Everolimus

Product NDC
51991-381
11-digit product format
519910381
Labeler code
51991
Product ID
51991-381_e7f5ef4d-6763-4908-9b64-c2a2f600b2c8
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Everolimus tablets
Dosage form
TABLET
Route
ORAL
Labeler
Breckenridge Pharmaceutical, Inc.
Application
ANDA205432
Marketing category
ANDA
Marketing start
2021-05-21
Substance
EVEROLIMUS
Active strength
.75 mg/1
Pharmacologic classes
Cytochrome P450 2D6 Inhibitors [MoA], Cytochrome P450 3A4 Inhibitors [MoA], Decreased Immunologic Activity [PE], Kinase Inhibitor [EPC], Protein Kinase Inhibitors [MoA], mTOR Inhibitor Immunosuppressant [EPC], mTOR Inhibitors [MoA]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 4 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A205432-001EVEROLIMUSEVEROLIMUS0.25MGTABLET / ORALAB2021-05-20
A205432-002EVEROLIMUSEVEROLIMUS0.5MGTABLET / ORALAB2021-05-20
A205432-003EVEROLIMUSEVEROLIMUS0.75MGTABLET / ORALAB2021-05-20
A205432-004EVEROLIMUSEVEROLIMUS1MGTABLET / ORALAB2025-09-03

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 4 matching rows.

Application-product, TE code table
Application-productTE code
A205432-001AB
A205432-002AB
A205432-003AB
A205432-004AB

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 3 · 102 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02A205432-001EVEROLIMUS0.25MGTABLET / ORALAB2021-05-20011fe1cb6892…
2026-02-19 14:30 UTC2026-02A205432-002EVEROLIMUS0.5MGTABLET / ORALAB2021-05-20011fe1cb6892…
2026-02-19 14:30 UTC2026-02A205432-003EVEROLIMUS0.75MGTABLET / ORALAB2021-05-20011fe1cb6892…
2026-02-19 14:30 UTC2026-02A205432-004EVEROLIMUS1MGTABLET / ORALAB2025-09-03011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A205432-001EVEROLIMUS0.25MGTABLET / ORALAB2021-05-2031067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A205432-002EVEROLIMUS0.5MGTABLET / ORALAB2021-05-2031067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A205432-003EVEROLIMUS0.75MGTABLET / ORALAB2021-05-2031067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A205432-004EVEROLIMUS1MGTABLET / ORALAB2025-09-0331067a03dcf5…
2025-08-23 18:47 UTC2025-08A205432-001EVEROLIMUS0.25MGTABLET / ORALAB2021-05-206a471c1ec25d…
2025-08-23 18:47 UTC2025-08A205432-002EVEROLIMUS0.5MGTABLET / ORALAB2021-05-206a471c1ec25d…
2025-08-23 18:47 UTC2025-08A205432-003EVEROLIMUS0.75MGTABLET / ORALAB2021-05-206a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A205432-001EVEROLIMUS0.25MGTABLET / ORALAB2021-05-20fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A205432-002EVEROLIMUS0.5MGTABLET / ORALAB2021-05-20fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A205432-003EVEROLIMUS0.75MGTABLET / ORALAB2021-05-20fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A205432-001EVEROLIMUS0.25MGTABLET / ORALAB2021-05-20b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A205432-002EVEROLIMUS0.5MGTABLET / ORALAB2021-05-20b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A205432-003EVEROLIMUS0.75MGTABLET / ORALAB2021-05-20b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A205432-001EVEROLIMUS0.25MGTABLET / ORALAB2021-05-2003ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A205432-002EVEROLIMUS0.5MGTABLET / ORALAB2021-05-2003ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A205432-003EVEROLIMUS0.75MGTABLET / ORALAB2021-05-2003ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A205432-001EVEROLIMUS0.25MGTABLET / ORALAB2021-05-202680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A205432-002EVEROLIMUS0.5MGTABLET / ORALAB2021-05-202680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A205432-003EVEROLIMUS0.75MGTABLET / ORALAB2021-05-202680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A205432-001EVEROLIMUS0.25MGTABLET / ORALAB2021-05-205bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A205432-002EVEROLIMUS0.5MGTABLET / ORALAB2021-05-205bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A205432-003EVEROLIMUS0.75MGTABLET / ORALAB2021-05-205bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A205432-001EVEROLIMUS0.25MGTABLET / ORALAB2021-05-20d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A205432-002EVEROLIMUS0.5MGTABLET / ORALAB2021-05-20d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A205432-003EVEROLIMUS0.75MGTABLET / ORALAB2021-05-20d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A205432-001EVEROLIMUS0.25MGTABLET / ORALAB2021-05-20d06236e962d9…
2024-10-29 15:01 UTC2024-10A205432-002EVEROLIMUS0.5MGTABLET / ORALAB2021-05-20d06236e962d9…
2024-10-29 15:01 UTC2024-10A205432-003EVEROLIMUS0.75MGTABLET / ORALAB2021-05-20d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A205432-001EVEROLIMUS0.25MGTABLET / ORALAB2021-05-2079d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A205432-002EVEROLIMUS0.5MGTABLET / ORALAB2021-05-2079d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A205432-003EVEROLIMUS0.75MGTABLET / ORALAB2021-05-2079d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A205432-001EVEROLIMUS0.25MGTABLET / ORALAB2021-05-20301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A205432-002EVEROLIMUS0.5MGTABLET / ORALAB2021-05-20301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A205432-003EVEROLIMUS0.75MGTABLET / ORALAB2021-05-20301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A205432-001EVEROLIMUS0.25MGTABLET / ORALAB2021-05-201e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A205432-002EVEROLIMUS0.5MGTABLET / ORALAB2021-05-201e350fbaab3a…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 3 · 102 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02A205432-001AB1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A205432-002AB1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A205432-003AB1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A205432-004AB1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A205432-001AB131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A205432-002AB131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A205432-003AB131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A205432-004AB131067a03dcf5…
2025-08-23 18:47 UTC2025-08A205432-001AB16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A205432-002AB16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A205432-003AB16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A205432-001AB1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A205432-002AB1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A205432-003AB1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A205432-001AB1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A205432-002AB1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A205432-003AB1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A205432-001AB103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A205432-002AB103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A205432-003AB103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A205432-001AB12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A205432-002AB12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A205432-003AB12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A205432-001AB15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A205432-002AB15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A205432-003AB15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A205432-001AB1d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A205432-002AB1d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A205432-003AB1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A205432-001AB1d06236e962d9…
2024-10-29 15:01 UTC2024-10A205432-002AB1d06236e962d9…
2024-10-29 15:01 UTC2024-10A205432-003AB1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A205432-001AB179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A205432-002AB179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A205432-003AB179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A205432-001AB1301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A205432-002AB1301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A205432-003AB1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A205432-001AB11e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A205432-002AB11e350fbaab3a…

Additional Listing Data#

Finished product
Yes
Brand name base
Everolimus
Listing expiration
2027-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
EVEROLIMUS.75 mg/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
9HW64Q8G6GInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 4 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
977427Internal RxNorm lookup
977434Internal RxNorm lookup
977438Internal RxNorm lookup
2056895Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
c7bb6ba1-9a7f-43f5-b058-ef26d4b59221Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
807eb842-6749-6eff-f9ce-2751c69fde93Product name420260122
151279ee-9f3c-b884-3327-05b3fa99d863Product name620251027

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
51991-381-06Everolimus60 in 1 BOTTLETABLET608
51991-381-60Everolimus60 in 1 CARTONTABLET608
51991-381-99Everolimus10 in 1 BLISTER PACKTABLET108

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
51991-381-06EA - Each51991-381f7905440-fdd8-4bdf-9131-5f78e3c506eb12023-07-06
51991-381-60EA - Each51991-38130fc4007-f027-4f8e-b23b-59310cfc489612021-08-05
51991-381-99EA - Each51991-38131ec2c0a-1c9f-4aea-a199-bef55c36751c12021-08-05

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
51991-381EVEROLIMUS (EVEROLIMUS TABLETS) TABLET [BRECKENRIDGE PHARMACEUTICAL, INC.]4Current NDC, Legacy NDC, 3 package rows20240328_c7bb6ba1-9a7f-43f5-b058-ef26d4b59221.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 2 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
EverolimusEVEROLIMUS TABLETSBreckenridge Pharmaceutical, Inc.c7bb6ba1-9a7f-43f5-b058-ef26d4b592212026-07-06Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 205432
application number: ANDA205432
ndc (product): 51991-381
EverolimusEVEROLIMUSNatco Pharma Limitedd44998bb-5deb-4ee7-a0a5-979fe3f495572025-10-14Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 205432
application number: ANDA205432

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
977427everolimus 0.25 MG Oral TabletPSNc7bb6ba1-9a7f-43f5-b058-ef26d4b592218
977434everolimus 0.5 MG Oral TabletPSNc7bb6ba1-9a7f-43f5-b058-ef26d4b592218
977438everolimus 0.75 MG Oral TabletPSNc7bb6ba1-9a7f-43f5-b058-ef26d4b592218
2056895everolimus 1 MG Oral TabletPSNc7bb6ba1-9a7f-43f5-b058-ef26d4b592218
977427everolimus 0.25 MG Oral TabletSCDc7bb6ba1-9a7f-43f5-b058-ef26d4b592218
977434everolimus 0.5 MG Oral TabletSCDc7bb6ba1-9a7f-43f5-b058-ef26d4b592218
977438everolimus 0.75 MG Oral TabletSCDc7bb6ba1-9a7f-43f5-b058-ef26d4b592218
2056895everolimus 1 MG Oral TabletSCDc7bb6ba1-9a7f-43f5-b058-ef26d4b592218
977434everolimus 500 MCG Oral TabletSYc7bb6ba1-9a7f-43f5-b058-ef26d4b592218
977438everolimus 750 MCG Oral TabletSYc7bb6ba1-9a7f-43f5-b058-ef26d4b592218

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
51991-381-065199103810660 TABLET in 1 BOTTLE (51991-381-06) 60 tablet2023-03-13NoNoCurrent
51991-381-605199103816060 BLISTER PACK in 1 CARTON (51991-381-60) / 10 TABLET in 1 BLISTER PACK (51991-381-99) 60 blister pack2021-05-210000-00-00NoNoCurrent
51991-381-995199103819910 in 1 BLISTER PACKHistorical