Cladribine

Product NDC
42658-010
11-digit product format
426580010
Labeler code
42658
Product ID
42658-010_2c5c0edf-8718-40f2-e063-6294a90aacd0
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Cladribine
Dosage form
INJECTION, SOLUTION
Route
INTRAVENOUS
Labeler
Hisun Pharmaceuticals USA, Inc.
Application
ANDA210856
Marketing category
ANDA
Marketing start
2020-05-18
Substance
CLADRIBINE
Active strength
1 mg/mL
Pharmacologic classes
Purine Antimetabolite [EPC]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Observed NDC auxiliary status history#

This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.

Historic NDC status page 1 of 1 · 4 matching rows.

View current auxiliary records. · View the auxiliary file history.

Captured / source date, Dataset, Scope table
Captured / source dateDatasetScopePackage NDCSnapshotSource SHA-256
2025-01-20 13:05 UTC · source 2025-01-20excluded productproducted331223b511…672a5bd82f5f…
2025-01-20 13:05 UTC · source 2025-01-20excluded packagepackage42658-010-91ed331223b511…672a5bd82f5f…
2025-01-11 03:41 UTC · source 2025-01-10excluded productproduct0efc9e666f02…f202fb6c5f17…
2025-01-11 03:41 UTC · source 2025-01-10excluded packagepackage42658-010-910efc9e666f02…f202fb6c5f17…

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A210856-001CLADRIBINECLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-25

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-productTE code
A210856-001AP

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-25011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-2531067a03dcf5…
2025-08-23 18:47 UTC2025-08A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-256a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-25fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-25b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-2503ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-252680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-255bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-25d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-25d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-2579d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-25301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-251e350fbaab3a…
2024-05-31 18:47 UTC2024-05A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-258072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-255c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-255d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-254b0b4de00fa7…
2022-03-09 01:35 UTC2022-03A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-25bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-25782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-2587673890dc5c…
2021-03-12 10:30 UTC2021-03A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-255aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-258869cabd3fbd…
2020-11-12 02:37 UTC2020-11A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-25c0c555d07b60…
2019-12-14 00:12 UTC2019-12A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-253f01610625f2…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-256a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-251c564ffb4f44…
2023-12-20 04:57 UTC2023-12A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-25ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-25a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-259b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-25a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-253f0d92c62455…
2023-05-13 08:27 UTC2023-05A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-25053a50430f4f…
2023-01-26 05:58 UTC2023-01A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-253bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-253a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-25f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-25e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-25cb3db0bc1861…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A210856-001CLADRIBINE1MG/MLINJECTABLE / INJECTIONAP2019-11-25a50c72e98297…

Observed Orange Book normalized TE history#

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02A210856-001AP1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A210856-001AP131067a03dcf5…
2025-08-23 18:47 UTC2025-08A210856-001AP16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A210856-001AP1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A210856-001AP1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A210856-001AP103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A210856-001AP12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A210856-001AP15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A210856-001AP1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A210856-001AP1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A210856-001AP179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A210856-001AP1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A210856-001AP11e350fbaab3a…
2024-05-31 18:47 UTC2024-05A210856-001AP18072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A210856-001AP15c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A210856-001AP15d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A210856-001AP14b0b4de00fa7…
2022-03-09 01:35 UTC2022-03A210856-001AP1bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A210856-001AP1782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A210856-001AP187673890dc5c…
2021-03-12 10:30 UTC2021-03A210856-001AP15aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A210856-001AP18869cabd3fbd…
2020-11-12 02:37 UTC2020-11A210856-001AP1c0c555d07b60…
2019-12-14 00:12 UTC2019-12A210856-001AP13f01610625f2…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A210856-001AP16a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A210856-001AP11c564ffb4f44…
2023-12-20 04:57 UTC2023-12A210856-001AP1ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A210856-001AP1a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A210856-001AP19b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A210856-001AP1a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A210856-001AP13f0d92c62455…
2023-05-13 08:27 UTC2023-05A210856-001AP1053a50430f4f…
2023-01-26 05:58 UTC2023-01A210856-001AP13bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A210856-001AP13a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A210856-001AP1f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A210856-001AP1e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07A210856-001AP1cb3db0bc1861…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A210856-001AP1a50c72e98297…

Additional Listing Data#

Finished product
Yes
Brand name base
Cladribine
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
CLADRIBINE1 mg/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
47M74X9YT5Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
240754Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
f538cba9-001a-4a21-e053-2a95a90a00ecAvailable on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
e6341a9e-3b90-6d63-7529-e3c0b6be164aProduct name220200511
21075a88-376d-46da-a075-a9797650ce34Product name120190702
7cda52fc-125f-421c-8fea-bc1974370c49Product name220180703

FDA-Initiated Inactive NDC Indexing#

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
42658-010-01Cladribine1 mL in 1 VIAL, SINGLE-DOSEINJECTION, SOLUTION16
42658-010-91Cladribine1 mL in 1 VIAL, SINGLE-DOSEINJECTION, SOLUTION12

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
42658-010-01ML - Milliliter42658-01073cf5d85-2e0e-4794-bf44-1b9977cd48ff12020-06-05
42658-010-91ML - Milliliter42658-010da9c3791-3ac4-4ac4-ad4f-804f5915426812023-06-06

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
42658-010CLADRIBINE INJECTION, SOLUTION [HISUN PHARMACEUTICALS USA, INC.]5Current NDC, Legacy NDC, 1 package rows20240228_71c39b37-33b5-42e1-bf4f-93ff751cc7fe.zip
42658-010CLADRIBINE INJECTION, SOLUTION [HISUN PHARMACEUTICALS USA, INC.]2Current NDC, Legacy NDC, 1 package rows20250125_f538cba9-001a-4a21-e053-2a95a90a00ec.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 2 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
CladribineCLADRIBINEHisun Pharmaceuticals USA, Inc.71c39b37-33b5-42e1-bf4f-93ff751cc7fe2025-12-23Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 210856
application number: ANDA210856
ndc (product): 42658-010
CladribineCLADRIBINEHisun Pharmaceuticals USA, Inc.f538cba9-001a-4a21-e053-2a95a90a00ec2025-01-23Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 210856
application number: ANDA210856
ndc (product): 42658-010

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
240754cladribine 10 MG in 10 ML InjectionPSN71c39b37-33b5-42e1-bf4f-93ff751cc7fe6
24075410 ML cladribine 1 MG/ML InjectionSCD71c39b37-33b5-42e1-bf4f-93ff751cc7fe6
240754cladribine 10 MG per 10 ML InjectionSY71c39b37-33b5-42e1-bf4f-93ff751cc7fe6
240754cladribine 10 MG in 10 ML InjectionPSNf538cba9-001a-4a21-e053-2a95a90a00ec2
24075410 ML cladribine 1 MG/ML InjectionSCDf538cba9-001a-4a21-e053-2a95a90a00ec2
240754cladribine 10 MG per 10 ML InjectionSYf538cba9-001a-4a21-e053-2a95a90a00ec2

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
42658-010-01426580010011 mL in 1 VIAL, SINGLE-DOSE (42658-010-01) 1 ml2020-05-180000-00-00NoNoCurrent
42658-010-91426580010911 mL in 1 VIAL, SINGLE-DOSE (42658-010-91) 1 ml2023-02-28NoNoCurrent