Endari

Product NDC
42457-420
11-digit product format
424570420
Labeler code
42457
Product ID
42457-420_10f5d160-6687-44d5-a607-6bf69a7312b6
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Glutamine
Dosage form
POWDER, FOR SOLUTION
Route
ORAL
Labeler
Emmaus Medical, Inc.
Application
NDA208587
Marketing category
NDA
Marketing start
2017-07-07
Substance
GLUTAMINE
Active strength
5 g/1
Pharmacologic classes
Amino Acid [EPC], Amino Acids [CS]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Observed NDC auxiliary status history#

This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.

Historic NDC status page 1 of 1 · 4 matching rows.

View current auxiliary records. · View the auxiliary file history.

Captured / source date, Dataset, Scope table
Captured / source dateDatasetScopePackage NDCSnapshotSource SHA-256
2022-04-09 23:13 UTC · source 2022-04-08excluded productproduct86f5da6cb304…a595104c45d7…
2022-04-09 23:13 UTC · source 2022-04-08excluded packagepackage42457-420-6086f5da6cb304…a595104c45d7…
2022-04-04 05:40 UTC · source 2022-04-01excluded productproductbd6a592717d7…303034d00443…
2022-04-04 05:40 UTC · source 2022-04-01excluded packagepackage42457-420-60bd6a592717d7…303034d00443…

Source provenance: Browse the complete Orange Book source catalog · source snapshot 42.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
N208587-001ENDARIL-GLUTAMINE5GM/PACKETFOR SOLUTION / ORALAARLD2017-07-07

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-productTE code
N208587-001AA

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 42 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-08-18 06:07:402026-07N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALAARLD2017-07-07caaa826d4ba7…
2026-02-19 14:30 UTC2026-02N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALAARLD2017-07-07011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALAARLD2017-07-0731067a03dcf5…
2025-08-23 18:47 UTC2025-08N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALAARLD2017-07-076a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALAARLD2017-07-07fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALAARLD2017-07-07b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALAARLD2017-07-0703ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALAARLD2017-07-072680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALAARLD2017-07-075bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALAARLD2017-07-07d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALAARLD2017-07-07d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALAARLD2017-07-0779d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALAARLD2017-07-07301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALRLD2017-07-071e350fbaab3a…
2024-05-31 18:47 UTC2024-05N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALRLD2017-07-078072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALRLD2017-07-075c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALRLD2017-07-075d02ea3f76ae…
2022-04-04 05:41 UTC2022-04N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALRLD2017-07-074b0b4de00fa7…
2019-12-13 00:20 UTC2019-12N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALRLD2017-07-0774a2ff9319b5…
2022-03-09 01:35 UTC2022-03N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALRLD2017-07-07bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALRLD2017-07-07782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALRLD2017-07-0787673890dc5c…
2021-03-12 10:30 UTC2021-03N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALRLD2017-07-075aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALRLD2017-07-078869cabd3fbd…
2020-11-12 02:37 UTC2020-11N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALRLD2017-07-07c0c555d07b60…
2019-12-14 00:12 UTC2019-12N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALRLD2017-07-073f01610625f2…
2019-09-15 20:21 UTC2019-09N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALRLD2017-07-07b00525d2431f…
2019-07-19 19:46 UTC2019-07N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALRLD2017-07-07ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALRLD2017-07-076a51e52b5d6a…
2024-02-18 07:12 UTC2024-02N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALRLD2017-07-071c564ffb4f44…
2023-12-20 04:57 UTC2023-12N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALRLD2017-07-07ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALRLD2017-07-07a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALRLD2017-07-079b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALRLD2017-07-07a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALRLD2017-07-073f0d92c62455…
2023-05-13 08:27 UTC2023-05N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALRLD2017-07-07053a50430f4f…
2023-01-26 05:58 UTC2023-01N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALRLD2017-07-073bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALRLD2017-07-073a93d1ddd44b…
2022-10-28 04:53 UTC2022-10N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALRLD2017-07-07f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09N208587-001ENDARI5GM/PACKETFOR SOLUTION / ORALRLD2017-07-07e64feba35796…

Observed Orange Book normalized TE history#

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-08-18 06:07:402026-07N208587-001AA1caaa826d4ba7…
2026-02-19 14:30 UTC2026-02N208587-001AA1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N208587-001AA131067a03dcf5…
2025-08-23 18:47 UTC2025-08N208587-001AA16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N208587-001AA1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N208587-001AA1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N208587-001AA103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N208587-001AA12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N208587-001AA15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N208587-001AA1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N208587-001AA1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N208587-001AA179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N208587-001AA1301d65b070ca…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06N208587-001AA1a50c72e98297…

Observed Orange Book exclusivity history#

Exclusivity history page 1 of 2 · 41 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productExclusivity codeExpirationSource SHA-256
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N208587-001ODE-1502024-07-0703ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N208587-001ODE-1502024-07-072680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N208587-001ODE-1502024-07-075bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N208587-001ODE-1502024-07-07d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N208587-001ODE-1502024-07-07d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N208587-001ODE-1502024-07-0779d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N208587-001ODE-1502024-07-07301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N208587-001ODE-1502024-07-071e350fbaab3a…
2024-05-31 18:47 UTC2024-05N208587-001ODE-1502024-07-078072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N208587-001ODE-1502024-07-075c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04N208587-001ODE-1502024-07-075d02ea3f76ae…
2022-04-04 05:41 UTC2022-04N208587-001ODE-1502024-07-074b0b4de00fa7…
2019-12-13 00:20 UTC2019-12N208587-001I-7482020-07-0774a2ff9319b5…
2019-12-13 00:20 UTC2019-12N208587-001ODE-1502024-07-0774a2ff9319b5…
2022-03-09 01:35 UTC2022-03N208587-001ODE-1502024-07-07bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12N208587-001ODE-1502024-07-07782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N208587-001ODE-1502024-07-0787673890dc5c…
2021-03-12 10:30 UTC2021-03N208587-001ODE-1502024-07-075aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12N208587-001I-7482020-07-078869cabd3fbd…
2020-12-22 03:56 UTC2020-12N208587-001ODE-1502024-07-078869cabd3fbd…
2020-11-12 02:37 UTC2020-11N208587-001I-7482020-07-07c0c555d07b60…
2020-11-12 02:37 UTC2020-11N208587-001ODE-1502024-07-07c0c555d07b60…
2019-12-14 00:12 UTC2019-12N208587-001I-7482020-07-073f01610625f2…
2019-12-14 00:12 UTC2019-12N208587-001ODE-1502024-07-073f01610625f2…
2019-09-15 20:21 UTC2019-09N208587-001I-7482020-07-07b00525d2431f…
2019-09-15 20:21 UTC2019-09N208587-001ODE-1502024-07-07b00525d2431f…
2019-07-19 19:46 UTC2019-07N208587-001I-7482020-07-07ea99ee380514…
2019-07-19 19:46 UTC2019-07N208587-001ODE-1502024-07-07ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03N208587-001ODE-1502024-07-076a51e52b5d6a…
2024-02-18 07:12 UTC2024-02N208587-001ODE-1502024-07-071c564ffb4f44…
2023-12-20 04:57 UTC2023-12N208587-001ODE-1502024-07-07ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11N208587-001ODE-1502024-07-07a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10N208587-001ODE-1502024-07-079b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07N208587-001ODE-1502024-07-07a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06N208587-001ODE-1502024-07-073f0d92c62455…
2023-05-13 08:27 UTC2023-05N208587-001ODE-1502024-07-07053a50430f4f…
2023-01-26 05:58 UTC2023-01N208587-001ODE-1502024-07-073bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11N208587-001ODE-1502024-07-073a93d1ddd44b…
2022-10-28 04:53 UTC2022-10N208587-001ODE-1502024-07-07f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09N208587-001ODE-1502024-07-07e64feba35796…

Additional Listing Data#

Finished product
Yes
Brand name base
Endari
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
GLUTAMINE5 g/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
0RH81L854JInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1869684Internal RxNorm lookup
1928941Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
d5a783f4-12ef-4326-8faa-40018e45ba3bAvailable on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
73df98bc-429f-4587-8299-6ad8d52a4f36Product name220250304
64b87b8d-6ae7-cef1-8fd2-34228b0cc1bcProduct name120140508

FDA-Initiated Inactive NDC Indexing#

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
42457-420-01Endari1 in 1 PACKETPOWDER, FOR SOLUTION110
42457-420-60Endari60 in 1 CARTONPOWDER, FOR SOLUTION6010

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
42457-420-01EA - Each42457-42016857e27-1feb-4dc0-ba9c-1158f29e991912017-10-13
42457-420-60EA - Each42457-420bd1af523-a76c-469d-bb00-dcda025ec01212017-10-13

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
42457-420ENDARI (GLUTAMINE) POWDER, FOR SOLUTION [EMMAUS MEDICAL, INC.]8Current NDC, Legacy NDC, 2 package rows20220820_d5a783f4-12ef-4326-8faa-40018e45ba3b.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
EndariGLUTAMINEEmmaus Medical, Inc.d5a783f4-12ef-4326-8faa-40018e45ba3b2025-06-20Adverse reactionsExact identifier
application applno (NDA): 208587
application number: NDA208587
ndc (product): 42457-420

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
1928941Endari 5 GM Powder for Oral SolutionPSNd5a783f4-12ef-4326-8faa-40018e45ba3b10
1869684glutamine 5 GM Powder for Oral SolutionPSNd5a783f4-12ef-4326-8faa-40018e45ba3b10
1928941glutamine 5000 MG Powder for Oral Solution [Endari]SBDd5a783f4-12ef-4326-8faa-40018e45ba3b10
1869684glutamine 5000 MG Powder for Oral SolutionSCDd5a783f4-12ef-4326-8faa-40018e45ba3b10
1928941Endari 5000 MG Powder for Oral SolutionSYd5a783f4-12ef-4326-8faa-40018e45ba3b10
1869684l-glutamine 5 GM Powder for Oral SolutionSYd5a783f4-12ef-4326-8faa-40018e45ba3b10

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
42457-420-01424570420011 in 1 PACKETHistorical
42457-420-604245704206060 PACKET in 1 CARTON (42457-420-60) / 1 POWDER, FOR SOLUTION in 1 PACKET (42457-420-01) 60 packet2017-07-070000-00-00NoNoCurrent