Roflumilast

Product NDC
51407-975
11-digit product format
514070975
Labeler code
51407
Product ID
51407-975_30dd6be3-6f60-c6a9-e063-6294a90afaa4
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Roflumilast
Dosage form
TABLET
Route
ORAL
Labeler
Golden State Medical Supply, Inc.
Application
ANDA212490
Marketing category
ANDA
Marketing start
2023-04-18
Substance
ROFLUMILAST
Active strength
500 ug/1
Pharmacologic classes
Phosphodiesterase 4 Inhibitor [EPC], Phosphodiesterase 4 Inhibitors [MoA]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 42.

Orange Book products#

Current product rows page 1 of 1 · 2 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A212490-001ROFLUMILASTROFLUMILAST250MCGTABLET / ORALAB2023-04-18
A212490-002ROFLUMILASTROFLUMILAST500MCGTABLET / ORALAB2023-04-18

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 2 matching rows.

Application-product, TE code table
Application-productTE code
A212490-001AB
A212490-002AB

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 46 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-08-18 06:07:402026-07A212490-001ROFLUMILAST250MCGTABLET / ORALAB2023-04-18caaa826d4ba7…
2026-08-18 06:07:402026-07A212490-002ROFLUMILAST500MCGTABLET / ORALAB2023-04-18caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A212490-001ROFLUMILAST250MCGTABLET / ORALAB2023-04-18011fe1cb6892…
2026-02-19 14:30 UTC2026-02A212490-002ROFLUMILAST500MCGTABLET / ORALAB2023-04-18011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A212490-001ROFLUMILAST250MCGTABLET / ORALAB2023-04-1831067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A212490-002ROFLUMILAST500MCGTABLET / ORALAB2023-04-1831067a03dcf5…
2025-08-23 18:47 UTC2025-08A212490-001ROFLUMILAST250MCGTABLET / ORALAB2023-04-186a471c1ec25d…
2025-08-23 18:47 UTC2025-08A212490-002ROFLUMILAST500MCGTABLET / ORALAB2023-04-186a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A212490-001ROFLUMILAST250MCGTABLET / ORALAB2023-04-18fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A212490-002ROFLUMILAST500MCGTABLET / ORALAB2023-04-18fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A212490-001ROFLUMILAST250MCGTABLET / ORALAB2023-04-18b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A212490-002ROFLUMILAST500MCGTABLET / ORALAB2023-04-18b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A212490-001ROFLUMILAST250MCGTABLET / ORALAB2023-04-1803ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A212490-002ROFLUMILAST500MCGTABLET / ORALAB2023-04-1803ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A212490-001ROFLUMILAST250MCGTABLET / ORALAB2023-04-182680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A212490-002ROFLUMILAST500MCGTABLET / ORALAB2023-04-182680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A212490-001ROFLUMILAST250MCGTABLET / ORALAB2023-04-185bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A212490-002ROFLUMILAST500MCGTABLET / ORALAB2023-04-185bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A212490-001ROFLUMILAST250MCGTABLET / ORALAB2023-04-18d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A212490-002ROFLUMILAST500MCGTABLET / ORALAB2023-04-18d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A212490-001ROFLUMILAST250MCGTABLET / ORALAB2023-04-18d06236e962d9…
2024-10-29 15:01 UTC2024-10A212490-002ROFLUMILAST500MCGTABLET / ORALAB2023-04-18d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A212490-001ROFLUMILAST250MCGTABLET / ORALAB2023-04-1879d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A212490-002ROFLUMILAST500MCGTABLET / ORALAB2023-04-1879d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A212490-001ROFLUMILAST250MCGTABLET / ORALAB2023-04-18301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A212490-002ROFLUMILAST500MCGTABLET / ORALAB2023-04-18301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A212490-001ROFLUMILAST250MCGTABLET / ORALAB2023-04-181e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A212490-002ROFLUMILAST500MCGTABLET / ORALAB2023-04-181e350fbaab3a…
2024-05-31 18:47 UTC2024-05A212490-001ROFLUMILAST250MCGTABLET / ORALAB2023-04-188072bd15b7f6…
2024-05-31 18:47 UTC2024-05A212490-002ROFLUMILAST500MCGTABLET / ORALAB2023-04-188072bd15b7f6…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A212490-001ROFLUMILAST250MCGTABLET / ORALAB2023-04-186a51e52b5d6a…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A212490-002ROFLUMILAST500MCGTABLET / ORALAB2023-04-186a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A212490-001ROFLUMILAST250MCGTABLET / ORALAB2023-04-181c564ffb4f44…
2024-02-18 07:12 UTC2024-02A212490-002ROFLUMILAST500MCGTABLET / ORALAB2023-04-181c564ffb4f44…
2023-12-20 04:57 UTC2023-12A212490-001ROFLUMILAST250MCGTABLET / ORALAB2023-04-18ea1830bbd6c7…
2023-12-20 04:57 UTC2023-12A212490-002ROFLUMILAST500MCGTABLET / ORALAB2023-04-18ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A212490-001ROFLUMILAST250MCGTABLET / ORALAB2023-04-18a72a2bbeb626…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A212490-002ROFLUMILAST500MCGTABLET / ORALAB2023-04-18a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A212490-001ROFLUMILAST250MCGTABLET / ORALAB2023-04-189b2671bbb829…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A212490-002ROFLUMILAST500MCGTABLET / ORALAB2023-04-189b2671bbb829…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 2 · 46 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-08-18 06:07:402026-07A212490-001AB1caaa826d4ba7…
2026-08-18 06:07:402026-07A212490-002AB1caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A212490-001AB1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A212490-002AB1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A212490-001AB131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A212490-002AB131067a03dcf5…
2025-08-23 18:47 UTC2025-08A212490-001AB16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A212490-002AB16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A212490-001AB1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A212490-002AB1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A212490-001AB1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A212490-002AB1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A212490-001AB103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A212490-002AB103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A212490-001AB12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A212490-002AB12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A212490-001AB15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A212490-002AB15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A212490-001AB1d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A212490-002AB1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A212490-001AB1d06236e962d9…
2024-10-29 15:01 UTC2024-10A212490-002AB1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A212490-001AB179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A212490-002AB179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A212490-001AB1301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A212490-002AB1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A212490-001AB11e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A212490-002AB11e350fbaab3a…
2024-05-31 18:47 UTC2024-05A212490-001AB18072bd15b7f6…
2024-05-31 18:47 UTC2024-05A212490-002AB18072bd15b7f6…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A212490-001AB16a51e52b5d6a…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A212490-002AB16a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A212490-001AB11c564ffb4f44…
2024-02-18 07:12 UTC2024-02A212490-002AB11c564ffb4f44…
2023-12-20 04:57 UTC2023-12A212490-001AB1ea1830bbd6c7…
2023-12-20 04:57 UTC2023-12A212490-002AB1ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A212490-001AB1a72a2bbeb626…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A212490-002AB1a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A212490-001AB19b2671bbb829…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A212490-002AB19b2671bbb829…

Additional Listing Data#

Finished product
Yes
Brand name base
Roflumilast
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
ROFLUMILAST500 ug/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
0P6C6ZOP5UInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1091839Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
30dd6eae-6435-cae1-e063-6294a90a003bAvailable on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
dcb8b904-8d4f-458b-b954-4eae028a2651Product name220250305
a1a743b6-f2e2-4044-a176-5c60c71ece24Product name120250102
6ac6be18-9820-1c07-b72b-a35dcf9d14c7Product name920240501

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
51407-975-90Roflumilast90 in 1 BOTTLETABLET901

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
51407-975-90EA - Each51407-9756a19ef38-dd14-4583-ad5f-dd09edc9fb8812025-05-14

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
51407-975ROFLUMILAST TABLET [GOLDEN STATE MEDICAL SUPPLY, INC.]1Current NDC, 1 package rows20250326_30dd6eae-6435-cae1-e063-6294a90a003b.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 2 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
RoflumilastROFLUMILASTGolden State Medical Supply, Inc.30dd6eae-6435-cae1-e063-6294a90a003b2025-03-21Warnings, Adverse reactionsExact identifier
application applno (ANDA): 212490
application number: ANDA212490
ndc (product): 51407-975
RoflumilastROFLUMILASTAscend Laboratories, LLC93d72a99-64dc-4fde-a5b8-78331fa607872025-03-13Warnings, Adverse reactionsExact identifier
application applno (ANDA): 212490
application number: ANDA212490

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
1091839roflumilast 500 MCG Oral TabletPSN30dd6eae-6435-cae1-e063-6294a90a003b1
1091839roflumilast 0.5 MG Oral TabletSCD30dd6eae-6435-cae1-e063-6294a90a003b1
1091839roflumilast 500 MCG Oral TabletSY30dd6eae-6435-cae1-e063-6294a90a003b1

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startSampleExclude flagStatus
51407-975-905140709759090 TABLET in 1 BOTTLE (51407-975-90) 90 tablet2025-02-13NoNoCurrent