REBIF

Product NDC: 44087-0022
11-digit product format: 440870022
Labeler code: 44087
Product ID: 44087-0022_037d2645-544b-41bb-bea8-00b578366ac6
Type: HUMAN PRESCRIPTION DRUG
Nonproprietary name: INTERFERON BETA-1A
Dosage form: INJECTION, SOLUTION
Route: SUBCUTANEOUS
Labeler: EMD Serono, Inc.
Application: BLA103780
Marketing category: BLA
Marketing start: 2002-03-07
Substance: INTERFERON BETA-1A
Active strength: 22 ug/.5mL
Pharmacologic classes: Interferon beta [EPC], Interferon-beta [CS]
NDC exclude flag: No
Listing certified through: 2026-12-31
Current FDA listing: Yes

Additional Listing Data#

Finished product: Yes
Brand name base: REBIF
Listing expiration: 2026-12-31

Active Ingredients#

Ingredient, Strength table
Ingredient	Strength
INTERFERON BETA-1A	22 ug/.5mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
XRO4566Q4R	Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 16 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
758025	Internal RxNorm lookup
758027	Internal RxNorm lookup
758028	Internal RxNorm lookup
758029	Internal RxNorm lookup
758030	Internal RxNorm lookup
758032	Internal RxNorm lookup
795748	Internal RxNorm lookup
795749	Internal RxNorm lookup
1649994	Internal RxNorm lookup
1649996	Internal RxNorm lookup
1650003	Internal RxNorm lookup
1650004	Internal RxNorm lookup
1650011	Internal RxNorm lookup
1650012	Internal RxNorm lookup
1650268	Internal RxNorm lookup
1650282	Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product concept	Relation	Version	Effective
6bd95106-a412-1dad-b9cc-4cb74bfb27ce	Product name	2	20230315
326327f0-4d6d-4c84-bc6d-8d84a27e249f	Product name	1	20191002
d5e51f11-ad28-caa4-4b49-4143974782ad	Product name	1	20150831
290f523a-f9db-9774-b5a9-e1f908ac1782	Product name	1	20150828
0ca1d589-929b-4b33-bc5b-1d84abdafa6a	Product name	1	20150324
fc363c46-397b-4476-ac0f-70e43e8e4592	Product name	1	20150324
c6b65c52-69c7-df49-550a-a50c137f6218	Product name	1	20140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	Strength	SPL version
44087-0022-3	REBIF	12 in 1 CARTON	INJECTION, SOLUTION	12		27
44087-0022-9	REBIF	0.5 mL in 1 SYRINGE, GLASS	INJECTION, SOLUTION	0.5		27

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDC	Billing unit	Product NDC	DailyMed indexing SPL	SPL version	Effective
44087-0022-3	ML - Milliliter	44087-0022	440baa3e-d7e6-44e0-937a-051d3325e0a7	1	2012-07-24
44087-0022-9	ML - Milliliter	44087-0022	ef8dea59-4fda-4df2-8f07-73e9e0539ffe	1	2015-07-20

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
Ingredient	Type	UNII	DailyMed label	SPL version
INTERFERON BETA-1A	ACTIVE INGREDIENT	XRO4566Q4R	REBIF (INTERFERON BETA-1A) KIT REBIF REBIDOSE (INTERFERON BETA-1A) KIT REBIF (INTERFERON BETA-1A ) INJECTION, SOLUTION REBIF (INTERFERON BETA-1A) INJECTION, SOLUTION REBIF REBIDOSE (INTERFERON BETA-1A ) INJECTION, SOLUTION [EMD SERONO, INC.]	11
INTERFERON BETA-1A	ACTIVE MOIETY	XRO4566Q4R	REBIF (INTERFERON BETA-1A) KIT REBIF REBIDOSE (INTERFERON BETA-1A) KIT REBIF (INTERFERON BETA-1A ) INJECTION, SOLUTION REBIF (INTERFERON BETA-1A) INJECTION, SOLUTION REBIF REBIDOSE (INTERFERON BETA-1A ) INJECTION, SOLUTION [EMD SERONO, INC.]	11
ALBUMIN HUMAN	INACTIVE INGREDIENT	ZIF514RVZR	REBIF (INTERFERON BETA-1A) KIT REBIF REBIDOSE (INTERFERON BETA-1A) KIT REBIF (INTERFERON BETA-1A ) INJECTION, SOLUTION REBIF (INTERFERON BETA-1A) INJECTION, SOLUTION REBIF REBIDOSE (INTERFERON BETA-1A ) INJECTION, SOLUTION [EMD SERONO, INC.]	11
MANNITOL	INACTIVE INGREDIENT	3OWL53L36A	REBIF (INTERFERON BETA-1A) KIT REBIF REBIDOSE (INTERFERON BETA-1A) KIT REBIF (INTERFERON BETA-1A ) INJECTION, SOLUTION REBIF (INTERFERON BETA-1A) INJECTION, SOLUTION REBIF REBIDOSE (INTERFERON BETA-1A ) INJECTION, SOLUTION [EMD SERONO, INC.]	11
SODIUM ACETATE	INACTIVE INGREDIENT	4550K0SC9B	REBIF (INTERFERON BETA-1A) KIT REBIF REBIDOSE (INTERFERON BETA-1A) KIT REBIF (INTERFERON BETA-1A ) INJECTION, SOLUTION REBIF (INTERFERON BETA-1A) INJECTION, SOLUTION REBIF REBIDOSE (INTERFERON BETA-1A ) INJECTION, SOLUTION [EMD SERONO, INC.]	11
WATER	INACTIVE INGREDIENT	059QF0KO0R	REBIF (INTERFERON BETA-1A) KIT REBIF REBIDOSE (INTERFERON BETA-1A) KIT REBIF (INTERFERON BETA-1A ) INJECTION, SOLUTION REBIF (INTERFERON BETA-1A) INJECTION, SOLUTION REBIF REBIDOSE (INTERFERON BETA-1A ) INJECTION, SOLUTION [EMD SERONO, INC.]	11

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
44087-0022	REBIF (INTERFERON BETA-1A) KIT REBIF REBIDOSE (INTERFERON BETA-1A) KIT REBIF (INTERFERON BETA-1A ) INJECTION, SOLUTION REBIF (INTERFERON BETA-1A) INJECTION, SOLUTION REBIF REBIDOSE (INTERFERON BETA-1A ) INJECTION, SOLUTION [EMD SERONO, INC.]	26	Current NDC, Legacy NDC, 2 package rows	20230806_c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
REBIF	INTERFERON BETA-1A	EMD Serono, Inc.	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	2025-09-22	Warnings, Adverse reactions	Exact identifier application number: BLA103780 ndc (product): 44087-0022

Purple Book Biologic Products#

BLA, Proprietary name, Proper name table
BLA	Proprietary name	Proper name	License type	Status	Latest source
103780	Rebif	interferon beta-1a	351(a)	Rx	2026-06-01

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
XRO4566Q4R	INTERFERON BETA-1A	145258-61-3	INTERFERON BETA-1A

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUI	RxNorm string	TTY	DailyMed	SPL version
1650282	{6 (0.2 ML interferon beta-1a 0.044 MG/ML Auto-Injector [Rebif]) / 6 (0.5 ML interferon beta-1a 0.044 MG/ML Auto-Injector [Rebif]) } Pack [Rebif Rebidose]	BPCK	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
795749	{6 (0.2 ML interferon beta-1a 0.044 MG/ML Prefilled Syringe [Rebif]) / 6 (0.5 ML interferon beta-1a 0.044 MG/ML Prefilled Syringe [Rebif]) } Pack [Rebif Titration]	BPCK	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
1650268	{6 (0.2 ML interferon beta-1a 0.044 MG/ML Auto-Injector) / 6 (0.5 ML interferon beta-1a 0.044 MG/ML Auto-Injector) } Pack	GPCK	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
758030	{6 (0.2 ML interferon beta-1a 0.044 MG/ML Prefilled Syringe) / 6 (0.5 ML interferon beta-1a 0.044 MG/ML Prefilled Syringe) } Pack	GPCK	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
1649994	interferon beta-1a 22 MCG in 0.5 mL Auto-Injector	PSN	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
758029	interferon beta-1a 22 MCG in 0.5 ML Prefilled Syringe	PSN	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
1650003	interferon beta-1a 44 MCG in 0.5 mL Auto-Injector	PSN	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
758025	interferon beta-1a 44 MCG in 0.5 ML Prefilled Syringe	PSN	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
1650268	interferon beta-1a 8.8 MCG in 0.2 ML (6) Auto-Injector / interferon beta-1a 22 MCG in 0.5 ML (6) Auto-Injector Pack	PSN	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
758030	interferon beta-1a 8.8 MCG in 0.2 ML (6) Prefilled Syringe / interferon beta-1a 22 MCG in 0.5 ML (6) Prefilled Syringe Pack	PSN	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
1650011	Interferon beta-1a 8.8 MCG in 0.2 ML Auto-Injector	PSN	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
758028	interferon beta-1a 8.8 MCG in 0.2 ML Prefilled Syringe	PSN	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
1649996	Rebif 22 MCG in 0.5 ML Auto-Injector	PSN	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
758032	Rebif 22 MCG in 0.5 ML Prefilled Syringe	PSN	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
1650004	Rebif 44 MCG in 0.5 ML Auto-Injector	PSN	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
758027	Rebif 44 MCG in 0.5 ML Prefilled Syringe	PSN	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
1650012	Rebif 8.8 MCG in 0.2 ML Auto-Injector	PSN	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
795748	Rebif 8.8 MCG in 0.2 ML Prefilled Syringe	PSN	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
1650282	Rebif Rebidose Titration Pack	PSN	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
795749	Rebif Titration Pack	PSN	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
1650012	0.2 ML interferon beta-1a 0.044 MG/ML Auto-Injector [Rebif]	SBD	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
795748	0.2 ML interferon beta-1a 0.044 MG/ML Prefilled Syringe [Rebif]	SBD	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
1649996	0.5 ML interferon beta-1a 0.044 MG/ML Auto-Injector [Rebif]	SBD	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
758032	0.5 ML interferon beta-1a 0.044 MG/ML Prefilled Syringe [Rebif]	SBD	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
1650004	0.5 ML interferon beta-1a 0.088 MG/ML Auto-Injector [Rebif]	SBD	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
758027	0.5 ML interferon beta-1a 0.088 MG/ML Prefilled Syringe [Rebif]	SBD	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
1650011	0.2 ML interferon beta-1a 0.044 MG/ML Auto-Injector	SCD	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
758028	0.2 ML interferon beta-1a 0.044 MG/ML Prefilled Syringe	SCD	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
1649994	0.5 ML interferon beta-1a 0.044 MG/ML Auto-Injector	SCD	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
758029	0.5 ML interferon beta-1a 0.044 MG/ML Prefilled Syringe	SCD	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
1650003	0.5 ML interferon beta-1a 0.088 MG/ML Auto-Injector	SCD	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
758025	0.5 ML interferon beta-1a 0.088 MG/ML Prefilled Syringe	SCD	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
1650012	0.2 ML Rebif 0.044 MG/ML Auto-Injector	SY	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
795748	0.2 ML Rebif 0.044 MG/ML Prefilled Syringe	SY	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
1649996	0.5 ML Rebif 0.044 MG/ML Auto-Injector	SY	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
758032	0.5 ML Rebif 0.044 MG/ML Prefilled Syringe	SY	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
1650004	0.5 ML Rebif 0.088 MG/ML Auto-Injector	SY	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
758027	0.5 ML Rebif 0.088 MG/ML Prefilled Syringe	SY	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
758028	interferon beta-1a 0.0088 MG per 0.2 ML Prefilled Syringe	SY	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
758029	interferon beta-1a 0.022 MG per 0.5 ML Prefilled Syringe	SY	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
758025	interferon beta-1a 0.044 MG per 0.5 ML Prefilled Syringe	SY	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
1649994	interferon beta-1a 22 MCG per 0.5 ML Auto-Injector	SY	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
758029	interferon beta-1a 22 MCG per 0.5 ML Prefilled Syringe	SY	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
1650003	interferon beta-1a 44 MCG per 0.5 ML Auto-Injector	SY	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
758025	interferon beta-1a 44 MCG per 0.5 ML Prefilled Syringe	SY	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
1650011	Interferon beta-1a 8.8 MCG in 0.2 ML Auto-Injector	SY	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
758028	interferon beta-1a 8.8 MCG per 0.2 ML Prefilled Syringe	SY	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
795748	Rebif 0.0088 MG per 0.2 ML Prefilled Syringe	SY	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
758032	Rebif 0.022 MG per 0.5 ML Prefilled Syringe	SY	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
758027	Rebif 0.044 MG per 0.5 ML Prefilled Syringe	SY	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
1649996	Rebif 22 MCG per 0.5 ML Auto-Injector	SY	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
758032	Rebif 22 MCG per 0.5 ML Prefilled Syringe	SY	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
1650004	Rebif 44 MCG per 0.5 ML Auto-Injector	SY	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
758027	Rebif 44 MCG per 0.5 ML Prefilled Syringe	SY	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
1650012	Rebif 8.8 MCG per 0.2 ML Auto-Injector	SY	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
795748	Rebif 8.8 MCG per 0.2 ML Prefilled Syringe	SY	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
1650282	Rebif Rebidose Titration Pack	SY	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
795749	Rebif Titration Pack	SY	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27
795749	Rebif Titration Pack, (6 Rebif 8.8 MCG Prefilled Syringes & 6 Rebif 22 MCG Prefilled Syringes)	SY	c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f	27

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Units	Marketing start	Marketing end	Sample	Exclude flag	Status
44087-0022-3	44087002203	12 SYRINGE, GLASS in 1 CARTON (44087-0022-3) / .5 mL in 1 SYRINGE, GLASS (44087-0022-9)		2002-03-07	0000-00-00	No	No	Current
44087-0022-9	44087002209	0.5 mL in 1 SYRINGE, GLASS	0.5 ml					Historical