Crest Pro-Health Multi-Protection

Product NDC: 37000-451
Requested package NDC: 37000-451-01
11-digit product format: 370000451
Labeler code: 37000
Product ID: 37000-451_47e4e758-d6de-4e88-e063-6394a90ac40e
Type: HUMAN OTC DRUG
Nonproprietary name: Cetylpyridinium chloride
Dosage form: RINSE
Route: ORAL
Labeler: The Procter & Gamble Manufacturing Company
Application: M022
Marketing category: OTC MONOGRAPH DRUG
Marketing start: 2011-02-03
Substance: CETYLPYRIDINIUM CHLORIDE
Active strength: .014 g/20mL
NDC exclude flag: No
Listing certified through: 2027-12-31
Current FDA listing: Yes

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

Additional Listing Data#

Finished product: Yes
Brand name base: Crest Pro-Health Multi-Protection
Brand name suffix: Refreshing Clean Mint
Listing expiration: 2027-12-31

Active Ingredients#

Ingredient, Strength table
Ingredient	Strength
CETYLPYRIDINIUM CHLORIDE	.014 g/20mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
D9OM4SK49P	Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
1100924	Internal RxNorm lookup
1251371	Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
8867d791-7e93-4f39-aaaf-bfbee8296fd9	Available on FDA.report

FDA-Initiated Inactive NDC Indexing#

NDC, Effective, Related label table
NDC	Effective	Related label
37000-451-01	2023-05-19	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-01	2023-05-19	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-01	2023-05-19	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-02	2023-05-19	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-02	2023-05-19	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-02	2023-05-19	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-03	2023-05-19	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-03	2023-05-19	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-03	2023-05-19	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-04	2023-05-19	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-04	2023-05-19	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-04	2023-05-19	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-05	2023-05-19	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-05	2023-05-19	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-05	2023-05-19	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-06	2023-05-19	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-06	2023-05-19	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-06	2023-05-19	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-10	2023-05-19	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-10	2023-05-19	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-10	2023-05-19	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-01	2023-01-30	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-01	2023-01-30	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-01	2023-01-30	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-02	2023-01-30	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-02	2023-01-30	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-02	2023-01-30	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-03	2023-01-30	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-03	2023-01-30	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-03	2023-01-30	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-04	2023-01-30	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-04	2023-01-30	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-04	2023-01-30	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-05	2023-01-30	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-05	2023-01-30	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-05	2023-01-30	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-06	2023-01-30	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-06	2023-01-30	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-06	2023-01-30	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-10	2023-01-30	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-10	2023-01-30	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-10	2023-01-30	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-01	2021-02-12	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-01	2021-02-12	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-01	2021-02-12	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-03	2021-02-12	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-03	2021-02-12	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-03	2021-02-12	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-04	2021-02-12	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-04	2021-02-12	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-04	2021-02-12	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-05	2021-02-12	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-05	2021-02-12	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-05	2021-02-12	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-06	2021-02-12	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-06	2021-02-12	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-06	2021-02-12	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-10	2021-02-12	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-10	2021-02-12	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-10	2021-02-12	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-01	2021-01-29	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-01	2021-01-29	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-01	2021-01-29	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-03	2021-01-29	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-03	2021-01-29	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-03	2021-01-29	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-04	2021-01-29	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-04	2021-01-29	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-04	2021-01-29	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-05	2021-01-29	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-05	2021-01-29	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-05	2021-01-29	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-06	2021-01-29	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-06	2021-01-29	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-06	2021-01-29	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-10	2021-01-29	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-10	2021-01-29	Crest ® Pro-Health ® Multi-Protection Clean Mint
37000-451-10	2021-01-29	Crest ® Pro-Health ® Multi-Protection Clean Mint

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	SPL version
37000-451-01	Crest Pro-Health Multi-ProtectionRefreshing Clean Mint	36 mL in 1 BOTTLE, PLASTIC	RINSE	36	14
37000-451-02	Crest Pro-Health Multi-ProtectionRefreshing Clean Mint	100 mL in 1 BOTTLE, PLASTIC	RINSE	100	14
37000-451-03	Crest Pro-Health Multi-ProtectionRefreshing Clean Mint	250 mL in 1 BOTTLE, PLASTIC	RINSE	250	14
37000-451-04	Crest Pro-Health Multi-ProtectionRefreshing Clean Mint	500 mL in 1 BOTTLE, PLASTIC	RINSE	500	14
37000-451-05	Crest Pro-Health Multi-ProtectionRefreshing Clean Mint	1000 mL in 1 BOTTLE, PLASTIC	RINSE	1000	14
37000-451-06	Crest Pro-Health Multi-ProtectionRefreshing Clean Mint	1500 mL in 1 BOTTLE, PLASTIC	RINSE	1500	14
37000-451-10	Crest Pro-Health Multi-ProtectionRefreshing Clean Mint	2 in 1 PACKAGE	RINSE	2	14
37000-451-10	Crest Pro-Health Multi-ProtectionRefreshing Clean Mint	1000 mL in 1 BOTTLE	RINSE	1000	14
37000-451-11	Crest Pro-Health Multi-ProtectionRefreshing Clean Mint	3 in 1 CELLO PACK	RINSE	3	14
37000-451-11	Crest Pro-Health Multi-ProtectionRefreshing Clean Mint	1000 mL in 1 BOTTLE, PLASTIC	RINSE	1000	14

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
Ingredient	Type	UNII	DailyMed label	SPL version
Cetylpyridinium chloride	ACTIVE INGREDIENT	D9OM4SK49P	CREST PRO-HEALTH MULTI-PROTECTION REFRESHING CLEAN MINT (CETYLPYRIDINIUM CHLORIDE) RINSE [PROCTER & GAMBLE MANUFACTURING COMPANY]	1
Cetylpyridinium	ACTIVE MOIETY	CUB7JI0JV3	CREST PRO-HEALTH MULTI-PROTECTION REFRESHING CLEAN MINT (CETYLPYRIDINIUM CHLORIDE) RINSE [PROCTER & GAMBLE MANUFACTURING COMPANY]	1
FD&C blue no. 1	INACTIVE INGREDIENT	H3R47K3TBD	CREST PRO-HEALTH MULTI-PROTECTION REFRESHING CLEAN MINT (CETYLPYRIDINIUM CHLORIDE) RINSE [PROCTER & GAMBLE MANUFACTURING COMPANY]	1
glycerin	INACTIVE INGREDIENT	PDC6A3C0OX	CREST PRO-HEALTH MULTI-PROTECTION REFRESHING CLEAN MINT (CETYLPYRIDINIUM CHLORIDE) RINSE [PROCTER & GAMBLE MANUFACTURING COMPANY]	1
methylparaben	INACTIVE INGREDIENT	A2I8C7HI9T	CREST PRO-HEALTH MULTI-PROTECTION REFRESHING CLEAN MINT (CETYLPYRIDINIUM CHLORIDE) RINSE [PROCTER & GAMBLE MANUFACTURING COMPANY]	1
poloxamer 407	INACTIVE INGREDIENT	TUF2IVW3M2	CREST PRO-HEALTH MULTI-PROTECTION REFRESHING CLEAN MINT (CETYLPYRIDINIUM CHLORIDE) RINSE [PROCTER & GAMBLE MANUFACTURING COMPANY]	1
propylparaben	INACTIVE INGREDIENT	Z8IX2SC1OH	CREST PRO-HEALTH MULTI-PROTECTION REFRESHING CLEAN MINT (CETYLPYRIDINIUM CHLORIDE) RINSE [PROCTER & GAMBLE MANUFACTURING COMPANY]	1
saccharin sodium dihydrate	INACTIVE INGREDIENT	SB8ZUX40TY	CREST PRO-HEALTH MULTI-PROTECTION REFRESHING CLEAN MINT (CETYLPYRIDINIUM CHLORIDE) RINSE [PROCTER & GAMBLE MANUFACTURING COMPANY]	1
water	INACTIVE INGREDIENT	059QF0KO0R	CREST PRO-HEALTH MULTI-PROTECTION REFRESHING CLEAN MINT (CETYLPYRIDINIUM CHLORIDE) RINSE [PROCTER & GAMBLE MANUFACTURING COMPANY]	1

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
37000-451	CREST PRO-HEALTH MULTI-PROTECTION REFRESHING CLEAN MINT (CETYLPYRIDINIUM CHLORIDE) RINSE [THE PROCTER & GAMBLE MANUFACTURING COMPANY]	11	Current NDC, Legacy NDC, 10 package rows	20250309_8867d791-7e93-4f39-aaaf-bfbee8296fd9.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 32 of 40 · 782 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
NATURAL LEMON MINT HERB THROAT DROPS	MENTHOL	Ricola USA Inc.	6a81e5c7-834d-44da-853f-8f6103236311	2024-12-10	Warnings	Exact identifier application number: M022
SUGAR FREE SWISS CHERRY HERB THROAT DROPS	MENTHOL	Ricola USA Inc.	8a24f614-8e21-4ab2-8c0e-6af947911ccd	2024-12-10	Warnings	Exact identifier application number: M022
RICOLA MAX NASAL CARE COOL MENTHOL	MENTHOL	Ricola USA Inc.	a2e189a2-65ae-48a9-99ad-8795334082df	2024-12-10	Warnings	Exact identifier application number: M022
COOL RELIEF LEMON FROST ORAL ANESTHETIC	MENTHOL	Ricola USA Inc.	40c3a80a-a116-4607-bb4a-c89d255ee076	2024-12-10	Warnings	Exact identifier application number: M022
COOL RELIEF ORAL ANESTHETIC	MENTHOL	Ricola USA Inc.	d66f47a9-35ab-4bf9-8065-c81abcb503f5	2024-12-10	Warnings	Exact identifier application number: M022
Natural Cherry Honey Herb Throat Drops	MENTHOL	Ricola USA Inc.	62a631d3-e6d0-4fca-ad0c-7c1b67d2a827	2024-12-10	Warnings	Exact identifier application number: M022
COOL RELIEF ORAL ANESTHETIC	MENTHOL	Ricola USA Inc.	3f93919f-e63e-470d-9d9a-f6ea3492c23d	2024-12-10	Warnings	Exact identifier application number: M022
Throat Balm Caramel Pectin	PECTIN	Ricola USA Inc.	23cf2ba5-9d4d-409b-ab0e-a1d702f0bb15	2024-12-10	Warnings	Exact identifier application number: M022
Cherry Throat Drops	MENTHOL	Ricola USA Inc.	4cbf9094-6b50-4bef-bb36-2df6cb868ac7	2024-12-10	Warnings	Exact identifier application number: M022
SUCRETS VAPOR CHERRY	DYCLONINE HYDROCHLORIDE AND MENTHOL	Insight Pharmaceuticals LLC	471af502-5b3a-4897-b22d-78859b73a217	2024-12-05	Warnings	Exact identifier application number: M022
Cherry Throat Drops	MENTHOL	Ricola Ag	bb236392-1f7c-4cb5-ae9a-9cb1c60d133e	2024-12-05	Warnings	Exact identifier application number: M022
RICOLA MAX NASAL CARE COOL MENTHOL	MENTHOL	Ricola Ag	dfecd10f-adbe-4be7-854d-f9f202fef145	2024-12-05	Warnings	Exact identifier application number: M022
COOL RELIEF ORAL ANESTHETIC	MENTHOL	Ricola Ag	3698a69f-b5c0-4235-8ef8-71c867f1ac0d	2024-12-05	Warnings	Exact identifier application number: M022
Throat Balm Caramel Pectin	PECTIN	Ricola Ag	edbd7a73-8f06-4a1e-a459-3d7a4355fc9b	2024-12-05	Warnings	Exact identifier application number: M022
SUGAR FREE SWISS CHERRY HERB THROAT DROPS	MENTHOL	Ricola Ag	e2a939a5-4447-4707-865c-70de9a0471c6	2024-12-05	Warnings	Exact identifier application number: M022
Natural Cherry Honey Herb Throat Drops	MENTHOL	Ricola Ag	ec6cad6b-9e92-44c9-a470-cf924fb1b6d7	2024-12-05	Warnings	Exact identifier application number: M022
Natural Cherry Honey Herb Throat Drops	MENTHOL	Ricola Ag	229a7feb-c646-4557-85e5-0832682ab926	2024-12-05	Warnings	Exact identifier application number: M022
NATURAL LEMON MINT HERB THROAT DROPS	MENTHOL	Ricola Ag	0e135eb0-4a40-4930-ade4-fb7df87db1f4	2024-12-05	Warnings	Exact identifier application number: M022
Cherry Throat Drops	MENTHOL	Ricola Ag	73d767e2-bb80-4eff-8420-500c2a4067aa	2024-12-05	Warnings	Exact identifier application number: M022
COOL RELIEF ORAL ANESTHETIC	MENTHOL	Ricola Ag	951e9836-e6a3-4094-8a6b-f226c85c897a	2024-12-05	Warnings	Exact identifier application number: M022

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
D9OM4SK49P	CETYLPYRIDINIUM CHLORIDE	6004-24-6	CETYLPYRIDINIUM CHLORIDE

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUI	RxNorm string	TTY	DailyMed	SPL version
1100924	cetylpyridinium chloride 0.07 % Oral Rinse	PSN	8867d791-7e93-4f39-aaaf-bfbee8296fd9	14
1251371	Crest Pro-Health 0.07 % Oral Rinse	PSN	8867d791-7e93-4f39-aaaf-bfbee8296fd9	14
1251371	cetylpyridinium chloride 0.7 MG/ML Mouthwash [Crest Mouthwash]	SBD	8867d791-7e93-4f39-aaaf-bfbee8296fd9	14
1100924	cetylpyridinium chloride 0.7 MG/ML Mouthwash	SCD	8867d791-7e93-4f39-aaaf-bfbee8296fd9	14
1100924	cetylpyridinium chloride 0.07 % Oral Rinse	SY	8867d791-7e93-4f39-aaaf-bfbee8296fd9	14
1251371	Crest 0.07 % Mouthwash	SY	8867d791-7e93-4f39-aaaf-bfbee8296fd9	14
1100924	cetylpyridinium chloride 0.07 % Oral Rinse	PSN	65bf17a9-21ad-27cb-e053-2991aa0afc40	4
1251371	Crest Pro-Health 0.07 % Oral Rinse	PSN	65bf17a9-21ad-27cb-e053-2991aa0afc40	4
1251371	cetylpyridinium chloride 0.7 MG/ML Mouthwash [Crest Mouthwash]	SBD	65bf17a9-21ad-27cb-e053-2991aa0afc40	4
1100924	cetylpyridinium chloride 0.7 MG/ML Mouthwash	SCD	65bf17a9-21ad-27cb-e053-2991aa0afc40	4
1100924	cetylpyridinium chloride 0.07 % Oral Rinse	SY	65bf17a9-21ad-27cb-e053-2991aa0afc40	4
1251371	Crest 0.07 % Mouthwash	SY	65bf17a9-21ad-27cb-e053-2991aa0afc40	4

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Units	Marketing start	Marketing end	Sample	Exclude flag	Status
37000-451-01	37000045101	36 mL in 1 BOTTLE, PLASTIC (37000-451-01)	36 ml	2011-02-03	0000-00-00	No	No	Current

Title, Manufacturer, Effective date table
Title	Manufacturer	Effective date	Type	Version
Crest ® Pro-Health ® Multi-Protection Clean Mint	The Procter & Gamble Manufacturing Company	2026-01-08	HUMAN OTC DRUG LABEL	14
Crest Pro Health	Navajo Manufacturing Company Inc.	2024-10-02	HUMAN OTC DRUG LABEL	4