BUPIVACAINE HYDROCHLORIDE

Product NDC
51662-1396
11-digit product format
516621396
Labeler code
51662
Product ID
51662-1396_1b5824c7-c46a-48c6-e063-6394a90a22ce
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
BUPIVACAINE HYDROCHLORIDE
Dosage form
INJECTION, SOLUTION
Route
PERINEURAL
Labeler
HF Acquisition Co LLC, DBA HealthFirst
Application
ANDA070597
Marketing category
ANDA
Marketing start
2019-10-16
Substance
BUPIVACAINE HYDROCHLORIDE
Active strength
5 mg/mL
Pharmacologic classes
Amide Local Anesthetic [EPC], Amides [CS], Local Anesthesia [PE]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 42.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A070597-001BUPIVACAINE HYDROCHLORIDEBUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-03

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-productTE code
A070597-001AP

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 42 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-08-18 06:07:402026-07A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-03caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-03011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-0331067a03dcf5…
2025-08-23 18:47 UTC2025-08A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-036a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-03fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-03b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-0303ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-032680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-035bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-03d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-03d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-0379d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-03301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-031e350fbaab3a…
2024-05-31 18:47 UTC2024-05A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-038072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-035c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-035d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-034b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-0374a2ff9319b5…
2022-03-09 01:35 UTC2022-03A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-03bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-03782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-0387673890dc5c…
2021-03-12 10:30 UTC2021-03A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-035aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-038869cabd3fbd…
2020-11-12 02:37 UTC2020-11A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-03c0c555d07b60…
2019-12-14 00:12 UTC2019-12A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-033f01610625f2…
2019-09-15 20:21 UTC2019-09A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-03b00525d2431f…
2019-07-19 19:46 UTC2019-07A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-03ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-036a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-031c564ffb4f44…
2023-12-20 04:57 UTC2023-12A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-03ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-03a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-039b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-03a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-033f0d92c62455…
2023-05-13 08:27 UTC2023-05A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-03053a50430f4f…
2023-01-26 05:58 UTC2023-01A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-033bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-033a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-03f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A070597-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1987-03-03e64feba35796…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 2 · 42 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-08-18 06:07:402026-07A070597-001AP1caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A070597-001AP1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A070597-001AP131067a03dcf5…
2025-08-23 18:47 UTC2025-08A070597-001AP16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A070597-001AP1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A070597-001AP1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A070597-001AP103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A070597-001AP12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A070597-001AP15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A070597-001AP1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A070597-001AP1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A070597-001AP179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A070597-001AP1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A070597-001AP11e350fbaab3a…
2024-05-31 18:47 UTC2024-05A070597-001AP18072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A070597-001AP15c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A070597-001AP15d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A070597-001AP14b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A070597-001AP174a2ff9319b5…
2022-03-09 01:35 UTC2022-03A070597-001AP1bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A070597-001AP1782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A070597-001AP187673890dc5c…
2021-03-12 10:30 UTC2021-03A070597-001AP15aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A070597-001AP18869cabd3fbd…
2020-11-12 02:37 UTC2020-11A070597-001AP1c0c555d07b60…
2019-12-14 00:12 UTC2019-12A070597-001AP13f01610625f2…
2019-09-15 20:21 UTC2019-09A070597-001AP1b00525d2431f…
2019-07-19 19:46 UTC2019-07A070597-001AP1ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A070597-001AP16a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A070597-001AP11c564ffb4f44…
2023-12-20 04:57 UTC2023-12A070597-001AP1ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A070597-001AP1a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A070597-001AP19b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A070597-001AP1a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A070597-001AP13f0d92c62455…
2023-05-13 08:27 UTC2023-05A070597-001AP1053a50430f4f…
2023-01-26 05:58 UTC2023-01A070597-001AP13bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A070597-001AP13a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A070597-001AP1f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A070597-001AP1e64feba35796…

Additional Listing Data#

Finished product
Yes
Brand name base
BUPIVACAINE HYDROCHLORIDE
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
BUPIVACAINE HYDROCHLORIDE5 mg/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
7TQO7W3VT8Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1012396Internal RxNorm lookup
1012404Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
950d82b6-76a1-0c08-e053-2a95a90a3a92Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
cbf85893-59ef-423f-87d4-a573c000a8b9Product name820250731
5dad6767-dcd1-b0da-8727-7f3f7bc3a435Product name220250303
e3a99641-4540-4894-9108-00cab3c57b7eProduct name120211207
5da98533-f072-406b-9e1b-6ac19eca9926Product name120210622
306b993e-3140-4823-ad5e-88b708f9d2acProduct name120210510
a831e694-3663-4a83-82be-6c309429f750Product name220200608

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
51662-1396-1BUPIVACAINE HYDROCHLORIDE50 mL in 1 VIAL, MULTI-DOSEINJECTION, SOLUTION5011
51662-1396-2BUPIVACAINE HYDROCHLORIDE1 mL in 1 POUCHINJECTION, SOLUTION111
51662-1396-3BUPIVACAINE HYDROCHLORIDE25 in 1 CASEINJECTION, SOLUTION2511

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
51662-1396BUPIVACAINE HYDROCHLORIDE INJECTION, SOLUTION 0.25% BUPIVACAINE HCL INJECTION, SOLUTION [HF ACQUISITION CO LLC, DBA HEALTHFIRST]11Current NDC, Legacy NDC, 3 package rows20240622_950d82b6-76a1-0c08-e053-2a95a90a3a92.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 3 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Bupivacaine HydrochlorideBUPIVACAINE HYDROCHLORIDEHospira, Inc.02a845c3-4521-4926-e397-25ab536e7cf62026-03-09Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 070597
application number: ANDA070597
Bupivacaine HydrochlorideBUPIVACAINE HYDROCHLORIDEHenry Schein, Inc496ccd9e-d1c3-4b5a-93b6-0c457faa15892025-10-27Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 070597
application number: ANDA070597
BUPIVACAINE HYDROCHLORIDEBUPIVACAINE HYDROCHLORIDEHF Acquisition Co LLC, DBA HealthFirst950d82b6-76a1-0c08-e053-2a95a90a3a922024-06-20Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 070597
application number: ANDA070597
ndc (product): 51662-1396

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
1012396BUPivacaine HCl 0.25 % Injectable SolutionPSN950d82b6-76a1-0c08-e053-2a95a90a3a9211
1012404BUPivacaine HCl 0.5 % Injectable SolutionPSN950d82b6-76a1-0c08-e053-2a95a90a3a9211
1012396bupivacaine hydrochloride 2.5 MG/ML Injectable SolutionSCD950d82b6-76a1-0c08-e053-2a95a90a3a9211
1012404bupivacaine hydrochloride 5 MG/ML Injectable SolutionSCD950d82b6-76a1-0c08-e053-2a95a90a3a9211
1012396bupivacaine hydrochloride 0.25 % Injectable SolutionSY950d82b6-76a1-0c08-e053-2a95a90a3a9211
1012404bupivacaine hydrochloride 0.5 % Injectable SolutionSY950d82b6-76a1-0c08-e053-2a95a90a3a9211

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
51662-1396-15166213960150 mL in 1 VIAL, MULTI-DOSE (51662-1396-1) 50 ml2019-10-160000-00-00NoNoCurrent
51662-1396-2516621396021 mL in 1 POUCH1 mlHistorical
51662-1396-35166213960325 POUCH in 1 CASE (51662-1396-3) / 1 mL in 1 POUCH (51662-1396-2) 25 pouch2020-10-270000-00-00NoNoCurrent