Promethazine Hydrochloride

Product NDC
50090-5362
Requested package NDC
50090-5362-1
11-digit product format
500905362
Labeler code
50090
Product ID
50090-5362_adc38191-6564-4b9e-beea-13c792d566c4
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Promethazine Hydrochloride
Dosage form
SUPPOSITORY
Route
RECTAL
Labeler
A-S Medication Solutions
Application
ANDA040428
Marketing category
ANDA
Marketing start
2015-06-01
Marketing end
0000-00-00
Substance
PROMETHAZINE HYDROCHLORIDE
Active strength
25 mg/1
Pharmacologic classes
Phenothiazine [EPC],Phenothiazines [CS]
NDC exclude flag
No
Listing certified through
2022-12-31
Current FDA listing
Historical FDA.report record

NDC auxiliary status#

These records are reproduced from FDA’s unfinished, excluded, and compounder listings. They describe what appeared in the source files; a missing record does not establish a regulatory status. View all current auxiliary records, including entries without an NDC. · View the auxiliary file history.

Current NDC status page 1 of 1 · 1 matching rows.

Dataset, Scope, Product NDC table
DatasetScopeProduct NDCPackage NDCCodeStatusReporting periodSource date
excluded packagepackage50090-536250090-5362-1DDiscontinued by firm2026-08-03

Observed NDC auxiliary status history#

This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.

Historic NDC status page 1 of 1 · 11 matching rows.

View current auxiliary records. · View the auxiliary file history.

Captured / source date, Snapshot, Source SHA-256 table
Captured / source dateSnapshotSource SHA-256
2025-12-14 17:58 UTC · source 2025-12-05d630ba8d3edf…732f749b63fb…
2025-08-27 00:01 UTC · source 2025-08-26f5e01cc5f278…a2eaf40c39c3…
2025-04-01 02:39 UTC · source 2025-03-312ef7874e63bc…57b86245f4fa…
2025-03-28 20:22 UTC · source 2025-03-28a1b67e2a42f9…c4cf2c586c0d…
2025-03-22 03:12 UTC · source 2025-03-21cfe11265f3b6…090c488252e2…
2025-03-10 12:48 UTC · source 2025-03-10cdf11ea48f46…ba0047e9e063…
2025-02-02 03:52 UTC · source 2025-01-31302b2466d912…e7b80fea0513…
2025-01-20 13:05 UTC · source 2025-01-20ed331223b511…672a5bd82f5f…
2025-01-11 03:41 UTC · source 2025-01-100efc9e666f02…f202fb6c5f17…
2024-11-09 02:27 UTC · source 2024-11-08ad56d346431e…cc804d4bbf1e…
2024-10-04 04:10 UTC · source 2024-10-03367a005e9d99…383a685ebd0f…

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 2 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A040428-001PROMETHAZINE HYDROCHLORIDEPROMETHAZINE HYDROCHLORIDE25MGSUPPOSITORY / RECTALABRS2002-02-05
A040428-002PROMETHAZINE HYDROCHLORIDEPROMETHAZINE HYDROCHLORIDE12.5MGSUPPOSITORY / RECTALAB2003-03-31

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 2 matching rows.

Application-product, TE code table
Application-productTE code
A040428-001AB
A040428-002AB

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 3 · 82 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02A040428-001PROMETHAZINE HYDROCHLORIDE25MGSUPPOSITORY / RECTALABRS2002-02-05011fe1cb6892…
2026-02-19 14:30 UTC2026-02A040428-002PROMETHAZINE HYDROCHLORIDE12.5MGSUPPOSITORY / RECTALAB2003-03-31011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A040428-001PROMETHAZINE HYDROCHLORIDE25MGSUPPOSITORY / RECTALABRS2002-02-0531067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A040428-002PROMETHAZINE HYDROCHLORIDE12.5MGSUPPOSITORY / RECTALAB2003-03-3131067a03dcf5…
2025-08-23 18:47 UTC2025-08A040428-001PROMETHAZINE HYDROCHLORIDE25MGSUPPOSITORY / RECTALABRS2002-02-056a471c1ec25d…
2025-08-23 18:47 UTC2025-08A040428-002PROMETHAZINE HYDROCHLORIDE12.5MGSUPPOSITORY / RECTALAB2003-03-316a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A040428-001PROMETHAZINE HYDROCHLORIDE25MGSUPPOSITORY / RECTALABRS2002-02-05fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A040428-002PROMETHAZINE HYDROCHLORIDE12.5MGSUPPOSITORY / RECTALAB2003-03-31fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A040428-001PROMETHAZINE HYDROCHLORIDE25MGSUPPOSITORY / RECTALABRS2002-02-05b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A040428-002PROMETHAZINE HYDROCHLORIDE12.5MGSUPPOSITORY / RECTALAB2003-03-31b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A040428-001PROMETHAZINE HYDROCHLORIDE25MGSUPPOSITORY / RECTALABRS2002-02-0503ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A040428-002PROMETHAZINE HYDROCHLORIDE12.5MGSUPPOSITORY / RECTALAB2003-03-3103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A040428-001PROMETHAZINE HYDROCHLORIDE25MGSUPPOSITORY / RECTALABRS2002-02-052680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A040428-002PROMETHAZINE HYDROCHLORIDE12.5MGSUPPOSITORY / RECTALAB2003-03-312680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A040428-001PROMETHAZINE HYDROCHLORIDE25MGSUPPOSITORY / RECTALABRS2002-02-055bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A040428-002PROMETHAZINE HYDROCHLORIDE12.5MGSUPPOSITORY / RECTALAB2003-03-315bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A040428-001PROMETHAZINE HYDROCHLORIDE25MGSUPPOSITORY / RECTALABRS2002-02-05d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A040428-002PROMETHAZINE HYDROCHLORIDE12.5MGSUPPOSITORY / RECTALAB2003-03-31d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A040428-001PROMETHAZINE HYDROCHLORIDE25MGSUPPOSITORY / RECTALABRS2002-02-05d06236e962d9…
2024-10-29 15:01 UTC2024-10A040428-002PROMETHAZINE HYDROCHLORIDE12.5MGSUPPOSITORY / RECTALAB2003-03-31d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A040428-001PROMETHAZINE HYDROCHLORIDE25MGSUPPOSITORY / RECTALABRS2002-02-0579d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A040428-002PROMETHAZINE HYDROCHLORIDE12.5MGSUPPOSITORY / RECTALAB2003-03-3179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A040428-001PROMETHAZINE HYDROCHLORIDE25MGSUPPOSITORY / RECTALABRS2002-02-05301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A040428-002PROMETHAZINE HYDROCHLORIDE12.5MGSUPPOSITORY / RECTALAB2003-03-31301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A040428-001PROMETHAZINE HYDROCHLORIDE25MGSUPPOSITORY / RECTALABRS2002-02-051e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A040428-002PROMETHAZINE HYDROCHLORIDE12.5MGSUPPOSITORY / RECTALAB2003-03-311e350fbaab3a…
2024-05-31 18:47 UTC2024-05A040428-001PROMETHAZINE HYDROCHLORIDE25MGSUPPOSITORY / RECTALABRS2002-02-058072bd15b7f6…
2024-05-31 18:47 UTC2024-05A040428-002PROMETHAZINE HYDROCHLORIDE12.5MGSUPPOSITORY / RECTALAB2003-03-318072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A040428-001PROMETHAZINE HYDROCHLORIDE25MGSUPPOSITORY / RECTALABRS2002-02-055c6f7cd8ea54…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A040428-002PROMETHAZINE HYDROCHLORIDE12.5MGSUPPOSITORY / RECTALAB2003-03-315c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A040428-001PROMETHAZINE HYDROCHLORIDE25MGSUPPOSITORY / RECTALABRS2002-02-055d02ea3f76ae…
2022-04-08 23:34 UTC2022-04A040428-002PROMETHAZINE HYDROCHLORIDE12.5MGSUPPOSITORY / RECTALAB2003-03-315d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A040428-001PROMETHAZINE HYDROCHLORIDE25MGSUPPOSITORY / RECTALABRS2002-02-054b0b4de00fa7…
2022-04-04 05:41 UTC2022-04A040428-002PROMETHAZINE HYDROCHLORIDE12.5MGSUPPOSITORY / RECTALAB2003-03-314b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A040428-001PROMETHAZINE HYDROCHLORIDE25MGSUPPOSITORY / RECTALABRS2002-02-0574a2ff9319b5…
2019-12-13 00:20 UTC2019-12A040428-002PROMETHAZINE HYDROCHLORIDE12.5MGSUPPOSITORY / RECTALAB2003-03-3174a2ff9319b5…
2022-03-09 01:35 UTC2022-03A040428-001PROMETHAZINE HYDROCHLORIDE25MGSUPPOSITORY / RECTALABRS2002-02-05bb7c543d1eb4…
2022-03-09 01:35 UTC2022-03A040428-002PROMETHAZINE HYDROCHLORIDE12.5MGSUPPOSITORY / RECTALAB2003-03-31bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A040428-001PROMETHAZINE HYDROCHLORIDE25MGSUPPOSITORY / RECTALABRS2002-02-05782e0a99824c…
2021-12-28 21:50 UTC2021-12A040428-002PROMETHAZINE HYDROCHLORIDE12.5MGSUPPOSITORY / RECTALAB2003-03-31782e0a99824c…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 3 · 82 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02A040428-001AB1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A040428-002AB1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A040428-001AB131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A040428-002AB131067a03dcf5…
2025-08-23 18:47 UTC2025-08A040428-001AB16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A040428-002AB16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A040428-001AB1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A040428-002AB1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A040428-001AB1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A040428-002AB1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A040428-001AB103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A040428-002AB103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A040428-001AB12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A040428-002AB12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A040428-001AB15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A040428-002AB15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A040428-001AB1d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A040428-002AB1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A040428-001AB1d06236e962d9…
2024-10-29 15:01 UTC2024-10A040428-002AB1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A040428-001AB179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A040428-002AB179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A040428-001AB1301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A040428-002AB1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A040428-001AB11e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A040428-002AB11e350fbaab3a…
2024-05-31 18:47 UTC2024-05A040428-001AB18072bd15b7f6…
2024-05-31 18:47 UTC2024-05A040428-002AB18072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A040428-001AB15c6f7cd8ea54…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A040428-002AB15c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A040428-001AB15d02ea3f76ae…
2022-04-08 23:34 UTC2022-04A040428-002AB15d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A040428-001AB14b0b4de00fa7…
2022-04-04 05:41 UTC2022-04A040428-002AB14b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A040428-001AB174a2ff9319b5…
2019-12-13 00:20 UTC2019-12A040428-002AB174a2ff9319b5…
2022-03-09 01:35 UTC2022-03A040428-001AB1bb7c543d1eb4…
2022-03-09 01:35 UTC2022-03A040428-002AB1bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A040428-001AB1782e0a99824c…
2021-12-28 21:50 UTC2021-12A040428-002AB1782e0a99824c…

FDA-Initiated Inactive NDC Indexing#

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 2 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
PROMETHEGANPROMETHAZINE HYDROCHLORIDEPD-Rx Pharmaceuticals, Inc.6b72dcf9-a4a1-4cc1-b7c2-a0bc2740fe972025-10-20Boxed warning, Adverse reactionsExact identifier
application applno (ANDA): 040428
application number: ANDA040428
PROMETHEGANPROMETHAZINE HYDROCHLORIDECosette Pharmaceuticals, Inc.5f079815-f48b-8b21-2130-7f791d967c9a2023-11-30Boxed warning, Adverse reactionsExact identifier
application applno (ANDA): 040428
application number: ANDA040428

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
50090-5362-1500905362014 BLISTER PACK in 1 CARTON (50090-5362-1) > 1 SUPPOSITORY in 1 BLISTER PACK4 blister pack2020-11-170000-00-00NoNoCurrent