doxycycline hyclate

Product NDC
46708-362
11-digit product format
467080362
Labeler code
46708
Product ID
46708-362_aec76b17-b6ca-41f3-b39b-65b7b3dd5972
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
doxycycline hyclate
Dosage form
CAPSULE
Route
ORAL
Labeler
Alembic Pharmaceuticals Limited
Application
ANDA210527
Marketing category
ANDA
Marketing start
2018-06-18
Substance
DOXYCYCLINE HYCLATE
Active strength
50 mg/1
Pharmacologic classes
Tetracycline-class Drug [EPC], Tetracyclines [CS]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 2 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A210527-001DOXYCYCLINE HYCLATEDOXYCYCLINE HYCLATEEQ 50MG BASECAPSULE / ORALAB2018-06-13
A210527-002DOXYCYCLINE HYCLATEDOXYCYCLINE HYCLATEEQ 100MG BASECAPSULE / ORALAB2018-06-13

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 2 matching rows.

Application-product, TE code table
Application-productTE code
A210527-001AB
A210527-002AB

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 3 · 82 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02A210527-001DOXYCYCLINE HYCLATEEQ 50MG BASECAPSULE / ORALAB2018-06-13011fe1cb6892…
2026-02-19 14:30 UTC2026-02A210527-002DOXYCYCLINE HYCLATEEQ 100MG BASECAPSULE / ORALAB2018-06-13011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A210527-001DOXYCYCLINE HYCLATEEQ 50MG BASECAPSULE / ORALAB2018-06-1331067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A210527-002DOXYCYCLINE HYCLATEEQ 100MG BASECAPSULE / ORALAB2018-06-1331067a03dcf5…
2025-08-23 18:47 UTC2025-08A210527-001DOXYCYCLINE HYCLATEEQ 50MG BASECAPSULE / ORALAB2018-06-136a471c1ec25d…
2025-08-23 18:47 UTC2025-08A210527-002DOXYCYCLINE HYCLATEEQ 100MG BASECAPSULE / ORALAB2018-06-136a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A210527-001DOXYCYCLINE HYCLATEEQ 50MG BASECAPSULE / ORALAB2018-06-13fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A210527-002DOXYCYCLINE HYCLATEEQ 100MG BASECAPSULE / ORALAB2018-06-13fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A210527-001DOXYCYCLINE HYCLATEEQ 50MG BASECAPSULE / ORALAB2018-06-13b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A210527-002DOXYCYCLINE HYCLATEEQ 100MG BASECAPSULE / ORALAB2018-06-13b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A210527-001DOXYCYCLINE HYCLATEEQ 50MG BASECAPSULE / ORALAB2018-06-1303ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A210527-002DOXYCYCLINE HYCLATEEQ 100MG BASECAPSULE / ORALAB2018-06-1303ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A210527-001DOXYCYCLINE HYCLATEEQ 50MG BASECAPSULE / ORALAB2018-06-132680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A210527-002DOXYCYCLINE HYCLATEEQ 100MG BASECAPSULE / ORALAB2018-06-132680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A210527-001DOXYCYCLINE HYCLATEEQ 50MG BASECAPSULE / ORALAB2018-06-135bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A210527-002DOXYCYCLINE HYCLATEEQ 100MG BASECAPSULE / ORALAB2018-06-135bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A210527-001DOXYCYCLINE HYCLATEEQ 50MG BASECAPSULE / ORALAB2018-06-13d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A210527-002DOXYCYCLINE HYCLATEEQ 100MG BASECAPSULE / ORALAB2018-06-13d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A210527-001DOXYCYCLINE HYCLATEEQ 50MG BASECAPSULE / ORALAB2018-06-13d06236e962d9…
2024-10-29 15:01 UTC2024-10A210527-002DOXYCYCLINE HYCLATEEQ 100MG BASECAPSULE / ORALAB2018-06-13d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A210527-001DOXYCYCLINE HYCLATEEQ 50MG BASECAPSULE / ORALAB2018-06-1379d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A210527-002DOXYCYCLINE HYCLATEEQ 100MG BASECAPSULE / ORALAB2018-06-1379d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A210527-001DOXYCYCLINE HYCLATEEQ 50MG BASECAPSULE / ORALAB2018-06-13301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A210527-002DOXYCYCLINE HYCLATEEQ 100MG BASECAPSULE / ORALAB2018-06-13301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A210527-001DOXYCYCLINE HYCLATEEQ 50MG BASECAPSULE / ORALAB2018-06-131e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A210527-002DOXYCYCLINE HYCLATEEQ 100MG BASECAPSULE / ORALAB2018-06-131e350fbaab3a…
2024-05-31 18:47 UTC2024-05A210527-001DOXYCYCLINE HYCLATEEQ 50MG BASECAPSULE / ORALAB2018-06-138072bd15b7f6…
2024-05-31 18:47 UTC2024-05A210527-002DOXYCYCLINE HYCLATEEQ 100MG BASECAPSULE / ORALAB2018-06-138072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A210527-001DOXYCYCLINE HYCLATEEQ 50MG BASECAPSULE / ORALAB2018-06-135c6f7cd8ea54…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A210527-002DOXYCYCLINE HYCLATEEQ 100MG BASECAPSULE / ORALAB2018-06-135c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A210527-001DOXYCYCLINE HYCLATEEQ 50MG BASECAPSULE / ORALAB2018-06-135d02ea3f76ae…
2022-04-08 23:34 UTC2022-04A210527-002DOXYCYCLINE HYCLATEEQ 100MG BASECAPSULE / ORALAB2018-06-135d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A210527-001DOXYCYCLINE HYCLATEEQ 50MG BASECAPSULE / ORALAB2018-06-134b0b4de00fa7…
2022-04-04 05:41 UTC2022-04A210527-002DOXYCYCLINE HYCLATEEQ 100MG BASECAPSULE / ORALAB2018-06-134b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A210527-001DOXYCYCLINE HYCLATEEQ 50MG BASECAPSULE / ORALAB2018-06-1374a2ff9319b5…
2019-12-13 00:20 UTC2019-12A210527-002DOXYCYCLINE HYCLATEEQ 100MG BASECAPSULE / ORALAB2018-06-1374a2ff9319b5…
2022-03-09 01:35 UTC2022-03A210527-001DOXYCYCLINE HYCLATEEQ 50MG BASECAPSULE / ORALAB2018-06-13bb7c543d1eb4…
2022-03-09 01:35 UTC2022-03A210527-002DOXYCYCLINE HYCLATEEQ 100MG BASECAPSULE / ORALAB2018-06-13bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A210527-001DOXYCYCLINE HYCLATEEQ 50MG BASECAPSULE / ORALAB2018-06-13782e0a99824c…
2021-12-28 21:50 UTC2021-12A210527-002DOXYCYCLINE HYCLATEEQ 100MG BASECAPSULE / ORALAB2018-06-13782e0a99824c…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 3 · 82 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02A210527-001AB1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A210527-002AB1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A210527-001AB131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A210527-002AB131067a03dcf5…
2025-08-23 18:47 UTC2025-08A210527-001AB16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A210527-002AB16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A210527-001AB1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A210527-002AB1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A210527-001AB1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A210527-002AB1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A210527-001AB103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A210527-002AB103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A210527-001AB12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A210527-002AB12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A210527-001AB15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A210527-002AB15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A210527-001AB1d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A210527-002AB1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A210527-001AB1d06236e962d9…
2024-10-29 15:01 UTC2024-10A210527-002AB1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A210527-001AB179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A210527-002AB179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A210527-001AB1301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A210527-002AB1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A210527-001AB11e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A210527-002AB11e350fbaab3a…
2024-05-31 18:47 UTC2024-05A210527-001AB18072bd15b7f6…
2024-05-31 18:47 UTC2024-05A210527-002AB18072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A210527-001AB15c6f7cd8ea54…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A210527-002AB15c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A210527-001AB15d02ea3f76ae…
2022-04-08 23:34 UTC2022-04A210527-002AB15d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A210527-001AB14b0b4de00fa7…
2022-04-04 05:41 UTC2022-04A210527-002AB14b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A210527-001AB174a2ff9319b5…
2019-12-13 00:20 UTC2019-12A210527-002AB174a2ff9319b5…
2022-03-09 01:35 UTC2022-03A210527-001AB1bb7c543d1eb4…
2022-03-09 01:35 UTC2022-03A210527-002AB1bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A210527-001AB1782e0a99824c…
2021-12-28 21:50 UTC2021-12A210527-002AB1782e0a99824c…

Additional Listing Data#

Finished product
Yes
Brand name base
doxycycline hyclate
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
DOXYCYCLINE HYCLATE50 mg/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
19XTS3T51UInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1649405Internal RxNorm lookup
1649988Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
e567b431-53fe-4e27-9b05-bf6eeb8abb51Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
b4321c75-2e87-4d90-9726-9a28fb2293a3Product name320260112
5e99724e-0654-4aec-b7a2-0b9b10e312eeProduct name320250227
d2d36660-68ce-7e7d-0630-ec4b0d859fadProduct name620220921
a239f4dd-cf93-4660-b190-f97d000f249fProduct name720210607
a9d03566-caeb-4466-8021-74599b048880Product name320210604
12750814-20f7-4f35-b5fa-dbc8811ba858Product name920201007
00a5dbaa-1b7d-4e56-be0c-fedc7bbf5adeProduct name120200706
7b4b06ac-8c50-45f0-9556-293ea558a294Product name120180808
6a5b4392-5ab0-af0d-e0be-47b34e9dbb84Product name520171121
01a4aa74-7e05-63bd-bc10-1b5ceb111371Product name220171115
58b1278c-6dce-49b6-a05e-ea16f389acbaProduct name120160620

FDA-Initiated Inactive NDC Indexing#

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
46708-362-50doxycycline hyclate50 in 1 BOTTLECAPSULE503
46708-362-71doxycycline hyclate500 in 1 BOTTLECAPSULE5003

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
46708-362DOXYCYCLINE HYCLATE CAPSULE [ALEMBIC PHARMACEUTICALS LIMITED]3Current NDC, Legacy NDC, 2 package rows20231212_e567b431-53fe-4e27-9b05-bf6eeb8abb51.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 2 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
doxycycline hyclateDOXYCYCLINE HYCLATEAlembic Pharmaceuticals Inc.131af052-0c4f-4a61-ae9a-e6165ae090762025-08-19Warnings, Adverse reactionsExact identifier
application applno (ANDA): 210527
application number: ANDA210527
doxycycline hyclateDOXYCYCLINE HYCLATEAlembic Pharmaceuticals Limitede567b431-53fe-4e27-9b05-bf6eeb8abb512023-12-11Warnings, Adverse reactionsExact identifier
application applno (ANDA): 210527
application number: ANDA210527
ndc (product): 46708-362

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
1649988doxycycline hyclate 100 MG Oral CapsulePSNe567b431-53fe-4e27-9b05-bf6eeb8abb513
1649405doxycycline hyclate 50 MG Oral CapsulePSNe567b431-53fe-4e27-9b05-bf6eeb8abb513
1649988doxycycline hyclate 100 MG Oral CapsuleSCDe567b431-53fe-4e27-9b05-bf6eeb8abb513
1649405doxycycline hyclate 50 MG Oral CapsuleSCDe567b431-53fe-4e27-9b05-bf6eeb8abb513
1649988doxycycline (as doxycycline hyclate) 100 MG Oral CapsuleSYe567b431-53fe-4e27-9b05-bf6eeb8abb513

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
46708-362-504670803625050 CAPSULE in 1 BOTTLE (46708-362-50) 50 capsule2018-06-180000-00-00NoNoCurrent
46708-362-7146708036271500 CAPSULE in 1 BOTTLE (46708-362-71) 500 capsule2018-06-180000-00-00NoNoCurrent