Esmolol Hydrochloride in Water

Product NDC
44567-812
11-digit product format
445670812
Labeler code
44567
Product ID
44567-812_0aee9e81-c563-4207-9157-8bf70a163010
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Esmolol Hydrochloride
Dosage form
INJECTION
Route
INTRAVENOUS
Labeler
WG Critical Care, LLC
Application
NDA205703
Marketing category
NDA
Marketing start
2017-12-04
Substance
ESMOLOL HYDROCHLORIDE
Active strength
20 mg/mL
Pharmacologic classes
Adrenergic beta-Antagonists [MoA], beta-Adrenergic Blocker [EPC]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 42.

Orange Book products#

Current product rows page 1 of 1 · 2 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
N205703-001ESMOLOL HYDROCHLORIDE IN PLASTIC CONTAINERESMOLOL HYDROCHLORIDE2.5GM/250ML (10MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-07
N205703-002ESMOLOL HYDROCHLORIDE DOUBLE STRENGTH IN PLASTIC CONTAINERESMOLOL HYDROCHLORIDE2GM/100ML (20MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-07

Orange Book patents#

Current patent rows page 1 of 1 · 4 matching rows.

Application-product, Patent, Expiration table
Application-productPatentExpirationUse codeCoverage / statusSubmission date
N205703-00188290542033-03-15Drug product2016-05-18
N205703-00188355052033-03-15Drug product2016-05-18
N205703-00288290542033-03-15Drug product2016-05-18
N205703-00288355052033-03-15Drug product2016-05-18

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 3 · 84 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-08-18 06:07:402026-07N205703-001ESMOLOL HYDROCHLORIDE IN PLASTIC CONTAINER2.5GM/250ML (10MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-07caaa826d4ba7…
2026-08-18 06:07:402026-07N205703-002ESMOLOL HYDROCHLORIDE DOUBLE STRENGTH IN PLASTIC CONTAINER2GM/100ML (20MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-07caaa826d4ba7…
2026-02-19 14:30 UTC2026-02N205703-001ESMOLOL HYDROCHLORIDE IN PLASTIC CONTAINER2.5GM/250ML (10MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-07011fe1cb6892…
2026-02-19 14:30 UTC2026-02N205703-002ESMOLOL HYDROCHLORIDE DOUBLE STRENGTH IN PLASTIC CONTAINER2GM/100ML (20MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-07011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N205703-001ESMOLOL HYDROCHLORIDE IN PLASTIC CONTAINER2.5GM/250ML (10MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-0731067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N205703-002ESMOLOL HYDROCHLORIDE DOUBLE STRENGTH IN PLASTIC CONTAINER2GM/100ML (20MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-0731067a03dcf5…
2025-08-23 18:47 UTC2025-08N205703-001ESMOLOL HYDROCHLORIDE IN PLASTIC CONTAINER2.5GM/250ML (10MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-076a471c1ec25d…
2025-08-23 18:47 UTC2025-08N205703-002ESMOLOL HYDROCHLORIDE DOUBLE STRENGTH IN PLASTIC CONTAINER2GM/100ML (20MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-076a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N205703-001ESMOLOL HYDROCHLORIDE IN PLASTIC CONTAINER2.5GM/250ML (10MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-07fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N205703-002ESMOLOL HYDROCHLORIDE DOUBLE STRENGTH IN PLASTIC CONTAINER2GM/100ML (20MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-07fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N205703-001ESMOLOL HYDROCHLORIDE IN PLASTIC CONTAINER2.5GM/250ML (10MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-07b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N205703-002ESMOLOL HYDROCHLORIDE DOUBLE STRENGTH IN PLASTIC CONTAINER2GM/100ML (20MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-07b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N205703-001ESMOLOL HYDROCHLORIDE IN PLASTIC CONTAINER2.5GM/250ML (10MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-0703ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N205703-002ESMOLOL HYDROCHLORIDE DOUBLE STRENGTH IN PLASTIC CONTAINER2GM/100ML (20MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-0703ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N205703-001ESMOLOL HYDROCHLORIDE IN PLASTIC CONTAINER2.5GM/250ML (10MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-072680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N205703-002ESMOLOL HYDROCHLORIDE DOUBLE STRENGTH IN PLASTIC CONTAINER2GM/100ML (20MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-072680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N205703-001ESMOLOL HYDROCHLORIDE IN PLASTIC CONTAINER2.5GM/250ML (10MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-075bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N205703-002ESMOLOL HYDROCHLORIDE DOUBLE STRENGTH IN PLASTIC CONTAINER2GM/100ML (20MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-075bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N205703-001ESMOLOL HYDROCHLORIDE IN PLASTIC CONTAINER2.5GM/250ML (10MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-07d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N205703-002ESMOLOL HYDROCHLORIDE DOUBLE STRENGTH IN PLASTIC CONTAINER2GM/100ML (20MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-07d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N205703-001ESMOLOL HYDROCHLORIDE IN PLASTIC CONTAINER2.5GM/250ML (10MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-07d06236e962d9…
2024-10-29 15:01 UTC2024-10N205703-002ESMOLOL HYDROCHLORIDE DOUBLE STRENGTH IN PLASTIC CONTAINER2GM/100ML (20MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-07d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N205703-001ESMOLOL HYDROCHLORIDE IN PLASTIC CONTAINER2.5GM/250ML (10MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-0779d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N205703-002ESMOLOL HYDROCHLORIDE DOUBLE STRENGTH IN PLASTIC CONTAINER2GM/100ML (20MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-0779d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N205703-001ESMOLOL HYDROCHLORIDE IN PLASTIC CONTAINER2.5GM/250ML (10MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-07301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N205703-002ESMOLOL HYDROCHLORIDE DOUBLE STRENGTH IN PLASTIC CONTAINER2GM/100ML (20MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-07301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N205703-001ESMOLOL HYDROCHLORIDE IN PLASTIC CONTAINER2.5GM/250ML (10MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-071e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N205703-002ESMOLOL HYDROCHLORIDE DOUBLE STRENGTH IN PLASTIC CONTAINER2GM/100ML (20MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-071e350fbaab3a…
2024-05-31 18:47 UTC2024-05N205703-001ESMOLOL HYDROCHLORIDE IN PLASTIC CONTAINER2.5GM/250ML (10MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-078072bd15b7f6…
2024-05-31 18:47 UTC2024-05N205703-002ESMOLOL HYDROCHLORIDE DOUBLE STRENGTH IN PLASTIC CONTAINER2GM/100ML (20MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-078072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N205703-001ESMOLOL HYDROCHLORIDE IN PLASTIC CONTAINER2.5GM/250ML (10MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-075c6f7cd8ea54…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N205703-002ESMOLOL HYDROCHLORIDE DOUBLE STRENGTH IN PLASTIC CONTAINER2GM/100ML (20MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-075c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04N205703-001ESMOLOL HYDROCHLORIDE IN PLASTIC CONTAINER2.5GM/250ML (10MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-075d02ea3f76ae…
2022-04-08 23:34 UTC2022-04N205703-002ESMOLOL HYDROCHLORIDE DOUBLE STRENGTH IN PLASTIC CONTAINER2GM/100ML (20MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-075d02ea3f76ae…
2022-04-04 05:41 UTC2022-04N205703-001ESMOLOL HYDROCHLORIDE IN PLASTIC CONTAINER2.5GM/250ML (10MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-074b0b4de00fa7…
2022-04-04 05:41 UTC2022-04N205703-002ESMOLOL HYDROCHLORIDE DOUBLE STRENGTH IN PLASTIC CONTAINER2GM/100ML (20MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-074b0b4de00fa7…
2019-12-13 00:20 UTC2019-12N205703-001ESMOLOL HYDROCHLORIDE IN PLASTIC CONTAINER2.5GM/250ML (10MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-0774a2ff9319b5…
2019-12-13 00:20 UTC2019-12N205703-002ESMOLOL HYDROCHLORIDE DOUBLE STRENGTH IN PLASTIC CONTAINER2GM/100ML (20MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-0774a2ff9319b5…
2022-03-09 01:35 UTC2022-03N205703-001ESMOLOL HYDROCHLORIDE IN PLASTIC CONTAINER2.5GM/250ML (10MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-07bb7c543d1eb4…
2022-03-09 01:35 UTC2022-03N205703-002ESMOLOL HYDROCHLORIDE DOUBLE STRENGTH IN PLASTIC CONTAINER2GM/100ML (20MG/ML)SOLUTION / INTRAVENOUSRLD, RS2016-04-07bb7c543d1eb4…

Observed Orange Book patent history#

Patent history page 1 of 6 · 204 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productPatentExpirationUse codeCoverage / statusSubmission dateSource SHA-256
2026-08-18 06:07:402026-07N205703-00188290542033-03-15Drug product2016-05-18caaa826d4ba7…
2026-08-18 06:07:402026-07N205703-00188355052033-03-15Drug product2016-05-18caaa826d4ba7…
2026-08-18 06:07:402026-07N205703-00288290542033-03-15Drug product2016-05-18caaa826d4ba7…
2026-08-18 06:07:402026-07N205703-00288355052033-03-15Drug product2016-05-18caaa826d4ba7…
2026-02-19 14:30 UTC2026-02N205703-00188290542033-03-15Drug product2016-05-18011fe1cb6892…
2026-02-19 14:30 UTC2026-02N205703-00188355052033-03-15Drug product2016-05-18011fe1cb6892…
2026-02-19 14:30 UTC2026-02N205703-00288290542033-03-15Drug product2016-05-18011fe1cb6892…
2026-02-19 14:30 UTC2026-02N205703-00288355052033-03-15Drug product2016-05-18011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N205703-00188290542033-03-15Drug product2016-05-1831067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N205703-00188355052033-03-15Drug product2016-05-1831067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N205703-00288290542033-03-15Drug product2016-05-1831067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N205703-00288355052033-03-15Drug product2016-05-1831067a03dcf5…
2025-08-23 18:47 UTC2025-08N205703-00188290542033-03-15Drug product2016-05-186a471c1ec25d…
2025-08-23 18:47 UTC2025-08N205703-00188355052033-03-15Drug product2016-05-186a471c1ec25d…
2025-08-23 18:47 UTC2025-08N205703-00288290542033-03-15Drug product2016-05-186a471c1ec25d…
2025-08-23 18:47 UTC2025-08N205703-00288355052033-03-15Drug product2016-05-186a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N205703-00188290542033-03-15Drug product2016-05-18fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N205703-00188355052033-03-15Drug product2016-05-18fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N205703-00288290542033-03-15Drug product2016-05-18fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N205703-00288355052033-03-15Drug product2016-05-18fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N205703-00188290542033-03-15Drug product2016-05-18b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N205703-00188355052033-03-15Drug product2016-05-18b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N205703-00288290542033-03-15Drug product2016-05-18b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N205703-00288355052033-03-15Drug product2016-05-18b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N205703-00188290542033-03-15Drug product2016-05-1803ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N205703-00188355052033-03-15Drug product2016-05-1803ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N205703-00288290542033-03-15Drug product2016-05-1803ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N205703-00288355052033-03-15Drug product2016-05-1803ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N205703-00188290542033-03-15Drug product2016-05-182680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N205703-00188355052033-03-15Drug product2016-05-182680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N205703-00288290542033-03-15Drug product2016-05-182680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N205703-00288355052033-03-15Drug product2016-05-182680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N205703-00188290542033-03-15Drug product2016-05-185bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N205703-00188355052033-03-15Drug product2016-05-185bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N205703-00288290542033-03-15Drug product2016-05-185bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N205703-00288355052033-03-15Drug product2016-05-185bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N205703-00188290542033-03-15Drug product2016-05-18d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N205703-00188355052033-03-15Drug product2016-05-18d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N205703-00288290542033-03-15Drug product2016-05-18d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N205703-00288355052033-03-15Drug product2016-05-18d8e5a09893c0…

Additional Listing Data#

Finished product
Yes
Brand name base
Esmolol Hydrochloride in Water
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
ESMOLOL HYDROCHLORIDE20 mg/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
V05260LC8DInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
979432Internal RxNorm lookup
1736541Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
60b10020-f802-4fef-a487-0f11eca246c5Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
ab3d10ea-fe48-4811-8e72-bb51600b35f9Product name520230103
9cb9173b-3912-466b-8256-366e71d49fceProduct name120190402

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
44567-812-10Esmolol Hydrochloride in Water100 mL in 1 BAGINJECTION10010
44567-812-10Esmolol Hydrochloride in Water10 in 1 CARTONINJECTION1010

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
44567-812-10ML - Milliliter44567-812c5309b17-bb75-4113-acae-a0b94b03dbf412018-03-08

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
44567-812ESMOLOL HYDROCHLORIDE IN WATER (ESMOLOL HYDROCHLORIDE) INJECTION [WG CRITICAL CARE, LLC]10Current NDC, Legacy NDC, 2 package rows20240809_60b10020-f802-4fef-a487-0f11eca246c5.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Esmolol Hydrochloride in WaterESMOLOL HYDROCHLORIDEWG Critical Care, LLC60b10020-f802-4fef-a487-0f11eca246c52024-05-31Warnings, Adverse reactionsExact identifier
application applno (NDA): 205703
application number: NDA205703
ndc (product): 44567-812

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
979432esmolol HCl 2000 MG in 100 ML InjectionPSN60b10020-f802-4fef-a487-0f11eca246c510
1736541esmolol HCl 2500 MG in 250 ML InjectionPSN60b10020-f802-4fef-a487-0f11eca246c510
979432100 ML esmolol hydrochloride 20 MG/ML InjectionSCD60b10020-f802-4fef-a487-0f11eca246c510
1736541250 ML esmolol hydrochloride 10 MG/ML InjectionSCD60b10020-f802-4fef-a487-0f11eca246c510
979432esmolol HCl 2000 MG per 100 ML InjectionSY60b10020-f802-4fef-a487-0f11eca246c510
1736541esmolol HCl 2500 MG per 250 ML InjectionSY60b10020-f802-4fef-a487-0f11eca246c510

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
44567-812-104456708121010 BAG in 1 CARTON (44567-812-10) / 100 mL in 1 BAG10 bag2017-12-040000-00-00NoNoCurrent