Naloxone Hydrochloride

Product NDC
54288-124
11-digit product format
542880124
Labeler code
54288
Product ID
54288-124_f0223f84-ddc4-45a8-94e8-22cd1a39f19e
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Naloxone Hydrochloride
Dosage form
INJECTION, SOLUTION
Route
INTRAMUSCULAR; INTRAVENOUS; SUBCUTANEOUS
Labeler
BPI Labs LLC
Application
ANDA216977
Marketing category
ANDA
Marketing start
2023-11-15
Substance
NALOXONE HYDROCHLORIDE
Active strength
1 mg/mL
Pharmacologic classes
Opioid Antagonist [EPC], Opioid Antagonists [MoA]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A216977-001NALOXONE HYDROCHLORIDENALOXONE HYDROCHLORIDE1MG/MLINJECTABLE / INJECTIONAP2023-10-06

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-productTE code
A216977-001AP

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02A216977-001NALOXONE HYDROCHLORIDE1MG/MLINJECTABLE / INJECTIONAP2023-10-06011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A216977-001NALOXONE HYDROCHLORIDE1MG/MLINJECTABLE / INJECTIONAP2023-10-0631067a03dcf5…
2025-08-23 18:47 UTC2025-08A216977-001NALOXONE HYDROCHLORIDE1MG/MLINJECTABLE / INJECTIONAP2023-10-066a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A216977-001NALOXONE HYDROCHLORIDE1MG/MLINJECTABLE / INJECTIONAP2023-10-06fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A216977-001NALOXONE HYDROCHLORIDE1MG/MLINJECTABLE / INJECTIONAP2023-10-06b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A216977-001NALOXONE HYDROCHLORIDE1MG/MLINJECTABLE / INJECTIONAP2023-10-0603ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A216977-001NALOXONE HYDROCHLORIDE1MG/MLINJECTABLE / INJECTIONAP2023-10-062680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A216977-001NALOXONE HYDROCHLORIDE1MG/MLINJECTABLE / INJECTIONAP2023-10-065bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A216977-001NALOXONE HYDROCHLORIDE1MG/MLINJECTABLE / INJECTIONAP2023-10-06d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A216977-001NALOXONE HYDROCHLORIDE1MG/MLINJECTABLE / INJECTIONAP2023-10-06d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A216977-001NALOXONE HYDROCHLORIDE1MG/MLINJECTABLE / INJECTIONAP2023-10-0679d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A216977-001NALOXONE HYDROCHLORIDE1MG/MLINJECTABLE / INJECTIONAP2023-10-06301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A216977-001NALOXONE HYDROCHLORIDE1MG/MLINJECTABLE / INJECTIONAP2023-10-061e350fbaab3a…
2024-05-31 18:47 UTC2024-05A216977-001NALOXONE HYDROCHLORIDE1MG/MLINJECTABLE / INJECTIONAP2023-10-068072bd15b7f6…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A216977-001NALOXONE HYDROCHLORIDE1MG/MLINJECTABLE / INJECTIONAP2023-10-066a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A216977-001NALOXONE HYDROCHLORIDE1MG/MLINJECTABLE / INJECTIONAP2023-10-061c564ffb4f44…
2023-12-20 04:57 UTC2023-12A216977-001NALOXONE HYDROCHLORIDE1MG/MLINJECTABLE / INJECTIONAP2023-10-06ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A216977-001NALOXONE HYDROCHLORIDE1MG/MLINJECTABLE / INJECTIONAP2023-10-06a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A216977-001NALOXONE HYDROCHLORIDE1MG/MLINJECTABLE / INJECTIONAP2023-10-069b2671bbb829…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A216977-001NALOXONE HYDROCHLORIDE1MG/MLINJECTABLE / INJECTIONAP2023-10-06a50c72e98297…

Observed Orange Book normalized TE history#

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02A216977-001AP1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A216977-001AP131067a03dcf5…
2025-08-23 18:47 UTC2025-08A216977-001AP16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A216977-001AP1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A216977-001AP1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A216977-001AP103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A216977-001AP12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A216977-001AP15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A216977-001AP1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A216977-001AP1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A216977-001AP179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A216977-001AP1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A216977-001AP11e350fbaab3a…
2024-05-31 18:47 UTC2024-05A216977-001AP18072bd15b7f6…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A216977-001AP16a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A216977-001AP11c564ffb4f44…
2023-12-20 04:57 UTC2023-12A216977-001AP1ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A216977-001AP1a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A216977-001AP19b2671bbb829…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A216977-001AP1a50c72e98297…

Additional Listing Data#

Finished product
Yes
Brand name base
Naloxone Hydrochloride
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
NALOXONE HYDROCHLORIDE1 mg/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
F850569PQRInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1191250Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
5de44ee7-6525-4857-9a67-8882e96dbeb5Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
c955d208-c333-9bd7-be34-d7e12986d44eProduct name620250626
e5f98bfa-66d5-4c3a-b22d-9543d3bee304Product name120250204
caa6391e-3db3-c912-335f-61b5fc00aa12Product name920240110
65a3bc34-04ff-4cf1-aad9-c7d92a062f6dProduct name120231003
e951cdf3-f269-4d97-a7d5-c1c3d7283a7dProduct name320230313
ab841ac7-728a-4fc9-be0a-35b96cecbf39Product name420230306
f327b80c-8fa2-404b-838a-df3eec141cf2Product name120221212
d4aa2fcf-79c3-4b5f-a00e-1a8e26e00119Product name120220511
b871fccd-1de6-4c7f-b9e5-045304641ee6Product name820220118
43b1efe2-1425-4b3e-b3a2-57d40f8478b9Product name120211026
4c23a34c-e8fc-424c-8fa0-ee064ba6eaefProduct name120170706
0b8c7273-1da3-495f-909a-7cf1e96d2361Product name120161212
3df867ed-9d48-45cf-bded-1394beaea0b1Product name320161206
8a245632-e24f-4ccc-b671-995d89c96ebcProduct name120141203

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
54288-124NALOXONE HYDROCHLORIDE INJECTION, SOLUTION [BPI LABS LLC]3Current NDC20250213_5de44ee7-6525-4857-9a67-8882e96dbeb5.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Naloxone HydrochlorideNALOXONE HYDROCHLORIDEBPI Labs LLC5de44ee7-6525-4857-9a67-8882e96dbeb52025-12-26Warnings, Adverse reactionsExact identifier
application applno (ANDA): 216977
application number: ANDA216977
ndc (product): 54288-124

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
1191250naloxone HCl 2 MG in 2 ML Prefilled SyringePSN5de44ee7-6525-4857-9a67-8882e96dbeb54
11912502 ML naloxone hydrochloride 1 MG/ML Prefilled SyringeSCD5de44ee7-6525-4857-9a67-8882e96dbeb54
1191250naloxone hydrochloride 2 MG per 2 ML Prefilled SyringeSY5de44ee7-6525-4857-9a67-8882e96dbeb54

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startSampleExclude flagStatus
54288-124-01542880124011 PACKAGE in 1 CARTON (54288-124-01) / 2 mL in 1 PACKAGE1 package2023-11-15NoNoCurrent
54288-124-105428801241010 PACKAGE in 1 CARTON (54288-124-10) / 2 mL in 1 PACKAGE10 package2023-11-15NoNoCurrent