Nicotine

Product NDC
59450-003
11-digit product format
594500003
Labeler code
59450
Product ID
59450-003_3545efa6-1a37-cbdd-ccdd-167992151d52
Type
HUMAN OTC DRUG
Nonproprietary name
Nicotine
Dosage form
PATCH, EXTENDED RELEASE
Route
TRANSDERMAL
Labeler
The Kroger Co.
Application
NDA020076
Marketing category
NDA
Marketing start
2015-08-25
Substance
NICOTINE
Active strength
21 mg/24h
Pharmacologic classes
Cholinergic Nicotinic Agonist [EPC], Nicotine [CS]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Orange Book products#

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
N020076-004HABITROLNICOTINE7MG/24HRFILM, EXTENDED RELEASE / TRANSDERMALRLD1999-11-12
N020076-005HABITROLNICOTINE14MG/24HRFILM, EXTENDED RELEASE / TRANSDERMALRLD1999-11-12
N020076-006HABITROLNICOTINE21MG/24HRFILM, EXTENDED RELEASE / TRANSDERMALRLD, RS1999-11-12

openFDA label cross-check#

Cross-check layer: openFDA label JSON enriches search and identifies hydration gaps. The DailyMed Structured Product Label remains the canonical label presentation on FDA.report.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Nicotine transdermal system step 3NICOTINEThe Kroger Co.13cdd780-4196-685b-3cab-f9694a3276182024-07-25WarningsExact identifier

Warnings cross-check#

openFDA text is shown for search and cross-checking; DailyMed SPL is canonical.

warnings

Warnings If you are pregnant or breast-feeding, only use this medicine on the advice of your health care provider. Smoking can seriously harm your child. Try to stop smoking without using any nicotine replacement medicine. This medicine is believed to be safer than smoking. However, the risks to your child from this medicine are not fully known. Ask a doctor before use if you have • heart disease, recent heart attack, or irregular heartbeat. Nicotine can increase your heart rate. • high blood pressure not controlled with medication. Nicotine can increase your blood pressure. • an allergy to adhesive tape or have skin problems, because you are more likely to get rashes. Ask a doctor or pharmacist before use if you are • using a non-nicotine stop smoking drug • taking a prescription medicine for depression or asthma. Your prescription dose may need to be adjusted. When using this product • do not smoke even when not wearing the patch. The nicotine in your skin will still be entering your blood stream for several hours after you take off the patch. • if you have vivid dreams or other sleep disturbances remove this patch at bedtime Stop use and ask a doctor if • skin redness caused by the patch does not go away after four days, or if your skin swells, or you get a rash • irregular heartbeat or palpitations occur • you get symptoms of nicotine overdose, such as nausea, vomiting, dizziness, weakness and rapid heartbeat Keep out of reach of children and pets. Used patches have enough nicotine to poison children and pets. If swallowed, get medical help or contact a Poison Control Center right away. Save pouch to use for patch disposal. Dispose of the used patches by folding sticky ends together and putting in pouch.

Additional Listing Data#

Finished product
Yes
Brand name base
Nicotine
Brand name suffix
transdermal system step 1
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
NICOTINE21 mg/24h

Harmonized Identifiers#

Field, Values table
FieldValues
Unii6M3C89ZY6R
Rxcui198029, 198030, 198031

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
dbebfdf8-6e0c-cfa8-fdbc-e5d7f1bf1562Product name120140508

FDA-Initiated Inactive NDC Indexing#

NDC, Effective, Action table
NDCEffectiveActionDocumentIndexing SPLRelated label
59450-003-742024-01-30C16284748780-11030e365-5540-111a-e063-dadaa90a10e2Drug Facts

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
59450-003-74Nicotine transdermal system step 114 in 1 CARTONPATCH, EXTENDED RELEASE149
59450-003-74Nicotine transdermal system step 124 h in 1 PATCHPATCH, EXTENDED RELEASE249

DailyMed Socrata Ingredients#

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
59450-003NICOTINE TRANSDERMAL SYSTEM STEP 1 (NICOTINE) PATCH, EXTENDED RELEASE NICOTINE TRANSDERMAL SYSTEM STEP 2 (NICOTINE) PATCH, EXTENDED RELEASE NICOTINE TRANSDERMAL SYSTEM STEP 3 (NICOTINE) PATCH, EXTENDED RELEASE [THE KROGER CO.]9Current NDC, Legacy NDC, 2 package rows20240726_13cdd780-4196-685b-3cab-f9694a327618.zip

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
198029nicotine 14 MG/Day 24HR Transdermal SystemPSN13cdd780-4196-685b-3cab-f9694a3276189
198030nicotine 21 MG/Day 24HR Transdermal SystemPSN13cdd780-4196-685b-3cab-f9694a3276189
198031nicotine 7 MG/Day 24HR Transdermal SystemPSN13cdd780-4196-685b-3cab-f9694a3276189
19803124 HR nicotine 0.292 MG/HR Transdermal SystemSCD13cdd780-4196-685b-3cab-f9694a3276189
19802924 HR nicotine 0.583 MG/HR Transdermal SystemSCD13cdd780-4196-685b-3cab-f9694a3276189
19803024 HR nicotine 0.875 MG/HR Transdermal SystemSCD13cdd780-4196-685b-3cab-f9694a3276189
198031nicotine 0.292 MG/HR 24HR Transdermal PatchSY13cdd780-4196-685b-3cab-f9694a3276189
198029nicotine 0.583 MG/HR 24HR Transdermal PatchSY13cdd780-4196-685b-3cab-f9694a3276189
198030nicotine 0.875 MG/HR 24HR Transdermal PatchSY13cdd780-4196-685b-3cab-f9694a3276189
198029nicotine 14 MG per 24HR 1 Day Transdermal PatchSY13cdd780-4196-685b-3cab-f9694a3276189
198029nicotine 14 MG/Day 24HR Transdermal SystemSY13cdd780-4196-685b-3cab-f9694a3276189
198030nicotine 21 MG per 24HR 1 Day Transdermal PatchSY13cdd780-4196-685b-3cab-f9694a3276189
198030nicotine 21 MG/Day 24HR Transdermal SystemSY13cdd780-4196-685b-3cab-f9694a3276189
198031nicotine 7 MG per 24HR 1 Day Transdermal PatchSY13cdd780-4196-685b-3cab-f9694a3276189
198031nicotine 7 MG/Day 24HR Transdermal SystemSY13cdd780-4196-685b-3cab-f9694a3276189

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
59450-003-745945000037414 PATCH in 1 CARTON (59450-003-74) / 24 h in 1 PATCH14 patch2015-08-250000-00-00NoNoCurrent