Diphenhydramine Hydrochloride and Zinc Acetate

Product NDC: 51672-2089
11-digit product format: 516722089
Labeler code: 51672
Product ID: 51672-2089_38e51539-2525-fa76-e063-6294a90a6b0a
Type: HUMAN OTC DRUG
Nonproprietary name: Diphenhydramine Hydrochloride and Zinc Acetate
Dosage form: CREAM
Route: TOPICAL
Labeler: Sun Pharmaceutical Industries, Inc.
Application: M017
Marketing category: OTC MONOGRAPH DRUG
Marketing start: 2005-09-20
Substance: DIPHENHYDRAMINE HYDROCHLORIDE; ZINC ACETATE
Active strength: 20; 1 mg/g; mg/g
Pharmacologic classes: Copper Absorption Inhibitor [EPC], Decreased Copper Ion Absorption [PE], Histamine H1 Receptor Antagonists [MoA], Histamine-1 Receptor Antagonist [EPC]
NDC exclude flag: No
Listing certified through: 2026-12-31
Current FDA listing: Yes

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

Additional Listing Data#

Finished product: Yes
Brand name base: Diphenhydramine Hydrochloride and Zinc Acetate
Listing expiration: 2026-12-31

Active Ingredients#

Ingredient, Strength table
Ingredient	Strength
DIPHENHYDRAMINE HYDROCHLORIDE	20 mg/g
ZINC ACETATE	1 mg/g

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
TC2D6JAD40	Internal UNII lookup
FM5526K07A	Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
1087026	Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
c89e3de8-7d71-485c-8fc5-2832d6024f16	Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product concept	Relation	Version	Effective
f47a510b-6679-4664-b2d6-47b5c4afe7cc	Product name	4	20260217
030ce964-9b2d-45aa-b5d3-f78ce03ef61c	Product name	2	20250515
0e2e0f88-b076-afe1-4bdd-32bca4375bec	Product name	3	20250127
0306390c-dd77-4363-afe0-63c58088b2a1	Product name	1	20220120
503ea967-4b9c-48cf-9e87-c7975295849d	Product name	2	20220120
190f2a5b-bbc8-65c7-fcb0-97891307b917	Product name	1	20140508
3e48c9c4-918d-5d23-2f0b-d2398b06be54	Product name	1	20140508
865c72dd-0d94-daac-f728-ddd4ded2a79e	Product name	1	20140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	Strength	SPL version
51672-2089-2	Diphenhydramine Hydrochloride and Zinc Acetate	1 in 1 CARTON	CREAM	1		6
51672-2089-2	Diphenhydramine Hydrochloride and Zinc Acetate	28.4 g in 1 TUBE	CREAM	28.4		6

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDC	Billing unit	Product NDC	DailyMed indexing SPL	SPL version	Effective
51672-2089-2	GM - Gram	51672-2089	094a11e1-37e8-4339-afe1-f0135085a2e7	1	2012-07-24

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
Ingredient	Type	UNII	DailyMed label	SPL version
Diphenhydramine Hydrochloride	ACTIVE INGREDIENT	TC2D6JAD40	DIPHENHYDRAMINE HYDROCHLORIDE AND ZINC ACETATE CREAM [TARO PHARMACEUTICALS U.S.A., INC.]	3
Zinc Acetate	ACTIVE INGREDIENT	FM5526K07A	DIPHENHYDRAMINE HYDROCHLORIDE AND ZINC ACETATE CREAM [TARO PHARMACEUTICALS U.S.A., INC.]	3
Diphenhydramine	ACTIVE MOIETY	8GTS82S83M	DIPHENHYDRAMINE HYDROCHLORIDE AND ZINC ACETATE CREAM [TARO PHARMACEUTICALS U.S.A., INC.]	3
zinc cation	ACTIVE MOIETY	13S1S8SF37	DIPHENHYDRAMINE HYDROCHLORIDE AND ZINC ACETATE CREAM [TARO PHARMACEUTICALS U.S.A., INC.]	3
cetyl alcohol	INACTIVE INGREDIENT	936JST6JCN	DIPHENHYDRAMINE HYDROCHLORIDE AND ZINC ACETATE CREAM [TARO PHARMACEUTICALS U.S.A., INC.]	3
glyceryl monostearate	INACTIVE INGREDIENT	230OU9XXE4	DIPHENHYDRAMINE HYDROCHLORIDE AND ZINC ACETATE CREAM [TARO PHARMACEUTICALS U.S.A., INC.]	3
methylparaben	INACTIVE INGREDIENT	A2I8C7HI9T	DIPHENHYDRAMINE HYDROCHLORIDE AND ZINC ACETATE CREAM [TARO PHARMACEUTICALS U.S.A., INC.]	3
PEG-100 stearate	INACTIVE INGREDIENT	YD01N1999R	DIPHENHYDRAMINE HYDROCHLORIDE AND ZINC ACETATE CREAM [TARO PHARMACEUTICALS U.S.A., INC.]	3
propylene glycol	INACTIVE INGREDIENT	6DC9Q167V3	DIPHENHYDRAMINE HYDROCHLORIDE AND ZINC ACETATE CREAM [TARO PHARMACEUTICALS U.S.A., INC.]	3
propylparaben	INACTIVE INGREDIENT	Z8IX2SC1OH	DIPHENHYDRAMINE HYDROCHLORIDE AND ZINC ACETATE CREAM [TARO PHARMACEUTICALS U.S.A., INC.]	3
water	INACTIVE INGREDIENT	059QF0KO0R	DIPHENHYDRAMINE HYDROCHLORIDE AND ZINC ACETATE CREAM [TARO PHARMACEUTICALS U.S.A., INC.]	3

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
51672-2089	DIPHENHYDRAMINE HYDROCHLORIDE AND ZINC ACETATE CREAM [TARO PHARMACEUTICALS U.S.A., INC.]	5	Current NDC, Legacy NDC, 2 package rows	20241105_c89e3de8-7d71-485c-8fc5-2832d6024f16.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 37 of 153 · 3,057 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
PAIN RELIEF PATCHES	LIDOCAINE	WALMART STORES INC	b82cfe42-f521-4784-8c60-98481524c5ec	2026-01-29	Warnings	Exact identifier application number: M017
Equate Pain Relief Patch Camphor/Menthol/Salicylate	CAMPHOR, MENTHOL, METHYL SALICYLATE	Walmart Stores Inc	b869848c-21e2-5ca2-e053-2995a90a86f2	2026-01-29	Warnings	Exact identifier application number: M017
HEATING PAIN RELIEF	METHYL SALICYLATE, MENTHOL	SUNSET NOVELTIES, INC	498cd2aa-ee59-67b5-e063-6294a90ac242	2026-01-29	Warnings	Exact identifier application number: M017
COOLING PAIN RELIEF	MENTHOL, CAMPHOR	SUNSET NOVELTIES, INC	498d76d8-788b-4cc7-e063-6294a90a1696	2026-01-29	Warnings	Exact identifier application number: M017
MQUPIN Lidocaine Gel-Patch	LIDOCAINE GEL-PATCH	Zhengzhou Miaoqi Medical Technology Co., Ltd.	49703717-69a6-e480-e063-6394a90ac69c	2026-01-28	Warnings	Exact identifier application number: M017
MQXUNMI LIDOCAINE Pain Relief Patch	LIDOCAINE PAIN RELIEF PATCH	Zhengzhou Miaoqi Medical Technology Co., Ltd.	49706db7-bacd-190f-e063-6394a90a3a8e	2026-01-28	Warnings	Exact identifier application number: M017
Joint and Muscle Relief Topical Analgesic	MENTHOL	Smart Cookie Solutions	1ecf56b1-ffcb-486f-9fdd-d4dc92aefc1d	2026-01-28	Warnings	Exact identifier application number: M017
VonaFlex Effective Pain Relief Topical Analgesic	LIDOCAINE HYDROCHLORIDE	OPTIMAL LABORATORIES, LLC	0901244a-7d41-413a-b424-92a807532f28	2026-01-28	Warnings	Exact identifier application number: M017
Lidocaine Pain Relief Gel Patch	LIDOCAINE PAIN RELIEF	Dynarex	960e4240-cd09-2560-e053-2a95a90a7bcf	2026-01-28	Warnings	Exact identifier application number: M017
ALOE ICE SUNBURN RELIEF	LIDOCAINE HYDROCHLORIDE	Aloe Care International, LLC	56866fa8-052e-497c-a954-978d7d628949	2026-01-28	Warnings	Exact identifier application number: M017
Walgreens Original Strength Anti Itch	DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE	Walgreen Company	a6a49dbb-74c7-47ca-88f2-3bb3d9acf914	2026-01-28	Warnings	Exact identifier application number: M017
Flobow QUIT SMOKING Nicotine	NICOTINE18% MENTHOL 0.3% QUIT SMOKING NICOTINE	Jiangxi Yudexi Pharmaceutical Co., LTD	495b10ce-3d2d-1aa4-e063-6294a90a4f35	2026-01-27	Warnings	Exact identifier application number: M017
PAIN	REUSEABLE PAIN	Shenzhen Mengyue Technology Co., Ltd.	44e058fc-e1c0-742b-e063-6294a90ad225	2026-01-27	Warnings	Exact identifier application number: M017
HealthWise Pain Relieving Cream Lavender	MENTHOL	Veridian Healthcare	495eb6e9-69da-f7b6-e063-6294a90accee	2026-01-27	Warnings	Exact identifier application number: M017
HealthWise Pain Relieving Cream	MENTHOL	Veridian Healthcare	49548ab2-267e-1e2a-e063-6394a90ab391	2026-01-27	Warnings	Exact identifier application number: M017
Itch Relief	DIPHENHYDRAMINE HCL	Wal-Mart Stores, Inc.	03feaaef-7401-d464-e063-6294a90a2b2d	2026-01-27	Warnings	Exact identifier application number: M017
Hydrocortisone with Aloe	HYDROCORTISONE	STRATEGIC SOURCING SERVICES LLC	4a113699-1eb7-49b8-8cdf-2ad57db89b81	2026-01-27	Warnings	Exact identifier application number: M017
Healthy Back Institute Rub On Relief	ANALGESIC	Fullstack Fulfillment	284c29a3-5722-ce70-e063-6394a90a7fa0	2026-01-26	Warnings	Exact identifier application number: M017
Velocx for Joint and Muscle Pain Roll-On Applicator	MENTHOL, METHYL SALICYLATE	JMAD Consulting LLC, dba JMAD Labs	dbf3eaa3-d85e-46b1-b4a5-a87ba4dc5d21	2026-01-26	Warnings	Exact identifier application number: M017
CAPSAICIN HEAT PATCHES BACK AND LARGE AREAS	CAPSAICIN	Meijer Distribution Inc	9b91658f-c15f-4222-bbd9-881b29de3b6e	2026-01-26	Warnings	Exact identifier application number: M017

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
TC2D6JAD40	DIPHENHYDRAMINE HYDROCHLORIDE	147-24-0	DIPHENHYDRAMINE HYDROCHLORIDE
FM5526K07A	ZINC ACETATE	5970-45-6	ZINC ACETATE

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUI	RxNorm string	TTY	DailyMed	SPL version
1087026	diphenhydrAMINE HCl 2 % / zinc acetate 0.1 % Topical Cream	PSN	c89e3de8-7d71-485c-8fc5-2832d6024f16	6
1087026	diphenhydramine hydrochloride 20 MG/ML / zinc acetate 1 MG/ML Topical Cream	SCD	c89e3de8-7d71-485c-8fc5-2832d6024f16	6
1087026	diphenhydramine hydrochloride 2 % / zinc acetate 0.1 % Topical Cream	SY	c89e3de8-7d71-485c-8fc5-2832d6024f16	6

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Units	Marketing start	Marketing end	Sample	Exclude flag	Status
51672-2089-2	51672208902	1 TUBE in 1 CARTON (51672-2089-2) / 28.4 g in 1 TUBE	1 tube	2005-09-20	0000-00-00	No	No	Current

Title, Manufacturer, Effective date table
Title	Manufacturer	Effective date	Type	Version
Anti-Itch Cream 2% Diphenhydramine Hydrochloride	Sun Pharmaceutical Industries, Inc. \| Sun Pharma Canada Inc.	2025-07-01	HUMAN OTC DRUG LABEL	6