Sirolimus

Product NDC
59762-1205
11-digit product format
597621205
Labeler code
59762
Product ID
59762-1205_1501a154-5d23-4ff0-a6ef-31715dcb2282
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
sirolimus
Dosage form
SOLUTION
Route
ORAL
Labeler
Mylan Pharmaceuticals Inc.
Application
NDA021083
Marketing category
NDA AUTHORIZED GENERIC
Marketing start
2019-07-22
Substance
SIROLIMUS
Active strength
1 mg/mL
Pharmacologic classes
Decreased Immunologic Activity [PE], Kinase Inhibitor [EPC], Protein Kinase Inhibitors [MoA], mTOR Inhibitor Immunosuppressant [EPC], mTOR Inhibitors [MoA]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 42.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
N021083-001RAPAMUNESIROLIMUS1MG/MLSOLUTION / ORALAARLD, RS1999-09-15

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-productTE code
N021083-001AA

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 42 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-08-18 06:07:402026-07N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-15caaa826d4ba7…
2026-02-19 14:30 UTC2026-02N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-15011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-1531067a03dcf5…
2025-08-23 18:47 UTC2025-08N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-156a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-15fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-15b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-1503ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-152680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-155bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-15d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-15d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-1579d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-15301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-151e350fbaab3a…
2024-05-31 18:47 UTC2024-05N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-158072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-155c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-155d02ea3f76ae…
2022-04-04 05:41 UTC2022-04N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-154b0b4de00fa7…
2019-12-13 00:20 UTC2019-12N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-1574a2ff9319b5…
2022-03-09 01:35 UTC2022-03N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-15bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-15782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-1587673890dc5c…
2021-03-12 10:30 UTC2021-03N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-155aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-158869cabd3fbd…
2020-11-12 02:37 UTC2020-11N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-15c0c555d07b60…
2019-12-14 00:12 UTC2019-12N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-153f01610625f2…
2019-09-15 20:21 UTC2019-09N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-15b00525d2431f…
2019-07-19 19:46 UTC2019-07N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-15ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-156a51e52b5d6a…
2024-02-18 07:12 UTC2024-02N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-151c564ffb4f44…
2023-12-20 04:57 UTC2023-12N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-15ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-15a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-159b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-15a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-153f0d92c62455…
2023-05-13 08:27 UTC2023-05N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-15053a50430f4f…
2023-01-26 05:58 UTC2023-01N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-153bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-153a93d1ddd44b…
2022-10-28 04:53 UTC2022-10N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-15f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09N021083-001RAPAMUNE1MG/MLSOLUTION / ORALAARLD, RS1999-09-15e64feba35796…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 2 · 42 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-08-18 06:07:402026-07N021083-001AA1caaa826d4ba7…
2026-02-19 14:30 UTC2026-02N021083-001AA1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N021083-001AA131067a03dcf5…
2025-08-23 18:47 UTC2025-08N021083-001AA16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N021083-001AA1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N021083-001AA1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N021083-001AA103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N021083-001AA12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N021083-001AA15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N021083-001AA1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N021083-001AA1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N021083-001AA179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N021083-001AA1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N021083-001AA11e350fbaab3a…
2024-05-31 18:47 UTC2024-05N021083-001AA18072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N021083-001AA15c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04N021083-001AA15d02ea3f76ae…
2022-04-04 05:41 UTC2022-04N021083-001AA14b0b4de00fa7…
2019-12-13 00:20 UTC2019-12N021083-001AA174a2ff9319b5…
2022-03-09 01:35 UTC2022-03N021083-001AA1bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12N021083-001AA1782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N021083-001AA187673890dc5c…
2021-03-12 10:30 UTC2021-03N021083-001AA15aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12N021083-001AA18869cabd3fbd…
2020-11-12 02:37 UTC2020-11N021083-001AA1c0c555d07b60…
2019-12-14 00:12 UTC2019-12N021083-001AA13f01610625f2…
2019-09-15 20:21 UTC2019-09N021083-001AA1b00525d2431f…
2019-07-19 19:46 UTC2019-07N021083-001AA1ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03N021083-001AA16a51e52b5d6a…
2024-02-18 07:12 UTC2024-02N021083-001AA11c564ffb4f44…
2023-12-20 04:57 UTC2023-12N021083-001AA1ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11N021083-001AA1a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10N021083-001AA19b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07N021083-001AA1a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06N021083-001AA13f0d92c62455…
2023-05-13 08:27 UTC2023-05N021083-001AA1053a50430f4f…
2023-01-26 05:58 UTC2023-01N021083-001AA13bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11N021083-001AA13a93d1ddd44b…
2022-10-28 04:53 UTC2022-10N021083-001AA1f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09N021083-001AA1e64feba35796…

Observed Orange Book exclusivity history#

Captured, Edition, Application-product table
CapturedEditionApplication-productExclusivity codeExpirationSource SHA-256
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N021083-001ODE-922022-05-285c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04N021083-001ODE-922022-05-285d02ea3f76ae…
2022-04-04 05:41 UTC2022-04N021083-001ODE-922022-05-284b0b4de00fa7…
2019-12-13 00:20 UTC2019-12N021083-001ODE-922022-05-2874a2ff9319b5…
2022-03-09 01:35 UTC2022-03N021083-001ODE-922022-05-28bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12N021083-001ODE-922022-05-28782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N021083-001ODE-922022-05-2887673890dc5c…
2021-03-12 10:30 UTC2021-03N021083-001ODE-922022-05-285aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12N021083-001ODE-922022-05-288869cabd3fbd…
2020-11-12 02:37 UTC2020-11N021083-001ODE-922022-05-28c0c555d07b60…
2019-12-14 00:12 UTC2019-12N021083-001ODE-922022-05-283f01610625f2…
2019-09-15 20:21 UTC2019-09N021083-001ODE-922022-05-28b00525d2431f…
2019-07-19 19:46 UTC2019-07N021083-001ODE-922022-05-28ea99ee380514…
2023-01-26 05:58 UTC2023-01N021083-001ODE-922022-05-283bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11N021083-001ODE-922022-05-283a93d1ddd44b…
2022-10-28 04:53 UTC2022-10N021083-001ODE-922022-05-28f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09N021083-001ODE-922022-05-28e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07N021083-001ODE-922022-05-28cb3db0bc1861…

Additional Listing Data#

Finished product
Yes
Brand name base
Sirolimus
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
SIROLIMUS1 mg/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
W36ZG6FT64Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
314230Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
384cb547-55a4-47fc-a0a6-054c18a51b84Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
e68235d1-1e8b-9d8c-fddb-764b8b692c25Product name720250331
9344cc31-0398-4e2f-a65e-a24a0de47fc4Product name120230103
741e13fe-61d8-4a4c-8c27-eb206b28f1bfProduct name120220613

FDA-Initiated Inactive NDC Indexing#

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
59762-1205-4Sirolimus60 mL in 1 BOTTLE, GLASSSOLUTION6017
59762-1205-4Sirolimus1 in 1 CARTONSOLUTION117
59762-1205-6Sirolimus1 in 1 KITSOLUTION117

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
59762-1205-4ML - Milliliter59762-1205e44188b9-4bd1-4d4f-acac-d3f3eb44ffbf12021-06-02
59762-1205-6ML - Milliliter59762-12056f8b1813-ce03-4645-b869-cf572f6ba77e12019-08-06

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
59762-1205SIROLIMUS SOLUTION [MYLAN PHARMACEUTICALS INC.]17Current NDC, Legacy NDC, 3 package rows20250529_384cb547-55a4-47fc-a0a6-054c18a51b84.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
SirolimusSIROLIMUSMylan Pharmaceuticals Inc.384cb547-55a4-47fc-a0a6-054c18a51b842025-05-27Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (NDA): 021083
application number: NDA021083
ndc (product): 59762-1205

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
314230sirolimus 1 MG in 1 mL Oral SolutionPSN384cb547-55a4-47fc-a0a6-054c18a51b8417
314230sirolimus 1 MG/ML Oral SolutionSCD384cb547-55a4-47fc-a0a6-054c18a51b8417
314230sirolimus 1 MG per 1 ML Oral SolutionSY384cb547-55a4-47fc-a0a6-054c18a51b8417

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
59762-1205-45976212050460 mL in 1 BOTTLE, GLASS60 mlHistorical
59762-1205-6597621205061 CARTON in 1 KIT (59762-1205-6) / 1 BOTTLE, GLASS in 1 CARTON (59762-1205-4) / 60 mL in 1 BOTTLE, GLASS1 carton2019-07-220000-00-00NoNoCurrent