Metolazone

Product NDC
50742-350
11-digit product format
507420350
Labeler code
50742
Product ID
50742-350_40a518ac-5d45-4c61-e063-6294a90a6ec9
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Metolazone
Dosage form
TABLET
Route
ORAL
Labeler
Ingenus Pharmaceuticals LLC
Application
ANDA215616
Marketing category
ANDA
Marketing start
2023-01-24
Substance
METOLAZONE
Active strength
5 mg/1
Pharmacologic classes
Increased Diuresis [PE], Thiazide-like Diuretic [EPC]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 3 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A215616-001METOLAZONEMETOLAZONE2.5MGTABLET / ORALAB2022-10-24
A215616-002METOLAZONEMETOLAZONE5MGTABLET / ORALAB2022-10-24
A215616-003METOLAZONEMETOLAZONE10MGTABLET / ORALAB2022-10-24

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 3 matching rows.

Application-product, TE code table
Application-productTE code
A215616-001AB
A215616-002AB
A215616-003AB

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 75 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02A215616-001METOLAZONE2.5MGTABLET / ORALAB2022-10-24011fe1cb6892…
2026-02-19 14:30 UTC2026-02A215616-002METOLAZONE5MGTABLET / ORALAB2022-10-24011fe1cb6892…
2026-02-19 14:30 UTC2026-02A215616-003METOLAZONE10MGTABLET / ORALAB2022-10-24011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A215616-001METOLAZONE2.5MGTABLET / ORALAB2022-10-2431067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A215616-002METOLAZONE5MGTABLET / ORALAB2022-10-2431067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A215616-003METOLAZONE10MGTABLET / ORALAB2022-10-2431067a03dcf5…
2025-08-23 18:47 UTC2025-08A215616-001METOLAZONE2.5MGTABLET / ORALAB2022-10-246a471c1ec25d…
2025-08-23 18:47 UTC2025-08A215616-002METOLAZONE5MGTABLET / ORALAB2022-10-246a471c1ec25d…
2025-08-23 18:47 UTC2025-08A215616-003METOLAZONE10MGTABLET / ORALAB2022-10-246a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A215616-001METOLAZONE2.5MGTABLET / ORALAB2022-10-24fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A215616-002METOLAZONE5MGTABLET / ORALAB2022-10-24fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A215616-003METOLAZONE10MGTABLET / ORALAB2022-10-24fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A215616-001METOLAZONE2.5MGTABLET / ORALAB2022-10-24b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A215616-002METOLAZONE5MGTABLET / ORALAB2022-10-24b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A215616-003METOLAZONE10MGTABLET / ORALAB2022-10-24b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A215616-001METOLAZONE2.5MGTABLET / ORALAB2022-10-2403ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A215616-002METOLAZONE5MGTABLET / ORALAB2022-10-2403ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A215616-003METOLAZONE10MGTABLET / ORALAB2022-10-2403ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A215616-001METOLAZONE2.5MGTABLET / ORALAB2022-10-242680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A215616-002METOLAZONE5MGTABLET / ORALAB2022-10-242680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A215616-003METOLAZONE10MGTABLET / ORALAB2022-10-242680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A215616-001METOLAZONE2.5MGTABLET / ORALAB2022-10-245bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A215616-002METOLAZONE5MGTABLET / ORALAB2022-10-245bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A215616-003METOLAZONE10MGTABLET / ORALAB2022-10-245bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A215616-001METOLAZONE2.5MGTABLET / ORALAB2022-10-24d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A215616-002METOLAZONE5MGTABLET / ORALAB2022-10-24d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A215616-003METOLAZONE10MGTABLET / ORALAB2022-10-24d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A215616-001METOLAZONE2.5MGTABLET / ORALAB2022-10-24d06236e962d9…
2024-10-29 15:01 UTC2024-10A215616-002METOLAZONE5MGTABLET / ORALAB2022-10-24d06236e962d9…
2024-10-29 15:01 UTC2024-10A215616-003METOLAZONE10MGTABLET / ORALAB2022-10-24d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A215616-001METOLAZONE2.5MGTABLET / ORALAB2022-10-2479d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A215616-002METOLAZONE5MGTABLET / ORALAB2022-10-2479d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A215616-003METOLAZONE10MGTABLET / ORALAB2022-10-2479d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A215616-001METOLAZONE2.5MGTABLET / ORALAB2022-10-24301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A215616-002METOLAZONE5MGTABLET / ORALAB2022-10-24301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A215616-003METOLAZONE10MGTABLET / ORALAB2022-10-24301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A215616-001METOLAZONE2.5MGTABLET / ORALAB2022-10-241e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A215616-002METOLAZONE5MGTABLET / ORALAB2022-10-241e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A215616-003METOLAZONE10MGTABLET / ORALAB2022-10-241e350fbaab3a…
2024-05-31 18:47 UTC2024-05A215616-001METOLAZONE2.5MGTABLET / ORALAB2022-10-248072bd15b7f6…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 2 · 75 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02A215616-001AB1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A215616-002AB1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A215616-003AB1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A215616-001AB131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A215616-002AB131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A215616-003AB131067a03dcf5…
2025-08-23 18:47 UTC2025-08A215616-001AB16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A215616-002AB16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A215616-003AB16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A215616-001AB1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A215616-002AB1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A215616-003AB1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A215616-001AB1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A215616-002AB1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A215616-003AB1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A215616-001AB103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A215616-002AB103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A215616-003AB103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A215616-001AB12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A215616-002AB12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A215616-003AB12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A215616-001AB15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A215616-002AB15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A215616-003AB15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A215616-001AB1d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A215616-002AB1d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A215616-003AB1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A215616-001AB1d06236e962d9…
2024-10-29 15:01 UTC2024-10A215616-002AB1d06236e962d9…
2024-10-29 15:01 UTC2024-10A215616-003AB1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A215616-001AB179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A215616-002AB179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A215616-003AB179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A215616-001AB1301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A215616-002AB1301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A215616-003AB1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A215616-001AB11e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A215616-002AB11e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A215616-003AB11e350fbaab3a…
2024-05-31 18:47 UTC2024-05A215616-001AB18072bd15b7f6…

Additional Listing Data#

Finished product
Yes
Brand name base
Metolazone
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
METOLAZONE5 mg/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
TZ7V40X7VXInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 3 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
197978Internal RxNorm lookup
197979Internal RxNorm lookup
311671Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1e566c10-4498-4f79-8874-4cc8c4216213Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
4e48c581-6027-290d-65f0-1b09c39dc1e8Product name620250625

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
50742-350-01Metolazone100 in 1 BOTTLETABLET1007

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
50742-350-01EA - Each50742-350bdf9d516-28e1-496f-bb17-d98986c634a612023-04-07

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
50742-350METOLAZONE (METOLAZONE) TABLET [INGENUS PHARMACEUTICALS LLC]6Current NDC, 1 package rows20241215_1e566c10-4498-4f79-8874-4cc8c4216213.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 2 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
MetolazoneMETOLAZONEMajor Pharmaceuticals89201e19-d0e8-4192-b2a1-150e9d2c104d2025-11-20Warnings, Adverse reactionsExact identifier
application applno (ANDA): 215616
application number: ANDA215616
MetolazoneMETOLAZONEIngenus Pharmaceuticals LLC1e566c10-4498-4f79-8874-4cc8c42162132025-10-08Warnings, Adverse reactionsExact identifier
application applno (ANDA): 215616
application number: ANDA215616
ndc (product): 50742-350

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
197978metOLazone 10 MG Oral TabletPSN1e566c10-4498-4f79-8874-4cc8c42162137
197979metOLazone 2.5 MG Oral TabletPSN1e566c10-4498-4f79-8874-4cc8c42162137
311671metOLazone 5 MG Oral TabletPSN1e566c10-4498-4f79-8874-4cc8c42162137
197978metolazone 10 MG Oral TabletSCD1e566c10-4498-4f79-8874-4cc8c42162137
197979metolazone 2.5 MG Oral TabletSCD1e566c10-4498-4f79-8874-4cc8c42162137
311671metolazone 5 MG Oral TabletSCD1e566c10-4498-4f79-8874-4cc8c42162137
197979metOLazone 2.5 MG Oral TabletPSN89201e19-d0e8-4192-b2a1-150e9d2c104d1
311671metOLazone 5 MG Oral TabletPSN89201e19-d0e8-4192-b2a1-150e9d2c104d1
197979metolazone 2.5 MG Oral TabletSCD89201e19-d0e8-4192-b2a1-150e9d2c104d1
311671metolazone 5 MG Oral TabletSCD89201e19-d0e8-4192-b2a1-150e9d2c104d1

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startSampleExclude flagStatus
50742-350-0150742035001100 TABLET in 1 BOTTLE (50742-350-01) 100 tablet2023-01-24NoNoCurrent