Levothyroxine Sodium

Product NDC
25021-470
11-digit product format
250210470
Labeler code
25021
Product ID
25021-470_2662e418-ef9b-40be-abbd-db71401e3c20
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Levothyroxine Sodium Anhydrous
Dosage form
INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
Route
INTRAVENOUS
Labeler
Sagent Pharmaceuticals
Application
ANDA208749
Marketing category
ANDA
Marketing start
2024-01-01
Substance
LEVOTHYROXINE SODIUM ANHYDROUS
Active strength
500 ug/5mL
Pharmacologic classes
Thyroxine [CS], l-Thyroxine [EPC]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 42.

Orange Book products#

Current product rows page 1 of 1 · 3 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A208749-001LEVOTHYROXINE SODIUMLEVOTHYROXINE SODIUM100MCG/VIALPOWDER / INTRAVENOUSAP2018-12-21
A208749-002LEVOTHYROXINE SODIUMLEVOTHYROXINE SODIUM200MCG/VIALPOWDER / INTRAVENOUSAP2018-12-21
A208749-003LEVOTHYROXINE SODIUMLEVOTHYROXINE SODIUM500MCG/VIALPOWDER / INTRAVENOUSAP2018-12-21

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 3 matching rows.

Application-product, TE code table
Application-productTE code
A208749-001AP
A208749-002AP
A208749-003AP

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 4 · 126 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-08-18 06:07:402026-07A208749-001LEVOTHYROXINE SODIUM100MCG/VIALPOWDER / INTRAVENOUSAP2018-12-21caaa826d4ba7…
2026-08-18 06:07:402026-07A208749-002LEVOTHYROXINE SODIUM200MCG/VIALPOWDER / INTRAVENOUSAP2018-12-21caaa826d4ba7…
2026-08-18 06:07:402026-07A208749-003LEVOTHYROXINE SODIUM500MCG/VIALPOWDER / INTRAVENOUSAP2018-12-21caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A208749-001LEVOTHYROXINE SODIUM100MCG/VIALPOWDER / INTRAVENOUSAP2018-12-21011fe1cb6892…
2026-02-19 14:30 UTC2026-02A208749-002LEVOTHYROXINE SODIUM200MCG/VIALPOWDER / INTRAVENOUSAP2018-12-21011fe1cb6892…
2026-02-19 14:30 UTC2026-02A208749-003LEVOTHYROXINE SODIUM500MCG/VIALPOWDER / INTRAVENOUSAP2018-12-21011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A208749-001LEVOTHYROXINE SODIUM100MCG/VIALPOWDER / INTRAVENOUSAP2018-12-2131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A208749-002LEVOTHYROXINE SODIUM200MCG/VIALPOWDER / INTRAVENOUSAP2018-12-2131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A208749-003LEVOTHYROXINE SODIUM500MCG/VIALPOWDER / INTRAVENOUSAP2018-12-2131067a03dcf5…
2025-08-23 18:47 UTC2025-08A208749-001LEVOTHYROXINE SODIUM100MCG/VIALPOWDER / INTRAVENOUSAP2018-12-216a471c1ec25d…
2025-08-23 18:47 UTC2025-08A208749-002LEVOTHYROXINE SODIUM200MCG/VIALPOWDER / INTRAVENOUSAP2018-12-216a471c1ec25d…
2025-08-23 18:47 UTC2025-08A208749-003LEVOTHYROXINE SODIUM500MCG/VIALPOWDER / INTRAVENOUSAP2018-12-216a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A208749-001LEVOTHYROXINE SODIUM100MCG/VIALPOWDER / INTRAVENOUSAP2018-12-21fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A208749-002LEVOTHYROXINE SODIUM200MCG/VIALPOWDER / INTRAVENOUSAP2018-12-21fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A208749-003LEVOTHYROXINE SODIUM500MCG/VIALPOWDER / INTRAVENOUSAP2018-12-21fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A208749-001LEVOTHYROXINE SODIUM100MCG/VIALPOWDER / INTRAVENOUSAP2018-12-21b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A208749-002LEVOTHYROXINE SODIUM200MCG/VIALPOWDER / INTRAVENOUSAP2018-12-21b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A208749-003LEVOTHYROXINE SODIUM500MCG/VIALPOWDER / INTRAVENOUSAP2018-12-21b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A208749-001LEVOTHYROXINE SODIUM100MCG/VIALPOWDER / INTRAVENOUSAP2018-12-2103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A208749-002LEVOTHYROXINE SODIUM200MCG/VIALPOWDER / INTRAVENOUSAP2018-12-2103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A208749-003LEVOTHYROXINE SODIUM500MCG/VIALPOWDER / INTRAVENOUSAP2018-12-2103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A208749-001LEVOTHYROXINE SODIUM100MCG/VIALPOWDER / INTRAVENOUSAP2018-12-212680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A208749-002LEVOTHYROXINE SODIUM200MCG/VIALPOWDER / INTRAVENOUSAP2018-12-212680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A208749-003LEVOTHYROXINE SODIUM500MCG/VIALPOWDER / INTRAVENOUSAP2018-12-212680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A208749-001LEVOTHYROXINE SODIUM100MCG/VIALPOWDER / INTRAVENOUSAP2018-12-215bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A208749-002LEVOTHYROXINE SODIUM200MCG/VIALPOWDER / INTRAVENOUSAP2018-12-215bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A208749-003LEVOTHYROXINE SODIUM500MCG/VIALPOWDER / INTRAVENOUSAP2018-12-215bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A208749-001LEVOTHYROXINE SODIUM100MCG/VIALPOWDER / INTRAVENOUSAP2018-12-21d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A208749-002LEVOTHYROXINE SODIUM200MCG/VIALPOWDER / INTRAVENOUSAP2018-12-21d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A208749-003LEVOTHYROXINE SODIUM500MCG/VIALPOWDER / INTRAVENOUSAP2018-12-21d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A208749-001LEVOTHYROXINE SODIUM100MCG/VIALPOWDER / INTRAVENOUSAP2018-12-21d06236e962d9…
2024-10-29 15:01 UTC2024-10A208749-002LEVOTHYROXINE SODIUM200MCG/VIALPOWDER / INTRAVENOUSAP2018-12-21d06236e962d9…
2024-10-29 15:01 UTC2024-10A208749-003LEVOTHYROXINE SODIUM500MCG/VIALPOWDER / INTRAVENOUSAP2018-12-21d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A208749-001LEVOTHYROXINE SODIUM100MCG/VIALPOWDER / INTRAVENOUSAP2018-12-2179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A208749-002LEVOTHYROXINE SODIUM200MCG/VIALPOWDER / INTRAVENOUSAP2018-12-2179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A208749-003LEVOTHYROXINE SODIUM500MCG/VIALPOWDER / INTRAVENOUSAP2018-12-2179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A208749-001LEVOTHYROXINE SODIUM100MCG/VIALPOWDER / INTRAVENOUSAP2018-12-21301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A208749-002LEVOTHYROXINE SODIUM200MCG/VIALPOWDER / INTRAVENOUSAP2018-12-21301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A208749-003LEVOTHYROXINE SODIUM500MCG/VIALPOWDER / INTRAVENOUSAP2018-12-21301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A208749-001LEVOTHYROXINE SODIUM100MCG/VIALPOWDER / INTRAVENOUSAP2018-12-211e350fbaab3a…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 4 · 126 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-08-18 06:07:402026-07A208749-001AP1caaa826d4ba7…
2026-08-18 06:07:402026-07A208749-002AP1caaa826d4ba7…
2026-08-18 06:07:402026-07A208749-003AP1caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A208749-001AP1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A208749-002AP1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A208749-003AP1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A208749-001AP131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A208749-002AP131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A208749-003AP131067a03dcf5…
2025-08-23 18:47 UTC2025-08A208749-001AP16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A208749-002AP16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A208749-003AP16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A208749-001AP1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A208749-002AP1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A208749-003AP1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A208749-001AP1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A208749-002AP1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A208749-003AP1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A208749-001AP103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A208749-002AP103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A208749-003AP103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A208749-001AP12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A208749-002AP12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A208749-003AP12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A208749-001AP15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A208749-002AP15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A208749-003AP15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A208749-001AP1d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A208749-002AP1d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A208749-003AP1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A208749-001AP1d06236e962d9…
2024-10-29 15:01 UTC2024-10A208749-002AP1d06236e962d9…
2024-10-29 15:01 UTC2024-10A208749-003AP1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A208749-001AP179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A208749-002AP179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A208749-003AP179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A208749-001AP1301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A208749-002AP1301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A208749-003AP1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A208749-001AP11e350fbaab3a…

Additional Listing Data#

Finished product
Yes
Brand name base
Levothyroxine Sodium
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
LEVOTHYROXINE SODIUM ANHYDROUS500 ug/5mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
054I36CPMNInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 3 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
966219Internal RxNorm lookup
1115267Internal RxNorm lookup
1115269Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
f57e9b19-6f17-4520-80fc-511322cc56c9Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
97c252d3-9bb8-4530-bb44-9824dc7cf556Product name620250729
6c43b71c-35e6-4db3-ba24-c6ef42ff7003Product name320240207
890fd4bf-1a80-42b7-be1b-2d0259d5f0c8Product name520240207
c8ad26bf-af73-460b-b74e-1eff16cc4f9fProduct name520240207
01383843-4069-43cf-aa76-dc17a6f9f8c4Product name220230123
978cca7d-a938-4791-8322-da48d90a63efProduct name120230113
65f86ba3-8816-4e12-899b-18290c8de551Product name220210614
f16ab90f-08c2-40be-a543-66d9827cd1f3Product name120210601
6a33ec05-2ae2-45e5-ab82-2d94b3303923Product name120190709
93355a10-1c44-4c92-a11d-7d995e0200d9Product name120190219

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
25021-470-10Levothyroxine Sodium5 mL in 1 VIALINJECTION, POWDER, LYOPHILIZED,51
25021-470-10Levothyroxine Sodium1 in 1 CARTONINJECTION, POWDER, LYOPHILIZED,11

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
25021-470-10EA - Each25021-4705f8b205a-e3d9-4f52-b318-bde3da6a81df12024-03-12

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
25021-470LEVOTHYROXINE SODIUM (LEVOTHYROXINE SODIUM ANHYDROUS) INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [SAGENT PHARMACEUTICALS]1Current NDC, 2 package rows20240111_f57e9b19-6f17-4520-80fc-511322cc56c9.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 2 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Levothyroxine SodiumLEVOTHYROXINE SODIUM ANHYDROUSSagent Pharmaceuticalsf57e9b19-6f17-4520-80fc-511322cc56c92023-10-19Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 208749
application number: ANDA208749
ndc (product): 25021-470
Levothyroxine SodiumLEVOTHYROXINE SODIUM ANHYDROUSMAIA Pharmaceuticals, Inc.4e9adc35-3aba-4a0d-9c4e-7e7ee2ffdabd2019-01-30Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 208749
application number: ANDA208749

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
1115267levothyroxine sodium 100 MCG InjectionPSNf57e9b19-6f17-4520-80fc-511322cc56c91
1115269levothyroxine sodium 200 MCG InjectionPSNf57e9b19-6f17-4520-80fc-511322cc56c91
966219levothyroxine sodium 500 MCG InjectionPSNf57e9b19-6f17-4520-80fc-511322cc56c91
1115267levothyroxine sodium 0.1 MG InjectionSCDf57e9b19-6f17-4520-80fc-511322cc56c91
1115269levothyroxine sodium 0.2 MG InjectionSCDf57e9b19-6f17-4520-80fc-511322cc56c91
966219levothyroxine sodium 0.5 MG InjectionSCDf57e9b19-6f17-4520-80fc-511322cc56c91
1115267levothyroxine sodium 100 MCG InjectionSYf57e9b19-6f17-4520-80fc-511322cc56c91
1115269levothyroxine sodium 200 MCG InjectionSYf57e9b19-6f17-4520-80fc-511322cc56c91
966219levothyroxine sodium 500 MCG InjectionSYf57e9b19-6f17-4520-80fc-511322cc56c91

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startSampleExclude flagStatus
25021-470-10250210470101 VIAL in 1 CARTON (25021-470-10) / 5 mL in 1 VIAL1 vial2024-01-01NoNoCurrent