ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-12a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-129b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-12a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-123f0d92c62455…
2023-05-13 08:27 UTC2023-05N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-12053a50430f4f…
2023-01-26 05:58 UTC2023-01N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-123bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-123a93d1ddd44b…
2022-10-28 04:53 UTC2022-10N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-12f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09N208385-001DAPTOMYCIN350MG/VIALPOWDER / INTRAVENOUSAPRLD, RS2017-09-12e64feba35796…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 2 · 41 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-08-18 06:07:402026-07N208385-001AP1caaa826d4ba7…
2026-02-19 14:30 UTC2026-02N208385-001AP1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N208385-001AP131067a03dcf5…
2025-08-23 18:47 UTC2025-08N208385-001AP16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N208385-001AP1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N208385-001AP1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N208385-001AP103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N208385-001AP12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N208385-001AP15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N208385-001AP1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N208385-001AP1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N208385-001AP179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N208385-001AP1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N208385-001AP11e350fbaab3a…
2024-05-31 18:47 UTC2024-05N208385-001AP18072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N208385-001AP15c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04N208385-001AP15d02ea3f76ae…
2022-04-04 05:41 UTC2022-04N208385-001AP14b0b4de00fa7…
2019-12-13 00:20 UTC2019-12N208385-001AP174a2ff9319b5…
2022-03-09 01:35 UTC2022-03N208385-001AP1bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12N208385-001AP1782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N208385-001AP187673890dc5c…
2021-03-12 10:30 UTC2021-03N208385-001AP15aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12N208385-001AP18869cabd3fbd…
2020-11-12 02:37 UTC2020-11N208385-001AP1c0c555d07b60…
2019-12-14 00:12 UTC2019-12N208385-001AP13f01610625f2…
2019-09-15 20:21 UTC2019-09N208385-001AP1b00525d2431f…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03N208385-001AP16a51e52b5d6a…
2024-02-18 07:12 UTC2024-02N208385-001AP11c564ffb4f44…
2023-12-20 04:57 UTC2023-12N208385-001AP1ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11N208385-001AP1a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10N208385-001AP19b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07N208385-001AP1a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06N208385-001AP13f0d92c62455…
2023-05-13 08:27 UTC2023-05N208385-001AP1053a50430f4f…
2023-01-26 05:58 UTC2023-01N208385-001AP13bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11N208385-001AP13a93d1ddd44b…
2022-10-28 04:53 UTC2022-10N208385-001AP1f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09N208385-001AP1e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07N208385-001AP1cb3db0bc1861…

Additional Listing Data#

Finished product
Yes
Brand name base
Daptomycin
Listing expiration
2027-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
DAPTOMYCIN350 mg/7mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
NWQ5N31VKKInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1996246Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
548f3559-0531-4c95-9e1d-81f81a3801f1Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
45ca3ac7-6ee8-4e99-92a6-dc0b401e151aProduct name120250724
223d8260-7a4e-4ebd-9635-845422d6a8adProduct name920240909
ca803a62-3799-476f-bbc6-024f77cb0320Product name420240207
cad85d83-8fb9-49f8-a5a6-a399af412964Product name120230922
8e59a5ed-f224-4156-b534-1ae4d0b6dfd7Product name120230721
ea2c89ab-e8f8-425f-9693-c923fa1e1703Product name120220929

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
25021-179-15Daptomycin7 mL in 1 VIALINJECTION, POWDER, LYOPHILIZED,721
25021-179-15Daptomycin1 in 1 CARTONINJECTION, POWDER, LYOPHILIZED,121
25021-179-16Daptomycin10 in 1 CARTONINJECTION, POWDER, LYOPHILIZED,1021
25021-179-16Daptomycin7 mL in 1 VIALINJECTION, POWDER, LYOPHILIZED,721
25021-179-66Daptomycin7 mL in 1 VIALINJECTION, POWDER, LYOPHILIZED,73
25021-179-66Daptomycin1 in 1 CARTONINJECTION, POWDER, LYOPHILIZED,13
25021-179-67Daptomycin10 in 1 CARTONINJECTION, POWDER, LYOPHILIZED,103
25021-179-67Daptomycin7 mL in 1 VIALINJECTION, POWDER, LYOPHILIZED,73

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
25021-179-15EA - Each25021-179ebe9e8a5-003f-4315-a0a9-0ba94bd539ab12018-07-03
25021-179-16EA - Each25021-17992e699ce-bbb4-46d8-b6d5-f36c398f804512018-07-03
25021-179-66EA - Each25021-179f9cdfe10-e279-4383-9581-97d9afb4c20712020-08-06
25021-179-67EA - Each25021-1796bfd9098-afcf-4242-bee6-23c85e36ca4e12020-08-06

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
25021-179DAPTOMYCIN INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [SAGENT PHARMACEUTICALS]21Current NDC, Legacy NDC, 4 package rows20241024_548f3559-0531-4c95-9e1d-81f81a3801f1.zip
25021-179DAPTOMYCIN INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [SAGENT PHARMACEUTICALS]3Current NDC, Legacy NDC, 4 package rows20230629_4a0ad110-e55e-4d3b-84f8-dd0b924fe2f6.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
DaptomycinDAPTOMYCINSagent Pharmaceuticals548f3559-0531-4c95-9e1d-81f81a3801f12026-07-21Warnings, Adverse reactionsExact identifier
application applno (NDA): 208385
application number: NDA208385
ndc (product): 25021-179

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
1996246DAPTOmycin 350 MG InjectionPSN548f3559-0531-4c95-9e1d-81f81a3801f121
1996246daptomycin 350 MG InjectionSCD548f3559-0531-4c95-9e1d-81f81a3801f121
1996246DAPTOmycin 350 MG InjectionPSN4a0ad110-e55e-4d3b-84f8-dd0b924fe2f63
1996246daptomycin 350 MG InjectionSCD4a0ad110-e55e-4d3b-84f8-dd0b924fe2f63

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
25021-179-15250210179151 VIAL in 1 CARTON (25021-179-15) / 7 mL in 1 VIAL1 vial2018-01-150000-00-00NoNoCurrent
25021-179-162502101791610 VIAL in 1 CARTON (25021-179-16) / 7 mL in 1 VIAL10 vial2018-01-150000-00-00NoNoCurrent
25021-179-66250210179661 VIAL in 1 CARTON (25021-179-66) / 7 mL in 1 VIAL1 vial2020-02-010000-00-00NoNoCurrent
25021-179-672502101796710 VIAL in 1 CARTON (25021-179-67) / 7 mL in 1 VIAL10 vial2020-02-010000-00-00NoNoCurrent